IL-1β
type: Dna
cellular location: Nucleus
entity reference: IL-1β

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

Prostaglandin E2
type: SmallMoleculeReference
xref: Reference/CAS 363-24-6
xref: Reference/ChemSpider 4444059
xref: Reference/KEGG Compound C00584
xref: Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
xref: Reference/PubChem-compound 5280360
xref: Reference/ChEBI CHEBI 15551
xref: Reference/HMDB HMDB0001220
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C000949

Reference/KEGG Compound C00311
type: UnificationXref
id: C00311
db: KEGG Compound

Protein/76 Endoplasmic Reticulum Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Prostaglandin E synthase
stoichiometric coefficient: 3.0

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P31040
organism: Homo sapiens

direct_interaction
type: InteractionVocabulary

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Mitochondrial dicarboxylate carrier
type: Protein
entity reference: Mitochondrial dicarboxylate carrier

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/UniProt Q96KS0
type: UnificationXref
id: Q96KS0
db: UniProt

Cytosolic phospholipase A2
type: Protein
cellular location: Cytosol
entity reference: Cytosolic phospholipase A2

Unknown
type: ProteinReference

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Prostaglandin G/H synthase 1
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin G/H synthase 1

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin G2
right: Reduced acceptor
spontaneous: false
EC number: 1.14.99.1
left: Water
left: Acceptor
left: Prostaglandin H2
name: Acceptor + Prostaglandin H2 + Water ← Prostaglandin G2 + Reduced acceptor
conversion direction: RIGHT_TO_LEFT

Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

Protein/806 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fumarate hydratase, mitochondrial
stoichiometric coefficient: 4.0

citrate synthase
type: ProteinReference
xref: Reference/UniProt P08679
organism: Homo sapiens

Reference/UniProt P29474
type: UnificationXref
id: P29474
db: UniProt

Inflammation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117135
pathway component: SubPathwayInteraction117135
xref: Reference/SMPDB SMP0122567
xref: Reference/PathWhiz PW123878
name: SubPathway

Reference/UniProt P09622
type: UnificationXref
id: P09622
db: UniProt

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reaction217840
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxaloacetate
right: NADH
right: Hydrogen Ion
spontaneous: false
left: Malate
left: NAD
name: Malate + NAD → Hydrogen Ion + NADH + Oxaloacetate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reaction213363
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic617 Cytosol/Stoichiometry/1.0
right: Arachidonic acid
spontaneous: false
left: Phospholipids
name: Phospholipids → Arachidonic acid
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction117135
type: Interaction
name: SubPathway117135Reaction
name: SubPathwayReaction
participant: Prostaglandin E2
participant: Nitric oxide

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

SubPathwayInteraction117134
type: Interaction
name: SubPathway117134Reaction
name: SubPathwayReaction
participant: Hypoxia-inducible factor 1-alpha

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

SubPathwayInteraction117129
type: Interaction
name: SubPathwayReaction
name: SubPathway117129Reaction
participant: D-Glucose
participant: pyruvate

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Protein/840 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Compound/Generic369 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: pyruvate

Reference/KEGG Compound C00584
type: UnificationXref
id: C00584
db: KEGG Compound

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Reference/UniProt O14684
type: UnificationXref
id: O14684
db: UniProt

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 363-24-6
type: UnificationXref
id: 363-24-6
db: CAS

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O14521
organism: Homo sapiens

Reference/ChEBI CHEBI 30887
type: UnificationXref
id: CHEBI:30887
db: ChEBI

Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

ReactionCatalysis207193
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

Von Hippel-Lindau disease tumor suppressor
type: ProteinReference
xref: Reference/UniProt P40337
organism: Homo sapiens

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/19/Stoichiometry/4.0
component: Pyruvate carboxylase, mitochondrial

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/ChemSpider 1161
type: UnificationXref
id: 1161
db: ChemSpider

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/UniProt O43837
type: UnificationXref
id: O43837
db: UniProt

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/UniProt P40337
type: UnificationXref
id: P40337
db: UniProt

L-Arginine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Arginine

Protein/23937 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Transport279
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99643
organism: Homo sapiens

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Protein/53 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 60.0

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Reference/UniProt P50148
type: UnificationXref
id: P50148
db: UniProt

Compound/PW C000174 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt P19838
organism: Homo sapiens

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

ERK1 & ERK2
type: Complex
cellular location: Cytosol
component: Mitogen-activated protein kinase 3
component: Mitogen-activated protein kinase 1

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Prostaglandin G2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003235
xref: Reference/PubChem-compound 5280883
xref: Reference/ChEBI CHEBI 27647
xref: Reference/CAS 51982-36-6
xref: Reference/KEGG Compound C05956
xref: Reference/ChemSpider 4444406
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C001814

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11177
organism: Homo sapiens

Compound/PW C000396 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 1.0

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/ChemSpider 392800
type: UnificationXref
id: 392800
db: ChemSpider

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

Reactive oxygen species
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Reactive oxygen species

pyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: pyruvate
name: SubPathwayOutput

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11498

Interaction964
type: MolecularInteraction
interaction type: direct_interaction
name: Succinic acid activates Succinate receptor 1
participant: Succinic acid
participant: Succinate receptor 1

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Reference/KEGG Compound C05956
type: UnificationXref
id: C05956
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/UniProt P27361
type: UnificationXref
id: P27361
db: UniProt

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid

Phospholipids
type: SmallMolecule
cellular location: Cytosol
entity reference: Phospholipids

Reference/UniProt O14521
type: UnificationXref
id: O14521
db: UniProt

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin G2
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/UniProt Q9BXA5
type: UnificationXref
id: Q9BXA5
db: UniProt

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Oxaloacetate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxaloacetate

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayInput

ChemicalStructure/PW C108867
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/UniProt P50213
type: UnificationXref
id: P50213
db: UniProt

Reference/SMPDB SMP0122567
type: UnificationXref
id: SMP0122567
db: SMPDB

ChemicalStructure/PW C000051
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C\C(=C\C(O)=O)C(O)=O

L-Citrulline
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Citrulline

ChemicalStructure/PW C108868
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0001220
type: UnificationXref
id: HMDB0001220
db: HMDB

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Reference/UniProt P07954
type: UnificationXref
id: P07954
db: UniProt

Lipopolysaccharide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lipopolysaccharide

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Voltage-dependent anion-selective channel protein 2
type: ProteinReference
xref: Reference/UniProt P45880

Diacylglycerol
type: SmallMoleculeReference

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Compound/PW C108870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

Voltage-dependent anion-selective channel protein 1
type: ProteinReference
xref: Reference/UniProt P21796

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/PathWhiz PW123878
type: UnificationXref
id: PW123878
db: PathWhiz

ChemicalStructure/PW C108870
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Reaction218099
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
right: cis-Aconitic acid
right: Water
spontaneous: false
left: Citrate
name: Citrate ↔ Water + cis-Aconitic acid
conversion direction: REVERSIBLE

Malate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Malate

Reaction218098
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Citrate
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
left: Water
left: Oxaloacetate
name: Acetyl-CoA + Oxaloacetate + Water ↔ Citrate + Coenzyme A
conversion direction: REVERSIBLE

Reference/UniProt P51553
type: UnificationXref
id: P51553
db: UniProt

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Reference/UniProt O00206
type: UnificationXref
id: O00206
db: UniProt

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: Reference/UniProt Q16665
organism: Homo sapiens

Solute carrier family 13 member 3
type: ProteinReference
xref: Reference/UniProt Q8WWT9

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: Reference/UniProt Q16665
organism: Homo sapiens

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99798
organism: Homo sapiens

Succinate receptor 1
type: Protein
cellular location: Cell Membrane
entity reference: Succinate receptor 1

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Reference/UniProt Q99798
type: UnificationXref
id: Q99798
db: UniProt

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Reference/UniProt P21912
type: UnificationXref
id: P21912
db: UniProt

Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

Protein/52 Mitochondrial Matrix/Stoichiometry/24.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 24.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Transport13927
type: Transport
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Extracellular Space/Stoichiometry/1.0
right: Succinic acid
spontaneous: false
left: Succinic acid
name: Succinic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport13926
type: Transport
participant stoichiometry: Protein/23937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23937 Nucleus/Stoichiometry/1.0
right: Hypoxia-inducible factor 1-alpha
spontaneous: false
left: Hypoxia-inducible factor 1-alpha
name: Hydroxylated hypoxia-inducible factor 1-alpha (→) Transport: Homo sapiens, Cell, Nucleus to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport13928
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum Lumen to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P19838
type: UnificationXref
id: P19838
db: UniProt

Transport13925
type: Transport
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Nucleus/Stoichiometry/1.0
right: Succinic acid
spontaneous: false
left: Succinic acid
name: Succinic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Transport13924
type: Transport
participant stoichiometry: Compound/PW C000174 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
right: Succinic acid
spontaneous: false
left: Succinic acid
name: Succinic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: Reference/UniProt P50148
organism: Homo sapiens

Prostaglandin E2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin E2

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Transport13921
type: Transport
participant stoichiometry: Compound/PW C000174 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
spontaneous: false
left: Succinic acid
name: Succinic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C000353 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Prostaglandin H2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin H2

Succinate Immunometabolism Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2503419
pathway order: PathwayInteraction/964
pathway order: PathwayEnzymeReaction/2503378
pathway order: PathwayTransport/2503418
pathway order: PathwayInteraction/509
pathway order: PathwayEnzymeReaction/2503414
pathway order: PathwayEnzymeReaction/2503438
pathway order: PathwayTransport/2503379
pathway order: PathwayEnzymeReaction/2503370
pathway order: PathwayTransport/2503420
pathway order: PathwayEnzymeReaction/2503372
pathway order: PathwayInteraction/3528
pathway order: PathwayInteraction/3825
pathway order: PathwayEnzymeReaction/2503373
pathway order: PathwayInteraction/3824
pathway order: PathwayEnzymeReaction/2503374
pathway order: PathwayInteraction/3823
pathway order: PathwayEnzymeReaction/2503375
pathway order: PathwayInteraction/3822
pathway order: PathwayEnzymeReaction/2503376
pathway order: PathwayTransport/2503381
pathway order: PathwayEnzymeReaction/2503431
pathway order: PathwayEnzymeReaction/2503377
pathway order: PathwayTransport/2503380
pathway order: PathwaySubPathway/117137
pathway order: PathwaySubPathway/117134
pathway order: PathwayInteraction/242
pathway order: PathwaySubPathway/117135
pathway order: PathwayInteraction/976
pathway order: PathwayTransport/2503408
pathway order: PathwayTransport/2503409
pathway order: PathwayTransport/2503428
pathway order: PathwayEnzymeReaction/2503368
pathway order: PathwayEnzymeReaction/2503445
pathway order: PathwayEnzymeReaction/2503369
pathway order: PathwayTransport/2503404
pathway order: PathwayEnzymeReaction/2503426
pathway order: PathwayInteraction/3816
pathway order: PathwayInteraction/3815
pathway order: PathwayInteraction/3814
pathway order: PathwayInteraction/3813
pathway order: PathwayEnzymeReaction/2503440
pathway order: PathwayEnzymeReaction/2503442
pathway order: PathwayInteraction/3810
pathway order: PathwaySubPathway/117129
pathway component: ReactionCatalysis202959
pathway component: ReactionCatalysis202955
pathway component: 1.2.4.1
pathway component: Transport13912
pathway component: Transport13911
pathway component: 3.1.4.11
pathway component: ReactionCatalysis207369
pathway component: Interaction976
pathway component: Interaction3825
pathway component: 1.2.4.2
pathway component: Interaction3822
pathway component: ReactionCatalysis207481
pathway component: Interaction3823
pathway component: ReactionCatalysis207480
pathway component: Interaction3824
pathway component: Transport279
pathway component: TransportCatalysis4922
pathway component: TransportCatalysis4923
pathway component: ReactionCatalysis188
pathway component: 1.14.99.1
pathway component: ReactionCatalysis64
pathway component: ReactionCatalysis67
pathway component: Interaction3814
pathway component: Interaction3815
pathway component: Interaction3816
pathway component: Interaction509
pathway component: Reaction218099
pathway component: Interaction3810
pathway component: 4.2.1.3
pathway component: Glycolysis
pathway component: Reaction218098
pathway component: Interaction3813
pathway component: TransportCatalysis4934
pathway component: TransportCatalysis4931

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Endoplasmic Reticulum Lumen
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005788

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: NADPH
right: Carbon dioxide
spontaneous: false
EC number: 1.2.4.1
left: NADP
left: Coenzyme A
left: pyruvate
name: Coenzyme A + NADP + pyruvate ↔ Acetyl-CoA + Carbon dioxide + NADPH
conversion direction: REVERSIBLE

Transport13912
type: Transport
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: pyruvate
spontaneous: false
left: pyruvate
name: pyruvate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C096985
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

Transport13911
type: Transport
participant stoichiometry: Compound/PW C108870 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: pyruvate
spontaneous: false
left: pyruvate
name: pyruvate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/Generic631 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reactive oxygen species
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADP

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

ChemicalStructure/PW C001068
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
type: UnificationXref
id: 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
db: BioCyc

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0001381
type: UnificationXref
id: HMDB0001381
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Nucleus
entity reference: NF-kappa-B inhibitor alpha

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Prostaglandin E2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin E2
name: SubPathwayInput

Reference/CAS 585-84-2
type: UnificationXref
id: 585-84-2
db: CAS

Succinic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Succinic acid

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

SubPathwayInteraction117137
type: Interaction
name: SubPathwayReaction
name: SubPathway117137Reaction
participant: Toll-like receptor 4
participant: NFKB

Nitric oxide synthase, endothelial
type: ProteinReference
xref: Reference/UniProt P29474
organism: Homo sapiens

Protein/4308 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/UniProt P11177
type: UnificationXref
id: P11177
db: UniProt

Isocitric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Isocitric acid

Protein/2126 Endoplasmic Reticulum Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

NADPH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADPH

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P36957
organism: Homo sapiens

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/882 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 1.0

Nitric oxide synthase, endothelial
type: Protein
cellular location: Cytosol
entity reference: Nitric oxide synthase, endothelial

Reference/HMDB HMDB0000072
type: UnificationXref
id: HMDB0000072
db: HMDB

Reference/HMDB HMDB0000193
type: UnificationXref
id: HMDB0000193
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Prostaglandin G2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G2

Nitric-oxide synthase, endothelial
type: Complex
component stoichiometry: Protein/872 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Nitric oxide synthase, endothelial

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/BioCyc CIS-ACONITATE
type: UnificationXref
id: CIS-ACONITATE
db: BioCyc

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Compound/PW C001867 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 1.0

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/UniProt Q99643
type: UnificationXref
id: Q99643
db: UniProt

Reference/HMDB HMDB0003235
type: UnificationXref
id: HMDB0003235
db: HMDB

Protein kinase C alpha type
type: Protein
cellular location: Nucleus
entity reference: Protein kinase C alpha type

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Reference/PubChem-compound 11970143
type: UnificationXref
id: 11970143
db: PubChem-compound

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/UniProt Q16665
type: UnificationXref
id: Q16665
db: UniProt

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Reference/BioCyc PROSTAGLANDIN-H2
type: UnificationXref
id: PROSTAGLANDIN-H2
db: BioCyc

Von Hippel-Lindau disease tumor suppressor
type: Protein
cellular location: Cytosol
entity reference: Von Hippel-Lindau disease tumor suppressor

Succinyl-CoA ligase
type: Complex
component stoichiometry: Protein/834 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/832 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
component: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Protein/23937 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Reference/PubChem-compound 445049
type: UnificationXref
id: 445049
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5280360
type: UnificationXref
id: 5280360
db: PubChem-compound

Reference/PubChem-compound 31348
type: UnificationXref
id: 31348
db: PubChem-compound

Reference/SMPDB SMP0124909
type: UnificationXref
id: SMP0124909
db: SMPDB

Protein/52 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Prostaglandin G/H synthase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 1

Lipopolysaccharide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11970143
chemical formula: C205H366N3O117P5
molecular weight: 4897.147
structure: ChemicalStructure/PW C104587

Reference/UniProt P11498
type: UnificationXref
id: P11498
db: UniProt

Citrate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 31348
chemical formula: C6H5O7
molecular weight: 189.00352
structure: ChemicalStructure/PW C104585

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96I99
organism: Homo sapiens

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53597
organism: Homo sapiens

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Cytosol
entity reference: Hypoxia-inducible factor 1-alpha

Reference/UniProt Q9UBX3
type: UnificationXref
id: Q9UBX3
db: UniProt

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Aconitate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aconitate hydratase, mitochondrial

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117129
pathway component: SubPathwayInteraction117129
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/Generic617 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phospholipids
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C001860 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Isocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 320-77-4
xref: Reference/BioCyc threo-d(s)-iso-citrate
xref: Reference/ChEBI CHEBI 30887
xref: Reference/ChemSpider 1161
xref: Reference/HMDB HMDB0000193
xref: Reference/KEGG Compound C00311
xref: Reference/PubChem-compound 1198
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000125

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P50213
organism: Homo sapiens

L-Citrulline
type: SmallMoleculeReference
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C096985

Oxoglutarate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/4308 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/882 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
component: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: ProteinReference
xref: Reference/UniProt P51553
organism: Homo sapiens

Interaction3528
type: MolecularInteraction
interaction type: direct_interaction
name: Gq protein signaling cascade activates Phospholipase C
participant: Guanine nucleotide-binding protein G(q) subunit alpha
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

NFKB
type: Complex
cellular location: Nucleus
component: NF-kappa-B inhibitor alpha
component: Nuclear factor NF-kappa-B p105 subunit
name: SubPathwayOutput

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt O43837
organism: Homo sapiens

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/UniProt Q8WWT9
type: UnificationXref
id: Q8WWT9
db: UniProt

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/UniProt P35354
type: UnificationXref
id: P35354
db: UniProt

Oxaloacetate
type: SmallMoleculeReference
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C108867

Malate
type: SmallMoleculeReference
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C108868

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252
organism: Homo sapiens

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4
name: SubPathwayInput

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrial Matrix/Stoichiometry/24.0
component stoichiometry: Protein/12 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/53 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/44 Mitochondrial Matrix/Stoichiometry/60.0
cellular location: Mitochondrial Matrix
component: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Interaction242
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Solute carrier family 13 member 3
type: Protein
entity reference: Solute carrier family 13 member 3

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Reference/ChemSpider 558863
type: UnificationXref
id: 558863
db: ChemSpider

IL-1β
type: DnaReference
organism: Homo sapiens

pyruvate
type: SmallMoleculeReference
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C108870

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

TransportCatalysis227
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport279
control type: ACTIVATION

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/UniProt P40926
type: UnificationXref
id: P40926
db: UniProt

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/PubChem-compound 643757
type: UnificationXref
id: 643757
db: PubChem-compound

Acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Acceptor

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: Homo sapiens

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Voltage-dependent anion-selective channel protein 2
type: Protein
entity reference: Voltage-dependent anion-selective channel protein 2

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Phospholipids
type: SmallMoleculeReference

Malate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/803 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Malate dehydrogenase, mitochondrial

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

cis-Aconitic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: cis-Aconitic acid

Voltage-dependent anion-selective channel protein 1
type: Protein
entity reference: Voltage-dependent anion-selective channel protein 1

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/CAS 42935-17-1
type: UnificationXref
id: 42935-17-1
db: CAS

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydroquinone

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

ChemicalStructure/PW C104585
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt Q96HY7
type: UnificationXref
id: Q96HY7
db: UniProt

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Protein/23938 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

ChemicalStructure/PW C104587
type: ChemicalStructure
structure format: SMILES

Egl nine homolog 2
type: Protein
cellular location: Nucleus
entity reference: Egl nine homolog 2

Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

TransportCatalysis4922
type: Catalysis
controller: Voltage-dependent anion-selective channel protein 2
controlled: Transport13911
control type: ACTIVATION

Compound/PW C000949 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

TransportCatalysis4923
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: Transport13912
control type: ACTIVATION

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Nucleus
entity reference: Hypoxia-inducible factor 1-alpha

ReactionCatalysis188
type: Catalysis
controller: Prostaglandin E synthase
controlled: 5.3.99.3
control type: ACTIVATION

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Mitochondrial dicarboxylate carrier
type: ProteinReference
xref: Reference/UniProt Q9UBX3

Prostaglandin G/H synthase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 2

ReactionCatalysis64
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: 4.2.1.3
control type: ACTIVATION

Prostaglandin G/H synthase 1
type: ProteinReference
xref: Reference/UniProt P23219
organism: Homo sapiens

Prostaglandin G/H synthase 2
type: ProteinReference
xref: Reference/UniProt P35354
organism: Homo sapiens

ReactionCatalysis67
type: Catalysis
controller: Oxoglutarate dehydrogenase complex
controlled: 1.2.4.2
control type: ACTIVATION

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Malate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Malate dehydrogenase, mitochondrial

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

4.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
right: Isocitric acid
spontaneous: false
EC number: 4.2.1.3
left: cis-Aconitic acid
left: Water
name: Water + cis-Aconitic acid ↔ Isocitric acid
conversion direction: REVERSIBLE

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q96I99
type: UnificationXref
id: Q96I99
db: UniProt

Reference/UniProt P25963
type: UnificationXref
id: P25963
db: UniProt

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 3

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/UniProt P31040
type: UnificationXref
id: P31040
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

TransportCatalysis4934
type: Catalysis
controller: Voltage-dependent anion-selective channel protein 1
controlled: Transport13924
control type: ACTIVATION

TransportCatalysis4931
type: Catalysis
controller: Mitochondrial dicarboxylate carrier
controlled: Transport13921
control type: ACTIVATION

Egl nine homolog 2
type: ProteinReference
xref: Reference/UniProt Q96KS0
organism: Homo sapiens

Arachidonic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Arachidonic acid

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P07954
organism: Homo sapiens

Reactive oxygen species
type: SmallMoleculeReference

Compound/PW C000174 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444059
type: UnificationXref
id: 4444059
db: ChemSpider

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Malate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P40926
organism: Homo sapiens

TransportCatalysis4937
type: Catalysis
controller: Solute carrier family 13 member 3
controlled: Transport13927
control type: ACTIVATION

Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

TransportCatalysis4938
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport13928
control type: ACTIVATION

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

TransportCatalysis4935
type: Catalysis
controller: Unknown
controlled: Transport13925
control type: ACTIVATION

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

TransportCatalysis4936
type: Catalysis
controller: Unknown
controlled: Transport13926
control type: ACTIVATION

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt P23219
type: UnificationXref
id: P23219
db: UniProt

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

ReactionCatalysis70
type: Catalysis
controller: Isocitrate dehydrogenase
controlled: 1.1.1.41
control type: ACTIVATION

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Prostaglandin E synthase
type: Complex
component stoichiometry: Protein/76 Endoplasmic Reticulum Membrane/Stoichiometry/3.0
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin E synthase

cis-Aconitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 643757
xref: Reference/KEGG Compound C00417
xref: Reference/HMDB HMDB0000072
xref: Reference/ChEBI CHEBI 32805
xref: Reference/BioCyc CIS-ACONITATE
xref: Reference/ChemSpider 558863
xref: Reference/CAS 585-84-2
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000051

Reference/CAS 320-77-4
type: UnificationXref
id: 320-77-4
db: CAS

Reference/BioCyc threo-d(s)-iso-citrate
type: UnificationXref
id: threo-d(s)-iso-citrate
db: BioCyc

Reaction218109
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C096985 Cytosol/Stoichiometry/1.0
right: NADP
right: L-Citrulline
right: Nitric oxide
right: Water
spontaneous: false
left: Oxygen
left: Hydrogen Ion
left: L-Arginine
left: NADPH
name: Hydrogen Ion + L-Arginine + NADPH + Oxygen → L-Citrulline + NADP + Nitric oxide + Water
conversion direction: LEFT_TO_RIGHT

Pyruvate carboxylase, mitochondrial
type: Protein
entity reference: Pyruvate carboxylase, mitochondrial

Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Reaction218103
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
left: Succinic acid
left: Coenzyme A
left: Adenosine triphosphate
name: Adenosine triphosphate + Coenzyme A + Succinic acid ↔ Adenosine diphosphate + Phosphate + Succinyl-CoA
conversion direction: REVERSIBLE

Reaction218101
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: Water
spontaneous: false
left: Malate
name: Malate ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/Generic631 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001860 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Quinone
right: Succinic acid
spontaneous: false
EC number: 1.3.5.1
left: Fumaric acid
left: Hydroquinone
left: Reactive oxygen species
name: Fumaric acid + Hydroquinone + Reactive oxygen species ↔ Quinone + Succinic acid
conversion direction: REVERSIBLE

Reaction218107
type: BiochemicalReaction
participant stoichiometry: Protein/23937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23938 Cytosol/Stoichiometry/1.0
right: Hypoxia-inducible factor 1-alpha
spontaneous: false
left: Hypoxia-inducible factor 1-alpha
name: Hydroxylated hypoxia-inducible factor 1-alpha → Ubiquitinated hypoxia inducible factor 1 alpha
conversion direction: LEFT_TO_RIGHT

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin G2
spontaneous: false
EC number: 1.14.99.1
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → Prostaglandin G2
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis207434
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

Compound/PW C000174 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

1.14.11.29
type: BiochemicalReaction
participant stoichiometry: Protein/14788 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/23937 Nucleus/Stoichiometry/1.0
right: Hypoxia-inducible factor 1-alpha
spontaneous: false
EC number: 1.14.11.29
left: Hypoxia-inducible factor 1-alpha
name: hypoxia-inducible factor-1α → Hydroxylated hypoxia-inducible factor 1-alpha
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Reference/PathWhiz PW126414
type: UnificationXref
id: PW126414
db: PathWhiz

ChemicalStructure/PW C000125
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(CC(O)=O)C(O)=O)C(O)=O

Protein/12 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 60.0

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Arachidonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Arachidonic acid

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: pyruvate

Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Proteasomal degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117134
pathway component: SubPathwayInteraction117134
name: SubPathway

TLR4 receptor signaling pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117137
pathway component: SubPathwayInteraction117137
name: SubPathway

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96HY7
organism: Homo sapiens

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126 Endoplasmic Reticulum Membrane/Stoichiometry/4.0
cellular location: Endoplasmic Reticulum Membrane
component: Inositol 1,4,5-trisphosphate receptor type 1

Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643

Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis207369
type: Catalysis
controller: Malate dehydrogenase, mitochondrial
controlled: Reaction217840
control type: ACTIVATION

Interaction976
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Nitric-oxide synthase, endothelial
participant: Nitric-oxide synthase, endothelial
participant: Calcium

ChemicalStructure/PW C001814
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Carbon dioxide
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.4.2
left: Coenzyme A
left: Oxoglutaric acid
left: NAD
name: Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
conversion direction: LEFT_TO_RIGHT

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Reference/PubChem-compound 5280883
type: UnificationXref
id: 5280883
db: PubChem-compound

Protein/14788 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

ReactionCatalysis207481
type: Catalysis
controller: Nitric-oxide synthase, endothelial
controlled: Reaction218109
control type: ACTIVATION

ReactionCatalysis207480
type: Catalysis
controller: Prostaglandin G/H synthase 1&2
controlled: 1.14.99.1
control type: ACTIVATION

Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Prostaglandin G/H synthase 1&2
type: Complex
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin G/H synthase 2
component: Prostaglandin G/H synthase 1

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Fumarate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Fumarate hydratase, mitochondrial

citrate synthase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: citrate synthase

Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Prostaglandin E synthase
type: ProteinReference
xref: Reference/UniProt O14684
organism: Homo sapiens

Quinone
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Quinone

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Protein/803 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Malate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reduced acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced acceptor

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Protein/842 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Compound/PW C000174 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Interaction509
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Citrate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Citrate

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Compound/PW C001632 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Nucleus
entity reference: Hypoxia-inducible factor 1-alpha

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: Reference/UniProt Q16665
organism: Homo sapiens

Prostaglandin G/H synthase 1&2
type: Complex
cellular location: Cytosol
component: Prostaglandin G/H synthase 2
component: Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin G/H synthase 2

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: Reference/UniProt P08559
organism: Homo sapiens

ChemicalStructure/PW C000949
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Inositol 1,4,5-trisphosphate

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Cytosol
entity reference: Hypoxia-inducible factor 1-alpha
name: SubPathwayInput

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Succinic acid
type: SmallMolecule
cellular location: Nucleus
entity reference: Succinic acid

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt P25963
organism: Homo sapiens

Reference/UniProt P45880
type: UnificationXref
id: P45880
db: UniProt

Protein/872 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, endothelial
stoichiometric coefficient: 2.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Prostaglandin H2
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00427
xref: Reference/ChEBI CHEBI 15554
xref: Reference/CAS 42935-17-1
xref: Reference/BioCyc PROSTAGLANDIN-H2
xref: Reference/ChemSpider 392800
xref: Reference/PubChem-compound 445049
xref: Reference/HMDB HMDB0001381
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001068

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005788
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/UniProt P36957
type: UnificationXref
id: P36957
db: UniProt

Reference/ChEBI CHEBI 15554
type: UnificationXref
id: CHEBI:15554
db: ChEBI

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P10515
organism: Homo sapiens

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P09622
organism: Homo sapiens

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Succinate receptor 1
type: ProteinReference
xref: Reference/UniProt Q9BXA5
organism: Homo sapiens

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

Protein/843 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

ReactionCatalysis207479
type: Catalysis
controller: Von Hippel-Lindau disease tumor suppressor
controlled: Reaction218107
control type: ACTIVATION

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt P27361
organism: Homo sapiens

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ReactionCatalysis207478
type: Catalysis
controller: Egl nine homolog 2
controlled: 1.14.11.29
control type: ACTIVATION

Reference/ChEBI CHEBI 15551
type: UnificationXref
id: CHEBI:15551
db: ChEBI

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt O00206
organism: Homo sapiens

ReactionCatalysis207477
type: Catalysis
controller: Succinyl-CoA ligase
controlled: Reaction218103
control type: ACTIVATION

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt P47712
organism: Homo sapiens

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

ReactionCatalysis207476
type: Catalysis
controller: Succinate dehydrogenase
controlled: 1.3.5.1
control type: ACTIVATION

ReactionCatalysis207475
type: Catalysis
controller: Fumarate hydratase, mitochondrial
controlled: Reaction218101
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Calcium

ReactionCatalysis207473
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: Reaction218099
control type: ACTIVATION

ReactionCatalysis207472
type: Catalysis
controller: citrate synthase
controlled: Reaction218098
control type: ACTIVATION

Reference/ChEBI CHEBI 27647
type: UnificationXref
id: CHEBI:27647
db: ChEBI

Reference/UniProt P47712
type: UnificationXref
id: P47712
db: UniProt

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

Succinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinic acid

Compound/PW C000821 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Succinic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Succinic acid

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide
name: SubPathwayInput

Reference/ChemSpider 4444406
type: UnificationXref
id: 4444406
db: ChemSpider

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt P08679
type: UnificationXref
id: P08679
db: UniProt

Reference/UniProt P08559
type: UnificationXref
id: P08559
db: UniProt

ReactionCatalysis202959
type: Catalysis
controller: Cytosolic phospholipase A2
controlled: Reaction213363
control type: ACTIVATION

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ReactionCatalysis202955
type: Catalysis
controller: Prostaglandin G/H synthase 1&2
controlled: 1.14.99.1
control type: ACTIVATION

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic369 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/UniProt P10515
type: UnificationXref
id: P10515
db: UniProt

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Calcium

Interaction3825
type: MolecularInteraction
interaction type: direct_interaction
name: NFKB activates IL-1β
participant: IL-1β
participant: NFKB

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P21912
organism: Homo sapiens

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Interaction3822
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates ERK1 & ERK2
participant: ERK1 & ERK2
participant: Protein kinase C alpha type

Interaction3823
type: MolecularInteraction
interaction type: direct_interaction
name: ERK1 & ERK2 activates Prostaglandin G/H synthase 1&2
participant: Prostaglandin G/H synthase 1&2
participant: ERK1 & ERK2

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Reference/CAS 51982-36-6
type: UnificationXref
id: 51982-36-6
db: CAS

Interaction3824
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates NFKB
participant: NFKB
participant: Protein kinase C alpha type

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Fumarate hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/806 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Fumarate hydratase, mitochondrial

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Isocitrate dehydrogenase
type: Complex
component stoichiometry: Protein/840 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/842 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/843 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Succinic acid

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Protein/44 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
stoichiometric coefficient: 60.0

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Interaction3814
type: MolecularInteraction
interaction type: direct_interaction
name: hypoxia-inducible factor-1α activates IL-1β
participant: IL-1β
participant: Hypoxia-inducible factor 1-alpha

Interaction3815
type: MolecularInteraction
interaction type: direct_interaction
name: Succinate receptor 1 activates Gq protein signaling cascade
participant: Succinate receptor 1
participant: Guanine nucleotide-binding protein G(q) subunit alpha

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Protein/19/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase, mitochondrial
stoichiometric coefficient: 4.0

Interaction3816
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Prostaglandin G/H synthase 1&2
participant: Calcium
participant: Prostaglandin G/H synthase 1&2

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Interaction3810
type: MolecularInteraction
interaction type: direct_interaction
name: Lipopolysaccharide activates Toll-like receptor 4
participant: Lipopolysaccharide
participant: Toll-like receptor 4

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Interaction3813
type: MolecularInteraction
interaction type: direct_interaction
name: Succinic acid inhibits Prolyl hydroxylase EGLN2
participant: Succinic acid
participant: Egl nine homolog 2

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 32805
type: UnificationXref
id: CHEBI:32805
db: ChEBI

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cell Membrane
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/KEGG Compound C00417
type: UnificationXref
id: C00417
db: KEGG Compound

Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: cis-Aconitic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Reference/PubChem-compound 1198
type: UnificationXref
id: 1198
db: PubChem-compound

Protein/832 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

5.3.99.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000949 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin E2
spontaneous: false
EC number: 5.3.99.3
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin E2
conversion direction: LEFT_TO_RIGHT

Protein/834 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Prostaglandin E synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin E synthase

Reference/UniProt P21796
type: UnificationXref
id: P21796
db: UniProt

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

1.1.1.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Oxoglutaric acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.41
left: Isocitric acid
left: NAD
name: Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00427
type: UnificationXref
id: C00427
db: KEGG Compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt P53597
type: UnificationXref
id: P53597
db: UniProt

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Toll-like receptor 4
type: Protein
cellular location: Extracellular Space
entity reference: Toll-like receptor 4

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C096985 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Citrulline
stoichiometric coefficient: 1.0