Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: BiologicalState1056

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C000146 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

TransportCatalysis5123
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport14226
control type: ACTIVATION

Compound/PW C000723 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 2.0

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/1845/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/1845 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Cyclic GMP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16356
xref: Reference/ChemSpider 22734
xref: Reference/KEGG Compound C00942
xref: Reference/HMDB HMDB0001314
xref: Reference/BioCyc CGMP
xref: Reference/PubChem-compound 24316
xref: Reference/CAS 7665-99-8
chemical formula: C10H12N5O7P
molecular weight: 345.04742
structure: ChemicalStructure/PW C001013

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
type: Protein
cellular location: Cytosol
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Compound/PW C001867 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16356
type: UnificationXref
id: CHEBI:16356
db: ChEBI

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Reference/UniProt P29474
type: UnificationXref
id: P29474
db: UniProt

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

Interaction476
type: MolecularInteraction
interaction type: direct_interaction
name: Nitric oxide activates Soluble guanylyl cyclase
participant: Nitric oxide
participant: Soluble guanylyl cyclase

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Interaction479
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic GMP activates cGMP-dependent protein kinase
participant: cGMP-dependent protein kinase
participant: Cyclic GMP

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Reference/UniProt Q02153
type: UnificationXref
id: Q02153
db: UniProt

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Caffeine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 2519
xref: Reference/ChEBI CHEBI 27732
xref: Reference/KEGG Compound C07481
xref: Reference/CAS 58-08-2
xref: Reference/ChemSpider 2424
xref: Reference/HMDB HMDB0001847
chemical formula: C8H10N4O2
molecular weight: 194.08037
structure: ChemicalStructure/PW C001222

ReactionCatalysis208032
type: Catalysis
controller: Nitric-oxide synthase, endothelial
controlled: 1.14.13.39
control type: ACTIVATION

Protein/1054 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cGMP-dependent protein kinase 1
stoichiometric coefficient: 1.0

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117963
pathway component: SubPathwayInteraction117963
name: SubPathway

cGMP-dependent protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: cGMP-dependent protein kinase 1

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

cGMP-dependent protein kinase
type: Complex
component stoichiometry: Protein/1054 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1058 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cGMP-dependent protein kinase 2
component: cGMP-dependent protein kinase 1

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Caffeine Vasodilation Action Pathway
type: Pathway
pathway order: PathwayInteraction/479
pathway order: PathwayTransport/2508546
pathway order: PathwayInteraction/2849
pathway order: PathwayTransport/2508537
pathway order: PathwayTransport/2508527
pathway order: PathwayEnzymeReaction/2508543
pathway order: PathwayTransport/2508528
pathway order: PathwayEnzymeReaction/2508540
pathway order: PathwayTransport/2508529
pathway order: PathwayEnzymeReaction/2508524
pathway order: PathwayEnzymeReaction/2508525
pathway order: PathwayEnzymeReaction/2508522
pathway order: PathwayEnzymeReaction/2508523
pathway order: PathwayInteraction/4117
pathway order: PathwayInteraction/4116
pathway order: PathwayInteraction/4113
pathway order: PathwayInteraction/4112
pathway order: PathwayInteraction/4110
pathway order: PathwayInteraction/476
pathway order: PathwaySubPathway/117963
pathway component: Interaction476
pathway component: Reaction217806
pathway component: Interaction4117
pathway component: Interaction479
pathway component: Interaction4116
pathway component: Transport14227
pathway component: Interaction4110
pathway component: Transport14226
pathway component: Interaction4113
pathway component: Interaction4112
pathway component: ReactionCatalysis203360
pathway component: ReactionCatalysis208032
pathway component: TransportCatalysis5123
pathway component: Muscle Relaxation
pathway component: Reaction213775
pathway component: 1.14.13.39
pathway component: 3.1.3.16
pathway component: TransportCatalysis5114
pathway component: TransportCatalysis5115
pathway component: ReactionCatalysis203359
pathway component: ReactionCatalysis207338
pathway component: Transport14216
pathway component: TransportCatalysis4803
pathway component: Reaction213774
pathway component: Transport14217
pathway component: Transport13740
pathway component: Interaction2849
xref: Reference/SMPDB SMP0125283
xref: Reference/PathWhiz PW126827
organism: Homo sapiens

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Guanylate cyclase soluble subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Guanylate cyclase soluble subunit beta-1

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
type: Protein
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: BiologicalState1056

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Soluble guanylyl cyclase
type: Complex
component stoichiometry: Protein/1001 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1007 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1003 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/1011 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Guanylate cyclase soluble subunit beta-2
component: Guanylate cyclase soluble subunit beta-1
component: Guanylate cyclase soluble subunit alpha-2
component: Guanylate cyclase soluble subunit alpha-3

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C001222
type: ChemicalStructure
structure format: SMILES
structure data: CN1C=NC2=C1C(=O)N(C)C(=O)N2C

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

L-Arginine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Arginine

Compound/PW C000396 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 2.0

Protein/1003 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit alpha-3
stoichiometric coefficient: 2.0

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Guanylate cyclase soluble subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P33402
organism: BiologicalState1056

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02153
organism: BiologicalState1056

Guanylate cyclase soluble subunit alpha-3
type: ProteinReference
xref: Reference/UniProt Q02108
organism: BiologicalState1056

ReactionCatalysis207338
type: Catalysis
controller: Soluble guanylyl cyclase
controlled: Reaction217806
control type: ACTIVATION

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

TransportCatalysis4803
type: Catalysis
controller: Voltage-depenent L-type calcium channel
controlled: Transport13740
control type: ACTIVATION

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Protein/1058 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cGMP-dependent protein kinase 2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Transport13740
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Muscle, Myocyte, Extracellular Space to Homo sapiens, Muscle, Myocyte, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001314
type: UnificationXref
id: HMDB0001314
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 4.0

Reference/PubChem-compound 24316
type: UnificationXref
id: 24316
db: PubChem-compound

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Ryanodine receptor 2

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

Reaction217806
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001013 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: Cyclic GMP
spontaneous: false
left: Guanosine triphosphate
name: Guanosine triphosphate → Cyclic GMP + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Protein/2706 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Guanylate cyclase soluble subunit beta-2
type: ProteinReference
xref: Reference/UniProt O75343
organism: BiologicalState1056

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: Homo sapiens

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChemSpider 22734
type: UnificationXref
id: 22734
db: ChemSpider

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/ChEBI CHEBI 27732
type: UnificationXref
id: CHEBI:27732
db: ChEBI

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

BiologicalState1134
type: BioSource
cell type: Endothelial cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, Endothelial cell
tissue: Blood Vessel

Protein/3195 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Reference/UniProt Q13976
type: UnificationXref
id: Q13976
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/KEGG Compound C00942
type: UnificationXref
id: C00942
db: KEGG Compound

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

TransportCatalysis5114
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport14216
control type: ACTIVATION

TransportCatalysis5115
type: Catalysis
controller: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
controlled: Transport14217
control type: ACTIVATION

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Guanylate cyclase soluble subunit alpha-3
type: Protein
cellular location: Cytosol
entity reference: Guanylate cyclase soluble subunit alpha-3

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/4920 Cytosol/Stoichiometry/4.0
component stoichiometry: Protein/2972 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Reference/CAS 7665-99-8
type: UnificationXref
id: 7665-99-8
db: CAS

Protein/2972 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

Reference/UniProt O75343
type: UnificationXref
id: O75343
db: UniProt

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Protein/1054 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: cGMP-dependent protein kinase 1
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000115
type: UnificationXref
id: CL:0000115
db: CELL TYPE ONTOLOGY

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

Protein/1845/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
type: ProteinReference
xref: Reference/UniProt O14983

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt O14983
type: UnificationXref
id: O14983
db: UniProt

Reference/KEGG Compound C07481
type: UnificationXref
id: C07481
db: KEGG Compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

Protein/1001 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit beta-1
stoichiometric coefficient: 1.0

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/BioCyc CGMP
type: UnificationXref
id: CGMP
db: BioCyc

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

cGMP-dependent protein kinase 2
type: ProteinReference
xref: Reference/UniProt Q13237
organism: Homo sapiens

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Transport14227
type: Transport
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/1.0
right: Nitric oxide
spontaneous: true
left: Nitric oxide
name: Nitric oxide (→) Transport: Homo sapiens, Blood Vessel, Endothelial cell, Cytosol to Homo sapiens, Muscle, Myocyte, Cytosol
conversion direction: REVERSIBLE

Transport14226
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Blood Vessel, Endothelial cell, Endoplasmic Reticulum Lumen to Homo sapiens, Blood Vessel, Endothelial cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Protein/1011 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit beta-2
stoichiometric coefficient: 1.0

cGMP-dependent protein kinase 1
type: ProteinReference
xref: Reference/UniProt Q13976
organism: Homo sapiens

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

Protein/872 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, endothelial
stoichiometric coefficient: 2.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Compound/PW C001065 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 4.0

cGMP-dependent protein kinase 2
type: Protein
cellular location: Cell Membrane
entity reference: cGMP-dependent protein kinase 2

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Reference/CAS 58-08-2
type: UnificationXref
id: 58-08-2
db: CAS

Endothelial cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000115

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

BiologicalState1056
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Reference/GENE ONTOLOGY GO 0005788
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Kv channel-interacting protein 2
type: Protein
cellular location: Cytosol
entity reference: Kv channel-interacting protein 2

Transport14216
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Muscle, Myocyte, Cytosol to Homo sapiens, Muscle, Myocyte, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

Compound/PW C000353 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reaction213774
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
left: Myosin light chain 3
name: Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Transport14217
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Muscle, Myocyte, Cytosol to Homo sapiens, Muscle, Myocyte, Sarcoplasmic Reticulum
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

cGMP-dependent protein kinase
type: Complex
component stoichiometry: Protein/1054 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1058 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: cGMP-dependent protein kinase 2
component: cGMP-dependent protein kinase 1

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

cGMP-dependent protein kinase 2
type: Protein
cellular location: Cytosol
entity reference: cGMP-dependent protein kinase 2

Reference/PubChem-compound 2519
type: UnificationXref
id: 2519
db: PubChem-compound

ChemicalStructure/PW C001013
type: ChemicalStructure
structure format: SMILES

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Endoplasmic Reticulum Lumen
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005788

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Interaction4117
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Nitric-oxide synthase, endothelial
participant: Nitric-oxide synthase, endothelial
participant: Calcium_Calmodulin (Homo sapiens)

Interaction4116
type: MolecularInteraction
interaction type: direct_interaction
name: Caffeine activates Ryanodine receptor 2
participant: Ryanodine receptor 2
participant: Caffeine

Ryanodine receptor 2
type: Protein
cellular location: Cytosol
entity reference: Ryanodine receptor 2

Interaction4110
type: MolecularInteraction
interaction type: direct_interaction
name: cGMP-dependent protein kinase activates Voltage Gated Potassium Channel
participant: cGMP-dependent protein kinase
participant: Voltage Gated Potassium Channel

Interaction4113
type: MolecularInteraction
interaction type: direct_interaction
name: cGMP-dependent protein kinase activates Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
participant: cGMP-dependent protein kinase
participant: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Interaction4112
type: MolecularInteraction
interaction type: direct_interaction
name: cGMP-dependent protein kinase inhibits Voltage-depenent L-type calcium channel
participant: cGMP-dependent protein kinase
participant: Voltage-depenent L-type calcium channel

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Calcium

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Potassium voltage-gated channel subfamily D member 2
type: Protein
cellular location: Cytosol
entity reference: Potassium voltage-gated channel subfamily D member 2

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

cGMP-dependent protein kinase 1
type: Protein
cellular location: Cell Membrane
entity reference: cGMP-dependent protein kinase 1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Protein/2706/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/UniProt Q13237
type: UnificationXref
id: Q13237
db: UniProt

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Caffeine
type: SmallMolecule
cellular location: Cytosol
entity reference: Caffeine

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

1.14.13.39
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000723 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/2.0
right: NADP
right: Nitric oxide
right: Water
right: Citrulline
spontaneous: false
EC number: 1.14.13.39
left: Oxygen
left: Hydrogen Ion
left: L-Arginine
left: NADPH
name: Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Protein/1007 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit alpha-2
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Cyclic GMP
type: SmallMolecule
cellular location: Cytosol
entity reference: Cyclic GMP

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/PathWhiz PW126827
type: UnificationXref
id: PW126827
db: PathWhiz

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Nitric oxide synthase, endothelial
type: ProteinReference
xref: Reference/UniProt P29474
organism: BiologicalState1134

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Compound/PW C001013 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic GMP
stoichiometric coefficient: 1.0

Protein/4920 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: Homo sapiens

Guanylate cyclase soluble subunit beta-2
type: Protein
cellular location: Cytosol
entity reference: Guanylate cyclase soluble subunit beta-2

SubPathwayInteraction117963
type: Interaction
name: SubPathwayReaction
name: SubPathway117963Reaction
participant: Myosin light chain 3

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C000143 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

Nitric oxide synthase, endothelial
type: Protein
cellular location: Cytosol
entity reference: Nitric oxide synthase, endothelial

Guanylate cyclase soluble subunit alpha-2
type: Protein
cellular location: Cytosol
entity reference: Guanylate cyclase soluble subunit alpha-2

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/UniProt P33402
type: UnificationXref
id: P33402
db: UniProt

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Nitric-oxide synthase, endothelial
type: Complex
component stoichiometry: Protein/872 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Nitric oxide synthase, endothelial

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Protein/1845 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChemSpider 2424
type: UnificationXref
id: 2424
db: ChemSpider

Reference/HMDB HMDB0001847
type: UnificationXref
id: HMDB0001847
db: HMDB

Reference/UniProt Q02108
type: UnificationXref
id: Q02108
db: UniProt

ReactionCatalysis203359
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: Reaction213774
control type: ACTIVATION

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Reference/SMPDB SMP0125283
type: UnificationXref
id: SMP0125283
db: SMPDB

Protein/1058 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: cGMP-dependent protein kinase 2
stoichiometric coefficient: 1.0

Citrulline
type: SmallMolecule
cellular location: Cytosol
entity reference: Citrulline

Compound/PW C001867 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0