Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C113151/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine-4-O-glucuronide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Catechol O-methyltransferase
type: ProteinReference
xref: Reference/UniProt P21964
organism: BiologicalState26

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Ammonia

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Unknown
type: ProteinReference

ChemicalStructure/PW C002075
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC=C(OS(O)(=O)=O)C(O)=C1

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/HMDB HMDB0005784
type: UnificationXref
id: HMDB0005784
db: HMDB

Reference/CAS 554-52-9
type: UnificationXref
id: 554-52-9
db: CAS

Compound/PW C000052 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Phenylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt P11086
organism: BiologicalState26

ReactionCatalysis208069
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: Reaction218642
control type: ACTIVATION

ReactionCatalysis208068
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: Reaction218641
control type: ACTIVATION

Reference/UniProt P21964
type: UnificationXref
id: P21964
db: UniProt

ReactionCatalysis208067
type: Catalysis
controller: Catechol O-methyltransferase
controlled: Reaction218640
control type: ACTIVATION

ReactionCatalysis208066
type: Catalysis
controller: Catechol O-methyltransferase
controlled: Reaction218639
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState26

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Reference/ChEBI CHEBI 28111
type: UnificationXref
id: CHEBI:28111
db: ChEBI

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Dopamine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dopamine

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Aldehyde dehydrogenase, dimeric NADP-preferring
type: ProteinReference
xref: Reference/UniProt P30838
organism: BiologicalState26

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: BiologicalState26

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Reference/ChemSpider 5611
type: UnificationXref
id: 5611
db: ChemSpider

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Compound/PW C113150/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine-3-O-glucuronide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 119219
type: UnificationXref
id: 119219
db: PubChem-compound

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

UDP-glucuronosyltransferase 1-9
type: ProteinReference
xref: Reference/UniProt O60656
organism: BiologicalState26

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001969 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: 3,4-Dihydroxyphenylacetaldehyde
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Dopamine
left: Water
name: Dopamine + Oxygen + Water → 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000015 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: Homovanillin
spontaneous: false
EC number: 1.4.3.4
left: 3-Methoxytyramine
left: Oxygen
left: Water
name: 3-Methoxytyramine + Oxygen + Water → Ammonia + Homovanillin + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

ReactionCatalysis860
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/CAS 38339-02-5
type: UnificationXref
id: 38339-02-5
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Dopamine 3-O-sulfate
type: SmallMolecule
entity reference: Dopamine 3-O-sulfate
name: SubPathwayInput

Compound/PW C000117/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

3,4-Dihydroxyphenylacetaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04043
xref: Reference/ChemSpider 106504
xref: Reference/PubChem-compound 119219
xref: Reference/ChEBI CHEBI 27978
xref: Reference/CAS 5707-55-1
xref: Reference/HMDB HMDB0003791
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C001969

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Homovanillin
type: SmallMolecule
cellular location: Cytosol
entity reference: Homovanillin

Reference/HMDB HMDB0004148
type: UnificationXref
id: HMDB0004148
db: HMDB

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

ReactionCatalysis859
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Oxygen
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Oxygen

Reference/KEGG Compound C13691
type: UnificationXref
id: C13691
db: KEGG Compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C13690
type: UnificationXref
id: C13690
db: KEGG Compound

Compound/PW C113148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(2-Aminoethyl)-2-methoxyphenol
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState26

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Alcohol dehydrogenase [NADP(+)]
type: ProteinReference
xref: Reference/UniProt P14550
organism: BiologicalState26

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

ReactionCatalysis208075
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: Reaction218648
control type: ACTIVATION

ReactionCatalysis208074
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: 2.4.1.17
control type: ACTIVATION

ReactionCatalysis208073
type: Catalysis
controller: Sulfotransferase 1A1
controlled: Reaction218646
control type: ACTIVATION

ReactionCatalysis208072
type: Catalysis
controller: Sulfotransferase 1A1
controlled: Reaction218645
control type: ACTIVATION

Compound/PW C000048 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

ReactionCatalysis208071
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: 1.1.1.2
control type: ACTIVATION

ReactionCatalysis208070
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/PubChem-compound 122136
type: UnificationXref
id: 122136
db: PubChem-compound

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Reference/CAS 482-67-7
type: UnificationXref
id: 482-67-7
db: CAS

Reference/SMPDB SMP0125329
type: UnificationXref
id: SMP0125329
db: SMPDB

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Compound/PW C000052 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/UniProt P11086
type: UnificationXref
id: P11086
db: UniProt

Reference/ChemSpider 110461
type: UnificationXref
id: 110461
db: ChemSpider

Excretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118077
pathway component: SubPathwayInteraction118077
name: SubPathway

Reference/ChEBI CHEBI 68889
type: UnificationXref
id: CHEBI:68889
db: ChEBI

Compound/PW C002411 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: Neutral and basic amino acid transport protein rBAT
component: B(0,+)-type amino acid transporter 1

Reference/UniProt P30838
type: UnificationXref
id: P30838
db: UniProt

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Epinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Epinephrine

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Reference/UniProt P50225
type: UnificationXref
id: P50225
db: UniProt

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Dopamine 4-sulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine 4-sulfate

Reference/HMDB HMDB0000022
type: UnificationXref
id: HMDB0000022
db: HMDB

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Phosphoadenosine phosphosulfate
type: SmallMoleculeReference
xref: Reference/BioCyc PAPS
xref: Reference/HMDB HMDB0001134
xref: Reference/CAS 482-67-7
xref: Reference/ChemSpider 9799
xref: Reference/KEGG Compound C00053
xref: Reference/PubChem-compound 10214
xref: Reference/ChEBI CHEBI 17980
chemical formula: C10H15N5O13P2S
molecular weight: 506.98624
structure: ChemicalStructure/PW C000886

Reference/ChemSpider 140102
type: UnificationXref
id: 140102
db: ChemSpider

Dopamine 3-O-sulfate
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-7649
xref: Reference/KEGG Compound C13690
xref: Reference/ChEBI CHEBI 37946
xref: Reference/ChemSpider 108936
xref: Reference/CAS 51317-41-0
xref: Reference/PubChem-compound 122136
xref: Reference/HMDB HMDB0006275
chemical formula: C8H11NO5S
molecular weight: 233.0358
structure: ChemicalStructure/PW C002700

Reference/KEGG Compound C00054
type: UnificationXref
id: C00054
db: KEGG Compound

Compound/PW C113150 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine-3-O-glucuronide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00053
type: UnificationXref
id: C00053
db: KEGG Compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sulfotransferase 1A1
type: Complex
component stoichiometry: Protein/335 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Sulfotransferase 1A1

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/PubChem-compound 123932
type: UnificationXref
id: 123932
db: PubChem-compound

Dopamine-4-O-glucuronide
type: SmallMolecule
entity reference: Dopamine-4-O-glucuronide
name: SubPathwayInput

Dopamine-3-O-glucuronide
type: SmallMolecule
entity reference: Dopamine-3-O-glucuronide
name: SubPathwayInput

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Reference/PubChem-compound 151276
type: UnificationXref
id: 151276
db: PubChem-compound

3-Methoxytyramine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 3-Methoxytyramine

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

B(0,+)-type amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt P82251

Reference/ChemSpider 74680
type: UnificationXref
id: 74680
db: ChemSpider

Neutral and basic amino acid transport protein rBAT
type: ProteinReference
xref: Reference/UniProt Q07837

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/UniProt P82251
type: UnificationXref
id: P82251
db: UniProt

Sulfotransferase 1A1
type: ProteinReference
xref: Reference/UniProt P50225
organism: BiologicalState26

Reference/PubChem-compound 10214
type: UnificationXref
id: 10214
db: PubChem-compound

3,4-Dihydroxyphenylacetic acid
type: SmallMolecule
entity reference: 3,4-Dihydroxyphenylacetic acid
name: SubPathwayInput

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

4-(2-Aminoethyl)-2-methoxyphenol
type: SmallMolecule
entity reference: 4-(2-Aminoethyl)-2-methoxyphenol
name: SubPathwayInput

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Reference/HMDB HMDB0001134
type: UnificationXref
id: HMDB0001134
db: HMDB

ChemicalStructure/PW C000043
type: ChemicalStructure
structure format: SMILES

4-(2-Aminoethyl)-2-methoxyphenol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1669

3,4-Dihydroxyphenylacetic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01161

ChemicalStructure/PW C000048
type: ChemicalStructure
structure format: SMILES
structure data: CNC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Reference/KEGG Compound C01161
type: UnificationXref
id: C01161
db: KEGG Compound

Reference/PubChem-compound 1669
type: UnificationXref
id: 1669
db: PubChem-compound

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003791
type: UnificationXref
id: HMDB0003791
db: HMDB

Compound/PW C000043 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine 3',5'-diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/CAS 5703-24-2
type: UnificationXref
id: 5703-24-2
db: CAS

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Hydroxytyrosol
type: SmallMolecule
entity reference: Hydroxytyrosol
name: SubPathwayInput

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 306-08-1
type: UnificationXref
id: 306-08-1
db: CAS

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/PubChem-compound 1738
type: UnificationXref
id: 1738
db: PubChem-compound

Reference/UniProt P14550
type: UnificationXref
id: P14550
db: UniProt

Homovanillin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 151276
xref: Reference/CAS 5703-24-2
xref: Reference/KEGG Compound C05581
xref: Reference/HMDB HMDB0005175
xref: Reference/ChEBI CHEBI 28111
xref: Reference/ChemSpider 133331
chemical formula: C9H10O3
molecular weight: 166.06299
structure: ChemicalStructure/PW C002411

Phenylethanolamine N-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Phenylethanolamine N-methyltransferase

Reference/ChEBI CHEBI 37946
type: UnificationXref
id: CHEBI:37946
db: ChEBI

Dopamine-3-O-glucuronide
type: SmallMoleculeReference

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Dopamine-4-O-glucuronide
type: SmallMoleculeReference
xref: Reference/ChemSpider 58159296

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Reference/ChemSpider 1675
type: UnificationXref
id: 1675
db: ChemSpider

Reference/BioCyc L-EPINEPHRINE
type: UnificationXref
id: L-EPINEPHRINE
db: BioCyc

Compound/PW C000074/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000068
type: UnificationXref
id: HMDB0000068
db: HMDB

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Reference/HMDB HMDB0000061
type: UnificationXref
id: HMDB0000061
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

L-Dopa
type: SmallMolecule
entity reference: L-Dopa

Compound/PW C000015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

ChemicalStructure/PW C000074
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(CC(O)=O)=CC=C1O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C113151 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine-4-O-glucuronide
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Phosphoadenosine phosphosulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoadenosine phosphosulfate

Compound/PW C000048/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

Alcohol dehydrogenase [NADP(+)]
type: Protein
cellular location: Cytosol
entity reference: Alcohol dehydrogenase [NADP(+)]

Reference/CAS 10597-60-1
type: UnificationXref
id: 10597-60-1
db: CAS

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C113149/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetic acid
stoichiometric coefficient: 1.0

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 28918
type: UnificationXref
id: CHEBI:28918
db: ChEBI

3,4-Dihydroxyphenylacetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxyphenylacetaldehyde

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/UniProt Q07837
type: UnificationXref
id: Q07837
db: UniProt

Compound/PW C000074 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillic acid
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Dopamine

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Compound/PW C113148/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(2-Aminoethyl)-2-methoxyphenol
stoichiometric coefficient: 1.0

Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Epinephrine
type: SmallMolecule
entity reference: Epinephrine
name: SubPathwayInput

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Hydroxytyrosol
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydroxytyrosol

Reference/KEGG Compound C05582
type: UnificationXref
id: C05582
db: KEGG Compound

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Reference/PathWhiz PW126876
type: UnificationXref
id: PW126876
db: PathWhiz

Reference/KEGG Compound C05581
type: UnificationXref
id: C05581
db: KEGG Compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Adenosine 3',5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17985
xref: Reference/CAS 1053-73-2
xref: Reference/PubChem-compound 159296
xref: Reference/ChemSpider 140102
xref: Reference/BioCyc 3-5-ADP
xref: Reference/KEGG Compound C00054
xref: Reference/HMDB HMDB0000061
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000043

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Dopamine-4-O-glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dopamine-4-O-glucuronide

Compound/PW C113150 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine-3-O-glucuronide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C05587
type: UnificationXref
id: C05587
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Compound/PW C002557/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroxytyrosol
stoichiometric coefficient: 1.0

Compound/PW C002700/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine 3-O-sulfate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

3-Methoxytyramine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 742324
xref: Reference/PubChem-compound 1669
xref: Reference/CAS 554-52-9
xref: Reference/KEGG Compound C05587
xref: Reference/HMDB HMDB0000022
xref: Reference/ChemSpider 1606
chemical formula: C9H13NO2
molecular weight: 167.09464
structure: ChemicalStructure/PW C000015

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Hydroxytyrosol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 68889
xref: Reference/CAS 10597-60-1
xref: Reference/ChemSpider 74680
xref: Reference/PubChem-compound 82755
xref: Reference/HMDB HMDB0005784
chemical formula: C8H10O3
molecular weight: 154.06299
structure: ChemicalStructure/PW C002557

Dopamine 3-O-sulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine 3-O-sulfate

Compound/PW C001969 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Transport14299
type: Transport
participant stoichiometry: Compound/PW C113148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113148/Stoichiometry/1.0
right: 4-(2-Aminoethyl)-2-methoxyphenol
spontaneous: false
left: 4-(2-Aminoethyl)-2-methoxyphenol
name: 4-(2-Aminoethyl)-2-methoxyphenol (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14296
type: Transport
participant stoichiometry: Compound/PW C002700 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002700/Stoichiometry/1.0
right: Dopamine 3-O-sulfate
spontaneous: false
left: Dopamine 3-O-sulfate
name: Dopamine 3-O-sulfate (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14295
type: Transport
participant stoichiometry: Compound/PW C000048 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: Epinephrine
spontaneous: false
left: Epinephrine
name: Epinephrine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Transport14298
type: Transport
participant stoichiometry: Compound/PW C113151 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113151/Stoichiometry/1.0
right: Dopamine-4-O-glucuronide
spontaneous: false
left: Dopamine-4-O-glucuronide
name: Dopamine-4-O-glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14297
type: Transport
participant stoichiometry: Compound/PW C113150/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113150 Cytosol/Stoichiometry/1.0
right: Dopamine-3-O-glucuronide
spontaneous: false
left: Dopamine-3-O-glucuronide
name: Dopamine-3-O-glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Transport14292
type: Transport
participant stoichiometry: Compound/PW C113149/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113149 Cytosol/Stoichiometry/1.0
right: 3,4-Dihydroxyphenylacetic acid
spontaneous: false
left: 3,4-Dihydroxyphenylacetic acid
name: 3,4-Dihydroxyphenylacetic acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Aldehyde dehydrogenase, dimeric NADP-preferring
type: Protein
cellular location: Cytosol
entity reference: Aldehyde dehydrogenase, dimeric NADP-preferring

Reference/BioCyc 3-5-ADP
type: UnificationXref
id: 3-5-ADP
db: BioCyc

Transport14291
type: Transport
participant stoichiometry: Compound/PW C000074 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074/Stoichiometry/1.0
right: Homovanillic acid
spontaneous: false
left: Homovanillic acid
name: Homovanillic acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14294
type: Transport
participant stoichiometry: Compound/PW C002075 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002075/Stoichiometry/1.0
right: Dopamine 4-sulfate
spontaneous: false
left: Dopamine 4-sulfate
name: Dopamine 4-sulfate (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/CAS 51317-41-0
type: UnificationXref
id: 51317-41-0
db: CAS

Transport14293
type: Transport
participant stoichiometry: Compound/PW C002557 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002557/Stoichiometry/1.0
right: Hydroxytyrosol
spontaneous: false
left: Hydroxytyrosol
name: Hydroxytyrosol (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Compound/PW C113151 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine-4-O-glucuronide
stoichiometric coefficient: 1.0

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Adenosine 3',5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine 3',5'-diphosphate

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Amine oxidase [flavin-containing] A

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/CAS 1053-73-2
type: UnificationXref
id: 1053-73-2
db: CAS

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Reference/CAS 51-43-4
type: UnificationXref
id: 51-43-4
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Monocarboxylate transporter 10
type: ProteinReference
xref: Reference/UniProt Q8TF71

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/KEGG Compound C04043
type: UnificationXref
id: C04043
db: KEGG Compound

Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 742324
type: UnificationXref
id: CHEBI:742324
db: ChEBI

ChemicalStructure/PW C000015
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CCN)=C1

Reference/PubChem-compound 5816
type: UnificationXref
id: 5816
db: PubChem-compound

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Dopamine-3-O-glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dopamine-3-O-glucuronide

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChemSpider 1606
type: UnificationXref
id: 1606
db: ChemSpider

Homovanillic acid
type: SmallMoleculeReference
xref: Reference/CAS 306-08-1
xref: Reference/KEGG Compound C05582
xref: Reference/PubChem-compound 1738
xref: Reference/HMDB HMDB0000118
xref: Reference/ChemSpider 1675
xref: Reference/ChEBI CHEBI 545959
chemical formula: C9H10O4
molecular weight: 182.0579
structure: ChemicalStructure/PW C000074

Reference/UniProt Q8TF71
type: UnificationXref
id: Q8TF71
db: UniProt

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

SubPathwayInteraction118077
type: Interaction
name: SubPathway118077Reaction
name: SubPathwayReaction
participant: 4-(2-Aminoethyl)-2-methoxyphenol
participant: Homovanillic acid
participant: Dopamine 4-sulfate
participant: Dopamine-4-O-glucuronide
participant: Dopamine-3-O-glucuronide
participant: Epinephrine
participant: Hydroxytyrosol
participant: Dopamine 3-O-sulfate
participant: 3,4-Dihydroxyphenylacetic acid

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChemSpider 9799
type: UnificationXref
id: 9799
db: ChemSpider

ChemicalStructure/PW C002557
type: ChemicalStructure
structure format: SMILES
structure data: OCCC1=CC=C(O)C(O)=C1

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 159296
type: UnificationXref
id: 159296
db: PubChem-compound

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C002411 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Homovanillic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Homovanillic acid

Epinephrine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000068
xref: Reference/KEGG Compound C00788
xref: Reference/PubChem-compound 5816
xref: Reference/ChemSpider 5611
xref: Reference/CAS 51-43-4
xref: Reference/BioCyc L-EPINEPHRINE
xref: Reference/ChEBI CHEBI 28918
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000048

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Neutral and basic amino acid transport protein rBAT
type: Protein
entity reference: Neutral and basic amino acid transport protein rBAT

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

B(0,+)-type amino acid transporter 1
type: Protein
entity reference: B(0,+)-type amino acid transporter 1

ChemicalStructure/PW C002411
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CC=O)=C1

Homovanillic acid
type: SmallMolecule
entity reference: Homovanillic acid
name: SubPathwayInput

Compound/PW C002700 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine 3-O-sulfate
stoichiometric coefficient: 1.0

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Reference/HMDB HMDB0000118
type: UnificationXref
id: HMDB0000118
db: HMDB

Reference/ChEBI CHEBI 27978
type: UnificationXref
id: CHEBI:27978
db: ChEBI

Compound/PW C113149 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/BioCyc CPD-7649
type: UnificationXref
id: CPD-7649
db: BioCyc

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

4-(2-Aminoethyl)-2-methoxyphenol
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-(2-Aminoethyl)-2-methoxyphenol

3,4-Dihydroxyphenylacetaldehyde
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 3,4-Dihydroxyphenylacetaldehyde

Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/ChemSpider 133331
type: UnificationXref
id: 133331
db: ChemSpider

Reference/ChEBI CHEBI 17985
type: UnificationXref
id: CHEBI:17985
db: ChEBI

Reaction218639
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113148 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 4-(2-Aminoethyl)-2-methoxyphenol
right: Hydrogen Ion
spontaneous: false
left: L-Dopa
left: S-Adenosylmethionine
name: L-Dopa + S-Adenosylmethionine ↔ 4-(2-Aminoethyl)-2-methoxyphenol + Hydrogen Ion + S-Adenosylhomocysteine
conversion direction: REVERSIBLE

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Reference/CAS 5707-55-1
type: UnificationXref
id: 5707-55-1
db: CAS

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 17980
type: UnificationXref
id: CHEBI:17980
db: ChEBI

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/UniProt O60656
type: UnificationXref
id: O60656
db: UniProt

Dopamine 4-sulfate
type: SmallMolecule
entity reference: Dopamine 4-sulfate
name: SubPathwayInput

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Reaction218648
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113151 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Dopamine-4-O-glucuronide
right: Uridine 5'-diphosphate
right: Hydrogen Ion
spontaneous: false
left: Uridine diphosphate glucuronic acid
left: Dopamine
name: Dopamine + Uridine diphosphate glucuronic acid ↔ Dopamine-4-O-glucuronide + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: REVERSIBLE

Water
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Water

Compound/PW C002557 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroxytyrosol
stoichiometric coefficient: 1.0

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113149 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: Homovanillic acid
spontaneous: false
EC number: 2.1.1.6
left: 3,4-Dihydroxyphenylacetic acid
left: S-Adenosylmethionine
name: 3,4-Dihydroxyphenylacetic acid + S-Adenosylmethionine ↔ Homovanillic acid + Hydrogen Ion + S-Adenosylhomocysteine
conversion direction: REVERSIBLE

Reaction218642
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001969 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113149 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: 3,4-Dihydroxyphenylacetic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
left: NAD
left: 3,4-Dihydroxyphenylacetaldehyde
left: Water
name: 3,4-Dihydroxyphenylacetaldehyde + NAD + Water ↔ 3,4-Dihydroxyphenylacetic acid + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reaction218641
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Homovanillic acid
right: NADH
spontaneous: false
left: NAD
left: Homovanillin
left: Water
name: Homovanillin + NAD + Water ↔ Homovanillic acid + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reaction218640
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: 3-Methoxytyramine
spontaneous: false
left: Dopamine
left: S-Adenosylmethionine
name: Dopamine + S-Adenosylmethionine ↔ 3-Methoxytyramine + Hydrogen Ion + S-Adenosylhomocysteine
conversion direction: REVERSIBLE

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113150 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Dopamine-3-O-glucuronide
right: Uridine 5'-diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: Dopamine
name: Dopamine + Uridine diphosphate glucuronic acid ↔ Dopamine-3-O-glucuronide + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: REVERSIBLE

Reaction218646
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002075 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000886 Cytosol/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: Hydrogen Ion
right: Dopamine 4-sulfate
spontaneous: false
left: Phosphoadenosine phosphosulfate
left: Dopamine
name: Dopamine + Phosphoadenosine phosphosulfate ↔ Adenosine 3',5'-diphosphate + Dopamine 4-sulfate + Hydrogen Ion
conversion direction: REVERSIBLE

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reaction218645
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002700 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000886 Cytosol/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: Hydrogen Ion
right: Dopamine 3-O-sulfate
spontaneous: false
left: Phosphoadenosine phosphosulfate
left: Dopamine
name: Dopamine + Phosphoadenosine phosphosulfate ↔ Adenosine 3',5'-diphosphate + Dopamine 3-O-sulfate + Hydrogen Ion
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

1.1.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001969 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002557 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Hydroxytyrosol
right: NADP
spontaneous: false
EC number: 1.1.1.2
left: Hydrogen Ion
left: 3,4-Dihydroxyphenylacetaldehyde
left: NADPH
name: 3,4-Dihydroxyphenylacetaldehyde + Hydrogen Ion + NADPH ↔ Hydroxytyrosol + NADP
conversion direction: REVERSIBLE

Protein/335 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Sulfotransferase 1A1
stoichiometric coefficient: 2.0

Reference/ChemSpider 108936
type: UnificationXref
id: 108936
db: ChemSpider

Reference/ChemSpider 58159296
type: UnificationXref
id: 58159296
db: ChemSpider

Dopamine-3-O-glucuronide
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine-3-O-glucuronide

Reference/ChemSpider 106504
type: UnificationXref
id: 106504
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/PubChem-compound 82755
type: UnificationXref
id: 82755
db: PubChem-compound

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Hydrogen peroxide

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Levodopa Metabolism Pathway (New)
type: Pathway
pathway order: PathwayTransport/2509160
pathway order: PathwayTransport/2509164
pathway order: PathwayTransport/2509166
pathway order: PathwayTransport/2509167
pathway order: PathwayTransport/2509168
pathway order: PathwayEnzymeReaction/2509136
pathway order: PathwayEnzymeReaction/2509137
pathway order: PathwayEnzymeReaction/2509135
pathway order: PathwayEnzymeReaction/2509138
pathway order: PathwayEnzymeReaction/2509139
pathway order: PathwayEnzymeReaction/2509150
pathway order: PathwayEnzymeReaction/2509154
pathway order: PathwayEnzymeReaction/2509152
pathway order: PathwayEnzymeReaction/2509153
pathway order: PathwayTransport/2509170
pathway order: PathwayTransport/2509171
pathway order: PathwayTransport/2509172
pathway order: PathwayTransport/2509155
pathway order: PathwayTransport/2509156
pathway order: PathwayTransport/2509157
pathway order: PathwayTransport/2509158
pathway order: PathwayTransport/2509159
pathway order: PathwayEnzymeReaction/2509148
pathway order: PathwayEnzymeReaction/2509145
pathway order: PathwayEnzymeReaction/2509146
pathway order: PathwaySubPathway/118077
pathway order: PathwayEnzymeReaction/2509161
pathway order: PathwayEnzymeReaction/2509162
pathway order: PathwayEnzymeReaction/2509142
pathway component: Reaction218639
pathway component: 1.14.17.1
pathway component: 1.4.3.4
pathway component: Excretion
pathway component: ReactionCatalysis860
pathway component: Reaction218648
pathway component: 2.1.1.6
pathway component: Reaction218642
pathway component: Reaction218641
pathway component: Reaction218640
pathway component: 2.4.1.17
pathway component: Reaction218646
pathway component: Reaction218645
pathway component: 1.1.1.2
pathway component: ReactionCatalysis208069
pathway component: ReactionCatalysis208068
pathway component: ReactionCatalysis208067
pathway component: ReactionCatalysis208066
pathway component: TransportCatalysis5178
pathway component: ReactionCatalysis859
pathway component: TransportCatalysis5179
pathway component: ReactionCatalysis218
pathway component: TransportCatalysis5176
pathway component: TransportCatalysis5177
pathway component: TransportCatalysis5174
pathway component: TransportCatalysis5175
pathway component: ReactionCatalysis214
pathway component: TransportCatalysis5173
pathway component: Transport14303
pathway component: TransportCatalysis5181
pathway component: Transport14300
pathway component: TransportCatalysis5182
pathway component: Transport14302
pathway component: TransportCatalysis5180
pathway component: Transport14301
pathway component: ReactionCatalysis208075
pathway component: ReactionCatalysis208074
pathway component: ReactionCatalysis208073
pathway component: ReactionCatalysis208072
pathway component: ReactionCatalysis208071
pathway component: ReactionCatalysis208070
pathway component: TransportCatalysis5183
pathway component: TransportCatalysis5184
pathway component: Transport14299
pathway component: Transport14296
pathway component: Transport14295
pathway component: Transport14298
pathway component: Transport14297
pathway component: Transport14292

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0005175
type: UnificationXref
id: HMDB0005175
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

UDP-glucuronosyltransferase 1-9
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-9

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

3-Methoxytyramine
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Methoxytyramine

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

ChemicalStructure/PW C000886
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002700
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(OS(O)(=O)=O)=C(O)C=C1

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Dopamine-4-O-glucuronide
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine-4-O-glucuronide

Reference/BioCyc PAPS
type: UnificationXref
id: PAPS
db: BioCyc

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

3,4-Dihydroxyphenylacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxyphenylacetic acid

Reference/HMDB HMDB0006275
type: UnificationXref
id: HMDB0006275
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C002075 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine 4-sulfate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Catechol O-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Catechol O-methyltransferase

Homovanillin
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Homovanillin

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Compound/PW C000015 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

TransportCatalysis5178
type: Catalysis
controller: Unknown
controlled: Transport14296
control type: ACTIVATION

TransportCatalysis5179
type: Catalysis
controller: Unknown
controlled: Transport14297
control type: ACTIVATION

ReactionCatalysis218
type: Catalysis
controller: Phenylethanolamine N-methyltransferase
controlled: 2.1.1.28
control type: ACTIVATION

TransportCatalysis5176
type: Catalysis
controller: Unknown
controlled: Transport14294
control type: ACTIVATION

TransportCatalysis5177
type: Catalysis
controller: Unknown
controlled: Transport14295
control type: ACTIVATION

TransportCatalysis5174
type: Catalysis
controller: Unknown
controlled: Transport14292
control type: ACTIVATION

TransportCatalysis5175
type: Catalysis
controller: Unknown
controlled: Transport14293
control type: ACTIVATION

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

TransportCatalysis5173
type: Catalysis
controller: Unknown
controlled: Transport14291
control type: ACTIVATION

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 545959
type: UnificationXref
id: CHEBI:545959
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Sulfotransferase 1A1
type: Protein
cellular location: Cytosol
entity reference: Sulfotransferase 1A1

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Transport14303
type: Transport
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
left: L-Dopa
name: L-Dopa (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Dopamine 4-sulfate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004148
xref: Reference/KEGG Compound C13691
xref: Reference/PubChem-compound 123932
xref: Reference/CAS 38339-02-5
xref: Reference/ChemSpider 110461
chemical formula: C8H11NO5S
molecular weight: 233.0358
structure: ChemicalStructure/PW C002075

TransportCatalysis5181
type: Catalysis
controller: Unknown
controlled: Transport14299
control type: ACTIVATION

Transport14300
type: Transport
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
left: L-Dopa
name: L-Dopa (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

TransportCatalysis5182
type: Catalysis
controller: Unknown
controlled: Transport14301
control type: ACTIVATION

Transport14302
type: Transport
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
left: L-Dopa
name: L-Dopa (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

TransportCatalysis5180
type: Catalysis
controller: Unknown
controlled: Transport14298
control type: ACTIVATION

Transport14301
type: Transport
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
left: L-Dopa
name: L-Dopa (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

TransportCatalysis5183
type: Catalysis
controller: Monocarboxylate transporter 10
controlled: Transport14302
control type: ACTIVATION

TransportCatalysis5184
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport14303
control type: ACTIVATION

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Compound/PW C001969 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00788
type: UnificationXref
id: C00788
db: KEGG Compound

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Monocarboxylate transporter 10
type: Protein
entity reference: Monocarboxylate transporter 10

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Compound/PW C002075/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine 4-sulfate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001969
type: ChemicalStructure
structure format: SMILES
structure data: OC1=C(O)C=C(CC=O)C=C1

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

2.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Epinephrine
spontaneous: false
EC number: 2.1.1.28
left: Norepinephrine
left: S-Adenosylmethionine
name: Norepinephrine + S-Adenosylmethionine → Epinephrine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Compound/PW C000886 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoadenosine phosphosulfate
stoichiometric coefficient: 1.0

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase