Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 5605
type: UnificationXref
id: 5605
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

D-amino-acid oxidase
type: Protein
cellular location: Peroxisome
entity reference: D-amino-acid oxidase

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Succinic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Succinic acid

Reference/ChEBI CHEBI 27391
type: UnificationXref
id: CHEBI:27391
db: ChEBI

Unknown
type: ProteinReference
organism: BiologicalState26

Reference/HMDB HMDB0002273
type: UnificationXref
id: HMDB0002273
db: HMDB

Reference/HMDB HMDB0006511
type: UnificationXref
id: HMDB0006511
db: HMDB

4-Hydroxyproline
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Hydroxyproline

Protein/2104 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase
stoichiometric coefficient: 1.0

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Reference/KEGG Compound C00209
type: UnificationXref
id: C00209
db: KEGG Compound

Oxalic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalic acid

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Aspartate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P00505
organism: BiologicalState26

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P30038
organism: BiologicalState26

4-Hydroxy-2-oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 4-Hydroxy-2-oxoglutaric acid

Reference/BioCyc PRO
type: UnificationXref
id: PRO
db: BioCyc

Reference/ChEBI CHEBI 17203
type: UnificationXref
id: CHEBI:17203
db: ChEBI

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Sodium- and chloride-dependent transporter XTRP3
type: Protein
entity reference: Sodium- and chloride-dependent transporter XTRP3

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Transport13893
type: Transport
participant stoichiometry: Compound/PW C000031/Stoichiometry/1.0
right: Ascorbic acid
spontaneous: false
left: Ascorbic acid
name: Ascorbic acid (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport13892
type: Transport
participant stoichiometry: Compound/PW C000031/Stoichiometry/1.0
right: Ascorbic acid
spontaneous: false
left: Ascorbic acid
name: Ascorbic acid (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Compound/PW C000106 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Proline
stoichiometric coefficient: 1.0

Compound/PW C002643 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyproline
stoichiometric coefficient: 1.0

Transport13894
type: Transport
participant stoichiometry: Compound/PW C000031/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
right: Ascorbic acid
spontaneous: false
left: Ascorbic acid
name: Ascorbic acid (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport13891
type: Transport
participant stoichiometry: Compound/PW C001568/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001568 Cytosol/Stoichiometry/1.0
right: Oxalic acid
spontaneous: false
left: Oxalic acid
name: Oxalic acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport13890
type: Transport
participant stoichiometry: Compound/PW C002643 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002643 Cytosol/Stoichiometry/1.0
right: 4-Hydroxyproline
spontaneous: false
left: 4-Hydroxyproline
name: 4-Hydroxyproline (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C001568 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalic acid
stoichiometric coefficient: 1.0

Prolyl 4-hydroxylase (alpha(III)-type)
type: Complex
component stoichiometry: Protein/4317 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/2104 Endoplasmic Reticulum/Stoichiometry/1.0
cellular location: Endoplasmic Reticulum
component: Protein disulfide-isomerase
component: Prolyl 4-hydroxylase subunit alpha-3

Metabolism and Physiological Effects of Oxalic acid
type: Pathway
pathway order: PathwayTransport/2503038
pathway order: PathwayTransport/2503039
pathway order: PathwaySubPathway/117090
pathway order: PathwayEnzymeReaction/2503073
pathway order: PathwayTransport/2503088
pathway order: PathwayTransport/2503069
pathway order: PathwayTransport/2503102
pathway order: PathwayTransport/2503068
pathway order: PathwayTransport/2503101
pathway order: PathwayEnzymeReaction/2503077
pathway order: PathwayTransport/2503085
pathway order: PathwayTransport/2503084
pathway order: PathwayEnzymeReaction/2503079
pathway order: PathwayTransport/2503080
pathway order: PathwayTransport/2503083
pathway order: PathwayTransport/2503060
pathway order: PathwayEnzymeReaction/2503072
pathway order: PathwayEnzymeReaction/2503104
pathway order: PathwayEnzymeReaction/2503106
pathway order: PathwayEnzymeReaction/2503107
pathway order: PathwayTransport/2503103
pathway order: PathwayEnzymeReaction/2503041
pathway order: PathwayTransport/2503036
pathway order: PathwayEnzymeReaction/2503064
pathway order: PathwayEnzymeReaction/2503086
pathway order: PathwaySubPathway/117089
pathway order: PathwaySubPathway/117087
pathway order: PathwayTransport/2503091
pathway order: PathwayTransport/2503071
pathway order: PathwayTransport/2503090
pathway component: TransportCatalysis4911
pathway component: TransportCatalysis4912
pathway component: TransportCatalysis4910
pathway component: 1.4.3.3
pathway component: Reaction218036
pathway component: Transport13875
pathway component: Transport13874
pathway component: TransportCatalysis4913
pathway component: Transport13876
pathway component: ReactionCatalysis207444
pathway component: ReactionCatalysis207443
pathway component: ReactionCatalysis207442
pathway component: ReactionCatalysis207441
pathway component: ReactionCatalysis207440
pathway component: Reaction218051
pathway component: Reaction218052
pathway component: 4.1.3.16
pathway component: 1.5.5.3
pathway component: Reaction218054
pathway component: Inflammation
pathway component: TransportCatalysis4896
pathway component: TransportCatalysis4897
pathway component: Transport13893
pathway component: Transport13892
pathway component: Transport13894
pathway component: Reaction218066
pathway component: Transport13891
pathway component: Reaction218064
pathway component: Transport13890
pathway component: 2.3.1.85
pathway component: Neurotoxicity
pathway component: Cardiovascular disease
pathway component: TransportCatalysis4901
pathway component: TransportCatalysis4908
pathway component: ReactionCatalysis207439
pathway component: Transport13889
pathway component: TransportCatalysis4909
pathway component: ReactionCatalysis207438
pathway component: TransportCatalysis4906
pathway component: ReactionCatalysis207437
pathway component: TransportCatalysis4907
pathway component: Transport13886
pathway component: TransportCatalysis4905
pathway component: Transport13885
pathway component: TransportCatalysis4902
pathway component: Transport13888
pathway component: ReactionCatalysis207433
pathway component: TransportCatalysis4903
pathway component: Transport13887

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Transport13889
type: Transport
participant stoichiometry: Compound/PW C002643 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002643 Cytosol/Stoichiometry/1.0
right: 4-Hydroxyproline
spontaneous: false
left: 4-Hydroxyproline
name: 4-Hydroxyproline (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 946
type: UnificationXref
id: 946
db: ChemSpider

Transport13886
type: Transport
participant stoichiometry: Compound/PW C000106/Stoichiometry/1.0
right: L-Proline
spontaneous: false
left: L-Proline
name: L-Proline (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Compound/PW C000078 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Transport13885
type: Transport
participant stoichiometry: Compound/PW C000106/Stoichiometry/1.0
right: L-Proline
spontaneous: false
left: L-Proline
name: L-Proline (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Transport13888
type: Transport
participant stoichiometry: Compound/PW C000106 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000106 Cytosol/Stoichiometry/1.0
right: L-Proline
spontaneous: false
left: L-Proline
name: L-Proline (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Cell, Endoplasmic Reticulum Lumen
conversion direction: LEFT_TO_RIGHT

Transport13887
type: Transport
participant stoichiometry: Compound/PW C000106 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000106/Stoichiometry/1.0
right: L-Proline
spontaneous: false
left: L-Proline
name: L-Proline (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport13882
type: Transport
participant stoichiometry: Compound/PW C000075 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000075 Cytosol/Stoichiometry/1.0
right: Glyoxylic acid
spontaneous: false
left: Glyoxylic acid
name: Glyoxylic acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport13881
type: Transport
participant stoichiometry: Compound/PW C000075 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000075 Cytosol/Stoichiometry/1.0
right: Glyoxylic acid
spontaneous: false
left: Glyoxylic acid
name: Glyoxylic acid (←) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Peroxisome
conversion direction: LEFT_TO_RIGHT

Transport13884
type: Transport
participant stoichiometry: Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000075 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Glyoxylic acid
spontaneous: false
left: Glyoxylic acid
name: Glyoxylic acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix to Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Transport13880
type: Transport
participant stoichiometry: Compound/PW C000078 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytosol/Stoichiometry/1.0
right: Glycine
spontaneous: false
left: Glycine
name: Glycine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Peroxisome
conversion direction: LEFT_TO_RIGHT

Compound/PW C108873 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxoglutarate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002070
type: UnificationXref
id: HMDB0002070
db: HMDB

Water
type: SmallMolecule
cellular location: Peroxisome
entity reference: Water

Solute carrier family 23 member 1
type: Protein
entity reference: Solute carrier family 23 member 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Transport13875
type: Transport
participant stoichiometry: Compound/PW C000078/Stoichiometry/1.0
right: Glycine
spontaneous: false
left: Glycine
name: Glycine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport13874
type: Transport
participant stoichiometry: Compound/PW C000078/Stoichiometry/1.0
right: Glycine
spontaneous: false
left: Glycine
name: Glycine (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Compound/PW C000035 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Transport13876
type: Transport
participant stoichiometry: Compound/PW C000078/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytosol/Stoichiometry/1.0
right: Glycine
spontaneous: false
left: Glycine
name: Glycine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Compound/PW C000075 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyoxylic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C04575
type: UnificationXref
id: C04575
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChemSpider 1030
type: UnificationXref
id: 1030
db: ChemSpider

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/UniProt Q7Z4N8
type: UnificationXref
id: Q7Z4N8
db: UniProt

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/CAS 2485-33-8
type: UnificationXref
id: 2485-33-8
db: CAS

Reference/UniProt Q9NR77
type: UnificationXref
id: Q9NR77
db: UniProt

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Compound/PW C000106/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Proline
stoichiometric coefficient: 1.0

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxygen

Compound/PW C001316 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Hydrogen peroxide
type: SmallMolecule
cellular location: Peroxisome
entity reference: Hydrogen peroxide

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

L-Proline
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Proline

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Protein disulfide-isomerase
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Protein disulfide-isomerase

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Protein/4317 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prolyl 4-hydroxylase subunit alpha-3
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00148
type: UnificationXref
id: C00148
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/CAS 298-12-4
type: UnificationXref
id: 298-12-4
db: CAS

Reference/UniProt Q86XE5
type: UnificationXref
id: Q86XE5
db: UniProt

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

Reference/PubChem-compound 760
type: UnificationXref
id: 760
db: PubChem-compound

Reference/KEGG Compound C01127
type: UnificationXref
id: C01127
db: KEGG Compound

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Prolyl 4-hydroxylase subunit alpha-3
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Prolyl 4-hydroxylase subunit alpha-3

Compound/PW C001568/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalic acid
stoichiometric coefficient: 1.0

Peroxisomal membrane protein 2
type: ProteinReference
xref: Reference/UniProt Q9NR77

Reference/ChemSpider 128566
type: UnificationXref
id: 128566
db: ChemSpider

Reference/BioCyc CUPRIZONE
type: UnificationXref
id: CUPRIZONE
db: BioCyc

4-hydroxy-2-oxoglutarate aldolase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q86XE5
organism: BiologicalState26

Hydroxyproline dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q9UF12
organism: BiologicalState26

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/KEGG Compound C00048
type: UnificationXref
id: C00048
db: KEGG Compound

ChemicalStructure/PW C108870
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/UniProt P48029
type: UnificationXref
id: P48029
db: UniProt

Reference/HMDB HMDB0002329
type: UnificationXref
id: HMDB0002329
db: HMDB

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

ChemicalStructure/PW C108873
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Hydroquinone

4-Hydroxyproline
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 4-Hydroxyproline

Compound/PW C001057 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrroline hydroxycarboxylic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001391
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC(=O)C(O)=O)C(O)=O

SubPathwayInteraction117090
type: Interaction
name: SubPathwayReaction
name: SubPathway117090Reaction
participant: Oxalic acid

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Pyrroline hydroxycarboxylic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyrroline hydroxycarboxylic acid

Reference/PubChem-compound 53477844
type: UnificationXref
id: 53477844
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Aspartate aminotransferase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aspartate aminotransferase, mitochondrial

Hydroxyproline dehydrogenase
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Hydroxyproline dehydrogenase

Reference/BioCyc GLYOX
type: UnificationXref
id: GLYOX
db: BioCyc

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

D-amino-acid oxidase
type: ProteinReference
xref: Reference/UniProt P14920
organism: BiologicalState26

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001369
type: UnificationXref
id: HMDB0001369
db: HMDB

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

2,3-Diketo-L-gulonate
type: SmallMolecule
cellular location: Cytosol
entity reference: 2,3-Diketo-L-gulonate

Solute carrier organic anion transporter family member 2B1
type: ProteinReference
xref: Reference/UniProt O94956

SubPathwayInteraction117087
type: Interaction
name: SubPathway117087Reaction
name: SubPathwayReaction
participant: Oxalic acid

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

SubPathwayInteraction117089
type: Interaction
name: SubPathway117089Reaction
name: SubPathwayReaction
participant: Oxalic acid

Reference/KEGG Compound C01157
type: UnificationXref
id: C01157
db: KEGG Compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Reference/UniProt Q9UHI7
type: UnificationXref
id: Q9UHI7
db: UniProt

Reference/HMDB HMDB0000162
type: UnificationXref
id: HMDB0000162
db: HMDB

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

L-Proline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17203
xref: Reference/ChemSpider 128566
xref: Reference/BioCyc PRO
xref: Reference/CAS 147-85-3
xref: Reference/KEGG Compound C00148
xref: Reference/HMDB HMDB0000162
xref: Reference/PubChem-compound 145742
chemical formula: C5H9NO2
molecular weight: 115.06333
structure: ChemicalStructure/PW C000106

Endoplasmic Reticulum Lumen
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005788

1.4.3.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000075 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Peroxisome/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: Glyoxylic acid
spontaneous: false
EC number: 1.4.3.3
left: Oxygen
left: Water
left: Glycine
name: Glycine + Oxygen + Water ↔ Ammonia + Glyoxylic acid + Hydrogen peroxide
conversion direction: REVERSIBLE

Reaction218036
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000075 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001568 Cytosol/Stoichiometry/1.0
right: Oxalic acid
spontaneous: false
left: Glyoxylic acid
name: Glyoxylic acid → Oxalic acid
conversion direction: LEFT_TO_RIGHT

Protein/201 Peroxisome/Stoichiometry/2.0
type: Stoichiometry
physical entity: D-amino-acid oxidase
stoichiometric coefficient: 2.0

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Quinone
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Quinone

Reference/PubChem-compound 145742
type: UnificationXref
id: 145742
db: PubChem-compound

Ammonia
type: SmallMolecule
cellular location: Peroxisome
entity reference: Ammonia

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

D-amino-acid oxidase
type: Complex
component stoichiometry: Protein/201 Peroxisome/Stoichiometry/2.0
cellular location: Peroxisome
component: D-amino-acid oxidase

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

L-Proline
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: L-Proline

Glyoxylic acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: Glyoxylic acid

Oxalic acid
type: SmallMoleculeReference
xref: Reference/CAS 144-62-7
xref: Reference/PubChem-compound 971
xref: Reference/ChEBI CHEBI 16995
xref: Reference/HMDB HMDB0002329
xref: Reference/KEGG Compound C00209
xref: Reference/BioCyc CUPRIZONE
xref: Reference/ChemSpider 946
chemical formula: C2H2O4
molecular weight: 89.99531
structure: ChemicalStructure/PW C001568

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

Reaction218051
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001535 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001391 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108873 Mitochondrial Matrix/Stoichiometry/1.0
right: 2-Oxoglutarate
right: 4-Hydroxy-L-glutamic acid
spontaneous: false
left: 4-Hydroxy-2-oxoglutaric acid
left: L-Glutamic acid
name: 4-Hydroxy-2-oxoglutaric acid + L-Glutamic acid ↔ 2-Oxoglutarate + 4-Hydroxy-L-glutamic acid
conversion direction: REVERSIBLE

Reaction218052
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001535 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001057 Mitochondrion/Stoichiometry/1.0
right: Water
right: Pyrroline hydroxycarboxylic acid
right: NADP
spontaneous: false
left: 4-Hydroxy-L-glutamic acid
left: NADPH
left: Hydrogen Ion
name: 4-Hydroxy-L-glutamic acid + Hydrogen Ion + NADPH ↔ NADP + Pyrroline hydroxycarboxylic acid + Water
conversion direction: REVERSIBLE

4.1.3.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001391 Mitochondrial Matrix/Stoichiometry/1.0
right: 4-Hydroxy-2-oxoglutaric acid
spontaneous: false
EC number: 4.1.3.16
left: pyruvate
left: Glyoxylic acid
name: Glyoxylic acid + pyruvate ↔ 4-Hydroxy-2-oxoglutaric acid
conversion direction: REVERSIBLE

2,3-Diketo-L-gulonate
type: SmallMoleculeReference
xref: Reference/CAS 3445-22-5
xref: Reference/KEGG Compound C04575
xref: Reference/PubChem-compound 53477844
xref: Reference/ChEBI CHEBI 15622
xref: Reference/HMDB HMDB0006511
xref: Reference/BioCyc 2,3-diketo-l-gulonate
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C002783

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

1.5.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001860 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002643 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001057 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Hydroquinone
right: Pyrroline hydroxycarboxylic acid
spontaneous: false
EC number: 1.5.5.3
left: 4-Hydroxyproline
left: Quinone
name: 4-Hydroxyproline + Quinone ↔ Hydroquinone + Pyrroline hydroxycarboxylic acid
conversion direction: REVERSIBLE

Reaction218054
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002643 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000106 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Endoplasmic Reticulum/Stoichiometry/1.0
right: Succinic acid
right: Carbon dioxide
right: 4-Hydroxyproline
spontaneous: false
left: L-Proline
left: Oxoglutaric acid
left: Oxygen
name: L-Proline + Oxoglutaric acid + Oxygen ↔ 4-Hydroxyproline + Carbon dioxide + Succinic acid
conversion direction: REVERSIBLE

Pyrroline hydroxycarboxylic acid
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Pyrroline hydroxycarboxylic acid

Inflammation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117090
pathway component: SubPathwayInteraction117090
name: SubPathway

TransportCatalysis4896
type: Catalysis
controller: Sodium- and chloride-dependent creatine transporter 1
controlled: Transport13875
control type: ACTIVATION

TransportCatalysis4897
type: Catalysis
controller: Sodium- and chloride-dependent creatine transporter 1
controlled: Transport13876
control type: ACTIVATION

Compound/PW C000106 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Proline
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Compound/PW C001783 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

4-Hydroxy-L-glutamic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 4573749
xref: Reference/ChEBI CHEBI 16338
xref: Reference/HMDB HMDB0002273
xref: Reference/PubChem-compound 5460078
xref: Reference/KEGG Compound C03079
xref: Reference/CAS 2485-33-8
xref: Reference/BioCyc L-ERYTHRO-4-HYDROXY-GLUTAMATE
chemical formula: C5H9NO5
molecular weight: 163.04807
structure: ChemicalStructure/PW C001535

Oxalic acid
type: SmallMolecule
entity reference: Oxalic acid
name: SubPathwayInput

Glycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycine

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ChemicalStructure/PW C000075
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C=O

Compound/PW C001420 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reaction218066
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001568 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002783 Cytosol/Stoichiometry/1.0
right: Oxalic acid
spontaneous: false
left: 2,3-Diketo-L-gulonate
left: Hydrogen peroxide
name: 2,3-Diketo-L-gulonate + Hydrogen peroxide → Oxalic acid
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reaction218064
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
right: Dehydroascorbic acid
spontaneous: false
left: Ascorbic acid
name: Ascorbic acid → Dehydroascorbic acid
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

2.3.1.85
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002783 Cytosol/Stoichiometry/1.0
right: 2,3-Diketo-L-gulonate
spontaneous: false
EC number: 2.3.1.85
left: Dehydroascorbic acid
left: Water
name: Dehydroascorbic acid + Water → 2,3-Diketo-L-gulonate
conversion direction: LEFT_TO_RIGHT

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/151 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Neurotoxicity
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117089
pathway component: SubPathwayInteraction117089
name: SubPathway

Cardiovascular disease
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117087
pathway component: SubPathwayInteraction117087
name: SubPathway

Reference/PubChem-compound 971
type: UnificationXref
id: 971
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

4-Hydroxy-L-glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 4-Hydroxy-L-glutamic acid

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/SMPDB SMP0124875
type: UnificationXref
id: SMP0124875
db: SMPDB

4-Hydroxyproline
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 4-Hydroxyproline

L-Proline
type: SmallMolecule
entity reference: L-Proline

Reference/ChemSpider 740
type: UnificationXref
id: 740
db: ChemSpider

ChemicalStructure/PW C001057
type: ChemicalStructure
structure format: SMILES
structure data: OC1CC(N=C1)C(O)=O

4-Hydroxyproline
type: SmallMoleculeReference
xref: Reference/ChemSpider 5605
xref: Reference/ChEBI CHEBI 18095
xref: Reference/HMDB HMDB0000725
xref: Reference/CAS 51-35-4
xref: Reference/PubChem-compound 5810
xref: Reference/KEGG Compound C01157
xref: Reference/BioCyc L-4-HYDROXY-PROLINE
chemical formula: C5H9NO3
molecular weight: 131.05824
structure: ChemicalStructure/PW C002643

Compound/PW C002643 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyproline
stoichiometric coefficient: 1.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ChemicalStructure/PW C001535
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](C[C@@H](O)C(O)=O)C(O)=O

Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyoxylic acid
stoichiometric coefficient: 1.0

4-Hydroxy-L-glutamic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 4-Hydroxy-L-glutamic acid

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Compound/PW C000134 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Reference/PubChem-compound 599
type: UnificationXref
id: 599
db: PubChem-compound

L-Proline
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: L-Proline

Compound/PW C000075 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyoxylic acid
stoichiometric coefficient: 1.0

Reference/UniProt O94956
type: UnificationXref
id: O94956
db: UniProt

ChemicalStructure/PW C002643
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H]1CN[C@@H](C1)C(O)=O

Reference/CAS 3445-22-5
type: UnificationXref
id: 3445-22-5
db: CAS

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/PubChem-compound 5460078
type: UnificationXref
id: 5460078
db: PubChem-compound

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Ascorbic acid
type: SmallMolecule
entity reference: Ascorbic acid

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Reference/ChEBI CHEBI 18095
type: UnificationXref
id: CHEBI:18095
db: ChEBI

Compound/PW C001632 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/BioCyc L-ERYTHRO-4-HYDROXY-GLUTAMATE
type: UnificationXref
id: L-ERYTHRO-4-HYDROXY-GLUTAMATE
db: BioCyc

2-Oxoglutarate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 2-Oxoglutarate

Aspartate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/278 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Aspartate aminotransferase, mitochondrial

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

4-hydroxy-2-oxoglutarate aldolase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Compound/PW C001860 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

pyruvate
type: SmallMoleculeReference
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C108870

2-Oxoglutarate
type: SmallMoleculeReference
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C108873

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

TransportCatalysis4911
type: Catalysis
controller: Solute carrier organic anion transporter family member 2B1
controlled: Transport13891
control type: ACTIVATION

TransportCatalysis4912
type: Catalysis
controller: Solute carrier family 23 member 1
controlled: Transport13893
control type: ACTIVATION

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

TransportCatalysis4910
type: Catalysis
controller: Unknown
controlled: Transport13890
control type: ACTIVATION

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Compound/PW C000075 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyoxylic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/CAS 1187-99-1
type: UnificationXref
id: 1187-99-1
db: CAS

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 5810
type: UnificationXref
id: 5810
db: PubChem-compound

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

TransportCatalysis4913
type: Catalysis
controller: Solute carrier family 23 member 1
controlled: Transport13894
control type: ACTIVATION

Reference/ChemSpider 579
type: UnificationXref
id: 579
db: ChemSpider

ReactionCatalysis207444
type: Catalysis
controller: Unknown
controlled: Reaction218066
control type: ACTIVATION

ReactionCatalysis207443
type: Catalysis
controller: Unknown
controlled: 2.3.1.85
control type: ACTIVATION

ReactionCatalysis207442
type: Catalysis
controller: Unknown
controlled: Reaction218064
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

ReactionCatalysis207441
type: Catalysis
controller: Prolyl 4-hydroxylase (alpha(III)-type)
controlled: Reaction218054
control type: ACTIVATION

ReactionCatalysis207440
type: Catalysis
controller: Hydroxyproline dehydrogenase
controlled: 1.5.5.3
control type: ACTIVATION

Reference/KEGG Compound C04281
type: UnificationXref
id: C04281
db: KEGG Compound

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Peroxisomal membrane protein 2
type: Protein
entity reference: Peroxisomal membrane protein 2

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Glyoxylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc GLYOX
xref: Reference/ChemSpider 740
xref: Reference/CAS 298-12-4
xref: Reference/HMDB HMDB0000119
xref: Reference/PubChem-compound 760
xref: Reference/ChEBI CHEBI 16891
xref: Reference/KEGG Compound C00048
chemical formula: C2H2O3
molecular weight: 74.0004
structure: ChemicalStructure/PW C000075

Glycine
type: SmallMolecule
cellular location: Peroxisome
entity reference: Glycine

Solute carrier organic anion transporter family member 2B1
type: Protein
entity reference: Solute carrier organic anion transporter family member 2B1

Reference/KEGG Compound C03079
type: UnificationXref
id: C03079
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Compound/PW C001535 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxy-L-glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Pyrroline hydroxycarboxylic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04281
xref: Reference/HMDB HMDB0001369
xref: Reference/BioCyc PYRROLINE-HYDROXY-CARBOXYLATE
xref: Reference/CAS 22573-88-2
xref: Reference/ChEBI CHEBI 27391
xref: Reference/ChemSpider 1030
xref: Reference/PubChem-compound 1059
chemical formula: C5H7NO3
molecular weight: 129.04259
structure: ChemicalStructure/PW C001057

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Protein disulfide-isomerase
type: ProteinReference
xref: Reference/UniProt P07237
organism: BiologicalState26

Reference/ChEBI CHEBI 15622
type: UnificationXref
id: CHEBI:15622
db: ChEBI

ChemicalStructure/PW C000106
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CCCN1

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Protein/278 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/BioCyc D-4-HYDROXY-2-KETO-GLUTARATE
type: UnificationXref
id: D-4-HYDROXY-2-KETO-GLUTARATE
db: BioCyc

Reference/BioCyc 2,3-diketo-l-gulonate
type: UnificationXref
id: 2,3-diketo-l-gulonate
db: BioCyc

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Glycine
type: SmallMolecule
entity reference: Glycine

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Reference/UniProt P00338
type: UnificationXref
id: P00338
db: UniProt

Sodium- and chloride-dependent transporter XTRP3
type: ProteinReference
xref: Reference/UniProt Q9NP91

Reference/HMDB HMDB0000119
type: UnificationXref
id: HMDB0000119
db: HMDB

ReactionCatalysis207439
type: Catalysis
controller: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
controlled: Reaction218052
control type: ACTIVATION

L-lactate dehydrogenase A chain
type: ProteinReference
xref: Reference/UniProt P00338
organism: BiologicalState26

ChemicalStructure/PW C001568
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(O)=O

ReactionCatalysis207438
type: Catalysis
controller: Aspartate aminotransferase, mitochondrial
controlled: Reaction218051
control type: ACTIVATION

ReactionCatalysis207437
type: Catalysis
controller: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
controlled: 4.1.3.16
control type: ACTIVATION

ReactionCatalysis207433
type: Catalysis
controller: L-lactate dehydrogenase A chain
controlled: Reaction218036
control type: ACTIVATION

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

ReactionCatalysis207432
type: Catalysis
controller: D-amino-acid oxidase
controlled: 1.4.3.3
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

ChemicalStructure/PW C002783
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H](O)C(O)C(=O)C(=O)C(O)=O

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: pyruvate

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 147-85-3
type: UnificationXref
id: 147-85-3
db: CAS

4-Hydroxy-2-oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 599
xref: Reference/HMDB HMDB0002070
xref: Reference/ChEBI CHEBI 30923
xref: Reference/CAS 1187-99-1
xref: Reference/KEGG Compound C01127
xref: Reference/BioCyc D-4-HYDROXY-2-KETO-GLUTARATE
xref: Reference/ChemSpider 579
chemical formula: C5H6O6
molecular weight: 162.01643
structure: ChemicalStructure/PW C001391

Compound/PW C000078/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

L-lactate dehydrogenase A chain
type: Protein
cellular location: Cytosol
entity reference: L-lactate dehydrogenase A chain

Reference/ChEBI CHEBI 16891
type: UnificationXref
id: CHEBI:16891
db: ChEBI

Compound/PW C001535 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxy-L-glutamic acid
stoichiometric coefficient: 1.0

4-Hydroxyproline
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: 4-Hydroxyproline

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Glyoxylic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glyoxylic acid

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Prolyl 4-hydroxylase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt Q7Z4N8
organism: BiologicalState26

Reference/UniProt P30038
type: UnificationXref
id: P30038
db: UniProt

Reference/UniProt P14920
type: UnificationXref
id: P14920
db: UniProt

Compound/PW C000174 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Solute carrier family 23 member 1
type: ProteinReference
xref: Reference/UniProt Q9UHI7

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Oxygen
type: SmallMolecule
cellular location: Peroxisome
entity reference: Oxygen

Sodium- and chloride-dependent creatine transporter 1
type: Protein
entity reference: Sodium- and chloride-dependent creatine transporter 1

Reference/ChEBI CHEBI 16995
type: UnificationXref
id: CHEBI:16995
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 22573-88-2
type: UnificationXref
id: 22573-88-2
db: CAS

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/BioCyc PYRROLINE-HYDROXY-CARBOXYLATE
type: UnificationXref
id: PYRROLINE-HYDROXY-CARBOXYLATE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005788
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

TransportCatalysis4901
type: Catalysis
controller: Unknown
controlled: Transport13880
control type: ACTIVATION

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Oxoglutaric acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxoglutaric acid

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

TransportCatalysis4908
type: Catalysis
controller: Unknown
controlled: Transport13888
control type: ACTIVATION

TransportCatalysis4909
type: Catalysis
controller: Unknown
controlled: Transport13889
control type: ACTIVATION

TransportCatalysis4906
type: Catalysis
controller: Sodium- and chloride-dependent transporter XTRP3
controlled: Transport13886
control type: ACTIVATION

TransportCatalysis4907
type: Catalysis
controller: Sodium- and chloride-dependent transporter XTRP3
controlled: Transport13887
control type: ACTIVATION

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

TransportCatalysis4905
type: Catalysis
controller: Unknown
controlled: Transport13884
control type: ACTIVATION

TransportCatalysis4902
type: Catalysis
controller: Peroxisomal membrane protein 2
controlled: Transport13881
control type: ACTIVATION

Compound/PW C002783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-Diketo-L-gulonate
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

TransportCatalysis4903
type: Catalysis
controller: Unknown
controlled: Transport13882
control type: ACTIVATION

Reference/ChEBI CHEBI 30923
type: UnificationXref
id: CHEBI:30923
db: ChEBI

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChEBI CHEBI 16338
type: UnificationXref
id: CHEBI:16338
db: ChEBI

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/UniProt Q9UF12
type: UnificationXref
id: Q9UF12
db: UniProt

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000725
type: UnificationXref
id: HMDB0000725
db: HMDB

Reference/PubChem-compound 1059
type: UnificationXref
id: 1059
db: PubChem-compound

Sodium- and chloride-dependent creatine transporter 1
type: ProteinReference
xref: Reference/UniProt P48029

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Compound/PW C002643 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyproline
stoichiometric coefficient: 1.0

Glyoxylic acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Glyoxylic acid

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Glyoxylic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyoxylic acid

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt P07237
type: UnificationXref
id: P07237
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C001057 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrroline hydroxycarboxylic acid
stoichiometric coefficient: 1.0

Compound/PW C000106 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Proline
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/CAS 51-35-4
type: UnificationXref
id: 51-35-4
db: CAS

Reference/BioCyc L-4-HYDROXY-PROLINE
type: UnificationXref
id: L-4-HYDROXY-PROLINE
db: BioCyc

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C000078 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Compound/PW C002643 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyproline
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

Reference/ChemSpider 4573749
type: UnificationXref
id: 4573749
db: ChemSpider

Protein/151 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/CAS 144-62-7
type: UnificationXref
id: 144-62-7
db: CAS

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Carbon dioxide
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Carbon dioxide

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000031/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Reference/UniProt P00505
type: UnificationXref
id: P00505
db: UniProt

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Compound/PW C001065 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PathWhiz PW126379
type: UnificationXref
id: PW126379
db: PathWhiz

Reference/UniProt Q9NP91
type: UnificationXref
id: Q9NP91
db: UniProt

Compound/PW C001391 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxy-2-oxoglutaric acid
stoichiometric coefficient: 1.0