Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: Homo sapiens

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Actin, cytoplasmic 1
type: Protein
cellular location: Cytosol
entity reference: Actin, cytoplasmic 1
name: SubPathwayInput

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Alpha-2A adrenergic receptor
type: Protein
entity reference: Alpha-2A adrenergic receptor

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

direct_interaction
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState48

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/PathWhiz PW126622
type: UnificationXref
id: PW126622
db: PathWhiz

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState48

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState48

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

ReactionCatalysis207629
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: Reaction218277
control type: ACTIVATION

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Compound/Generic369 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

TransportCatalysis4986
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14005
control type: ACTIVATION

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

TransportCatalysis4984
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport14002
control type: ACTIVATION

Interaction242
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

TransportCatalysis4985
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14003
control type: ACTIVATION

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0125087
type: UnificationXref
id: SMP0125087
db: SMPDB

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Norepinephrine
type: SmallMolecule
entity reference: Norepinephrine

ReactionCatalysis207193
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Inositol 1,4,5-trisphosphate receptor type 1

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: Homo sapiens

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
name: SubPathwayOutput

Protein/2126 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Alpha-2A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08913
organism: BiologicalState48

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

SubPathwayInteraction117535
type: Interaction
name: SubPathway117535Reaction
name: SubPathwayReaction
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: Alpha-1A adrenergic receptor

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

SubPathwayInteraction117533
type: Interaction
name: SubPathway117533Reaction
name: SubPathwayReaction
participant: Myosin light chain 3
participant: Actin, cytoplasmic 1

SubPathwayInteraction117534
type: Interaction
name: SubPathwayReaction
name: SubPathway117534Reaction
participant: Myosin light chain 3

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

BiologicalState48
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: Homo sapiens

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: Homo sapiens

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt P60709
type: UnificationXref
id: P60709
db: UniProt

Norepinephrine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Norepinephrine

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Methyldopa Action Pathway
type: Pathway
pathway order: PathwayInteraction/3140
pathway order: PathwayEnzymeReaction/2505579
pathway order: PathwayEnzymeReaction/2505578
pathway order: PathwayInteraction/2849
pathway order: PathwayTransport/2505589
pathway order: PathwayTransport/2505588
pathway order: PathwayInteraction/3935
pathway order: PathwayEnzymeReaction/2505586
pathway order: PathwayInteraction/3933
pathway order: PathwayEnzymeReaction/2505585
pathway order: PathwayTransport/2505595
pathway order: PathwayEnzymeReaction/2505577
pathway order: PathwayTransport/2505581
pathway order: PathwayEnzymeReaction/2505587
pathway order: PathwayTransport/2505591
pathway order: PathwaySubPathway/117533
pathway order: PathwayInteraction/242
pathway order: PathwayEnzymeReaction/2505580
pathway order: PathwaySubPathway/117534
pathway order: PathwayInteraction/3581
pathway order: PathwaySubPathway/117535
pathway component: Interaction3140
pathway component: Interaction3581
pathway component: TransportCatalysis2134
pathway component: ReactionCatalysis207629
pathway component: 1.14.17.1
pathway component: Reaction218277
pathway component: 3.1.4.11
pathway component: ReactionCatalysis203360
pathway component: Transport14003
pathway component: Transport14002
pathway component: Transport14005
pathway component: Transport14004
pathway component: Reaction213775
pathway component: 3.1.3.16
pathway component: TransportCatalysis4986
pathway component: TransportCatalysis4984
pathway component: Transport10978
pathway component: Interaction242
pathway component: TransportCatalysis4985
pathway component: ReactionCatalysis203359
pathway component: Reaction213774
pathway component: Interaction3935
pathway component: Interaction2849
pathway component: Gq signaling cascade
pathway component: Interaction3933
pathway component: ReactionCatalysis207193
pathway component: 4.1.1.28
pathway component: Relaxation
pathway component: ReactionCatalysis118
pathway component: Contraction
pathway component: ReactionCatalysis214
xref: Reference/PathWhiz PW126622
xref: Reference/SMPDB SMP0125087
organism: Homo sapiens

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Norepinephrine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Norepinephrine

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Interaction3581
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-2A adrenergic receptor
participant: Norepinephrine
participant: Alpha-2A adrenergic receptor

TransportCatalysis2134
type: Catalysis
controller: L type Calcium channel
controlled: Transport10978
control type: ACTIVATION

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643

Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Transport14003
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron, Cytosol to Homo sapiens, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport14002
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Sarcoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14005
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Nervous System, Neuron, Synapse to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Transport14004
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron, Exocytic Vesicle to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Reference/UniProt P08913
type: UnificationXref
id: P08913
db: UniProt

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Alpha-1A adrenergic receptor
type: Protein
cellular location: Cytosol
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayInput

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Alpha-2A adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Alpha-2A adrenergic receptor

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

Myosin light chain 3
type: Protein
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Reaction213774
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
left: Myosin light chain 3
name: Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Alpha-1A adrenergic receptor
type: Protein
entity reference: Alpha-1A adrenergic receptor

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reaction218277
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: Tetrahydrobiopterin
name: L-Tyrosine + Oxygen + Tetrahydrobiopterin ↔ Dihydrobiopterin + L-Dopa + Water
conversion direction: REVERSIBLE

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic369 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Actin, cytoplasmic 1
type: ProteinReference
xref: Reference/UniProt P60709
organism: Homo sapiens

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Interaction3935
type: MolecularInteraction
interaction type: direct_interaction
name: Alpha-2A adrenergic receptor inhibits L type Calcium channel
participant: Alpha-2A adrenergic receptor
participant: L type Calcium channel

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Interaction3933
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Norepinephrine
participant: Calcium
participant: Norepinephrine

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: Homo sapiens

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Calcium
type: SmallMolecule
entity reference: Calcium

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Transport10978
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

ReactionCatalysis203359
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: Reaction213774
control type: ACTIVATION

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Gq signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117535
pathway component: SubPathwayInteraction117535
name: SubPathway

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117534
pathway component: SubPathwayInteraction117534
name: SubPathway

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117533
pathway component: SubPathwayInteraction117533
name: SubPathway

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202