Rap guanine nucleotide exchange factor 4
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Rap guanine nucleotide exchange factor 4

Adenylate cyclase type 10
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 10

Adenylate cyclase type 10
type: ProteinReference
xref: Reference/UniProt Q96PN6
organism: BiologicalState67

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState67

L type Calcium channel
type: Complex
component stoichiometry: Protein/2712 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-2

Protein kinase A
type: Complex
component stoichiometry: Protein/1315 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3359 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3358 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1990 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1134 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3357 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

Oxidative Phosphorylation (Homo Sapiens
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116856
pathway component: SubPathwayInteraction116856
name: SubPathway

direct_interaction
type: InteractionVocabulary

Protein/1134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000639
type: UnificationXref
id: CL:0000639
db: CELL TYPE ONTOLOGY

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736
organism: BiologicalState67

GLP-1-(9-36) amide
type: SmallMoleculeReference
chemical formula: C16H32O2
molecular weight: 256.24023
structure: ChemicalStructure/PW C112790

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116855
pathway component: SubPathwayInteraction116855
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Glucagon-like peptide 1 receptor
type: ProteinReference
xref: Reference/UniProt P43220
organism: BiologicalState67

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase catalytic subunit beta

TransportCatalysis4857
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport13827
control type: ACTIVATION

Glucagon-like peptide 1
type: SmallMoleculeReference
xref: Reference/PubChem-compound 16135499
chemical formula: C149H226N40O45
molecular weight: 3295.6626
structure: ChemicalStructure/PW C104577

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Interaction3762
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Rap guanine nucleotide exchange factor 4
participant: Rap guanine nucleotide exchange factor 4
participant: cAMP

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

ATP-binding cassette sub-family C member 8
type: ProteinReference
xref: Reference/UniProt Q09428

Rap guanine nucleotide exchange factor 4
type: Protein
cellular location: Cytoplasm
entity reference: Rap guanine nucleotide exchange factor 4

Beta cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000639

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Interaction3760
type: MolecularInteraction
interaction type: direct_interaction
name: Potassium activates L type Calcium channel
participant: Potassium
participant: L type Calcium channel

Protein/2720 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Interaction3761
type: MolecularInteraction
interaction type: direct_interaction
name: Sitagliptin inhibits Dipeptidyl peptidase 4
participant: Sitagliptin
participant: Dipeptidyl peptidase 4

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Insulin
type: Protein
cellular location: Extracellular Space
entity reference: Insulin

Interaction3768
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A inhibits ATP-binding cassette sub-family C member 8
participant: Protein kinase A
participant: ATP-binding cassette sub-family C member 8

Interaction3769
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Insulin
participant: Insulin
participant: Calcium

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Transport143
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Pancreas, Beta cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport142
type: Transport
participant stoichiometry: Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Pancreas, Beta cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

3.4.14.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C112790 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104577 Extracellular Space/Stoichiometry/1.0
right: GLP-1-(9-36) amide
spontaneous: false
EC number: 3.4.14.5
left: Glucagon-like peptide 1
name: Glucagon-like peptide 1 → GLP-1-(9-36) amide
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/UniProt Q96PN6
type: UnificationXref
id: Q96PN6
db: UniProt

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Glucagon-like peptide 1
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Glucagon-like peptide 1

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Protein/2712 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/ChemSpider 3571948
type: UnificationXref
id: 3571948
db: ChemSpider

ChemicalStructure/PW C104577
type: ChemicalStructure
structure format: SMILES

TransportCatalysis105
type: Catalysis
controller: ATP-binding cassette sub-family C member 8
controlled: Transport143
control type: ACTIVATION

TransportCatalysis104
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport142
control type: ACTIVATION

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Protein/5775 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 2.0

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Protein/1990 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Protein/3359 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

BiologicalState67
type: BioSource
cell type: Beta cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Pancreas, Beta cell
tissue: Pancreas

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Protein/3358 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000988
type: UnificationXref
id: BTO:0000988
db: BRENDA TISSUE ONTOLOGY

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

TransportCatalysis176
type: Catalysis
controller: L type Calcium channel
controlled: Transport210
control type: ACTIVATION

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Protein/5775 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 2.0

Insulin
type: Protein
cellular location: Cytosol
entity reference: Insulin

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Protein/1315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Protein/1262 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Protein/3357 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Protein/3357 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Interaction3770
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A activates L type Calcium channel
participant: Protein kinase A
participant: L type Calcium channel

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Interaction3771
type: MolecularInteraction
interaction type: direct_interaction
name: Rap guanine nucleotide exchange factor 4 activates Ryanodine receptor 2
participant: Rap guanine nucleotide exchange factor 4
participant: Ryanodine receptor 2

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ProteinComplex/999 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Glucagon-like peptide 1 receptor
type: Protein
cellular location: Cell Membrane
entity reference: Glucagon-like peptide 1 receptor
name: SubPathwayInput

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/HMDB HMDB0015390
type: UnificationXref
id: HMDB0015390
db: HMDB

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

ATP-binding cassette sub-family C member 8
type: Protein
cellular location: Cytosol
entity reference: ATP-binding cassette sub-family C member 8

Insulin
type: Complex
component stoichiometry: Protein/5775 Extracellular Space/Stoichiometry/2.0
cellular location: Extracellular Space
component: Insulin

Protein kinase A
type: Complex
component stoichiometry: Protein/1990 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1315 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3357 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3358 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3359 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1134 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Protein/3359 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState67

Interaction1026
type: MolecularInteraction
interaction type: direct_interaction
name: Glucagon-like peptide 1 activates Glucagon-like peptide 1 receptor
participant: Glucagon-like peptide 1
participant: Glucagon-like peptide 1 receptor

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/UniProt P01308
type: UnificationXref
id: P01308
db: UniProt

Ryanodine receptor 2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Ryanodine receptor 2

Sitagliptin
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0015390
xref: Reference/ChEBI CHEBI 40237
xref: Reference/PubChem-compound 4369359
xref: Reference/ChemSpider 3571948
xref: Reference/CAS 486460-32-6
chemical formula: C16H15F6N5O
molecular weight: 407.11807
structure: ChemicalStructure/PW C009667

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt P27487
type: UnificationXref
id: P27487
db: UniProt

Reference/ChEBI CHEBI 40237
type: UnificationXref
id: CHEBI:40237
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Insulin
type: Complex
component stoichiometry: Protein/5775 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Insulin

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Protein/3195 Endoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Compound/PW C104577 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucagon-like peptide 1
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState67

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate
name: SubPathwayOutput

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Gs protein signaling
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116847
pathway component: SubPathwayInteraction116847
name: SubPathway

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

ChemicalStructure/PW C112790
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(O)=O

Reaction110775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Pyrophosphate
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

GLP-1-(9-36) amide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: GLP-1-(9-36) amide

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Protein/1990 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Glucagon-like peptide 1
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Glucagon-like peptide 1

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Sitagliptin
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sitagliptin

Adenylate cyclase type 10
type: Protein
cellular location: Cell Membrane
entity reference: Adenylate cyclase type 10
name: SubPathwayOutput

ChemicalStructure/PW C009667
type: ChemicalStructure
structure format: SMILES

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayInput

Reference/PubChem-compound 4369359
type: UnificationXref
id: 4369359
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Pancreas
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000988

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Protein/2706 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Compound/PW C112790 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: GLP-1-(9-36) amide
stoichiometric coefficient: 1.0

Transport13827
type: Transport
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Pancreas, Beta cell, Endoplasmic Reticulum to Homo sapiens, Pancreas, Beta cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Protein/1134 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

ReactionCatalysis207377
type: Catalysis
controller: Dipeptidyl peptidase 4
controlled: 3.4.14.5
control type: ACTIVATION

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Protein/3358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

ReactionCatalysis101096
type: Catalysis
controller: Adenylate cyclase type 10
controlled: Reaction110775
control type: ACTIVATION

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState67

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState67

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Insulin
type: Complex
component stoichiometry: Protein/5775 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Insulin

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/UniProt Q8WZA2
type: UnificationXref
id: Q8WZA2
db: UniProt

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState67

Insulin
type: ProteinReference
xref: Reference/UniProt P01308
organism: BiologicalState67

Reference/UniProt P43220
type: UnificationXref
id: P43220
db: UniProt

Reference/PubChem-compound 16135499
type: UnificationXref
id: 16135499
db: PubChem-compound

Interaction2835
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Protein kinase A
participant: Protein kinase A
participant: cAMP

Protein/1315 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Insulin
type: Protein
cellular location: Cytoplasm
entity reference: Insulin

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Reference/SMPDB SMP0124724
type: UnificationXref
id: SMP0124724
db: SMPDB

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Dipeptidyl peptidase 4
type: Protein
cellular location: Extracellular Space
entity reference: Dipeptidyl peptidase 4

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/PathWhiz PW126210
type: UnificationXref
id: PW126210
db: PathWhiz

Reference/CAS 486460-32-6
type: UnificationXref
id: 486460-32-6
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Potassium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Potassium

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Sitagliptin Action Pathway
type: Pathway
pathway order: PathwaySubPathway/116847
pathway order: PathwaySubPathway/116856
pathway order: PathwayTransport/2501627
pathway order: PathwayEnzymeReaction/2501587
pathway order: PathwayEnzymeReaction/2501585
pathway order: PathwayTransport/2501623
pathway order: PathwayTransport/2501634
pathway order: PathwayTransport/2501630
pathway order: PathwayTransport/2501621
pathway order: PathwayInteraction/3719
pathway order: PathwayInteraction/2835
pathway order: PathwayInteraction/3769
pathway order: PathwayInteraction/3768
pathway order: PathwayInteraction/1026
pathway order: PathwayInteraction/3762
pathway order: PathwayInteraction/3761
pathway order: PathwayInteraction/3760
pathway order: PathwayInteraction/3771
pathway order: PathwayInteraction/3770
pathway order: PathwaySubPathway/116855
pathway component: TransportCatalysis4857
pathway component: Transport211
pathway component: Transport210
pathway component: Interaction3762
pathway component: Interaction1026
pathway component: Interaction3760
pathway component: Interaction3761
pathway component: Interaction2835
pathway component: Oxidative Phosphorylation (Homo Sapiens
pathway component: Interaction3768
pathway component: Interaction3769
pathway component: Transport143
pathway component: TransportCatalysis176
pathway component: Transport142
pathway component: 3.4.14.5
pathway component: Transport13827
pathway component: Interaction3770
pathway component: Interaction3771
pathway component: ReactionCatalysis207377
pathway component: Glycolysis
pathway component: Gs protein signaling
pathway component: ReactionCatalysis101096
pathway component: TransportCatalysis105
pathway component: TransportCatalysis104
pathway component: Interaction3719
pathway component: Reaction110775
xref: Reference/SMPDB SMP0124724
xref: Reference/PathWhiz PW126210
organism: Homo sapiens

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState67

Rap guanine nucleotide exchange factor 4
type: ProteinReference
xref: Reference/UniProt Q8WZA2
organism: BiologicalState67

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

ProteinComplex/999 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

SubPathwayInteraction116855
type: Interaction
name: SubPathway116855Reaction
name: SubPathwayReaction
participant: D-Glucose

SubPathwayInteraction116856
type: Interaction
name: SubPathway116856Reaction
name: SubPathwayReaction
participant: Adenosine triphosphate

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Dipeptidyl peptidase 4
type: ProteinReference
xref: Reference/UniProt P27487
organism: Homo sapiens

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q09428
type: UnificationXref
id: Q09428
db: UniProt

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

SubPathwayInteraction116847
type: Interaction
name: SubPathwayReaction
name: SubPathway116847Reaction
participant: Glucagon-like peptide 1 receptor
participant: Adenylate cyclase type 10

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

ATP-binding cassette sub-family C member 8
type: Protein
entity reference: ATP-binding cassette sub-family C member 8

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Transport211
type: Transport
participant stoichiometry: ProteinComplex/999 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/999 Cytoplasm/Stoichiometry/1.0
right: Insulin
spontaneous: false
left: Insulin
name: Insulin (→) Transport: Homo sapiens, Pancreas, Beta cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Transport210
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Pancreas, Beta cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Protein/5775 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 2.0

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

Protein/1262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

D-Glucose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Glucose

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Endoplasmic Reticulum/Stoichiometry/4.0
cellular location: Endoplasmic Reticulum
component: Ryanodine receptor 2

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Interaction3719
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine triphosphate inhibits ATP-binding cassette sub-family C member 8
participant: Adenosine triphosphate
participant: ATP-binding cassette sub-family C member 8