Apolipoprotein A5
type: DnaReference
organism: Homo sapiens

Acyl-coenzyme A synthetase
type: DnaReference
organism: Homo sapiens

Lipoprotein lipase
type: Protein
cellular location: Cytosol
entity reference: Lipoprotein lipase
name: SubPathwayOutput

Fatty acid transport protein 1
type: DnaReference
organism: Homo sapiens

Acetyl-CoA carboxylase
type: DnaReference
organism: Homo sapiens

Reference/UniProt P02652
type: UnificationXref
id: P02652
db: UniProt

Retinoic acid receptor RXR-beta
type: ProteinReference
xref: Reference/UniProt P28702
organism: Homo sapiens

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Lipoprotein lipase
type: DnaReference
organism: Homo sapiens

Apolipoprotein A1
type: DnaReference
organism: Homo sapiens

Compound/Generic410/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acids
stoichiometric coefficient: 1.0

Apolipoprotein A2
type: DnaReference
organism: Homo sapiens

Apolipoprotein C3
type: DnaReference
organism: Homo sapiens

Apolipoprotein B-100
type: DnaReference
organism: Homo sapiens

HDL Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117945
pathway component: SubPathwayInteraction117945
name: SubPathway

direct_interaction
type: InteractionVocabulary

vLDL Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117947
pathway component: SubPathwayInteraction117947
name: SubPathway

ProteinComplex/7634 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Retinoic acid receptor RXR
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Long-chain fatty acid transport protein 1
type: Protein
cellular location: Cell Membrane
entity reference: Long-chain fatty acid transport protein 1

Reference/UniProt P02656
type: UnificationXref
id: P02656
db: UniProt

Protein/23795 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Long-chain fatty acid transport protein 1
stoichiometric coefficient: 1.0

Fatty Acids
type: SmallMoleculeReference

Protein/1837 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peroxisome proliferator-activated receptor alpha
stoichiometric coefficient: 1.0

Protein/304 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lipoprotein lipase
stoichiometric coefficient: 1.0

Protein/304 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lipoprotein lipase
stoichiometric coefficient: 1.0

Apolipoprotein A2
type: Dna
cellular location: Nucleus
entity reference: Apolipoprotein A2
name: SubPathwayInput

Retinoic acid receptor RXR-alpha
type: ProteinReference
xref: Reference/UniProt P19793
organism: Homo sapiens

Retinoic acid receptor RXR-gamma
type: ProteinReference
xref: Reference/UniProt P48443
organism: Homo sapiens

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Fatty Acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Fatty Acids
name: SubPathwayOutput
name: SubPathwayInput

Compound/Generic369 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Fatty acid metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117957
pathway component: SubPathwayInteraction117957
name: SubPathway

Reference/PathWhiz PW000167
type: UnificationXref
id: PW000167
db: PathWhiz

Fenofibrate Action Pathway (New)
type: Pathway
pathway order: PathwaySubPathway/117947
pathway order: PathwaySubPathway/117948
pathway order: PathwaySubPathway/117945
pathway order: PathwaySubPathway/117946
pathway order: PathwayTransport/2508449
pathway order: PathwayEnzymeReaction/2508446
pathway order: PathwayInteraction/4099
pathway order: PathwayInteraction/4098
pathway order: PathwayInteraction/4097
pathway order: PathwaySubPathway/117957
pathway order: PathwayTransport/2508440
pathway order: PathwayTransport/2508441
pathway order: PathwayTransport/2508443
pathway order: PathwayTransport/2508466
pathway order: PathwayTransport/2508467
pathway order: PathwayTransport/2508438
pathway order: PathwayInteraction/4109
pathway order: PathwayEnzymeReaction/2508437
pathway order: PathwayInteraction/4108
pathway order: PathwayInteraction/4107
pathway order: PathwayInteraction/4106
pathway order: PathwayInteraction/4105
pathway order: PathwayInteraction/4103
pathway order: PathwayInteraction/4102
pathway order: PathwayInteraction/4101
pathway order: PathwayInteraction/4100
pathway order: PathwaySubPathway/117944
pathway order: PathwaySubPathway/117941
pathway order: PathwaySubPathway/117942
pathway component: Interaction4098
pathway component: Interaction4097
pathway component: Transport14209
pathway component: Transport14208
pathway component: Interaction4099
pathway component: Transport14207
pathway component: ReactionCatalysis208015
pathway component: HDL Synthesis
pathway component: vLDL Synthesis
pathway component: Transcription/Translation
pathway component: Fatty Acid Biosynthesis
pathway component: TransportCatalysis5118
pathway component: Reaction218604
pathway component: TransportCatalysis5117
pathway component: Interaction4103
pathway component: Interaction4106
pathway component: Interaction4105
pathway component: Interaction4100
pathway component: Transport14215
pathway component: Interaction4102
pathway component: Interaction4101
pathway component: Transport14212
pathway component: Transport14211
pathway component: Transport14214
pathway component: Interaction4108
pathway component: Interaction4107
pathway component: Reaction218593
pathway component: Interaction4109
pathway component: Fatty acid metabolism
pathway component: TransportCatalysis5113
xref: Reference/SMPDB SMP0125276
xref: Reference/PathWhiz PW126820
organism: Homo sapiens

Compound/Generic25 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/PubChem-compound 3339
type: UnificationXref
id: 3339
db: PubChem-compound

Apolipoprotein A-II
type: ProteinReference
xref: Reference/UniProt P02652
organism: Homo sapiens

Apolipoprotein C-III
type: ProteinReference
xref: Reference/UniProt P02656
organism: Homo sapiens

Apolipoprotein B-100
type: ProteinReference
xref: Reference/UniProt P04114
organism: Homo sapiens

Reference/UniProt P28702
type: UnificationXref
id: P28702
db: UniProt

Compound/Generic410 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acids
stoichiometric coefficient: 1.0

Protein/1502 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Apolipoprotein A-I
stoichiometric coefficient: 1.0

Triglyceride
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00422

Reference/CAS 49562-28-9
type: UnificationXref
id: 49562-28-9
db: CAS

Protein/23795 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Long-chain fatty acid transport protein 1
stoichiometric coefficient: 1.0

Apolipoprotein A5
type: Dna
cellular location: Nucleus
entity reference: Apolipoprotein A5
name: SubPathwayInput

Fatty Acids
type: SmallMolecule
entity reference: Fatty Acids

Protein/24066 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Apolipoprotein A-II
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Diacylglycerol

Peroxisome proliferator-activated receptor alpha
type: Protein
cellular location: Nucleus
entity reference: Peroxisome proliferator-activated receptor alpha

Reference/UniProt P19793
type: UnificationXref
id: P19793
db: UniProt

Reference/UniProt P04114
type: UnificationXref
id: P04114
db: UniProt

Apolipoprotein A-V
type: Protein
cellular location: Cytosol
entity reference: Apolipoprotein A-V
name: SubPathwayOutput

Reference/ChemSpider 3222
type: UnificationXref
id: 3222
db: ChemSpider

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Apolipoprotein A-II
type: Protein
cellular location: Extracellular Space
entity reference: Apolipoprotein A-II
name: SubPathwayInput

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Retinoic acid receptor RXR-gamma
type: Protein
cellular location: Nucleus
entity reference: Retinoic acid receptor RXR-gamma

Compound/PW C009470 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibrate
stoichiometric coefficient: 1.0

Reference/UniProt Q13085
type: UnificationXref
id: Q13085
db: UniProt

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 35366
type: UnificationXref
id: CHEBI:35366
db: ChEBI

Apolipoprotein B-100
type: Dna
cellular location: Nucleus
entity reference: Apolipoprotein B-100
name: SubPathwayInput

Apolipoprotein A-V
type: ProteinReference
xref: Reference/UniProt Q6Q788
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Interaction4098
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA activates Lipoprotein lipase
participant: PPARA+RXRA
participant: Lipoprotein lipase

Interaction4097
type: MolecularInteraction
interaction type: direct_interaction
name: Fenofibrate activates Peroxisome proliferator-activated receptor alpha
participant: Fenofibrate
participant: Peroxisome proliferator-activated receptor alpha

Acyl-coenzyme A synthetase
type: Dna
cellular location: Nucleus
entity reference: Acyl-coenzyme A synthetase
name: SubPathwayInput

Apolipoprotein C-III
type: Protein
cellular location: Cytosol
entity reference: Apolipoprotein C-III
name: SubPathwayOutput

Interaction4099
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA activates Apolipoprotein A1
participant: PPARA+RXRA
participant: Apolipoprotein A1

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Transcription/Translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117941
pathway order: SubPathwayInteractionSteps/SubPathway117944
pathway order: SubPathwayInteractionSteps/SubPathway117946
pathway order: SubPathwayInteractionSteps/SubPathway117948
pathway component: SubPathwayInteraction117941
pathway component: SubPathwayInteraction117946
pathway component: SubPathwayInteraction117944
pathway component: SubPathwayInteraction117948
xref: Reference/SMPDB SMP0000019
xref: Reference/PathWhiz PW000455
name: SubPathway

Compound/PW C009470 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibrate
stoichiometric coefficient: 1.0

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Apolipoprotein A-I
type: Protein
cellular location: Extracellular Space
entity reference: Apolipoprotein A-I
name: SubPathwayInput

PPARA+RXRA
type: Complex
cellular location: Nucleus
component: Retinoic acid receptor RXR-alpha
component: Peroxisome proliferator-activated receptor alpha

TransportCatalysis5118
type: Catalysis
controller: Unknown
controlled: Transport14208
control type: ACTIVATION

TransportCatalysis5117
type: Catalysis
controller: Unknown
controlled: Transport14207
control type: ACTIVATION

Reference/HMDB HMDB0015173
type: UnificationXref
id: HMDB0015173
db: HMDB

Retinoic acid receptor RXR
type: Complex
cellular location: Nucleus
component: Retinoic acid receptor RXR-beta
component: Retinoic acid receptor RXR-alpha
component: Retinoic acid receptor RXR-gamma

Reference/KEGG Compound C07586
type: UnificationXref
id: C07586
db: KEGG Compound

Reference/UniProt Q07869
type: UnificationXref
id: Q07869
db: UniProt

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reaction218593
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic369 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic309 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic25 Extracellular Space/Stoichiometry/1.0
right: Diacylglycerol
right: Fatty Acid
spontaneous: false
left: Water
left: Triglyceride
name: Triglyceride + Water → Diacylglycerol + Fatty Acid
conversion direction: LEFT_TO_RIGHT

TransportCatalysis5113
type: Catalysis
controller: Long-chain fatty acid transport protein 1
controlled: Transport14211
control type: ACTIVATION

Reference/UniProt P02647
type: UnificationXref
id: P02647
db: UniProt

Acetyl-CoA carboxylase 1
type: Protein
cellular location: Cytosol
entity reference: Acetyl-CoA carboxylase 1
name: SubPathwayOutput
name: SubPathwayInput

Reference/SMPDB SMP0125276
type: UnificationXref
id: SMP0125276
db: SMPDB

HDL
type: Protein
entity reference: HDL
name: SubPathwayOutput

Protein/24066 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Apolipoprotein A-II
stoichiometric coefficient: 1.0

Lipoprotein lipase
type: ProteinReference
xref: Reference/UniProt P06858
organism: Homo sapiens

Unknown
type: Protein
entity reference: Unknown

Fenofibrate
type: SmallMolecule
cellular location: Nucleus
entity reference: Fenofibrate

Reference/UniProt P06858
type: UnificationXref
id: P06858
db: UniProt

Reference/UniProt Q6PCB7
type: UnificationXref
id: Q6PCB7
db: UniProt

Peroxisome proliferator-activated receptor alpha
type: ProteinReference
xref: Reference/UniProt Q07869
organism: Homo sapiens

Reference/SMPDB SMP0000019
type: UnificationXref
id: SMP0000019
db: SMPDB

Diacylglycerol
type: SmallMoleculeReference

Reference/PathWhiz PW000455
type: UnificationXref
id: PW000455
db: PathWhiz

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Long-chain fatty acid transport protein 1
type: Protein
entity reference: Long-chain fatty acid transport protein 1

Reference/UniProt Q08AH3
type: UnificationXref
id: Q08AH3
db: UniProt

Acetyl-CoA carboxylase
type: Dna
cellular location: Nucleus
entity reference: Acetyl-CoA carboxylase
name: SubPathwayInput

Acetyl-CoA carboxylase 1
type: ProteinReference
xref: Reference/UniProt Q13085
organism: Homo sapiens

Acyl-coenzyme A synthetase ACSM2A, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q08AH3
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

VLDL
type: SmallMoleculeReference

Fenofibrate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Fenofibrate

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Fatty Acid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117942
pathway component: SubPathwayInteraction117942
xref: Reference/PathWhiz PW000167
xref: Reference/SMPDB SMP0000456
name: SubPathway

Triglyceride
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Triglyceride

Apolipoprotein A-I
type: ProteinReference
xref: Reference/UniProt P02647
organism: Homo sapiens

Retinoic acid receptor RXR-alpha
type: Protein
cellular location: Nucleus
entity reference: Retinoic acid receptor RXR-alpha

Apolipoprotein A1
type: Dna
cellular location: Nucleus
entity reference: Apolipoprotein A1
name: SubPathwayInput

Transport14215
type: Transport
participant stoichiometry: Protein/304 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/304 Cytosol/Stoichiometry/1.0
right: Lipoprotein lipase
spontaneous: false
left: Lipoprotein lipase
name: Lipoprotein lipase (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport14212
type: Transport
participant stoichiometry: Protein/1502 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/1502 Cytosol/Stoichiometry/1.0
right: Apolipoprotein A-I
spontaneous: false
left: Apolipoprotein A-I
name: Apolipoprotein A1 (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport14211
type: Transport
participant stoichiometry: Compound/Generic410/Stoichiometry/1.0
participant stoichiometry: Compound/Generic410 Cytosol/Stoichiometry/1.0
right: Fatty Acids
spontaneous: false
left: Fatty Acids
name: Fatty Acids (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14214
type: Transport
participant stoichiometry: Protein/24066 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/24066 Extracellular Space/Stoichiometry/1.0
right: Apolipoprotein A-II
spontaneous: false
left: Apolipoprotein A-II
name: Apolipoprotein A2 (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q6Q788
type: UnificationXref
id: Q6Q788
db: UniProt

Fenofibrate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07586
xref: Reference/ChEBI CHEBI 5001
xref: Reference/PubChem-compound 3339
xref: Reference/HMDB HMDB0015173
xref: Reference/ChemSpider 3222
xref: Reference/CAS 49562-28-9
chemical formula: C20H21ClO4
molecular weight: 360.11282
structure: ChemicalStructure/PW C009470

Apolipoprotein A-II
type: Protein
cellular location: Cytosol
entity reference: Apolipoprotein A-II
name: SubPathwayOutput

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Apolipoprotein B-100
type: Protein
cellular location: Cytosol
entity reference: Apolipoprotein B-100
name: SubPathwayOutput
name: SubPathwayInput

Fatty acid transport protein 1
type: Dna
cellular location: Nucleus
entity reference: Fatty acid transport protein 1
name: SubPathwayInput

Transport14209
type: Transport
participant stoichiometry: Protein/23795 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/23795 Cytosol/Stoichiometry/1.0
right: Long-chain fatty acid transport protein 1
spontaneous: false
left: Long-chain fatty acid transport protein 1
name: Long-chain fatty acid transport protein 1 (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Cell Membrane
conversion direction: LEFT_TO_RIGHT

Transport14208
type: Transport
participant stoichiometry: Compound/PW C009470 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009470 Extracellular Space/Stoichiometry/1.0
right: Fenofibrate
spontaneous: false
left: Fenofibrate
name: Fenofibrate (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Fatty Acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 35366

Transport14207
type: Transport
participant stoichiometry: Compound/PW C009470 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009470 Nucleus/Stoichiometry/1.0
right: Fenofibrate
spontaneous: false
left: Fenofibrate
name: Fenofibrate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

VLDL
type: SmallMolecule
cellular location: Cytosol
entity reference: VLDL
name: SubPathwayOutput

Reference/ChEBI CHEBI 5001
type: UnificationXref
id: CHEBI:5001
db: ChEBI

ReactionCatalysis208015
type: Catalysis
controller: Lipoprotein lipase
controlled: Reaction218593
control type: ACTIVATION

SubPathwayInteraction117942
type: Interaction
name: SubPathway117942Reaction
name: SubPathwayReaction
participant: Acetyl-CoA carboxylase 1
participant: Fatty Acids

Long-chain fatty acid transport protein 1
type: ProteinReference
xref: Reference/UniProt Q6PCB7
organism: Homo sapiens

SubPathwayInteraction117941
type: Interaction
name: SubPathwayReaction
name: SubPathway117941Reaction
participant: Acetyl-CoA carboxylase 1
participant: Acetyl-CoA carboxylase
participant: Long-chain fatty acid transport protein 1
participant: Acyl-coenzyme A synthetase ACSM2A, mitochondrial
participant: Fatty acid transport protein 1
participant: Acyl-coenzyme A synthetase

SubPathwayInteraction117946
type: Interaction
name: SubPathway117946Reaction
name: SubPathwayReaction
participant: Apolipoprotein B-100

Reference/PathWhiz PW126820
type: UnificationXref
id: PW126820
db: PathWhiz

SubPathwayInteraction117947
type: Interaction
name: SubPathwayReaction
name: SubPathway117947Reaction
participant: Apolipoprotein B-100
participant: VLDL

SubPathwayInteraction117944
type: Interaction
name: SubPathwayReaction
name: SubPathway117944Reaction
participant: Apolipoprotein A-I
participant: Apolipoprotein A2
participant: Apolipoprotein A1
participant: Apolipoprotein A-II

SubPathwayInteraction117945
type: Interaction
name: SubPathway117945Reaction
name: SubPathwayReaction
participant: Apolipoprotein A-II
participant: HDL
participant: Apolipoprotein A-I

SubPathwayInteraction117948
type: Interaction
name: SubPathway117948Reaction
name: SubPathwayReaction
participant: Lipoprotein lipase
participant: Apolipoprotein A5
participant: Apolipoprotein A-V
participant: Apolipoprotein C3
participant: Apolipoprotein C-III

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C009470
type: ChemicalStructure
structure format: SMILES

Lipoprotein lipase
type: Dna
cellular location: Nucleus
entity reference: Lipoprotein lipase
name: SubPathwayInput

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reaction218604
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/7634 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7845 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1837 Nucleus/Stoichiometry/1.0
right: PPARA+RXRA
spontaneous: false
left: Retinoic acid receptor RXR
left: Peroxisome proliferator-activated receptor alpha
name: Peroxisome proliferator-activated receptor alpha + Retinoic acid receptor RXR → PPARA+RXRA
conversion direction: LEFT_TO_RIGHT

Lipoprotein lipase
type: Protein
cellular location: Extracellular Space
entity reference: Lipoprotein lipase

Reference/SMPDB SMP0000456
type: UnificationXref
id: SMP0000456
db: SMPDB

Compound/PW C009470 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibrate
stoichiometric coefficient: 1.0

Interaction4103
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA activates Apolipoprotein A5
participant: PPARA+RXRA
participant: Apolipoprotein A5

Compound/Generic309 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triglyceride
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

Interaction4106
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA activates Fatty acid transport protein 1
participant: PPARA+RXRA
participant: Fatty acid transport protein 1

Interaction4105
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA activates Acyl-coenzyme A synthetase
participant: PPARA+RXRA
participant: Acyl-coenzyme A synthetase

Interaction4100
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA activates Apolipoprotein A2
participant: PPARA+RXRA
participant: Apolipoprotein A2

Interaction4102
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA inhibits Apolipoprotein B-100
participant: PPARA+RXRA
participant: Apolipoprotein B-100

Interaction4101
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA inhibits Apolipoprotein C3
participant: PPARA+RXRA
participant: Apolipoprotein C3

Interaction4108
type: MolecularInteraction
interaction type: direct_interaction
name: Apolipoprotein A5 activates Lipoprotein lipase
participant: Lipoprotein lipase
participant: Apolipoprotein A-V

Interaction4107
type: MolecularInteraction
interaction type: direct_interaction
name: PPARA+RXRA inhibits Acetyl-CoA carboxylase
participant: PPARA+RXRA
participant: Acetyl-CoA carboxylase

Interaction4109
type: MolecularInteraction
interaction type: direct_interaction
name: Apolipoprotein C3 inhibits Lipoprotein lipase
participant: Lipoprotein lipase
participant: Apolipoprotein C-III

Acyl-coenzyme A synthetase ACSM2A, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Acyl-coenzyme A synthetase ACSM2A, mitochondrial
name: SubPathwayOutput
name: SubPathwayInput

HDL
type: ProteinReference
organism: BiologicalState51

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Retinoic acid receptor RXR-beta
type: Protein
cellular location: Nucleus
entity reference: Retinoic acid receptor RXR-beta

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Fatty Acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Fatty Acid

Long-chain fatty acid transport protein 1
type: Protein
cellular location: Cytosol
entity reference: Long-chain fatty acid transport protein 1
name: SubPathwayOutput

Apolipoprotein A-I
type: Protein
cellular location: Cytosol
entity reference: Apolipoprotein A-I
name: SubPathwayOutput

Reference/UniProt P48443
type: UnificationXref
id: P48443
db: UniProt

Fenofibrate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fenofibrate

Reference/KEGG Compound C00422
type: UnificationXref
id: C00422
db: KEGG Compound

SubPathwayInteraction117957
type: Interaction
name: SubPathway117957Reaction
name: SubPathwayReaction
participant: Fatty Acids
participant: Acyl-coenzyme A synthetase ACSM2A, mitochondrial

Protein/1502 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Apolipoprotein A-I
stoichiometric coefficient: 1.0

Apolipoprotein C3
type: Dna
cellular location: Nucleus
entity reference: Apolipoprotein C3
name: SubPathwayInput

ProteinComplex/7845 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: PPARA+RXRA
stoichiometric coefficient: 1.0