Interaction3185
type: MolecularInteraction
interaction type: direct_interaction
name: Fibrin (loose) activates Fibrin (mesh)
participant: Fibrin (loose)
participant: Fibrin (mesh)

Fibrinogen beta chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen beta chain

Coagulation factor V
type: ProteinReference
xref: Reference/UniProt P12259
organism: Homo sapiens

Interaction3186
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor XIII A chain activates Coagulation factor XIIIa
participant: Coagulation factor XIIIa
participant: Coagulation factor XIII A chain

Reference/ChEBI CHEBI 10033
type: UnificationXref
id: CHEBI:10033
db: ChEBI

Interaction3187
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor XIII B chain activates Coagulation factor XIIIa
participant: Coagulation factor XIII B chain
participant: Coagulation factor XIIIa

Reference/PathWhiz PW126506
type: UnificationXref
id: PW126506
db: PathWhiz

Reference/PubChem-compound 5284607
type: UnificationXref
id: 5284607
db: PubChem-compound

direct_interaction
type: InteractionVocabulary

Fibrin (loose)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

Thrombin
type: Protein
cellular location: Cytosol
entity reference: Thrombin

Reference/ChemSpider 82688
type: UnificationXref
id: 82688
db: ChemSpider

Interaction3174
type: MolecularInteraction
interaction type: direct_interaction
name: Tissue factor:Coagulation factor VIIa activates Prothrombinase Complex
participant: Tissue factor:Coagulation factor VIIa
participant: Prothrombinase Complex

ReactionCatalysis142
type: Catalysis
controller: Vitamin K epoxide reductase complex subunit 1
controlled: 1.1.4.1
control type: ACTIVATION

Reference/ChemSpider 4447652
type: UnificationXref
id: 4447652
db: ChemSpider

Fibrin (mesh)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

ChemicalStructure/PW C002089
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P00488
type: UnificationXref
id: P00488
db: UniProt

Tenase complex
type: Complex
cellular location: Cytosol
component: Coagulation factor VIII
component: Coagulation factor IX

Reference/ChemSpider 10442445
type: UnificationXref
id: 10442445
db: ChemSpider

Coagulation factor VIII
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor VIII

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt P02671
type: UnificationXref
id: P02671
db: UniProt

Fibrinogen gamma chain
type: ProteinReference
xref: Reference/UniProt P02679
organism: Homo sapiens

Reference/KEGG Compound C01541
type: UnificationXref
id: C01541
db: KEGG Compound

Warfarin Action Pathway (New)
type: Pathway
pathway order: PathwayEnzymeReaction/2504325
pathway order: PathwayEnzymeReaction/2504326
pathway order: PathwayEnzymeReaction/2504327
pathway order: PathwayEnzymeReaction/2504328
pathway order: PathwayEnzymeReaction/2504329
pathway order: PathwayInteraction/3205
pathway order: PathwayInteraction/3204
pathway order: PathwayInteraction/3203
pathway order: PathwayInteraction/3202
pathway order: PathwayInteraction/3201
pathway order: PathwayInteraction/3200
pathway order: PathwayInteraction/3165
pathway order: PathwayInteraction/3187
pathway order: PathwayInteraction/3164
pathway order: PathwayInteraction/3186
pathway order: PathwayInteraction/3185
pathway order: PathwayInteraction/3161
pathway order: PathwayEnzymeReaction/2504335
pathway order: PathwayEnzymeReaction/2504330
pathway order: PathwayInteraction/2846
pathway order: PathwayEnzymeReaction/2504331
pathway order: PathwayEnzymeReaction/2504332
pathway order: PathwayEnzymeReaction/2504333
pathway order: PathwayEnzymeReaction/2504334
pathway order: PathwayInteraction/3159
pathway order: PathwayInteraction/3158
pathway order: PathwayInteraction/3157
pathway order: PathwayInteraction/3156
pathway order: PathwayInteraction/3199
pathway order: PathwayInteraction/3174
pathway component: Interaction3161
pathway component: Interaction3185
pathway component: Interaction3201
pathway component: Interaction3202
pathway component: Interaction3203
pathway component: Interaction3204
pathway component: Interaction3164
pathway component: Interaction3186
pathway component: Interaction3165
pathway component: Interaction3187
pathway component: Interaction3200
pathway component: Interaction3205
pathway component: ReactionCatalysis1129
pathway component: Reaction1391
pathway component: 1.1.4.1
pathway component: 4.1.1.90
pathway component: ReactionCatalysis1124
pathway component: Reaction213214
pathway component: Reaction213215
pathway component: Reaction213216
pathway component: Reaction213217
pathway component: Interaction3174
pathway component: ReactionCatalysis142
pathway component: Interaction3157
pathway component: Interaction3158
pathway component: Interaction3159
pathway component: Interaction3199
pathway component: Interaction3156
pathway component: Interaction2846
pathway component: 3.4.21.7
pathway component: Reaction1389
pathway component: Reaction662
pathway component: ReactionCatalysis1134
xref: Reference/PathWhiz PW126506
xref: Reference/SMPDB SMP0124982
organism: Homo sapiens

Coagulation factor VIII
type: ProteinReference
xref: Reference/UniProt P00451
organism: Homo sapiens

Coagulation factor IX
type: ProteinReference
xref: Reference/UniProt P00740
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/HMDB HMDB0002972
type: UnificationXref
id: HMDB0002972
db: HMDB

Reaction1391
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/634 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/635 Cytosol/Stoichiometry/1.0
right: Fibrin (loose)
spontaneous: false
left: Fibrinogen
name: Fibrinogen → Fibrin (loose)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P02675
type: UnificationXref
id: P02675
db: UniProt

1.1.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002089 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Reduced Vitamin K (phylloquinone)
spontaneous: false
EC number: 1.1.4.1
left: Vitamin K1 2,3-epoxide
name: Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P02679
type: UnificationXref
id: P02679
db: UniProt

Coagulation factor VIIa
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor VIIa

Tissue factor
type: ProteinReference
xref: Reference/UniProt P13726
organism: Homo sapiens

Collagen alpha-1(I) chain
type: ProteinReference
xref: Reference/UniProt P02452
organism: Homo sapiens

Tissue factor:Coagulation factor VIIa
type: Complex
cellular location: Extracellular Space
component: Coagulation factor VIIa
component: Tissue factor

Interaction3199
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor XIIa activates Coagulation factor XI
participant: Coagulation factor XIIa
participant: Coagulation factor XIa

ProteinComplex/641 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin degradation products
stoichiometric coefficient: 1.0

Reaction1389
type: BiochemicalReaction
participant stoichiometry: Protein/5692 Cytosol/Stoichiometry/1.0
right: Thrombin
spontaneous: false
left: Thrombin
name: Prothrombin → Thrombin
conversion direction: LEFT_TO_RIGHT

Reaction662
type: BiochemicalReaction
participant stoichiometry: Protein/5691 Cytosol/Stoichiometry/1.0
right: Coagulation factor XIa
spontaneous: false
left: Coagulation factor XIa
name: Coagulation factor XI → Coagulation factor XIa
conversion direction: LEFT_TO_RIGHT

Vitamin K epoxide reductase complex subunit 1
type: Protein
cellular location: Cell Membrane
entity reference: Vitamin K epoxide reductase complex subunit 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Tissue factor
type: Protein
cellular location: Extracellular Space
entity reference: Tissue factor

Reference/CAS 84-80-0
type: UnificationXref
id: 84-80-0
db: CAS

Fibrinogen beta chain
type: Protein
cellular location: Cytosol
entity reference: Fibrinogen beta chain

Fibrinogen
type: Complex
cellular location: Cytosol
component: Fibrinogen beta chain
component: Fibrinogen gamma chain
component: Fibrinogen alpha chain

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/PubChem-compound 91577
type: UnificationXref
id: 91577
db: PubChem-compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Plasminogen
type: Protein
cellular location: Extracellular Space
entity reference: Plasminogen

Warfarin
type: SmallMoleculeReference
xref: Reference/CAS 81-81-2
xref: Reference/HMDB HMDB0001935
xref: Reference/KEGG Compound C01541
xref: Reference/PubChem-compound 54678486
xref: Reference/ChEBI CHEBI 10033
xref: Reference/ChemSpider 10442445
chemical formula: C19H16O4
molecular weight: 308.10486
structure: ChemicalStructure/PW C001294

Reference/CAS 25486-55-9
type: UnificationXref
id: 25486-55-9
db: CAS

Reference/UniProt P03951
type: UnificationXref
id: P03951
db: UniProt

Fibrinogen gamma chain
type: Protein
cellular location: Cytosol
entity reference: Fibrinogen gamma chain

Reference/UniProt P03952
type: UnificationXref
id: P03952
db: UniProt

Reference/PubChem-compound 54678486
type: UnificationXref
id: 54678486
db: PubChem-compound

Reference/UniProt P00451
type: UnificationXref
id: P00451
db: UniProt

Interaction3201
type: MolecularInteraction
interaction type: direct_interaction
name: Prothrombin activates Coagulation factor VIII
participant: Coagulation factor VIII
participant: Thrombin

ProteinComplex/637 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (mesh)
stoichiometric coefficient: 1.0

Coagulation factor VIIa
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor VIIa

Interaction3202
type: MolecularInteraction
interaction type: direct_interaction
name: Prothrombin activates Coagulation factor V
participant: Thrombin
participant: Coagulation factor V

Interaction3203
type: MolecularInteraction
interaction type: direct_interaction
name: Tenase complex activates Coagulation factor X
participant: Coagulation factor X
participant: Tenase complex

Interaction3204
type: MolecularInteraction
interaction type: direct_interaction
name: Prothrombinase Complex activates Prothrombin
participant: Thrombin
participant: Prothrombinase Complex

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Interaction3200
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor XIa activates Coagulation factor IX
participant: Coagulation factor IX
participant: Coagulation factor XIa

Interaction3205
type: MolecularInteraction
interaction type: direct_interaction
name: Thrombin activates Fibrinogen
participant: Fibrinogen
participant: Thrombin

BiologicalState53
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Reaction213214
type: BiochemicalReaction
participant stoichiometry: Protein/1571 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/627 Cytosol/Stoichiometry/1.0
right: Tenase complex
spontaneous: false
left: Coagulation factor IX
name: Coagulation factor IX → Tenase complex
conversion direction: LEFT_TO_RIGHT

Reaction213215
type: BiochemicalReaction
participant stoichiometry: Protein/1570 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/627 Cytosol/Stoichiometry/1.0
right: Tenase complex
spontaneous: false
left: Coagulation factor VIII
name: Coagulation factor VIII → Tenase complex
conversion direction: LEFT_TO_RIGHT

Reaction213216
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/632 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1795 Cytosol/Stoichiometry/1.0
right: Prothrombinase Complex
spontaneous: false
left: Coagulation factor V
name: Coagulation factor V → Prothrombinase Complex
conversion direction: LEFT_TO_RIGHT

Reaction213217
type: BiochemicalReaction
participant stoichiometry: Protein/1730 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/632 Cytosol/Stoichiometry/1.0
right: Prothrombinase Complex
spontaneous: false
left: Coagulation factor X
name: Coagulation factor X → Prothrombinase Complex
conversion direction: LEFT_TO_RIGHT

Protein/5692 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Protein/5691 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor XIa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28371
type: UnificationXref
id: CHEBI:28371
db: ChEBI

Coagulation factor X
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor X

Reference/SMPDB SMP0124982
type: UnificationXref
id: SMP0124982
db: SMPDB

Coagulation factor IX
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor IX

Reference/KEGG Compound C05849
type: UnificationXref
id: C05849
db: KEGG Compound

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ProteinComplex/627 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tenase complex
stoichiometric coefficient: 1.0

Coagulation factor XIII B chain
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIII B chain

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Protein/Generic44 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/Generic45 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
EC number: 4.1.1.90
left: Precursors of Prothrombin and coagulation factors VII, IX, ad X
name: Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X
conversion direction: LEFT_TO_RIGHT

Plasminogen
type: ProteinReference
xref: Reference/UniProt P00747
organism: Homo sapiens

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Vitamin K1 2,3-epoxide
spontaneous: false
EC number: 4.1.1.90
left: Reduced Vitamin K (phylloquinone)
name: Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide
conversion direction: LEFT_TO_RIGHT

Fibrinogen alpha chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen alpha chain

Reference/KEGG Compound C05850
type: UnificationXref
id: C05850
db: KEGG Compound

Prothrombinase Complex
type: Complex
cellular location: Cytosol
component: Coagulation factor V
component: Coagulation factor X

Fibrinogen gamma chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen gamma chain

Reference/UniProt P38435
type: UnificationXref
id: P38435
db: UniProt

3.4.21.7
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/641 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/637 Extracellular Space/Stoichiometry/1.0
right: Fibrin degradation products
spontaneous: false
EC number: 3.4.21.7
left: Fibrin (mesh)
name: Fibrin (mesh) → Fibrin degradation products
conversion direction: LEFT_TO_RIGHT

Coagulation factor X
type: ProteinReference
xref: Reference/UniProt P00742
organism: Homo sapiens

Vitamin K epoxide reductase complex subunit 1
type: ProteinReference
xref: Reference/UniProt Q9BQB6
organism: BiologicalState10

Coagulation factor VIIa
type: ProteinReference
xref: Reference/UniProt P08709
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Coagulation factor XIa
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor XIa

Reference/UniProt P13726
type: UnificationXref
id: P13726
db: UniProt

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/HMDB HMDB0004198
type: UnificationXref
id: HMDB0004198
db: HMDB

Reference/UniProt Q9BQB6
type: UnificationXref
id: Q9BQB6
db: UniProt

Fibrin (loose)
type: Complex
cellular location: Cytosol
component: Fibrinogen beta chain
component: Fibrinogen gamma chain
component: Fibrinogen alpha chain

Vitamin K1 2,3-epoxide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Vitamin K1 2,3-epoxide

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Protein/Generic44 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precursors of Prothrombin and coagulation factors VII, IX, ad X
stoichiometric coefficient: 1.0

Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
type: UnificationXref
id: 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
db: BioCyc

Protein/1570 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor VIII
stoichiometric coefficient: 1.0

Vitamin K1 2,3-epoxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 82688
xref: Reference/HMDB HMDB0002972
xref: Reference/CAS 25486-55-9
xref: Reference/PubChem-compound 91577
xref: Reference/KEGG Compound C05849
xref: Reference/ChEBI CHEBI 28371
xref: Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
chemical formula: C31H46O3
molecular weight: 466.3447
structure: ChemicalStructure/PW C001746

Protein/1730 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Tissue factor:Coagulation factor VIIa
type: Complex
cellular location: Cytosol
component: Coagulation factor VIIa
component: Tissue factor

Reference/CAS 81-81-2
type: UnificationXref
id: 81-81-2
db: CAS

Reference/UniProt P08709
type: UnificationXref
id: P08709
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Collagen alpha-1(I) chain
type: Protein
cellular location: Extracellular Space
entity reference: Collagen alpha-1(I) chain

Coagulation factor XIIa
type: ProteinReference
xref: Reference/UniProt P00748
organism: Homo sapiens

Vitamin K-dependent gamma-carboxylase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Vitamin K-dependent gamma-carboxylase

Reference/UniProt P12259
type: UnificationXref
id: P12259
db: UniProt

Reference/UniProt P02452
type: UnificationXref
id: P02452
db: UniProt

Reference/HMDB HMDB0001935
type: UnificationXref
id: HMDB0001935
db: HMDB

Reference/UniProt P05160
type: UnificationXref
id: P05160
db: UniProt

ReactionCatalysis1129
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

Protein/1571 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor IX
stoichiometric coefficient: 1.0

ProteinComplex/632 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombinase Complex
stoichiometric coefficient: 1.0

ReactionCatalysis1124
type: Catalysis
controller: Plasminogen
controlled: 3.4.21.7
control type: ACTIVATION

Fibrin degradation products
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

ChemicalStructure/PW C001746
type: ChemicalStructure
structure format: SMILES

Reduced Vitamin K (phylloquinone)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced Vitamin K (phylloquinone)

Coagulation factor XIII A chain
type: ProteinReference
xref: Reference/UniProt P00488
organism: Homo sapiens

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: ProteinReference
xref: Reference/UniProt P00734
organism: BiologicalState10

Coagulation factor XIII A chain
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIII A chain

Prothrombin and coagulation factors VII, IX and X
type: ProteinReference
xref: Reference/UniProt P00734
organism: BiologicalState10

Coagulation factor V
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor V

Tissue factor
type: Protein
cellular location: Cytosol
entity reference: Tissue factor

Coagulation factor XIa
type: ProteinReference
xref: Reference/UniProt P03951
organism: Homo sapiens

Interaction2846
type: MolecularInteraction
interaction type: direct_interaction
name: Warfarin inhibits Vitamin K epoxide reductase complex subunit 1
participant: Warfarin
participant: Vitamin K epoxide reductase complex subunit 1

Thrombin
type: ProteinReference
xref: Reference/UniProt P00734
organism: Homo sapiens

ProteinComplex/634 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

Vitamin K epoxide reductase complex subunit 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Vitamin K epoxide reductase complex subunit 1

Compound/PW C001746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vitamin K1 2,3-epoxide
stoichiometric coefficient: 1.0

ReactionCatalysis1134
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

Protein/Generic45 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

Interaction3161
type: MolecularInteraction
interaction type: direct_interaction
name: Collagen alpha-1(I) chain activates Coagulation factor XIIa
participant: Collagen alpha-1(I) chain
participant: Coagulation factor XIIa

Plasma kallikrein
type: ProteinReference
xref: Reference/UniProt P03952
organism: Homo sapiens

Coagulation factor XIIIa
type: Complex
cellular location: Extracellular Space
component: Coagulation factor XIII B chain
component: Coagulation factor XIII A chain

Interaction3164
type: MolecularInteraction
interaction type: direct_interaction
name: Tissue factor activates Tissue factor:Coagulation factor VIIa
participant: Tissue factor:Coagulation factor VIIa
participant: Tissue factor

Coagulation factor XIII B chain
type: ProteinReference
xref: Reference/UniProt P05160
organism: Homo sapiens

Interaction3165
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor VII activates Tissue factor:Coagulation factor VIIa
participant: Coagulation factor VIIa
participant: Tissue factor:Coagulation factor VIIa

Fibrinogen alpha chain
type: ProteinReference
xref: Reference/UniProt P02671
organism: Homo sapiens

Fibrinogen beta chain
type: ProteinReference
xref: Reference/UniProt P02675
organism: Homo sapiens

ProteinComplex/635 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (loose)
stoichiometric coefficient: 1.0

Fibrinogen alpha chain
type: Protein
cellular location: Cytosol
entity reference: Fibrinogen alpha chain

Reference/UniProt P00734
type: UnificationXref
id: P00734
db: UniProt

Coagulation factor XIIa
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIIa

Vitamin K-dependent gamma-carboxylase
type: ProteinReference
xref: Reference/UniProt P38435
organism: BiologicalState10

Prothrombin and coagulation factors VII, IX and X
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prothrombin and coagulation factors VII, IX and X

Interaction3157
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor XIIa activates Plasma kallikrein
participant: Coagulation factor XIIa
participant: Plasma kallikrein

Interaction3158
type: MolecularInteraction
interaction type: direct_interaction
name: Plasma kallikrein activates Coagulation factor XIIa
participant: Coagulation factor XIIa
participant: Plasma kallikrein

Plasma kallikrein
type: Protein
cellular location: Extracellular Space
entity reference: Plasma kallikrein

Interaction3159
type: MolecularInteraction
interaction type: direct_interaction
name: Coagulation factor XII activates Coagulation factor XIIa
participant: Coagulation factor XIIa

Reference/ChEBI CHEBI 18067
type: UnificationXref
id: CHEBI:18067
db: ChEBI

Protein/1795 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor V
stoichiometric coefficient: 1.0

Interaction3156
type: MolecularInteraction
interaction type: direct_interaction
name: Plasma prekallikrein activates Plasma kallikrein
participant: Plasma kallikrein

Reference/UniProt P00747
type: UnificationXref
id: P00747
db: UniProt

Reference/UniProt P00748
type: UnificationXref
id: P00748
db: UniProt

Warfarin
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Warfarin

Reduced Vitamin K (phylloquinone)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5284607
xref: Reference/ChemSpider 4447652
xref: Reference/HMDB HMDB0004198
xref: Reference/KEGG Compound C05850
xref: Reference/ChEBI CHEBI 18067
xref: Reference/CAS 84-80-0
chemical formula: C31H48O2
molecular weight: 452.36542
structure: ChemicalStructure/PW C002089

Coagulation factor XIIa
type: Protein
cellular location: Cytosol
entity reference: Coagulation factor XIIa

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Precursors of Prothrombin and coagulation factors VII, IX, ad X

Reference/UniProt P00740
type: UnificationXref
id: P00740
db: UniProt

Compound/PW C002089 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Vitamin K (phylloquinone)
stoichiometric coefficient: 1.0

Reference/UniProt P00742
type: UnificationXref
id: P00742
db: UniProt

ChemicalStructure/PW C001294
type: ChemicalStructure
structure format: SMILES