Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
Malate + NAD → Hydrogen Ion + NADH + Oxaloacetate
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
D-Glucose (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Voltage-dependent anion-selective channel protein 2
Citrate ↔ Water + cis-Aconitic acid
Acetyl-CoA + Oxaloacetate + Water ↔ Citrate + Coenzyme A
Nuclear factor erythroid 2-related factor 2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Cyclic AMP-dependent transcription factor ATF-3
Reactive oxygen species (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Reactive oxygen species (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
Itaconic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
Itaconic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
Hypoxia-inducible factor 1-alpha (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
NRF2 (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
pyruvate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Mitochondrial Matrix
Coenzyme A + NADP + pyruvate ↔ Acetyl-CoA + Carbon dioxide + NADPH
pyruvate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Intermembrane Space
Itaconic acid (→) Transport: Homo sapiens, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
Itaconic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Mitochondrial Matrix
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Solute carrier family 2, facilitated glucose transporter member 2
Water + cis-Aconitic acid ↔ Isocitric acid
Activation of pro-inflammatory genes for IL-6, IL-10, IL1β and TNFα
cis-Aconitic acid ↔ Carbon dioxide + Itaconic acid
Adenosine triphosphate + Coenzyme A + Succinic acid ↔ Adenosine diphosphate + Phosphate + Succinyl-CoA
Fumaric acid + Hydroquinone + Reactive oxygen species ↔ Quinone + Succinic acid
Itaconic acid inhibits Succinate dehydrogenase
NF-kappa-B inhibitor zeta activates IL-6
Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
Hypoxia-inducible factor 1-alpha activates IL-1β
Itaconic acid inhibits Kelch-like ECH-associated protein 1
Kelch-like ECH-associated protein 1 inhibits NRF2
Reactive oxygen species activates Hypoxia-inducible factor 1-alpha
Glutathione inhibits Reactive oxygen species
Heme oxygenase 1 inhibits Reactive oxygen species
Dihydrolipoyl dehydrogenase, mitochondrial
Lipopolysaccharide activates Toll-like receptor 4
Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid