IL-1β
type: Dna
cellular location: Nucleus
entity reference: IL-1β

Reference/UniProt P09601
type: UnificationXref
id: P09601
db: UniProt

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C00311
type: UnificationXref
id: C00311
db: KEGG Compound

SubPathwayInteraction117111
type: Interaction
name: SubPathway117111Reaction
name: SubPathwayReaction
participant: D-Glucose
participant: pyruvate

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P31040
organism: Homo sapiens

direct_interaction
type: InteractionVocabulary

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Unknown
type: ProteinReference

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Cis-aconitate decarboxylase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Cis-aconitate decarboxylase

Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

Itaconic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Itaconic acid

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Protein/806 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fumarate hydratase, mitochondrial
stoichiometric coefficient: 4.0

Protein/23933 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor erythroid 2-related factor 2
stoichiometric coefficient: 1.0

IL-6
type: Dna
cellular location: Nucleus
entity reference: IL-6

citrate synthase
type: ProteinReference
xref: Reference/UniProt P08679
organism: Homo sapiens

Reference/UniProt P09622
type: UnificationXref
id: P09622
db: UniProt

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reaction217840
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxaloacetate
right: NADH
right: Hydrogen Ion
spontaneous: false
left: Malate
left: NAD
name: Malate + NAD → Hydrogen Ion + NADH + Oxaloacetate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc ITACONATE
type: UnificationXref
id: ITACONATE
db: BioCyc

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

SubPathwayInteraction117128
type: Interaction
name: SubPathway117128Reaction
name: SubPathwayReaction
participant: Toll-like receptor 4

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

SubPathwayInteraction117126
type: Interaction
name: SubPathwayReaction
name: SubPathway117126Reaction
participant: Glutathione
participant: Heme oxygenase-1
participant: Heme oxygenase 1

SubPathwayInteraction117127
type: Interaction
name: SubPathwayReaction
name: SubPathway117127Reaction
participant: Itaconic acid

Protein/840 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

NF-kappa-B inhibitor zeta
type: Protein
cellular location: Nucleus
entity reference: NF-kappa-B inhibitor zeta

Compound/PW C001406 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconic acid
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: pyruvate

Reference/PubChem-compound 811
type: UnificationXref
id: 811
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Itaconic acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Itaconic acid

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O14521
organism: Homo sapiens

Reference/ChEBI CHEBI 30887
type: UnificationXref
id: CHEBI:30887
db: ChEBI

Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/19/Stoichiometry/4.0
component: Pyruvate carboxylase, mitochondrial

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 1161
type: UnificationXref
id: 1161
db: ChemSpider

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Itaconic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Itaconic acid
name: SubPathwayInput

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/UniProt O43837
type: UnificationXref
id: O43837
db: UniProt

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/UniProt Q9BYH8
type: UnificationXref
id: Q9BYH8
db: UniProt

Transport279
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Glutathione
type: SmallMolecule
cellular location: Cytosol
entity reference: Glutathione
name: SubPathwayOutput

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Protein/23934 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Compound/Generic631 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reactive oxygen species
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99643
organism: Homo sapiens

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Protein/53 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 60.0

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Reference/KEGG Compound C00490
type: UnificationXref
id: C00490
db: KEGG Compound

Reference/HMDB HMDB0002092
type: UnificationXref
id: HMDB0002092
db: HMDB

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Kelch-like ECH-associated protein 1
type: Protein
cellular location: Cytosol
entity reference: Kelch-like ECH-associated protein 1

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11177
organism: Homo sapiens

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

pyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: pyruvate
name: SubPathwayOutput

Reactive oxygen species
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Reactive oxygen species

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11498

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid

Reference/UniProt O14521
type: UnificationXref
id: O14521
db: UniProt

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

Oxaloacetate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxaloacetate

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Heme oxygenase 1
type: Protein
cellular location: Cytosol
entity reference: Heme oxygenase 1
name: SubPathwayOutput

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayInput

ChemicalStructure/PW C108867
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/UniProt P50213
type: UnificationXref
id: P50213
db: UniProt

ChemicalStructure/PW C000051
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C\C(=C\C(O)=O)C(O)=O

ChemicalStructure/PW C108868
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt P07954
type: UnificationXref
id: P07954
db: UniProt

Lipopolysaccharide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lipopolysaccharide

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Voltage-dependent anion-selective channel protein 2
type: ProteinReference
xref: Reference/UniProt P45880

Reference/UniProt P18847
type: UnificationXref
id: P18847
db: UniProt

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Itaconic acid
type: SmallMoleculeReference
xref: Reference/CAS 97-65-4
xref: Reference/HMDB HMDB0002092
xref: Reference/KEGG Compound C00490
xref: Reference/PubChem-compound 811
xref: Reference/ChEBI CHEBI 30838
xref: Reference/BioCyc ITACONATE
xref: Reference/ChemSpider 789
chemical formula: C5H6O4
molecular weight: 130.02661
structure: ChemicalStructure/PW C001406

Compound/PW C108870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C108870
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Reaction218099
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
right: cis-Aconitic acid
right: Water
spontaneous: false
left: Citrate
name: Citrate ↔ Water + cis-Aconitic acid
conversion direction: REVERSIBLE

Malate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Malate

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reaction218098
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Citrate
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
left: Water
left: Oxaloacetate
name: Acetyl-CoA + Oxaloacetate + Water ↔ Citrate + Coenzyme A
conversion direction: REVERSIBLE

Reference/UniProt P51553
type: UnificationXref
id: P51553
db: UniProt

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Reference/UniProt O00206
type: UnificationXref
id: O00206
db: UniProt

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: Reference/UniProt Q16665
organism: Homo sapiens

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99798
organism: Homo sapiens

Cis-aconitate decarboxylase
type: ProteinReference
xref: Reference/UniProt A6NK06
organism: Homo sapiens

NF-kappa-B inhibitor zeta
type: ProteinReference
xref: Reference/UniProt Q9BYH8
organism: Homo sapiens

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Kelch-like ECH-associated protein 1
type: ProteinReference
xref: Reference/UniProt Q14145
organism: Homo sapiens

Nuclear factor erythroid 2-related factor 2
type: ProteinReference
xref: Reference/UniProt Q16236
organism: Homo sapiens

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Reference/UniProt Q99798
type: UnificationXref
id: Q99798
db: UniProt

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Reference/UniProt P21912
type: UnificationXref
id: P21912
db: UniProt

Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

Protein/52 Mitochondrial Matrix/Stoichiometry/24.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 24.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: Reference/UniProt P18847
organism: Homo sapiens

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/ChemSpider 789
type: UnificationXref
id: 789
db: ChemSpider

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Transport13920
type: Transport
participant stoichiometry: Compound/Generic631 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic631 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Reactive oxygen species
spontaneous: false
left: Reactive oxygen species
name: Reactive oxygen species (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Itaconate Immunometabolism Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2503312
pathway order: PathwayEnzymeReaction/2503358
pathway order: PathwayInteraction/3809
pathway order: PathwayTransport/2503359
pathway order: PathwayInteraction/3808
pathway order: PathwayTransport/2503334
pathway order: PathwayInteraction/3807
pathway order: PathwayInteraction/3805
pathway order: PathwayInteraction/3804
pathway order: PathwayTransport/2503289
pathway order: PathwayInteraction/3803
pathway order: PathwayInteraction/3802
pathway order: PathwayInteraction/3801
pathway order: PathwayEnzymeReaction/2503331
pathway order: PathwayTransport/2503340
pathway order: PathwayInteraction/3800
pathway order: PathwaySubPathway/117111
pathway order: PathwayEnzymeReaction/2503311
pathway order: PathwayTransport/2503360
pathway order: PathwayEnzymeReaction/2503292
pathway order: PathwayTransport/2503347
pathway order: PathwayTransport/2503276
pathway order: PathwayEnzymeReaction/2503282
pathway order: PathwayTransport/2503332
pathway order: PathwayTransport/2503354
pathway order: PathwayEnzymeReaction/2503283
pathway order: PathwayTransport/2503333
pathway order: PathwayEnzymeReaction/2503286
pathway order: PathwayEnzymeReaction/2503287
pathway order: PathwayInteraction/3799
pathway order: PathwayInteraction/3810
pathway order: PathwayInteraction/3798
pathway order: PathwayTransport/2503290
pathway order: PathwayInteraction/3797
pathway order: PathwaySubPathway/117126
pathway order: PathwayInteraction/3794
pathway order: PathwayEnzymeReaction/2503280
pathway order: PathwaySubPathway/117127
pathway order: PathwayEnzymeReaction/2503281
pathway order: PathwaySubPathway/117128
pathway component: Transport13919
pathway component: Transport13916
pathway component: Transport13915
pathway component: Transport13918
pathway component: Transport13917
pathway component: Transport13912
pathway component: 1.2.4.1
pathway component: Transport13911
pathway component: Transport13914
pathway component: Transport13913
pathway component: ReactionCatalysis207369
pathway component: 1.2.4.2
pathway component: Transport279
pathway component: TransportCatalysis4922
pathway component: TransportCatalysis4923
pathway component: ReactionCatalysis64
pathway component: TransportCatalysis4928
pathway component: TransportCatalysis4929
pathway component: ReactionCatalysis67
pathway component: TransportCatalysis4926
pathway component: TransportCatalysis4927
pathway component: TransportCatalysis4924
pathway component: TransportCatalysis4925
pathway component: Reaction218099
pathway component: Interaction3810
pathway component: 4.2.1.3
pathway component: Glycolysis
pathway component: Reaction218098
pathway component: TransportCatalysis4930
pathway component: Reaction217840
pathway component: Interaction3803
pathway component: Interaction3804
pathway component: Interaction3805
pathway component: Activation of pro-inflammatory genes for IL-6, IL-10, IL1β and TNFα
pathway component: ReactionCatalysis70
pathway component: 4.1.1.6
pathway component: Interaction3800
pathway component: Interaction3801
pathway component: Interaction3802

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Transport13919
type: Transport
participant stoichiometry: Compound/Generic631 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic631 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Reactive oxygen species
spontaneous: false
left: Reactive oxygen species
name: Reactive oxygen species (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Transport13916
type: Transport
participant stoichiometry: Compound/PW C001406 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001406 Nucleus/Stoichiometry/1.0
right: Itaconic acid
spontaneous: false
left: Itaconic acid
name: Itaconic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Transport13915
type: Transport
participant stoichiometry: Compound/PW C001406 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001406 Cytosol/Stoichiometry/1.0
right: Itaconic acid
spontaneous: false
left: Itaconic acid
name: Itaconic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Transport13918
type: Transport
participant stoichiometry: Protein/23934 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23934 Nucleus/Stoichiometry/1.0
right: Hypoxia-inducible factor 1-alpha
spontaneous: false
left: Hypoxia-inducible factor 1-alpha
name: Hypoxia-inducible factor 1-alpha (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Transport13917
type: Transport
participant stoichiometry: Protein/23933 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23933 Nucleus/Stoichiometry/1.0
right: Nuclear factor erythroid 2-related factor 2
spontaneous: false
left: Nuclear factor erythroid 2-related factor 2
name: NRF2 (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Transport13912
type: Transport
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: pyruvate
spontaneous: false
left: pyruvate
name: pyruvate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: NADPH
right: Carbon dioxide
spontaneous: false
EC number: 1.2.4.1
left: NADP
left: Coenzyme A
left: pyruvate
name: Coenzyme A + NADP + pyruvate ↔ Acetyl-CoA + Carbon dioxide + NADPH
conversion direction: REVERSIBLE

Transport13911
type: Transport
participant stoichiometry: Compound/PW C108870 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: pyruvate
spontaneous: false
left: pyruvate
name: pyruvate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Transport13914
type: Transport
participant stoichiometry: Compound/PW C001406 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001406 Mitochondrial Matrix/Stoichiometry/1.0
right: Itaconic acid
spontaneous: false
left: Itaconic acid
name: Itaconic acid (→) Transport: Homo sapiens, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Transport13913
type: Transport
participant stoichiometry: Compound/PW C001406 Mitochondrial Matrix/Stoichiometry/1.0
right: Itaconic acid
spontaneous: false
left: Itaconic acid
name: Itaconic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Nucleus
entity reference: Hypoxia-inducible factor 1-alpha

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/Generic631 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reactive oxygen species
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADP

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/CAS 585-84-2
type: UnificationXref
id: 585-84-2
db: CAS

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Protein/4308 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
stoichiometric coefficient: 1.0

Reference/UniProt P11177
type: UnificationXref
id: P11177
db: UniProt

Isocitric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Isocitric acid

NADPH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADPH

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P36957
organism: Homo sapiens

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/882 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000072
type: UnificationXref
id: HMDB0000072
db: HMDB

Reference/HMDB HMDB0000193
type: UnificationXref
id: HMDB0000193
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/BioCyc CIS-ACONITATE
type: UnificationXref
id: CIS-ACONITATE
db: BioCyc

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/UniProt Q99643
type: UnificationXref
id: Q99643
db: UniProt

Reference/PubChem-compound 11970143
type: UnificationXref
id: 11970143
db: PubChem-compound

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/UniProt Q16665
type: UnificationXref
id: Q16665
db: UniProt

Succinyl-CoA ligase
type: Complex
component stoichiometry: Protein/834 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/832 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
component: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 31348
type: UnificationXref
id: 31348
db: PubChem-compound

Reactive oxygen species
type: SmallMolecule
cellular location: Cytosol
entity reference: Reactive oxygen species

Protein/52 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/SMPDB SMP0124904
type: UnificationXref
id: SMP0124904
db: SMPDB

Lipopolysaccharide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11970143
chemical formula: C205H366N3O117P5
molecular weight: 4897.147
structure: ChemicalStructure/PW C104587

Reference/UniProt P11498
type: UnificationXref
id: P11498
db: UniProt

Citrate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 31348
chemical formula: C6H5O7
molecular weight: 189.00352
structure: ChemicalStructure/PW C104585

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96I99
organism: Homo sapiens

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53597
organism: Homo sapiens

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Aconitate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aconitate hydratase, mitochondrial

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117111
pathway component: SubPathwayInteraction117111
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C001860 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Isocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 320-77-4
xref: Reference/BioCyc threo-d(s)-iso-citrate
xref: Reference/ChEBI CHEBI 30887
xref: Reference/ChemSpider 1161
xref: Reference/HMDB HMDB0000193
xref: Reference/KEGG Compound C00311
xref: Reference/PubChem-compound 1198
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000125

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P50213
organism: Homo sapiens

Oxoglutarate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/4308 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/882 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
component: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: ProteinReference
xref: Reference/UniProt P51553
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt O43837
organism: Homo sapiens

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Oxaloacetate
type: SmallMoleculeReference
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C108867

Malate
type: SmallMoleculeReference
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C108868

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4
name: SubPathwayInput

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrial Matrix/Stoichiometry/24.0
component stoichiometry: Protein/12 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/53 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/44 Mitochondrial Matrix/Stoichiometry/60.0
cellular location: Mitochondrial Matrix
component: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Reactive oxygen species
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Reactive oxygen species

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

IL-6
type: DnaReference
organism: Homo sapiens

Heme oxygenase-1
type: DnaReference
organism: Homo sapiens

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Reference/ChemSpider 558863
type: UnificationXref
id: 558863
db: ChemSpider

Glutathione
type: DnaReference
organism: Homo sapiens

ChemicalStructure/PW C001406
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=C)C(O)=O

IL-1β
type: DnaReference
organism: Homo sapiens

pyruvate
type: SmallMoleculeReference
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C108870

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

TransportCatalysis227
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport279
control type: ACTIVATION

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Cytosol
entity reference: Hypoxia-inducible factor 1-alpha

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/UniProt P40926
type: UnificationXref
id: P40926
db: UniProt

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/PubChem-compound 643757
type: UnificationXref
id: 643757
db: PubChem-compound

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Voltage-dependent anion-selective channel protein 2
type: Protein
entity reference: Voltage-dependent anion-selective channel protein 2

Malate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/803 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Malate dehydrogenase, mitochondrial

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

cis-Aconitic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: cis-Aconitic acid

Compound/PW C001406 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydroquinone

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

ChemicalStructure/PW C104585
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt Q96HY7
type: UnificationXref
id: Q96HY7
db: UniProt

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

ChemicalStructure/PW C104587
type: ChemicalStructure
structure format: SMILES

Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

TransportCatalysis4922
type: Catalysis
controller: Voltage-dependent anion-selective channel protein 2
controlled: Transport13911
control type: ACTIVATION

TransportCatalysis4923
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: Transport13912
control type: ACTIVATION

Reference/UniProt Q16236
type: UnificationXref
id: Q16236
db: UniProt

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

ReactionCatalysis64
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: 4.2.1.3
control type: ACTIVATION

TransportCatalysis4928
type: Catalysis
controller: Unknown
controlled: Transport13918
control type: ACTIVATION

TransportCatalysis4929
type: Catalysis
controller: Unknown
controlled: Transport13919
control type: ACTIVATION

ReactionCatalysis67
type: Catalysis
controller: Oxoglutarate dehydrogenase complex
controlled: 1.2.4.2
control type: ACTIVATION

TransportCatalysis4926
type: Catalysis
controller: Unknown
controlled: Transport13916
control type: ACTIVATION

TransportCatalysis4927
type: Catalysis
controller: Unknown
controlled: Transport13917
control type: ACTIVATION

TransportCatalysis4924
type: Catalysis
controller: Unknown
controlled: Transport13914
control type: ACTIVATION

TransportCatalysis4925
type: Catalysis
controller: Unknown
controlled: Transport13915
control type: ACTIVATION

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Compound/Generic631 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reactive oxygen species
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Malate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Malate dehydrogenase, mitochondrial

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

4.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
right: Isocitric acid
spontaneous: false
EC number: 4.2.1.3
left: cis-Aconitic acid
left: Water
name: Water + cis-Aconitic acid ↔ Isocitric acid
conversion direction: REVERSIBLE

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q96I99
type: UnificationXref
id: Q96I99
db: UniProt

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/UniProt P31040
type: UnificationXref
id: P31040
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/UniProt Q14145
type: UnificationXref
id: Q14145
db: UniProt

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P07954
organism: Homo sapiens

Reactive oxygen species
type: SmallMoleculeReference

TransportCatalysis4930
type: Catalysis
controller: Unknown
controlled: Transport13920
control type: ACTIVATION

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Malate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P40926
organism: Homo sapiens

Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Protein/23934 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Nuclear factor erythroid 2-related factor 2
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor erythroid 2-related factor 2

Activation of pro-inflammatory genes for IL-6, IL-10, IL1β and TNFα
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117128
pathway component: SubPathwayInteraction117128
name: SubPathway

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

ReactionCatalysis70
type: Catalysis
controller: Isocitrate dehydrogenase
controlled: 1.1.1.41
control type: ACTIVATION

4.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001406 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Itaconic acid
spontaneous: false
EC number: 4.1.1.6
left: cis-Aconitic acid
name: cis-Aconitic acid ↔ Carbon dioxide + Itaconic acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Transcription/Translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117126
pathway component: SubPathwayInteraction117126
xref: Reference/SMPDB SMP0000019
xref: Reference/PathWhiz PW000455
name: SubPathway

Protein/23933 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor erythroid 2-related factor 2
stoichiometric coefficient: 1.0

Macrophage M2 polarization
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117127
pathway component: SubPathwayInteraction117127
name: SubPathway

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

cis-Aconitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 643757
xref: Reference/KEGG Compound C00417
xref: Reference/HMDB HMDB0000072
xref: Reference/ChEBI CHEBI 32805
xref: Reference/BioCyc CIS-ACONITATE
xref: Reference/ChemSpider 558863
xref: Reference/CAS 585-84-2
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000051

Reference/CAS 320-77-4
type: UnificationXref
id: 320-77-4
db: CAS

Reference/BioCyc threo-d(s)-iso-citrate
type: UnificationXref
id: threo-d(s)-iso-citrate
db: BioCyc

Pyruvate carboxylase, mitochondrial
type: Protein
entity reference: Pyruvate carboxylase, mitochondrial

Reaction218103
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
left: Succinic acid
left: Coenzyme A
left: Adenosine triphosphate
name: Adenosine triphosphate + Coenzyme A + Succinic acid ↔ Adenosine diphosphate + Phosphate + Succinyl-CoA
conversion direction: REVERSIBLE

Reaction218101
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: Water
spontaneous: false
left: Malate
name: Malate ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

Interaction3797
type: MolecularInteraction
interaction type: direct_interaction
name: Itaconic acid activates ATF3
participant: Itaconic acid
participant: Cyclic AMP-dependent transcription factor ATF-3

Interaction3798
type: MolecularInteraction
interaction type: direct_interaction
name: ATF3 inhibits NF-kappa-B inhibitor zeta
participant: NF-kappa-B inhibitor zeta
participant: Cyclic AMP-dependent transcription factor ATF-3

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/Generic631 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001860 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Quinone
right: Succinic acid
spontaneous: false
EC number: 1.3.5.1
left: Fumaric acid
left: Hydroquinone
left: Reactive oxygen species
name: Fumaric acid + Hydroquinone + Reactive oxygen species ↔ Quinone + Succinic acid
conversion direction: REVERSIBLE

ReactionCatalysis207434
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

Reference/PathWhiz PW126408
type: UnificationXref
id: PW126408
db: PathWhiz

Interaction3794
type: MolecularInteraction
interaction type: direct_interaction
name: Itaconic acid inhibits Succinate dehydrogenase
participant: Itaconic acid
participant: Succinate dehydrogenase

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

ChemicalStructure/PW C000125
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(CC(O)=O)C(O)=O)C(O)=O

Protein/12 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 60.0

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Interaction3799
type: MolecularInteraction
interaction type: direct_interaction
name: NF-kappa-B inhibitor zeta activates IL-6
participant: NF-kappa-B inhibitor zeta
participant: IL-6

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: pyruvate

Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96HY7
organism: Homo sapiens

Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis207369
type: Catalysis
controller: Malate dehydrogenase, mitochondrial
controlled: Reaction217840
control type: ACTIVATION

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Carbon dioxide
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.4.2
left: Coenzyme A
left: Oxoglutaric acid
left: NAD
name: Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 30838
type: UnificationXref
id: CHEBI:30838
db: ChEBI

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Fumarate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Fumarate hydratase, mitochondrial

citrate synthase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: citrate synthase

Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Nuclear factor erythroid 2-related factor 2
type: Protein
cellular location: Cytosol
entity reference: Nuclear factor erythroid 2-related factor 2

Quinone
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Quinone

Reference/SMPDB SMP0000019
type: UnificationXref
id: SMP0000019
db: SMPDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/PathWhiz PW000455
type: UnificationXref
id: PW000455
db: PathWhiz

Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Protein/803 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Malate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Protein/842 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Citrate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Citrate

Compound/PW C001632 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: Reference/UniProt P08559
organism: Homo sapiens

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Compound/PW C001406 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Glutathione
type: Dna
cellular location: Nucleus
entity reference: Glutathione
name: SubPathwayInput

Reference/UniProt P45880
type: UnificationXref
id: P45880
db: UniProt

Interaction3803
type: MolecularInteraction
interaction type: direct_interaction
name: NRF2 activates Glutathione
participant: Nuclear factor erythroid 2-related factor 2
participant: Glutathione

Interaction3804
type: MolecularInteraction
interaction type: direct_interaction
name: NRF2 inhibits IL-1β
participant: Nuclear factor erythroid 2-related factor 2
participant: IL-1β

Interaction3805
type: MolecularInteraction
interaction type: direct_interaction
name: Hypoxia-inducible factor 1-alpha activates IL-1β
participant: IL-1β
participant: Hypoxia-inducible factor 1-alpha

Interaction3800
type: MolecularInteraction
interaction type: direct_interaction
name: Itaconic acid inhibits Kelch-like ECH-associated protein 1
participant: Kelch-like ECH-associated protein 1
participant: Itaconic acid

Interaction3801
type: MolecularInteraction
interaction type: direct_interaction
name: Kelch-like ECH-associated protein 1 inhibits NRF2
participant: Kelch-like ECH-associated protein 1
participant: Nuclear factor erythroid 2-related factor 2

Interaction3802
type: MolecularInteraction
interaction type: direct_interaction
name: NRF2 activates Heme oxygenase-1
participant: Nuclear factor erythroid 2-related factor 2
participant: Heme oxygenase-1

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Interaction3807
type: MolecularInteraction
interaction type: direct_interaction
name: Reactive oxygen species activates Hypoxia-inducible factor 1-alpha
participant: Reactive oxygen species
participant: Hypoxia-inducible factor 1-alpha

Interaction3808
type: MolecularInteraction
interaction type: direct_interaction
name: Glutathione inhibits Reactive oxygen species
participant: Glutathione
participant: Reactive oxygen species

Interaction3809
type: MolecularInteraction
interaction type: direct_interaction
name: Heme oxygenase 1 inhibits Reactive oxygen species
participant: Reactive oxygen species
participant: Heme oxygenase 1

Reference/UniProt P36957
type: UnificationXref
id: P36957
db: UniProt

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P10515
organism: Homo sapiens

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P09622
organism: Homo sapiens

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Protein/843 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt O00206
organism: Homo sapiens

ReactionCatalysis207477
type: Catalysis
controller: Succinyl-CoA ligase
controlled: Reaction218103
control type: ACTIVATION

ReactionCatalysis207476
type: Catalysis
controller: Succinate dehydrogenase
controlled: 1.3.5.1
control type: ACTIVATION

ReactionCatalysis207475
type: Catalysis
controller: Fumarate hydratase, mitochondrial
controlled: Reaction218101
control type: ACTIVATION

ReactionCatalysis207474
type: Catalysis
controller: Cis-aconitate decarboxylase
controlled: 4.1.1.6
control type: ACTIVATION

ReactionCatalysis207473
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: Reaction218099
control type: ACTIVATION

ReactionCatalysis207472
type: Catalysis
controller: citrate synthase
controlled: Reaction218098
control type: ACTIVATION

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt P08679
type: UnificationXref
id: P08679
db: UniProt

Reference/UniProt P08559
type: UnificationXref
id: P08559
db: UniProt

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Heme oxygenase-1
type: Dna
cellular location: Nucleus
entity reference: Heme oxygenase-1
name: SubPathwayInput

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/UniProt P10515
type: UnificationXref
id: P10515
db: UniProt

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P21912
organism: Homo sapiens

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Fumarate hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/806 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Fumarate hydratase, mitochondrial

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Isocitrate dehydrogenase
type: Complex
component stoichiometry: Protein/840 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/842 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/843 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Protein/44 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
stoichiometric coefficient: 60.0

Compound/PW C001406 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconic acid
stoichiometric coefficient: 1.0

Protein/19/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase, mitochondrial
stoichiometric coefficient: 4.0

Reference/UniProt A6NK06
type: UnificationXref
id: A6NK06
db: UniProt

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Interaction3810
type: MolecularInteraction
interaction type: direct_interaction
name: Lipopolysaccharide activates Toll-like receptor 4
participant: Lipopolysaccharide
participant: Toll-like receptor 4

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

Heme oxygenase 1
type: ProteinReference
xref: Reference/UniProt P09601
organism: Homo sapiens

Reference/ChEBI CHEBI 32805
type: UnificationXref
id: CHEBI:32805
db: ChEBI

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/KEGG Compound C00417
type: UnificationXref
id: C00417
db: KEGG Compound

Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: cis-Aconitic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1198
type: UnificationXref
id: 1198
db: PubChem-compound

Protein/832 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

Reference/CAS 97-65-4
type: UnificationXref
id: 97-65-4
db: CAS

Itaconic acid
type: SmallMolecule
cellular location: Nucleus
entity reference: Itaconic acid

Protein/834 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

1.1.1.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Oxoglutaric acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.41
left: Isocitric acid
left: NAD
name: Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt P53597
type: UnificationXref
id: P53597
db: UniProt

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Cyclic AMP-dependent transcription factor ATF-3
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-dependent transcription factor ATF-3

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Toll-like receptor 4
type: Protein
cellular location: Extracellular Space
entity reference: Toll-like receptor 4

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS