Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Compound/PW C000146 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Malate dehydrogenase, cytoplasmic

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

2.3.1.85
type: BiochemicalReaction
participant stoichiometry: Compound/Generic626 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: Carbon dioxide
right: NADP
right: Long chain fatty acid
right: Water
spontaneous: false
EC number: 2.3.1.85
left: Malonyl-CoA
left: Acetyl-CoA
left: NADPH
name: Acetyl-CoA + Malonyl-CoA + NADPH → Carbon dioxide + Coenzyme A + Long chain fatty acid + NADP + Water
conversion direction: LEFT_TO_RIGHT

Prostaglandin E2
type: SmallMoleculeReference
xref: Reference/CAS 363-24-6
xref: Reference/ChemSpider 4444059
xref: Reference/KEGG Compound C00584
xref: Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
xref: Reference/PubChem-compound 5280360
xref: Reference/ChEBI CHEBI 15551
xref: Reference/HMDB HMDB0001220
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C000949

Reference/KEGG Compound C00311
type: UnificationXref
id: C00311
db: KEGG Compound

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P31040
organism: Homo sapiens

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Tricarboxylate transport protein, mitochondrial
type: Protein
entity reference: Tricarboxylate transport protein, mitochondrial

Unknown
type: ProteinReference

Compound/PW C000723 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 2.0

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Nitric oxide synthase, inducible
type: Protein
cellular location: Cytosol
entity reference: Nitric oxide synthase, inducible

Cis-aconitate decarboxylase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Cis-aconitate decarboxylase

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

1.1.1.37
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Oxaloacetate
spontaneous: false
EC number: 1.1.1.37
left: NAD
left: Malate
name: Malate + NAD ↔ Hydrogen Ion + NADH + Oxaloacetate
conversion direction: REVERSIBLE

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Itaconic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Itaconic acid

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

ReactionCatalysis202881
type: Catalysis
controller: Nitric oxide synthase, inducible
controlled: Reaction213297
control type: ACTIVATION

Protein/10 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-citrate synthase
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

Protein/806 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fumarate hydratase, mitochondrial
stoichiometric coefficient: 4.0

IL-6
type: Dna
cellular location: Nucleus
entity reference: IL-6
name: SubPathwayOutput

citrate synthase
type: ProteinReference
xref: Reference/UniProt P08679
organism: Homo sapiens

Inflammation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117144
pathway order: SubPathwayInteractionSteps/SubPathway117145
pathway component: SubPathwayInteraction117144
pathway component: SubPathwayInteraction117145
xref: Reference/SMPDB SMP0122567
xref: Reference/PathWhiz PW123878
name: SubPathway

Reference/UniProt P09622
type: UnificationXref
id: P09622
db: UniProt

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reaction217840
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxaloacetate
right: NADH
right: Hydrogen Ion
spontaneous: false
left: Malate
left: NAD
name: Malate + NAD → Hydrogen Ion + NADH + Oxaloacetate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/BioCyc ITACONATE
type: UnificationXref
id: ITACONATE
db: BioCyc

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Protein/840 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

TNFα
type: Rna
cellular location: Nucleus
entity reference: TNFα

NADPH oxidase 4
type: Protein
cellular location: Cytosol
entity reference: NADPH oxidase 4

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: pyruvate

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

Reference/PubChem-compound 811
type: UnificationXref
id: 811
db: PubChem-compound

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

Reference/KEGG Compound C00584
type: UnificationXref
id: C00584
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 363-24-6
type: UnificationXref
id: 363-24-6
db: CAS

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O14521
organism: Homo sapiens

Reference/ChEBI CHEBI 30887
type: UnificationXref
id: CHEBI:30887
db: ChEBI

Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/19/Stoichiometry/4.0
component: Pyruvate carboxylase, mitochondrial

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Reference/ChemSpider 1161
type: UnificationXref
id: 1161
db: ChemSpider

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/UniProt O43837
type: UnificationXref
id: O43837
db: UniProt

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glyceraldehyde-3-phosphate dehydrogenase
name: SubPathwayOutput

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

L-Arginine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Arginine

Transport279
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000396 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Compound/PW C104585 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Fatty acid synthase
type: ProteinReference
xref: Reference/UniProt P49327
organism: Homo sapiens

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99643
organism: Homo sapiens

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Protein/53 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 60.0

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Reference/KEGG Compound C00490
type: UnificationXref
id: C00490
db: KEGG Compound

Protein/23940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Reference/HMDB HMDB0002092
type: UnificationXref
id: HMDB0002092
db: HMDB

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11177
organism: Homo sapiens

Reference/UniProt P05231
type: UnificationXref
id: P05231
db: UniProt

ATP-citrate synthase
type: ProteinReference
xref: Reference/UniProt P53396
organism: Homo sapiens

Protein/1766 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

pyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: pyruvate
name: SubPathwayOutput

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11498

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/UniProt P48163
type: UnificationXref
id: P48163
db: UniProt

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid

Reference/UniProt O14521
type: UnificationXref
id: O14521
db: UniProt

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

Oxaloacetate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxaloacetate

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayInput

ChemicalStructure/PW C108867
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/UniProt P50213
type: UnificationXref
id: P50213
db: UniProt

Reference/SMPDB SMP0122567
type: UnificationXref
id: SMP0122567
db: SMPDB

ChemicalStructure/PW C000051
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C\C(=C\C(O)=O)C(O)=O

Long chain fatty acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Long chain fatty acid
name: SubPathwayInput

ChemicalStructure/PW C108868
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Nitric oxide synthase, inducible
type: Complex
component stoichiometry: Protein/869 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Nitric oxide synthase, inducible

Reference/HMDB HMDB0001220
type: UnificationXref
id: HMDB0001220
db: HMDB

Reference/UniProt P07954
type: UnificationXref
id: P07954
db: UniProt

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Voltage-dependent anion-selective channel protein 2
type: ProteinReference
xref: Reference/UniProt P45880

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Malate
type: SmallMolecule
cellular location: Cytosol
entity reference: Malate

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Itaconic acid
type: SmallMoleculeReference
xref: Reference/CAS 97-65-4
xref: Reference/HMDB HMDB0002092
xref: Reference/KEGG Compound C00490
xref: Reference/PubChem-compound 811
xref: Reference/ChEBI CHEBI 30838
xref: Reference/BioCyc ITACONATE
xref: Reference/ChemSpider 789
chemical formula: C5H6O4
molecular weight: 130.02661
structure: ChemicalStructure/PW C001406

Compound/PW C108870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

Voltage-dependent anion-selective channel protein 1
type: ProteinReference
xref: Reference/UniProt P21796

Reference/PathWhiz PW123878
type: UnificationXref
id: PW123878
db: PathWhiz

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

IL-6
type: Dna
cellular location: Cytosol
entity reference: IL-6

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C108870
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Reaction218099
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
right: cis-Aconitic acid
right: Water
spontaneous: false
left: Citrate
name: Citrate ↔ Water + cis-Aconitic acid
conversion direction: REVERSIBLE

Malate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Malate

Reaction218098
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Citrate
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
left: Water
left: Oxaloacetate
name: Acetyl-CoA + Oxaloacetate + Water ↔ Citrate + Coenzyme A
conversion direction: REVERSIBLE

Protein/659 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 1.0

Reference/UniProt P51553
type: UnificationXref
id: P51553
db: UniProt

DNA/365 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: IL-10
stoichiometric coefficient: 1.0

Compound/PW C000940 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99798
organism: Homo sapiens

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Transport13930
type: Transport
participant stoichiometry: Compound/PW C104585 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Cytosol/Stoichiometry/1.0
right: Citrate
spontaneous: false
left: Citrate
name: Citrate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Cis-aconitate decarboxylase
type: ProteinReference
xref: Reference/UniProt A6NK06
organism: Homo sapiens

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Transport13931
type: Transport
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Nucleus/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
left: Acetyl-CoA
name: Acetyl-CoA (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Reference/UniProt Q99798
type: UnificationXref
id: Q99798
db: UniProt

Reference/UniProt P49327
type: UnificationXref
id: P49327
db: UniProt

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Compound/PW C001065 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 4.0

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Reference/UniProt P21912
type: UnificationXref
id: P21912
db: UniProt

Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Protein/52 Mitochondrial Matrix/Stoichiometry/24.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 24.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Transport13929
type: Transport
participant stoichiometry: Compound/PW C104585 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
right: Citrate
spontaneous: false
left: Citrate
name: Citrate (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Citrate Immunometabolism Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2503499
pathway order: PathwayEnzymeReaction/2503510
pathway order: PathwayTransport/2503538
pathway order: PathwayEnzymeReaction/2503512
pathway order: PathwayEnzymeReaction/2503459
pathway order: PathwayEnzymeReaction/2503514
pathway order: PathwayEnzymeReaction/2503515
pathway order: PathwayEnzymeReaction/2503516
pathway order: PathwayEnzymeReaction/2503517
pathway order: PathwayEnzymeReaction/2503539
pathway order: PathwaySubPathway/117155
pathway order: PathwayEnzymeReaction/2503498
pathway order: PathwaySubPathway/117158
pathway order: PathwaySubPathway/117159
pathway order: PathwaySubPathway/117156
pathway order: PathwaySubPathway/117138
pathway order: PathwayEnzymeReaction/2503507
pathway order: PathwayEnzymeReaction/2503508
pathway order: PathwayEnzymeReaction/2503509
pathway order: PathwayEnzymeReaction/2503466
pathway order: PathwayEnzymeReaction/2503467
pathway order: PathwayTransport/2503501
pathway order: PathwayTransport/2503469
pathway order: PathwayTransport/2503502
pathway order: PathwayEnzymeReaction/2503505
pathway order: PathwayEnzymeReaction/2503506
pathway order: PathwaySubPathway/117161
pathway order: PathwayEnzymeReaction/2503462
pathway order: PathwayTransport/2503471
pathway order: PathwaySubPathway/117143
pathway order: PathwayEnzymeReaction/2503463
pathway order: PathwayEnzymeReaction/2503540
pathway order: PathwaySubPathway/117144
pathway order: PathwayEnzymeReaction/2503465
pathway order: PathwayTransport/2503470
pathway order: PathwaySubPathway/117147
pathway order: PathwaySubPathway/117148
pathway order: PathwaySubPathway/117145
pathway component: Transport13912
pathway component: 1.2.4.1
pathway component: 1.6.3.-
pathway component: Transport13911
pathway component: Reaction218115
pathway component: Reaction218112
pathway component: 1.1.1.40
pathway component: 2.3.1.85
pathway component: ReactionCatalysis207369
pathway component: ReactionCatalysis207368
pathway component: Reaction218116
pathway component: Reaction218117
pathway component: 1.2.4.2
pathway component: ReactionCatalysis207486
pathway component: ReactionCatalysis207485
pathway component: ReactionCatalysis207484
pathway component: ReactionCatalysis207483
pathway component: ReactionCatalysis207482
pathway component: Prostaglandin Synthesis
pathway component: Transport279
pathway component: Protein translation
pathway component: Malonylation
pathway component: TransportCatalysis4922
pathway component: TransportCatalysis4923
pathway component: Acetylation of histone and non-histone proteins
pathway component: 1.1.1.37
pathway component: ReactionCatalysis64
pathway component: ReactionCatalysis67
pathway component: ReactionCatalysis202881
pathway component: Reaction218099
pathway component: 4.2.1.3
pathway component: Glycolysis
pathway component: Reaction218098
pathway component: Membrane expansion
pathway component: Inflammation
pathway component: Reaction217840
pathway component: TransportCatalysis4939
pathway component: Transport13930
pathway component: Transport13931
pathway component: ReactionCatalysis70

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Reference/ChemSpider 789
type: UnificationXref
id: 789
db: ChemSpider

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Interleukin-6
type: ProteinReference
xref: Reference/UniProt P05231
organism: Homo sapiens

Compound/PW C104585 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

ATP-citrate synthase
type: Complex
component stoichiometry: Protein/10 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: ATP-citrate synthase

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Compound/PW C104585 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Transport13912
type: Transport
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: pyruvate
spontaneous: false
left: pyruvate
name: pyruvate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: NADPH
right: Carbon dioxide
spontaneous: false
EC number: 1.2.4.1
left: NADP
left: Coenzyme A
left: pyruvate
name: Coenzyme A + NADP + pyruvate ↔ Acetyl-CoA + Carbon dioxide + NADPH
conversion direction: REVERSIBLE

Transport13911
type: Transport
participant stoichiometry: Compound/PW C108870 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: pyruvate
spontaneous: false
left: pyruvate
name: pyruvate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Nitric oxide synthase, inducible
type: ProteinReference
xref: Reference/UniProt P35228
organism: Homo sapiens

SubPathwayInteraction117158
type: Interaction
name: SubPathwayReaction
name: SubPathway117158Reaction
participant: Acetyl-CoA
participant: Citrate

SubPathwayInteraction117155
type: Interaction
name: SubPathwayReaction
name: SubPathway117155Reaction
participant: IL-6
participant: Acetyl-CoA
participant: IL-10

SubPathwayInteraction117156
type: Interaction
name: SubPathwayReaction
name: SubPathway117156Reaction
participant: D-Glucose
participant: pyruvate

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADP

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

SubPathwayInteraction117148
type: Interaction
name: SubPathway117148Reaction
name: SubPathwayReaction
participant: Tumor necrosis factor
participant: TNFα

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
type: UnificationXref
id: 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
db: BioCyc

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Tumor necrosis factor
type: ProteinReference
xref: Reference/UniProt P01375
organism: Homo sapiens

Reference/UniProt P01375
type: UnificationXref
id: P01375
db: UniProt

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

SubPathwayInteraction117143
type: Interaction
name: SubPathwayReaction
name: SubPathway117143Reaction
participant: Prostaglandin E2
participant: Long chain fatty acid

BoundComplex/576 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens)_TNFα
stoichiometric coefficient: 1.0

Prostaglandin E2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin E2
name: SubPathwayOutput
name: SubPathwayInput

SubPathwayInteraction117147
type: Interaction
name: SubPathway117147Reaction
name: SubPathwayReaction
participant: Glyceraldehyde-3-phosphate dehydrogenase
participant: Malonyl-CoA

SubPathwayInteraction117144
type: Interaction
name: SubPathwayReaction
name: SubPathway117144Reaction
participant: Prostaglandin E2
participant: Nitric oxide

Reference/CAS 585-84-2
type: UnificationXref
id: 585-84-2
db: CAS

SubPathwayInteraction117145
type: Interaction
name: SubPathway117145Reaction
name: SubPathwayReaction
participant: Reactive oxygen species

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

SubPathwayInteraction117138
type: Interaction
name: SubPathwayReaction
name: SubPathway117138Reaction
participant: D-Glucose
participant: pyruvate

Protein/4308 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/UniProt P11177
type: UnificationXref
id: P11177
db: UniProt

Isocitric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Isocitric acid

Reference/UniProt P04406
type: UnificationXref
id: P04406
db: UniProt

NADPH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADPH

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

IL-10
type: Dna
cellular location: Cytosol
entity reference: IL-10

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/UniProt Q9NPH5
type: UnificationXref
id: Q9NPH5
db: UniProt

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P36957
organism: Homo sapiens

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/882 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 1.0

Compound/PW C000911 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000072
type: UnificationXref
id: HMDB0000072
db: HMDB

Reference/HMDB HMDB0000193
type: UnificationXref
id: HMDB0000193
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

SubPathwayInteraction117161
type: Interaction
name: SubPathway117161Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: Reference/UniProt P04406
organism: Homo sapiens

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/BioCyc CIS-ACONITATE
type: UnificationXref
id: CIS-ACONITATE
db: BioCyc

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA
name: SubPathwayInput

Reference/UniProt Q99643
type: UnificationXref
id: Q99643
db: UniProt

SubPathwayInteraction117159
type: Interaction
name: SubPathway117159Reaction
name: SubPathwayReaction
participant: Long chain fatty acid

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Succinyl-CoA ligase
type: Complex
component stoichiometry: Protein/834 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/832 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
component: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1.6.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/Generic631 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
right: Reactive oxygen species
spontaneous: false
EC number: 1.6.3.-
left: NADPH
name: NADPH → Reactive oxygen species
conversion direction: LEFT_TO_RIGHT

Reaction218115
type: BiochemicalReaction
participant stoichiometry: Protein/659 Nucleus/Stoichiometry/1.0
participant stoichiometry: RNA/364 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/576 Nucleus/Stoichiometry/1.0
right: TNFα
right: Glyceraldehyde-3-phosphate dehydrogenase
spontaneous: false
left: Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens)_TNFα
name: Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens) + TNFα → Malonylated Glyceraldehyde-3-phosphate dehydrogenase + TNFα
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Reaction218112
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Malonyl-CoA
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Acetyl-CoA
left: Hydrogen carbonate
name: Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ Adenosine diphosphate + Malonyl-CoA + Phosphate
conversion direction: REVERSIBLE

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

1.1.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: pyruvate
right: NADPH
spontaneous: false
EC number: 1.1.1.40
left: Malate
left: NADP
name: Malate + NADP ↔ Carbon dioxide + NADPH + pyruvate
conversion direction: REVERSIBLE

Reference/PubChem-compound 5280360
type: UnificationXref
id: 5280360
db: PubChem-compound

Reference/PubChem-compound 31348
type: UnificationXref
id: 31348
db: PubChem-compound

Reaction218116
type: BiochemicalReaction
participant stoichiometry: Protein/23940 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/360 Cytosol/Stoichiometry/1.0
right: Interleukin-6
spontaneous: false
left: IL-6
name: IL-6 → Interleukin-6
conversion direction: LEFT_TO_RIGHT

Reaction218117
type: BiochemicalReaction
participant stoichiometry: Protein/20827 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/365 Cytosol/Stoichiometry/1.0
right: Interleukin-10
spontaneous: false
left: IL-10
name: IL-10 → Interleukin-10
conversion direction: LEFT_TO_RIGHT

Reactive oxygen species
type: SmallMolecule
cellular location: Cytosol
entity reference: Reactive oxygen species
name: SubPathwayInput

Protein/52 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Prostaglandin Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117143
pathway component: SubPathwayInteraction117143
name: SubPathway

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayInput

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Protein translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117148
pathway component: SubPathwayInteraction117148
name: SubPathway

Malonylation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117147
pathway component: SubPathwayInteraction117147
name: SubPathway

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

Reference/UniProt P11498
type: UnificationXref
id: P11498
db: UniProt

Acetylation of histone and non-histone proteins
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117161
pathway component: SubPathwayInteraction117161
name: SubPathway

Citrate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 31348
chemical formula: C6H5O7
molecular weight: 189.00352
structure: ChemicalStructure/PW C104585

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96I99
organism: Homo sapiens

NADPH oxidase 4
type: ProteinReference
xref: Reference/UniProt Q9NPH5
organism: Homo sapiens

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53597
organism: Homo sapiens

Compound/PW C108868 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Aconitate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aconitate hydratase, mitochondrial

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117156
pathway order: SubPathwayInteractionSteps/SubPathway117138
pathway component: SubPathwayInteraction117138
pathway component: SubPathwayInteraction117156
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

TNFα
type: RnaReference
organism: Homo sapiens

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Acetylation of histone and non-histone proteins
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117155
pathway component: SubPathwayInteraction117155
name: SubPathway

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Membrane expansion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117159
pathway component: SubPathwayInteraction117159
name: SubPathway

Compound/PW C001867 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 2.0

Interleukin-10
type: ProteinReference
xref: Reference/UniProt P22301
organism: Homo sapiens

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Malonyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Malonyl-CoA
name: SubPathwayInput

Compound/PW C001860 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Isocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 320-77-4
xref: Reference/BioCyc threo-d(s)-iso-citrate
xref: Reference/ChEBI CHEBI 30887
xref: Reference/ChemSpider 1161
xref: Reference/HMDB HMDB0000193
xref: Reference/KEGG Compound C00311
xref: Reference/PubChem-compound 1198
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000125

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P50213
organism: Homo sapiens

Oxoglutarate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/4308 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/882 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
component: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: ProteinReference
xref: Reference/UniProt P51553
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt O43837
organism: Homo sapiens

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Oxaloacetate
type: SmallMoleculeReference
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C108867

Malate
type: SmallMoleculeReference
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C108868

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
cellular location: Nucleus
entity reference: Glyceraldehyde-3-phosphate dehydrogenase

DNA/360 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: IL-6
stoichiometric coefficient: 1.0

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117158
pathway component: SubPathwayInteraction117158
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

Reference/UniProt P35228
type: UnificationXref
id: P35228
db: UniProt

IL-10
type: DnaReference
organism: Homo sapiens

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrial Matrix/Stoichiometry/24.0
component stoichiometry: Protein/12 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/53 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/44 Mitochondrial Matrix/Stoichiometry/60.0
cellular location: Mitochondrial Matrix
component: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

TNFα
type: Rna
cellular location: Cytosol
entity reference: TNFα
name: SubPathwayInput

IL-6
type: DnaReference
organism: Homo sapiens

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Reference/ChemSpider 558863
type: UnificationXref
id: 558863
db: ChemSpider

ChemicalStructure/PW C001406
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=C)C(O)=O

Oxaloacetate
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxaloacetate

Protein/659 Nucleus/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 4.0

pyruvate
type: SmallMoleculeReference
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C108870

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

TransportCatalysis227
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport279
control type: ACTIVATION

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Citrate
type: SmallMolecule
cellular location: Cytosol
entity reference: Citrate

Reference/UniProt P40926
type: UnificationXref
id: P40926
db: UniProt

Reference/UniProt P40925
type: UnificationXref
id: P40925
db: UniProt

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/PubChem-compound 643757
type: UnificationXref
id: 643757
db: PubChem-compound

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Voltage-dependent anion-selective channel protein 2
type: Protein
entity reference: Voltage-dependent anion-selective channel protein 2

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Malate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/803 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Malate dehydrogenase, mitochondrial

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Tumor necrosis factor
type: Protein
cellular location: Cytosol
entity reference: Tumor necrosis factor

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

cis-Aconitic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: cis-Aconitic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Voltage-dependent anion-selective channel protein 1
type: Protein
entity reference: Voltage-dependent anion-selective channel protein 1

Protein/802 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: NADP-dependent malic enzyme
stoichiometric coefficient: 4.0

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydroquinone

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C104585
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Reference/UniProt Q96HY7
type: UnificationXref
id: Q96HY7
db: UniProt

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

IL-10
type: Dna
cellular location: Nucleus
entity reference: IL-10
name: SubPathwayOutput

Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

TransportCatalysis4922
type: Catalysis
controller: Voltage-dependent anion-selective channel protein 2
controlled: Transport13911
control type: ACTIVATION

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

TransportCatalysis4923
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: Transport13912
control type: ACTIVATION

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt Q13085
type: UnificationXref
id: Q13085
db: UniProt

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Tricarboxylate transport protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53007

ReactionCatalysis64
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: 4.2.1.3
control type: ACTIVATION

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ReactionCatalysis67
type: Catalysis
controller: Oxoglutarate dehydrogenase complex
controlled: 1.2.4.2
control type: ACTIVATION

Protein/869 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Compound/Generic631 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reactive oxygen species
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Malate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Malate dehydrogenase, mitochondrial

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

4.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
right: Isocitric acid
spontaneous: false
EC number: 4.2.1.3
left: cis-Aconitic acid
left: Water
name: Water + cis-Aconitic acid ↔ Isocitric acid
conversion direction: REVERSIBLE

Reference/UniProt Q96I99
type: UnificationXref
id: Q96I99
db: UniProt

Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens)_TNFα
type: Complex
component stoichiometry: ProteinComplex/291 Nucleus/Stoichiometry/1.0
component stoichiometry: RNA/364 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Glyceraldehyde-3-phosphate dehydrogenase
component: TNFα

Compound/PW C001420 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 4.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/UniProt P31040
type: UnificationXref
id: P31040
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P07954
organism: Homo sapiens

Reactive oxygen species
type: SmallMoleculeReference

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P40925
organism: Homo sapiens

Reference/ChemSpider 4444059
type: UnificationXref
id: 4444059
db: ChemSpider

NADP-dependent malic enzyme
type: ProteinReference
xref: Reference/UniProt P48163
organism: Homo sapiens

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

TransportCatalysis4939
type: Catalysis
controller: Tricarboxylate transport protein, mitochondrial
controlled: Transport13929
control type: ACTIVATION

Malate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P40926
organism: Homo sapiens

Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Compound/Generic626 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Long chain fatty acid
stoichiometric coefficient: 1.0

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

ReactionCatalysis70
type: Catalysis
controller: Isocitrate dehydrogenase
controlled: 1.1.1.41
control type: ACTIVATION

4.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001406 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Itaconic acid
spontaneous: false
EC number: 4.1.1.6
left: cis-Aconitic acid
name: cis-Aconitic acid ↔ Carbon dioxide + Itaconic acid
conversion direction: REVERSIBLE

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

cis-Aconitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 643757
xref: Reference/KEGG Compound C00417
xref: Reference/HMDB HMDB0000072
xref: Reference/ChEBI CHEBI 32805
xref: Reference/BioCyc CIS-ACONITATE
xref: Reference/ChemSpider 558863
xref: Reference/CAS 585-84-2
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000051

Reference/CAS 320-77-4
type: UnificationXref
id: 320-77-4
db: CAS

Reference/BioCyc threo-d(s)-iso-citrate
type: UnificationXref
id: threo-d(s)-iso-citrate
db: BioCyc

Long chain fatty acid
type: SmallMoleculeReference

Pyruvate carboxylase, mitochondrial
type: Protein
entity reference: Pyruvate carboxylase, mitochondrial

TransportCatalysis4940
type: Catalysis
controller: Voltage-dependent anion-selective channel protein 1
controlled: Transport13930
control type: ACTIVATION

TransportCatalysis4941
type: Catalysis
controller: Unknown
controlled: Transport13931
control type: ACTIVATION

Reaction218103
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
left: Succinic acid
left: Coenzyme A
left: Adenosine triphosphate
name: Adenosine triphosphate + Coenzyme A + Succinic acid ↔ Adenosine diphosphate + Phosphate + Succinyl-CoA
conversion direction: REVERSIBLE

Reaction218101
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: Water
spontaneous: false
left: Malate
name: Malate ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

Interleukin-10
type: Protein
cellular location: Cytosol
entity reference: Interleukin-10

ReactionCatalysis207434
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

Reference/PathWhiz PW126417
type: UnificationXref
id: PW126417
db: PathWhiz

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000125
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(CC(O)=O)C(O)=O)C(O)=O

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Protein/12 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 60.0

Reaction218110
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001860 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Quinone
right: Succinic acid
spontaneous: false
left: Fumaric acid
left: Hydroquinone
name: Fumaric acid + Hydroquinone ← Quinone + Succinic acid
conversion direction: RIGHT_TO_LEFT

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reaction218111
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Acetyl-CoA
right: Oxaloacetate
spontaneous: false
left: Adenosine triphosphate
left: Coenzyme A
left: Citrate
name: Adenosine triphosphate + Citrate + Coenzyme A → Acetyl-CoA + Adenosine diphosphate + Oxaloacetate + Phosphate
conversion direction: LEFT_TO_RIGHT

pyruvate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: pyruvate

Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0124912
type: UnificationXref
id: SMP0124912
db: SMPDB

Acetyl-CoA carboxylase 1
type: Protein
cellular location: Cytosol
entity reference: Acetyl-CoA carboxylase 1

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96HY7
organism: Homo sapiens

Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis207369
type: Catalysis
controller: Malate dehydrogenase, mitochondrial
controlled: Reaction217840
control type: ACTIVATION

ReactionCatalysis207368
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: 1.1.1.37
control type: ACTIVATION

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Carbon dioxide
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.4.2
left: Coenzyme A
left: Oxoglutaric acid
left: NAD
name: Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis207486
type: Catalysis
controller: NADPH oxidase 4
controlled: 1.6.3.-
control type: ACTIVATION

ReactionCatalysis207485
type: Catalysis
controller: NADP-dependent malic enzyme
controlled: 1.1.1.40
control type: ACTIVATION

ReactionCatalysis207484
type: Catalysis
controller: Acetyl-CoA carboxylase 1
controlled: Reaction218112
control type: ACTIVATION

ReactionCatalysis207483
type: Catalysis
controller: ATP-citrate synthase
controlled: Reaction218111
control type: ACTIVATION

ReactionCatalysis207482
type: Catalysis
controller: Succinate dehydrogenase
controlled: Reaction218110
control type: ACTIVATION

Reference/UniProt P22301
type: UnificationXref
id: P22301
db: UniProt

Reference/ChEBI CHEBI 30838
type: UnificationXref
id: CHEBI:30838
db: ChEBI

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Fumarate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Fumarate hydratase, mitochondrial

citrate synthase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: citrate synthase

Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Quinone
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Quinone

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Protein/803 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Malate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Tumor necrosis factor
name: SubPathwayOutput

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Protein/842 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Citrate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Citrate
name: SubPathwayOutput

Compound/PW C001632 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Acetyl-CoA carboxylase 1
type: ProteinReference
xref: Reference/UniProt Q13085
organism: Homo sapiens

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: Reference/UniProt P08559
organism: Homo sapiens

ChemicalStructure/PW C000949
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Acetyl-CoA
type: SmallMolecule
cellular location: Nucleus
entity reference: Acetyl-CoA
name: SubPathwayInput

Reference/UniProt P45880
type: UnificationXref
id: P45880
db: UniProt

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Fatty acid synthase
type: Protein
cellular location: Cytosol
entity reference: Fatty acid synthase

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

RNA/364 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: TNFα
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/UniProt P53396
type: UnificationXref
id: P53396
db: UniProt

Reference/UniProt P36957
type: UnificationXref
id: P36957
db: UniProt

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P10515
organism: Homo sapiens

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P09622
organism: Homo sapiens

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

ProteinComplex/291 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 1.0

Protein/843 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/ChEBI CHEBI 15551
type: UnificationXref
id: CHEBI:15551
db: ChEBI

ReactionCatalysis207477
type: Catalysis
controller: Succinyl-CoA ligase
controlled: Reaction218103
control type: ACTIVATION

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

ReactionCatalysis207475
type: Catalysis
controller: Fumarate hydratase, mitochondrial
controlled: Reaction218101
control type: ACTIVATION

ReactionCatalysis207474
type: Catalysis
controller: Cis-aconitate decarboxylase
controlled: 4.1.1.6
control type: ACTIVATION

ReactionCatalysis207473
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: Reaction218099
control type: ACTIVATION

ReactionCatalysis207472
type: Catalysis
controller: citrate synthase
controlled: Reaction218098
control type: ACTIVATION

ReactionCatalysis207350
type: Catalysis
controller: Fatty acid synthase
controlled: 2.3.1.85
control type: ACTIVATION

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide
name: SubPathwayInput

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt P08679
type: UnificationXref
id: P08679
db: UniProt

NADP-dependent malic enzyme
type: Complex
component stoichiometry: Protein/802 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: NADP-dependent malic enzyme

Reference/UniProt P08559
type: UnificationXref
id: P08559
db: UniProt

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/UniProt P53007
type: UnificationXref
id: P53007
db: UniProt

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/UniProt P10515
type: UnificationXref
id: P10515
db: UniProt

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P21912
organism: Homo sapiens

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Protein/20827 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-10
stoichiometric coefficient: 1.0

Fumarate hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/806 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Fumarate hydratase, mitochondrial

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

Isocitrate dehydrogenase
type: Complex
component stoichiometry: Protein/840 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/842 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/843 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Glyceraldehyde-3-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/659 Nucleus/Stoichiometry/4.0
cellular location: Nucleus
component: Glyceraldehyde-3-phosphate dehydrogenase

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Protein/44 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
stoichiometric coefficient: 60.0

Compound/PW C001406 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconic acid
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Protein/19/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase, mitochondrial
stoichiometric coefficient: 4.0

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Reference/UniProt A6NK06
type: UnificationXref
id: A6NK06
db: UniProt

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 32805
type: UnificationXref
id: CHEBI:32805
db: ChEBI

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

Reference/KEGG Compound C00417
type: UnificationXref
id: C00417
db: KEGG Compound

Citrate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Citrate

Compound/PW C000051 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: cis-Aconitic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Interleukin-6
type: Protein
cellular location: Cytosol
entity reference: Interleukin-6

Protein/832 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1198
type: UnificationXref
id: 1198
db: PubChem-compound

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

Reference/CAS 97-65-4
type: UnificationXref
id: 97-65-4
db: CAS

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Protein/834 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Compound/PW C000143 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

Reference/UniProt P21796
type: UnificationXref
id: P21796
db: UniProt

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

1.1.1.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Oxoglutaric acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.41
left: Isocitric acid
left: NAD
name: Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C108867 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt P53597
type: UnificationXref
id: P53597
db: UniProt

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reaction213297
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000723 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/2.0
right: NADP
right: Nitric oxide
right: Citrulline
right: Water
spontaneous: false
left: Oxygen
left: Hydrogen Ion
left: L-Arginine
left: NADPH
name: Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Citrulline
type: SmallMolecule
cellular location: Cytosol
entity reference: Citrulline

ATP-citrate synthase
type: Protein
cellular location: Cytosol
entity reference: ATP-citrate synthase

NADP-dependent malic enzyme
type: Protein
cellular location: Cytosol
entity reference: NADP-dependent malic enzyme

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc