Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/PubChem-compound 439280
type: UnificationXref
id: 439280
db: PubChem-compound

Catechol O-methyltransferase
type: ProteinReference
xref: Reference/UniProt P21964
organism: BiologicalState789

Compound/PW C000178 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

5-hydroxytryptamine receptor 2A
type: ProteinReference
xref: Reference/UniProt P28223
organism: BiologicalState37

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

Chromaffin granule amine transporter
type: Protein
entity reference: Chromaffin granule amine transporter

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0124452
type: UnificationXref
id: SMP0124452
db: SMPDB

Reference/UniProt P31645
type: UnificationXref
id: P31645
db: UniProt

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Reference/CAS 554-52-9
type: UnificationXref
id: 554-52-9
db: CAS

Interaction4028
type: MolecularInteraction
interaction type: direct_interaction
name: Trace amine-associated receptor 1 inhibits Sodium-dependent noradrenaline transporter
participant: Trace amine-associated receptor 1
participant: Sodium-dependent noradrenaline transporter

Reference/UniProt P21964
type: UnificationXref
id: P21964
db: UniProt

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Methamphetamine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Methamphetamine

Reference/UniProt P21728
type: UnificationXref
id: P21728
db: UniProt

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Reference/ChEBI CHEBI 28111
type: UnificationXref
id: CHEBI:28111
db: ChEBI

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Interaction4050
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(4) Dopamine receptor
participant: D(4) dopamine receptor
participant: Dopamine

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

D(4) dopamine receptor
type: Protein
cellular location: Synapse
entity reference: D(4) dopamine receptor

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Transport13773
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: BiologicalState789

ReactionCatalysis847
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Reference/PubChem-compound 1826
type: UnificationXref
id: 1826
db: PubChem-compound

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Sodium-dependent serotonin transporter
type: Protein
cellular location: Extracellular Space
entity reference: Sodium-dependent serotonin transporter

Compound/PW C000358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-L-tryptophan
stoichiometric coefficient: 1.0

Sapropterin
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000787
xref: Reference/KEGG Compound C00272
xref: Reference/ChEBI CHEBI 64491
xref: Reference/PubChem-compound 9816201
xref: Reference/ChemSpider 7991951
xref: Reference/CAS 62989-33-7
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000627

Interaction4074
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine activates Alpha-2A adrenergic receptor
participant: Methamphetamine
participant: Alpha-2A adrenergic receptor

Interaction4073
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Amine oxidase [flavin-containing] A
participant: Methamphetamine
participant: Amine oxidase [flavin-containing] A

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Interaction4076
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Sodium-dependent serotonin transporter
participant: Methamphetamine
participant: Sodium-dependent serotonin transporter

Interaction4075
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Chromaffin granule amine transporter
participant: Chromaffin granule amine transporter
participant: Methamphetamine

Interaction4070
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Sodium-dependent noradrenaline transporter
participant: Methamphetamine
participant: Sodium-dependent noradrenaline transporter

Interaction4072
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine activates Trace amine-associated receptor 1
participant: Methamphetamine
participant: Trace amine-associated receptor 1

Interaction4071
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits vesicular monoamine transporter 2
participant: Synaptic vesicular amine transporter
participant: Methamphetamine

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Compound/PW C000609 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxyindoleacetic acid
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/SMPDB SMP0125231
type: UnificationXref
id: SMP0125231
db: SMPDB

Interaction4077
type: MolecularInteraction
interaction type: direct_interaction
name: Trace amine-associated receptor 1 inhibits Sodium-dependent serotonin transporter
participant: Trace amine-associated receptor 1
participant: Sodium-dependent serotonin transporter

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Serotonin
type: SmallMolecule
cellular location: Synapse
entity reference: Serotonin

Transport13990
type: Transport
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 3,4-Dihydroxymandelaldehyde
spontaneous: false
EC number: 1.4.3.4
left: Norepinephrine
left: Oxygen
left: Water
name: Norepinephrine + Oxygen + Water → 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Trace amine-associated receptor 1
type: Protein
cellular location: Presynaptic membrane
entity reference: Trace amine-associated receptor 1

Trace amine-associated receptor 1
type: ProteinReference
xref: Reference/UniProt Q96RJ0
organism: BiologicalState789

D(1B) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21918
organism: BiologicalState789

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Interaction4069
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Sodium-dependent dopamine transporter
participant: Methamphetamine
participant: Sodium-dependent dopamine transporter

Epinephrine Pathway (New)
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117878
pathway component: SubPathwayInteraction117878
xref: Reference/SMPDB SMP0124452
xref: Reference/PathWhiz PW125908
name: SubPathway

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Homovanillin
type: SmallMolecule
cellular location: Cytosol
entity reference: Homovanillin

Gq Signalling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117915
pathway component: SubPathwayInteraction117915
name: SubPathway

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

TransportCatalysis5109
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14185
control type: ACTIVATION

Reference/ChemSpider 388413
type: UnificationXref
id: 388413
db: ChemSpider

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/UniProt P28223
type: UnificationXref
id: P28223
db: UniProt

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

5-Hydroxyindoleacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000763
xref: Reference/PubChem-compound 1826
xref: Reference/BioCyc 5-HYDROXYINDOLE ACETATE
xref: Reference/ChEBI CHEBI 27823
xref: Reference/KEGG Compound C05635
xref: Reference/CAS 54-16-0
xref: Reference/ChemSpider 1760
chemical formula: C10H9NO3
molecular weight: 191.05824
structure: ChemicalStructure/PW C000609

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState789

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Alpha-1A adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayInput

Methamphetamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 6809
xref: Reference/KEGG Compound C07164
xref: Reference/HMDB HMDB0015517
xref: Reference/CAS 537-46-2
xref: Reference/PubChem-compound 10836
xref: Reference/ChemSpider 10379
chemical formula: C10H15N
molecular weight: 149.12045
structure: ChemicalStructure/PW C009782

TransportCatalysis5100
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14172
control type: ACTIVATION

Sodium-dependent serotonin transporter
type: ProteinReference
xref: Reference/UniProt P31645
organism: BiologicalState789

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Alpha-2A adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Alpha-2A adrenergic receptor
name: SubPathwayInput

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

D(1B) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(1B) dopamine receptor
name: SubPathwayInput

Methamphetamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Methamphetamine

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxymandelaldehyde

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Interaction3581
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-2A adrenergic receptor
participant: Norepinephrine
participant: Alpha-2A adrenergic receptor

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Beta-1 adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayInput

Dopamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Dopamine

Reference/ChemSpider 1760
type: UnificationXref
id: 1760
db: ChemSpider

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Reference/UniProt P08913
type: UnificationXref
id: P08913
db: UniProt

Sodium-dependent serotonin transporter
type: Protein
cellular location: Presynaptic membrane
entity reference: Sodium-dependent serotonin transporter

BiologicalState37
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Nervous System, Neuron
tissue: Nervous System

Reference/HMDB HMDB0015517
type: UnificationXref
id: HMDB0015517
db: HMDB

Compound/PW C002411 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Dopamine

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Reference/UniProt P17752
type: UnificationXref
id: P17752
db: UniProt

Interaction3219
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(1A) dopamine receptor
participant: Dopamine
participant: D(1A) dopamine receptor

Protein/1983 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent dopamine transporter
stoichiometric coefficient: 1.0

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Reference/HMDB HMDB0000022
type: UnificationXref
id: HMDB0000022
db: HMDB

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Reference/PathWhiz PW125908
type: UnificationXref
id: PW125908
db: PathWhiz

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 62989-33-7
type: UnificationXref
id: 62989-33-7
db: CAS

Compound/PW C000627 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sapropterin
stoichiometric coefficient: 1.0

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 13023-73-9
type: UnificationXref
id: 13023-73-9
db: CAS

Reference/UniProt P21918
type: UnificationXref
id: P21918
db: UniProt

Reference/UniProt P21917
type: UnificationXref
id: P21917
db: UniProt

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Reference/PubChem-compound 151276
type: UnificationXref
id: 151276
db: PubChem-compound

1.14.16.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000627 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
EC number: 1.14.16.2
left: Sapropterin
left: Oxygen
left: L-Tyrosine
name: L-Tyrosine + Oxygen + Sapropterin → Dihydrobiopterin + L-Dopa + Water
conversion direction: LEFT_TO_RIGHT

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/KEGG Compound C05635
type: UnificationXref
id: C05635
db: KEGG Compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: Reference/UniProt P17752
organism: BiologicalState37

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Reference/PubChem-compound 1669
type: UnificationXref
id: 1669
db: PubChem-compound

Trace amine-associated receptor 1
type: Protein
cellular location: Cell Membrane
entity reference: Trace amine-associated receptor 1

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Cytosol
entity reference: Amine oxidase [flavin-containing] A

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Interaction3141
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-1 adrenergic receptor
participant: Norepinephrine
participant: Beta-1 adrenergic receptor

Reference/CAS 5703-24-2
type: UnificationXref
id: 5703-24-2
db: CAS

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Reference/ChEBI CHEBI 64491
type: UnificationXref
id: CHEBI:64491
db: ChEBI

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState789

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Reaction218277
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: Tetrahydrobiopterin
name: L-Tyrosine + Oxygen + Tetrahydrobiopterin ↔ Dihydrobiopterin + L-Dopa + Water
conversion direction: REVERSIBLE

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Serotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: Serotonin

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Interaction3143
type: MolecularInteraction
interaction type: direct_interaction
name: Serotonin activates 5-hydroxytryptamine receptor 2A
participant: Serotonin
participant: 5-hydroxytryptamine receptor 2A

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Homovanillin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 151276
xref: Reference/CAS 5703-24-2
xref: Reference/KEGG Compound C05581
xref: Reference/HMDB HMDB0005175
xref: Reference/ChEBI CHEBI 28111
xref: Reference/ChemSpider 133331
chemical formula: C9H10O3
molecular weight: 166.06299
structure: ChemicalStructure/PW C002411

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

TransportCatalysis4991
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport14010
control type: ACTIVATION

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/CAS 54-16-0
type: UnificationXref
id: 54-16-0
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

5-Hydroxy-L-tryptophan
type: SmallMoleculeReference
xref: Reference/ChemSpider 388413
xref: Reference/CAS 4350-09-8
xref: Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
xref: Reference/ChEBI CHEBI 17780
xref: Reference/KEGG Compound C00643
xref: Reference/PubChem-compound 439280
xref: Reference/HMDB HMDB0000472
chemical formula: C11H12N2O3
molecular weight: 220.0848
structure: ChemicalStructure/PW C000358

Reference/PathWhiz PW126707
type: UnificationXref
id: PW126707
db: PathWhiz

Interaction3375
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(1B) dopamine receptor
participant: Dopamine
participant: D(1B) dopamine receptor

ReactionCatalysis207970
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: Reaction218550
control type: ACTIVATION

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

Sodium-dependent dopamine transporter
type: Protein
cellular location: Extracellular Space
entity reference: Sodium-dependent dopamine transporter

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/ChemSpider 133725
type: UnificationXref
id: 133725
db: ChemSpider

5-hydroxytryptamine receptor 2A
type: Protein
cellular location: Synapse
entity reference: 5-hydroxytryptamine receptor 2A

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Compound/PW C000015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

5-hydroxytryptamine receptor 2A
type: Protein
cellular location: post-synaptic membrane
entity reference: 5-hydroxytryptamine receptor 2A
name: SubPathwayInput

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Sodium-dependent dopamine transporter
type: Protein
cellular location: Cell Membrane
entity reference: Sodium-dependent dopamine transporter

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

5-Hydroxy-L-tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-L-tryptophan

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Cell Membrane
entity reference: Amine oxidase [flavin-containing] A

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

Synaptic vesicular amine transporter
type: Protein
cellular location: Exocytic Vesicle
entity reference: Synaptic vesicular amine transporter

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Presynaptic membrane
entity reference: Sodium-dependent noradrenaline transporter

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Trace amine-associated receptor 1
type: Protein
entity reference: Trace amine-associated receptor 1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState789

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Reference/KEGG Compound C05577
type: UnificationXref
id: C05577
db: KEGG Compound

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Reference/HMDB HMDB0000787
type: UnificationXref
id: HMDB0000787
db: HMDB

Reference/KEGG Compound C05581
type: UnificationXref
id: C05581
db: KEGG Compound

Reference/ChEBI CHEBI 27823
type: UnificationXref
id: CHEBI:27823
db: ChEBI

Compound/PW C002683 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

TransportCatalysis4973
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport13990
control type: ACTIVATION

ReactionCatalysis207629
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: Reaction218277
control type: ACTIVATION

Reference/KEGG Compound C05587
type: UnificationXref
id: C05587
db: KEGG Compound

Sodium-dependent serotonin transporter
type: Protein
entity reference: Sodium-dependent serotonin transporter

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Transport14185
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Nervous System, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 7991951
type: UnificationXref
id: 7991951
db: ChemSpider

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

3-Methoxytyramine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 742324
xref: Reference/PubChem-compound 1669
xref: Reference/CAS 554-52-9
xref: Reference/KEGG Compound C05587
xref: Reference/HMDB HMDB0000022
xref: Reference/ChemSpider 1606
chemical formula: C9H13NO2
molecular weight: 167.09464
structure: ChemicalStructure/PW C000015

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Norepinephrine Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117877
pathway component: SubPathwayInteraction117877
xref: Reference/SMPDB SMP0125166
xref: Reference/PathWhiz PW126707
name: SubPathway

Methamphetamine
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Methamphetamine

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Extracellular Space
entity reference: Sodium-dependent noradrenaline transporter

Sapropterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Sapropterin

Norepinephrine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Norepinephrine

3,4-Dihydroxymandelaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27852
xref: Reference/PubChem-compound 151725
xref: Reference/ChemSpider 133725
xref: Reference/CAS 13023-73-9
xref: Reference/HMDB HMDB0006242
xref: Reference/KEGG Compound C05577
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C002683

SubPathwayInteraction117914
type: Interaction
name: SubPathway117914Reaction
name: SubPathwayReaction
participant: 5-hydroxytryptamine receptor 2A

Transport14170
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: true
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14173
type: Transport
participant stoichiometry: Protein/1822 Presynaptic membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1822 Cytosol/Stoichiometry/1.0
right: Sodium-dependent serotonin transporter
spontaneous: true
left: Sodium-dependent serotonin transporter
name: Sodium-dependent serotonin transporter (→) Transport: Homo sapiens, Brain, Neuron, Presynaptic membrane to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

SubPathwayInteraction117915
type: Interaction
name: SubPathwayReaction
name: SubPathway117915Reaction
participant: 5-hydroxytryptamine receptor 2A

Transport14172
type: Transport
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

D(4) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21917
organism: BiologicalState789

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

D(1A) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(1A) dopamine receptor
name: SubPathwayInput

Transport14168
type: Transport
participant stoichiometry: Protein/1814 Presynaptic membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1814 Cytosol/Stoichiometry/1.0
right: Sodium-dependent noradrenaline transporter
spontaneous: true
left: Sodium-dependent noradrenaline transporter
name: Sodium-dependent noradrenaline transporter (→) Transport: Homo sapiens, Brain, Neuron, Presynaptic membrane to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14167
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Transport14169
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 742324
type: UnificationXref
id: CHEBI:742324
db: ChEBI

ChemicalStructure/PW C000015
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CCN)=C1

Transport14164
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: true
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14163
type: Transport
participant stoichiometry: Compound/PW C009782 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Transport14165
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: true
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Transport14162
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 1606
type: UnificationXref
id: 1606
db: ChemSpider

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine
name: SubPathwayInput

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Protein/1822 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent serotonin transporter
stoichiometric coefficient: 1.0

D(4) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(4) dopamine receptor
name: SubPathwayInput

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Alpha-2A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08913
organism: BiologicalState789

Chromaffin granule amine transporter
type: ProteinReference
xref: Reference/UniProt P54219

ReactionCatalysis207695
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: Reaction218332
control type: ACTIVATION

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

ReactionCatalysis207694
type: Catalysis
controller: Catechol O-methyltransferase
controlled: Reaction218331
control type: ACTIVATION

Reaction218331
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 3-Methoxytyramine
spontaneous: false
left: Dopamine
left: S-Adenosylmethionine
name: Dopamine + S-Adenosylmethionine ↔ 3-Methoxytyramine + S-Adenosylhomocysteine
conversion direction: REVERSIBLE

ChemicalStructure/PW C002683
type: ChemicalStructure
structure format: SMILES
structure data: OC(C=O)C1=CC(O)=C(O)C=C1

Reference/PathWhiz PW126797
type: UnificationXref
id: PW126797
db: PathWhiz

Reference/PubChem-compound 10836
type: UnificationXref
id: 10836
db: PubChem-compound

Reference/PubChem-compound 9816201
type: UnificationXref
id: 9816201
db: PubChem-compound

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C009782 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Serotonin
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Serotonin

Sodium-dependent dopamine transporter
type: Protein
cellular location: Cytosol
entity reference: Sodium-dependent dopamine transporter

5-Hydroxyindoleacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxyindoleacetic acid

D(1A) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21728
organism: BiologicalState789

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Cytosol
entity reference: Sodium-dependent noradrenaline transporter

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

Reaction218332
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Homovanillin
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: 3-Methoxytyramine
left: Water
name: 3-Methoxytyramine + Oxygen + Water ↔ Ammonia + Homovanillin + Hydrogen peroxide
conversion direction: REVERSIBLE

Methamphetamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Methamphetamine

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

ChemicalStructure/PW C002411
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CC=O)=C1

Reference/ChEBI CHEBI 27852
type: UnificationXref
id: CHEBI:27852
db: ChEBI

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
type: UnificationXref
id: 5-HYDROXY-TRYPTOPHAN
db: BioCyc

Protein/1814 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent noradrenaline transporter
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/HMDB HMDB0000472
type: UnificationXref
id: HMDB0000472
db: HMDB

TransportCatalysis4823
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport13773
control type: ACTIVATION

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

ChemicalStructure/PW C000358
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

Alpha-2A adrenergic receptor
type: Protein
cellular location: Synapse
entity reference: Alpha-2A adrenergic receptor

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Transport14013
type: Transport
participant stoichiometry: Protein/1983 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1983 Cytosol/Stoichiometry/1.0
right: Sodium-dependent dopamine transporter
spontaneous: false
left: Sodium-dependent dopamine transporter
name: Sodium-dependent dopamine transporter (→) Transport: Homo sapiens, Brain, Neuron, Cell Membrane to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0001484
type: UnificationXref
id: BTO:0001484
db: BRENDA TISSUE ONTOLOGY

Transport14010
type: Transport
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Transport14012
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW126773
type: UnificationXref
id: PW126773
db: PathWhiz

1.14.16.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: 5-Hydroxy-L-tryptophan
spontaneous: false
EC number: 1.14.16.4
left: Oxygen
left: L-Tryptophan
left: Tetrahydrobiopterin
name: L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Serotonin
spontaneous: false
EC number: 4.1.1.28
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 133331
type: UnificationXref
id: 133331
db: ChemSpider

ChemicalStructure/PW C000609
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CNC2=C1C=C(O)C=C2

Reference/ChEBI CHEBI 6809
type: UnificationXref
id: CHEBI:6809
db: ChEBI

Compound/PW C000052 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

ChemicalStructure/PW C009782
type: ChemicalStructure
structure format: SMILES
structure data: CN[C@@H](C)CC1=CC=CC=C1

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Sodium-dependent serotonin transporter
type: Protein
cellular location: Cytosol
entity reference: Sodium-dependent serotonin transporter

Reference/CAS 4350-09-8
type: UnificationXref
id: 4350-09-8
db: CAS

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Protein/1814 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent noradrenaline transporter
stoichiometric coefficient: 1.0

Transport14119
type: Transport
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

TransportCatalysis5094
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport14162
control type: ACTIVATION

Transport14112
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport14115
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14114
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Protein/1822 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent serotonin transporter
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

TransportCatalysis5097
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14167
control type: ACTIVATION

Compound/PW C000178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006242
type: UnificationXref
id: HMDB0006242
db: HMDB

TransportCatalysis5098
type: Catalysis
controller: Chromaffin granule amine transporter
controlled: Transport14169
control type: ACTIVATION

TransportCatalysis5095
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14163
control type: ACTIVATION

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

ReactionCatalysis213
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: 1.14.16.2
control type: ACTIVATION

Reference/SMPDB SMP0125254
type: UnificationXref
id: SMP0125254
db: SMPDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/PubChem-compound 151725
type: UnificationXref
id: 151725
db: PubChem-compound

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/UniProt Q96RJ0
type: UnificationXref
id: Q96RJ0
db: UniProt

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

SubPathwayInteraction117880
type: Interaction
name: SubPathway117880Reaction
name: SubPathwayReaction
participant: Beta-1 adrenergic receptor

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Dopamine
type: SmallMolecule
cellular location: Synapse
entity reference: Dopamine

Compound/PW C009782 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

SubPathwayInteraction117881
type: Interaction
name: SubPathway117881Reaction
name: SubPathwayReaction
participant: Alpha-1A adrenergic receptor

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

SubPathwayInteraction117882
type: Interaction
name: SubPathwayReaction
name: SubPathway117882Reaction
participant: Alpha-2A adrenergic receptor

SubPathwayInteraction117876
type: Interaction
name: SubPathwayReaction
name: SubPathway117876Reaction
participant: D(4) dopamine receptor

SubPathwayInteraction117877
type: Interaction
name: SubPathwayReaction
name: SubPathway117877Reaction
participant: Norepinephrine

SubPathwayInteraction117874
type: Interaction
name: SubPathway117874Reaction
name: SubPathwayReaction
participant: D(1A) dopamine receptor

SubPathwayInteraction117875
type: Interaction
name: SubPathway117875Reaction
name: SubPathwayReaction
participant: D(1B) dopamine receptor

Tryptophan 5-hydroxylase 1
type: Protein
cellular location: Cytosol
entity reference: Tryptophan 5-hydroxylase 1

Reaction218550
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000609 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: 5-Hydroxyindoleacetic acid
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: Serotonin
left: Water
name: Oxygen + Serotonin + Water → 5-Hydroxyindoleacetic acid + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Chromaffin granule amine transporter
type: Protein
cellular location: Exocytic Vesicle
entity reference: Chromaffin granule amine transporter

SubPathwayInteraction117878
type: Interaction
name: SubPathway117878Reaction
name: SubPathwayReaction
participant: Norepinephrine

Reference/HMDB HMDB0005175
type: UnificationXref
id: HMDB0005175
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Reference/CAS 537-46-2
type: UnificationXref
id: 537-46-2
db: CAS

3-Methoxytyramine
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Methoxytyramine

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Reference/UniProt P54219
type: UnificationXref
id: P54219
db: UniProt

Reference/ChEBI CHEBI 17780
type: UnificationXref
id: CHEBI:17780
db: ChEBI

Intestinal Serotonin pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117914
pathway component: SubPathwayInteraction117914
xref: Reference/SMPDB SMP0125254
xref: Reference/PathWhiz PW126797
name: SubPathway

Interaction3946
type: MolecularInteraction
interaction type: direct_interaction
name: Trace amine-associated receptor 1 inhibits Sodium-dependent dopamine transporter
participant: Trace amine-associated receptor 1
participant: Sodium-dependent dopamine transporter

Reference/BioCyc 5-HYDROXYINDOLE ACETATE
type: UnificationXref
id: 5-HYDROXYINDOLE_ACETATE
db: BioCyc

ReactionCatalysis1364
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

ReactionCatalysis1363
type: Catalysis
controller: Tryptophan 5-hydroxylase 1
controlled: 1.14.16.4
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Catechol O-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Catechol O-methyltransferase

Reference/KEGG Compound C00643
type: UnificationXref
id: C00643
db: KEGG Compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Gi signalling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117876
pathway component: SubPathwayInteraction117876
name: SubPathway

Reference/KEGG Compound C07164
type: UnificationXref
id: C07164
db: KEGG Compound

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

Gs signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117875
pathway component: SubPathwayInteraction117875
name: SubPathway

Reference/ChemSpider 10379
type: UnificationXref
id: 10379
db: ChemSpider

Gs signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117874
pathway component: SubPathwayInteraction117874
name: SubPathway

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Methamphetamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Methamphetamine

Methamphetamine Action Pathway
type: Pathway
pathway order: PathwayTransport/2507937
pathway order: PathwayTransport/2507936
pathway order: PathwayTransport/2507934
pathway order: PathwayTransport/2507933
pathway order: PathwayTransport/2507932
pathway order: PathwayTransport/2507976
pathway order: PathwayTransport/2507941
pathway order: PathwaySubPathway/117874
pathway order: PathwaySubPathway/117877
pathway order: PathwaySubPathway/117878
pathway order: PathwaySubPathway/117875
pathway order: PathwayTransport/2508190
pathway order: PathwaySubPathway/117876
pathway order: PathwaySubPathway/117914
pathway order: PathwaySubPathway/117915
pathway order: PathwayInteraction/4050
pathway order: PathwayTransport/2507908
pathway order: PathwayTransport/2507907
pathway order: PathwayEnzymeReaction/2507904
pathway order: PathwayEnzymeReaction/2507903
pathway order: PathwayEnzymeReaction/2507947
pathway order: PathwayEnzymeReaction/2507906
pathway order: PathwayEnzymeReaction/2507905
pathway order: PathwaySubPathway/117880
pathway order: PathwaySubPathway/117881
pathway order: PathwayEnzymeReaction/2508193
pathway order: PathwayEnzymeReaction/2508191
pathway order: PathwaySubPathway/117882
pathway order: PathwayEnzymeReaction/2508192
pathway order: PathwayTransport/2507913
pathway order: PathwayTransport/2507912
pathway order: PathwayTransport/2507911
pathway order: PathwayInteraction/3946
pathway order: PathwayEnzymeReaction/2507931
pathway order: PathwayEnzymeReaction/2507930
pathway order: PathwayInteraction/3143
pathway order: PathwayInteraction/4077
pathway order: PathwayInteraction/3581
pathway order: PathwayInteraction/3141
pathway order: PathwayInteraction/4076
pathway order: PathwayInteraction/3140
pathway order: PathwayInteraction/4075
pathway order: PathwayInteraction/4074
pathway order: PathwayInteraction/4073
pathway order: PathwayInteraction/4072
pathway order: PathwayInteraction/4071
pathway order: PathwayInteraction/4070
pathway order: PathwayTransport/2507926
pathway order: PathwayTransport/2507923
pathway order: PathwayTransport/2507967
pathway order: PathwayTransport/2507922
pathway order: PathwayTransport/2507965
pathway order: PathwayInteraction/3219
pathway order: PathwayTransport/2507972
pathway order: PathwayTransport/2507971
pathway order: PathwayInteraction/4028
pathway order: PathwayInteraction/4069
pathway order: PathwayInteraction/3375
pathway component: Interaction4074
pathway component: Interaction4073
pathway component: Interaction3140
pathway component: Interaction4076
pathway component: Interaction3581
pathway component: Interaction3141
pathway component: Interaction4075
pathway component: Interaction4070
pathway component: Interaction4072
pathway component: 1.14.17.1
pathway component: Interaction4071
pathway component: Intestinal Serotonin pathway
pathway component: Reaction218277
pathway component: Interaction4077
pathway component: Interaction3143
pathway component: Interaction3946
pathway component: Transport14168
pathway component: Transport14167
pathway component: Transport14169
pathway component: Transport14164
pathway component: Transport14163

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000627
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

Gi Signalling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117882
pathway component: SubPathwayInteraction117882
name: SubPathway

TransportCatalysis5069
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14112
control type: ACTIVATION

Methamphetamine
type: SmallMolecule
cellular location: Synapse
entity reference: Methamphetamine

Gq Signalling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117881
pathway component: SubPathwayInteraction117881
name: SubPathway

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Gs Signalling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117880
pathway component: SubPathwayInteraction117880
name: SubPathway

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/SMPDB SMP0125166
type: UnificationXref
id: SMP0125166
db: SMPDB

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Protein/1983 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent dopamine transporter
stoichiometric coefficient: 1.0

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

TransportCatalysis5071
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14115
control type: ACTIVATION

Reference/HMDB HMDB0000763
type: UnificationXref
id: HMDB0000763
db: HMDB

TransportCatalysis5070
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14114
control type: ACTIVATION

Nervous System
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001484

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202

TransportCatalysis5074
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14119
control type: ACTIVATION