Canalicular multispecific organic anion transporter 2
ATP-binding cassette sub-family C member 3
2 Farnesyl pyrophosphate + Hydrogen Ion + NADPH → NADP + 2 Pyrophosphate + Squalene
Solute carrier organic anion transporter family member 1B1
N-Desmethylterbinafine dihydrodiol derivative (1)
Terbinafine inhibits Squalene monooxygenase
Terbinafine → N-Desmethylterbinafine
N-Desmethylterbinafine + NADPH + Oxygen → Hydrogen Ion + N-Desmethylhydroxyterbinafine + NADP + Water
NADPH + Oxygen + Terbinafine → Hydrogen Ion + Hydroxyterbinafine + NADP + Water
N-Desmethylterbinafine dihydrodiol derivative (2) (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
Carboxyterbinafine (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
1-Naphthoic acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
1-Naphthalenemethanol (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
Hydroxyterbinafine → N-Desmethylhydroxyterbinafine
N-Desmethylterbinafine + 2 NADPH + Oxygen → N-Desmethylterbinafine dihydrodiol derivative (2) + 2 NADP
N-Desmethylterbinafine + 2 NADPH + Oxygen → N-Desmethylterbinafine dihydrodiol derivative (1) + NADP
N-Desmethylhydroxyterbinafine (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
Oxygen + Terbinafine → Terbinafine dihydrodiol derivative (1)
Terbinafine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane
1-Naphthaldehyde + 2 Hydrogen Ion + NADPH + Oxygen → 1-Naphthoic acid + NADP + Water
2 Hydrogen Ion + Hydroxyterbinafine + Oxygen → Carboxyterbinafine + Water
N-Desmethylterbinafine dihydrodiol derivative (1) (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
1-Naphthaldehyde + NADPH → 1-Naphthalenemethanol + NADP
Terbinafine dihydrodiol derivative (2) → N-Desmethylterbinafine dihydrodiol derivative (2)
2 NADPH + Oxygen + Terbinafine → 2 NADP + Terbinafine dihydrodiol derivative (2)
Terbinafine (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Blood Vessel
Terbinafine dihydrodiol derivative (1) → N-Desmethylterbinafine dihydrodiol derivative (1)
Terbinafine (→) Transport: Homo sapiens, Stomach to Homo sapiens, Intestine
NADPH + Oxygen + Squalene → (S)-2,3-Epoxysqualene + NADP + Water
Terbinafine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell
N-Desmethylterbinafine dihydrodiol derivative (2)