Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 6029
type: UnificationXref
id: 6029
db: PubChem-compound

ReactionCatalysis1208
type: Catalysis
controller: CAD protein
controlled: Reaction1487
control type: ACTIVATION

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ReactionCatalysis207418
type: Catalysis
controller: Cytosolic 5'-nucleotidase 1B
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis207417
type: Catalysis
controller: Uridine 5'-monophosphate synthase
controlled: Reaction217984
control type: ACTIVATION

ReactionCatalysis207416
type: Catalysis
controller: Uridine 5'-monophosphate synthase
controlled: 2.4.2.10
control type: ACTIVATION

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

ReactionCatalysis207415
type: Catalysis
controller: Dihydroorotate dehydrogenase (quinone), mitochondrial
controlled: 1.3.5.2
control type: ACTIVATION

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

ReactionCatalysis207414
type: Catalysis
controller: CAD protein
controlled: Reaction217980
control type: ACTIVATION

ReactionCatalysis207413
type: Catalysis
controller: CAD protein
controlled: Reaction217978
control type: ACTIVATION

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Reference/UniProt Q02127
type: UnificationXref
id: Q02127
db: UniProt

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/UniProt P27708
type: UnificationXref
id: P27708
db: UniProt

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reaction1487
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Carbamoyl phosphate
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
left: L-Glutamine
left: Adenosine triphosphate
left: Hydrogen carbonate
left: Water
name: 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Cytosolic 5'-nucleotidase 1B
type: ProteinReference
xref: Reference/UniProt Q96P26
organism: BiologicalState26

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Neutral amino acid transporter B(0)
type: Protein
entity reference: Neutral amino acid transporter B(0)

Uridine 5'-monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-monophosphate

Compound/PW C000202 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine
stoichiometric coefficient: 1.0

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Orotate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Orotate

Compound/PW C001632 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

5-Phospho-alpha-D-ribose 1-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Phospho-alpha-D-ribose 1-diphosphate

Compound/PW C000862 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 272
type: UnificationXref
id: 272
db: ChemSpider

Reaction217978
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: N-Carbamoyl-L-aspartate
spontaneous: false
left: Carbamoyl phosphate
left: L-Aspartic acid
name: Carbamoyl phosphate + L-Aspartic acid ↔ N-Carbamoyl-L-aspartate + Phosphate
conversion direction: REVERSIBLE

Reference/KEGG Compound C00105
type: UnificationXref
id: C00105
db: KEGG Compound

Reference/PubChem-compound 6030
type: UnificationXref
id: 6030
db: PubChem-compound

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Orotate
type: SmallMolecule
cellular location: Cytosol
entity reference: Orotate

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Metabolism and Physiological Effects of Uridine
type: Pathway
pathway order: PathwayEnzymeReaction/2502856
pathway order: PathwayEnzymeReaction/2502855
pathway order: PathwayTransport/2502844
pathway order: PathwayTransport/2502843
pathway order: PathwayTransport/2502857
pathway order: PathwayEnzymeReaction/2502839
pathway order: PathwayTransport/2502840
pathway order: PathwayEnzymeReaction/2502838
pathway order: PathwayEnzymeReaction/2502849
pathway order: PathwayEnzymeReaction/2502837
pathway order: PathwayTransport/2502842
pathway order: PathwayEnzymeReaction/2502836
pathway order: PathwayTransport/2502841
pathway order: PathwaySubPathway/117098
pathway component: 2.4.2.10
pathway component: Reaction217980
pathway component: Transport13859
pathway component: 1.3.5.2
pathway component: Reaction217984
pathway component: 3.1.3.5
pathway component: ReactionCatalysis1208
pathway component: TransportCatalysis4887
pathway component: Reaction217978
pathway component: TransportCatalysis4885
pathway component: TransportCatalysis4883
pathway component: TransportCatalysis4884
pathway component: ReactionCatalysis207418
pathway component: ReactionCatalysis207417
pathway component: ReactionCatalysis207416
pathway component: ReactionCatalysis207415
pathway component: ReactionCatalysis207414
pathway component: ReactionCatalysis207413
pathway component: Transport13863
pathway component: Transport13865
pathway component: Transport13860
pathway component: Transport13862
pathway component: Transport13861
pathway component: TransportCatalysis4882
pathway component: Kidney disease
pathway component: Reaction1487
xref: Reference/SMPDB SMP0124871
xref: Reference/PathWhiz PW126375
organism: Homo sapiens

Compound/PW C001860 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: Reference/UniProt Q02127
organism: BiologicalState26

ChemicalStructure/PW C000202
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/HMDB HMDB0001096
type: UnificationXref
id: HMDB0001096
db: HMDB

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

ChemicalStructure/PW C108936
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@](CC(O)=O)(NC(O)=N)C(O)=O

5-Phospho-alpha-D-ribose 1-diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3419
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C108758

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Carbamoyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 278
xref: Reference/BioCyc CARBAMOYL-P
xref: Reference/ChemSpider 272
xref: Reference/HMDB HMDB0001096
xref: Reference/CAS 590-55-6
xref: Reference/KEGG Compound C00169
xref: Reference/ChEBI CHEBI 17672
chemical formula: CH4NO5P
molecular weight: 140.98271
structure: ChemicalStructure/PW C000862

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Dihydroorotate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dihydroorotate

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Cytosolic 5'-nucleotidase 1B
type: Protein
cellular location: Cytosol
entity reference: Cytosolic 5'-nucleotidase 1B

Compound/PW C000500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C108944
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC(O)=NC(O)=N1

ChemicalStructure/PW C108943
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@]1(CC(O)=NC(O)=N1)C(O)=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Protein/2335 Cytosol/Stoichiometry/6.0
type: Stoichiometry
physical entity: CAD protein
stoichiometric coefficient: 6.0

ChemicalStructure/PW C108946
type: ChemicalStructure
structure format: SMILES

Uridine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000288
xref: Reference/CAS 58-97-9
xref: Reference/KEGG Compound C00105
xref: Reference/PubChem-compound 6030
xref: Reference/BioCyc UMP
xref: Reference/ChEBI CHEBI 16695
xref: Reference/ChemSpider 5808
chemical formula: C9H13N2O9P
molecular weight: 324.03586
structure: ChemicalStructure/PW C000194

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C000194 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

CAD protein
type: ProteinReference
xref: Reference/UniProt P27708
organism: BiologicalState26

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Compound/PW C108944 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Transport13863
type: Transport
participant stoichiometry: Compound/PW C108944 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108944 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Orotate
spontaneous: false
left: Orotate
name: Orotate (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Inner Membrane to Homo sapiens, Liver, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc URIDINE
type: UnificationXref
id: URIDINE
db: BioCyc

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Transport13865
type: Transport
participant stoichiometry: Compound/PW C000202/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000202 Cytosol/Stoichiometry/1.0
right: Uridine
spontaneous: false
left: Uridine
name: Uridine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport13860
type: Transport
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport13862
type: Transport
participant stoichiometry: Compound/PW C108943 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108943 Mitochondrion/Stoichiometry/1.0
right: Dihydroorotate
spontaneous: false
left: Dihydroorotate
name: Dihydroorotate (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Mitochondrion
conversion direction: LEFT_TO_RIGHT

Transport13861
type: Transport
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Compound/PW C000414 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Transport13859
type: Transport
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/PubChem-compound 3419
type: UnificationXref
id: 3419
db: PubChem-compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 16704
type: UnificationXref
id: CHEBI:16704
db: ChEBI

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Sodium/nucleoside cotransporter 1
type: Protein
entity reference: Sodium/nucleoside cotransporter 1

Neutral amino acid transporter B(0)
type: ProteinReference
xref: Reference/UniProt Q15758

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Uridine 5'-monophosphate synthase
type: Protein
cellular location: Cytosol
entity reference: Uridine 5'-monophosphate synthase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Dihydroorotate dehydrogenase (quinone), mitochondrial

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Unknown
type: Protein
entity reference: Unknown

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CARBAMOYL-P
type: UnificationXref
id: CARBAMOYL-P
db: BioCyc

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Compound/PW C000202/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine
stoichiometric coefficient: 1.0

Uridine
type: SmallMolecule
entity reference: Uridine
name: SubPathwayInput

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/KEGG Compound C00169
type: UnificationXref
id: C00169
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-97-9
type: UnificationXref
id: 58-97-9
db: CAS

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

ChemicalStructure/PW C000862
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)OP(O)(O)=O

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Hydroquinone

Compound/PW C108943 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroorotate
stoichiometric coefficient: 1.0

Uridine
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine

ChemicalStructure/PW C108758
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

SubPathwayInteraction117098
type: Interaction
name: SubPathwayReaction
name: SubPathway117098Reaction
participant: Uridine

Compound/PW C108936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Carbamoyl-L-aspartate
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00299
type: UnificationXref
id: C00299
db: KEGG Compound

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

N-Carbamoyl-L-aspartate
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Carbamoyl-L-aspartate

Reference/CAS 590-55-6
type: UnificationXref
id: 590-55-6
db: CAS

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/UniProt O00337
type: UnificationXref
id: O00337
db: UniProt

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0000288
type: UnificationXref
id: HMDB0000288
db: HMDB

Compound/PW C001034 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reference/CAS 58-96-8
type: UnificationXref
id: 58-96-8
db: CAS

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C108946 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotidine 5'-phosphate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

2.4.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108758 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108944 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108946 Cytosol/Stoichiometry/1.0
right: Orotidine 5'-phosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.4.2.10
left: 5-Phospho-alpha-D-ribose 1-diphosphate
left: Orotate
name: 5-Phospho-alpha-D-ribose 1-diphosphate + Orotate ↔ Orotidine 5'-phosphate + Pyrophosphate
conversion direction: REVERSIBLE

Reaction217980
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108943 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Dihydroorotate
right: Water
spontaneous: false
left: N-Carbamoyl-L-aspartate
name: N-Carbamoyl-L-aspartate ↔ Dihydroorotate + Water
conversion direction: REVERSIBLE

1.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001860 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108943 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108944 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Hydroquinone
right: Orotate
spontaneous: false
EC number: 1.3.5.2
left: Dihydroorotate
left: Quinone
name: Dihydroorotate + Quinone ↔ Hydroquinone + Orotate
conversion direction: REVERSIBLE

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Quinone
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Quinone

Reaction217984
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108946 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Uridine 5'-monophosphate
spontaneous: false
left: Orotidine 5'-phosphate
name: Orotidine 5'-phosphate ↔ Carbon dioxide + Uridine 5'-monophosphate
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 16695
type: UnificationXref
id: CHEBI:16695
db: ChEBI

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000202 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Uridine
spontaneous: false
EC number: 3.1.3.5
left: Uridine 5'-monophosphate
left: Water
name: Uridine 5'-monophosphate + Water → Phosphate + Uridine
conversion direction: LEFT_TO_RIGHT

CAD protein
type: Protein
cellular location: Cytosol
entity reference: CAD protein

Uridine 5'-monophosphate synthase
type: ProteinReference
xref: Reference/UniProt P11172
organism: BiologicalState26

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChemSpider 5807
type: UnificationXref
id: 5807
db: ChemSpider

Sodium/nucleoside cotransporter 1
type: ProteinReference
xref: Reference/UniProt O00337

Compound/PW C108944 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5808
type: UnificationXref
id: 5808
db: ChemSpider

Reference/HMDB HMDB0000296
type: UnificationXref
id: HMDB0000296
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/PubChem-compound 278
type: UnificationXref
id: 278
db: PubChem-compound

TransportCatalysis4887
type: Catalysis
controller: Sodium/nucleoside cotransporter 1
controlled: Transport13865
control type: ACTIVATION

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

TransportCatalysis4885
type: Catalysis
controller: Unknown
controlled: Transport13863
control type: ACTIVATION

TransportCatalysis4883
type: Catalysis
controller: Neutral amino acid transporter B(0)
controlled: Transport13861
control type: ACTIVATION

TransportCatalysis4884
type: Catalysis
controller: Unknown
controlled: Transport13862
control type: ACTIVATION

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Unknown
type: ProteinReference

Dihydroorotate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroorotate

Reference/ChEBI CHEBI 17672
type: UnificationXref
id: CHEBI:17672
db: ChEBI

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Compound/PW C108758 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Phospho-alpha-D-ribose 1-diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C108943 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroorotate
stoichiometric coefficient: 1.0

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

TransportCatalysis4882
type: Catalysis
controller: Neutral amino acid transporter B(0)
controlled: Transport13860
control type: ACTIVATION

Reference/UniProt P11172
type: UnificationXref
id: P11172
db: UniProt

Orotate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Orotate

N-Carbamoyl-L-aspartate
type: SmallMoleculeReference
chemical formula: C5H8N2O5
molecular weight: 176.04332
structure: ChemicalStructure/PW C108936

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Uridine
type: SmallMoleculeReference
xref: Reference/CAS 58-96-8
xref: Reference/ChEBI CHEBI 16704
xref: Reference/PubChem-compound 6029
xref: Reference/ChemSpider 5807
xref: Reference/BioCyc URIDINE
xref: Reference/HMDB HMDB0000296
xref: Reference/KEGG Compound C00299
chemical formula: C9H12N2O6
molecular weight: 244.06953
structure: ChemicalStructure/PW C000202

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/UniProt Q96P26
type: UnificationXref
id: Q96P26
db: UniProt

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

Carbamoyl phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbamoyl phosphate

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Compound/PW C108944 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotate
stoichiometric coefficient: 1.0

Dihydroorotate
type: SmallMoleculeReference
chemical formula: C5H6N2O4
molecular weight: 158.03276
structure: ChemicalStructure/PW C108943

Orotate
type: SmallMoleculeReference
chemical formula: C5H4N2O4
molecular weight: 156.0171
structure: ChemicalStructure/PW C108944

ChemicalStructure/PW C000194
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q15758
type: UnificationXref
id: Q15758
db: UniProt

Orotidine 5'-phosphate
type: SmallMoleculeReference
chemical formula: C10H13N2O11P
molecular weight: 368.0257
structure: ChemicalStructure/PW C108946

Orotidine 5'-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Orotidine 5'-phosphate

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/SMPDB SMP0124871
type: UnificationXref
id: SMP0124871
db: SMPDB

Reference/BioCyc UMP
type: UnificationXref
id: UMP
db: BioCyc

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

CAD protein
type: Complex
component stoichiometry: Protein/2335 Cytosol/Stoichiometry/6.0
cellular location: Cytosol
component: CAD protein

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Dihydroorotate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Dihydroorotate

Compound/PW C108943 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroorotate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW126375
type: UnificationXref
id: PW126375
db: PathWhiz

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Kidney disease
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117098
pathway component: SubPathwayInteraction117098
name: SubPathway