Reference/ChEBI CHEBI 17347
type: UnificationXref
id: CHEBI:17347
db: ChEBI

Reference/ChemSpider 82579
type: UnificationXref
id: 82579
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Transport15617
type: Transport
participant stoichiometry: Compound/PW C113316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113316 Synapse/Stoichiometry/1.0
right: Levonorgestrel
spontaneous: true
left: Levonorgestrel
name: Levonorgestrel (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, Synapse
conversion direction: REVERSIBLE

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Membrane-associated progesterone receptor component 1
type: Protein
cellular location: Cytosol
entity reference: Membrane-associated progesterone receptor component 1

Compound/PW C000037/Stoichiometry/1.0
type: Stoichiometry
physical entity: Androstenedione
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Reference/BioCyc CHOLESTEROL
type: UnificationXref
id: CHOLESTEROL
db: BioCyc

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ReactionCatalysis946
type: Catalysis
controller: Testosterone 17-beta-dehydrogenase 3
controlled: 1.1.1.64
control type: ACTIVATION

ReactionCatalysis944
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction51
control type: ACTIVATION

Compound/PW C113316 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Levonorgestrel
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6013
type: UnificationXref
id: 6013
db: PubChem-compound

Compound/PW C000240/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxyestradiol
stoichiometric coefficient: 1.0

Reference/BioCyc 3-BETA-HYDROXYANDROST-5-EN-17-ONE
type: UnificationXref
id: 3-BETA-HYDROXYANDROST-5-EN-17-ONE
db: BioCyc

Compound/PW C000094/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

NAD
type: SmallMolecule
entity reference: NAD

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

17β-estradiol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16469
xref: Reference/PubChem-compound 5757
chemical formula: C18H24O2
molecular weight: 272.17764
structure: ChemicalStructure/PW C112789

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reaction179451
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000173/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047/Stoichiometry/1.0
right: Pregnenolone
spontaneous: false
left: Cholesterol
name: Cholesterol → Pregnenolone
conversion direction: LEFT_TO_RIGHT

Steroidogenic acute regulatory protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt P49675

Protein/3625/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Progonadoliberin-1
type: Protein
cellular location: Cytosol
entity reference: Progonadoliberin-1

Interaction4173
type: MolecularInteraction
interaction type: direct_interaction
name: Androgen Receptor inhibits Progonadoliberin-1
participant: Androgen receptor
participant: Progonadoliberin-1

Reference/ChEBI CHEBI 16113
type: UnificationXref
id: CHEBI:16113
db: ChEBI

Interaction4172
type: MolecularInteraction
interaction type: direct_interaction
name: Testosterone activates Androgen Receptor
participant: Androgen receptor
participant: Testosterone

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

G protein complex
type: Complex
component: Gγ
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1

Interaction4171
type: MolecularInteraction
interaction type: direct_interaction
name: Membrane-associated progesterone receptor component 1 inhibits Progonadoliberin-1
participant: Progonadoliberin-1
participant: Membrane-associated progesterone receptor component 1

Interaction4170
type: MolecularInteraction
interaction type: direct_interaction
name: Progesterone activates Membrane-associated progesterone receptor component 1
participant: Progesterone
participant: Membrane-associated progesterone receptor component 1

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc PREGNENOLONE
type: UnificationXref
id: PREGNENOLONE
db: BioCyc

Levonorgestrel
type: SmallMolecule
entity reference: Levonorgestrel

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Transport13777
type: Transport
participant stoichiometry: Compound/PW C000047 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Cholesterol
spontaneous: false
left: Cholesterol
name: Cholesterol (→) Transport: Homo sapiens, Ovary, Theca Cell, Mitochondrial Outer Membrane to Homo sapiens, Ovary, Theca Cell, Mitochondrial Inner Membrane
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/ChemSpider 216475
type: UnificationXref
id: 216475
db: ChemSpider

Compound/PW C000457 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/PubChem-compound 247304
type: UnificationXref
id: 247304
db: PubChem-compound

Transport13770
type: Transport
participant stoichiometry: Compound/PW C000157/Stoichiometry/1.0
right: Testosterone
spontaneous: false
left: Testosterone
name: Testosterone (→) Transport: Homo sapiens, Ovary, Theca Cell to Homo sapiens, Ovary, Granulosa Cell
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 2710
type: UnificationXref
id: CHEBI:2710
db: ChEBI

Reaction1279
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273/Stoichiometry/1.0
right: 17-Hydroxyprogesterone
right: Acceptor
right: Water
spontaneous: false
left: Reduced acceptor
left: Oxygen
left: Progesterone
name: Oxygen + Progesterone + Reduced acceptor → 17-Hydroxyprogesterone + Acceptor + Water
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00468
type: UnificationXref
id: C00468
db: KEGG Compound

Reference/ChemSpider 24767911
type: UnificationXref
id: 24767911
db: ChemSpider

Reference/PubChem-compound 53477678
type: UnificationXref
id: 53477678
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Transport13769
type: Transport
participant stoichiometry: Compound/PW C000037/Stoichiometry/1.0
right: Androstenedione
spontaneous: false
left: Androstenedione
name: Androstenedione (→) Transport: Homo sapiens, Ovary, Theca Cell to Homo sapiens, Ovary, Granulosa Cell
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CELL TYPE ONTOLOGY CL 0000503
type: UnificationXref
id: CL:0000503
db: CELL TYPE ONTOLOGY

Compound/PW C000047 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Proto-oncogene c-Fos
type: Protein
cellular location: Nucleus
entity reference: Proto-oncogene c-Fos

Reference/CELL TYPE ONTOLOGY CL 0000501
type: UnificationXref
id: CL:0000501
db: CELL TYPE ONTOLOGY

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

PIP2(16:0/16:2(9Z,12Z))
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP2(16:0/16:2(9Z,12Z))

Compound/PW C001216/Stoichiometry/1.0
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17026
type: UnificationXref
id: CHEBI:17026
db: ChEBI

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Inhibin beta A chain
type: ProteinReference
xref: Reference/UniProt P08476
organism: BiologicalState51

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Follitropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01225
organism: BiologicalState949

Reference/ChEBI CHEBI 17263
type: UnificationXref
id: CHEBI:17263
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Inhibin alpha chain
type: ProteinReference
xref: Reference/UniProt P05111
organism: BiologicalState51

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Lutropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01229
organism: BiologicalState948

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt P01100
organism: Homo sapiens

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P05412
organism: Homo sapiens

Ovary
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000975

BiologicalState73
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Reference/UniProt O00264
type: UnificationXref
id: O00264
db: UniProt

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

ReactionCatalysis981
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction52
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Levonorgestrel
type: SmallMoleculeReference
chemical formula: C21H28O2
molecular weight: 312.20892
structure: ChemicalStructure/PW C113316

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Compound/PW C113316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Levonorgestrel
stoichiometric coefficient: 1.0

Reaction1284
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000173/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263/Stoichiometry/1.0
right: Acceptor
right: Water
right: 17a-Hydroxypregnenolone
spontaneous: false
left: Pregnenolone
left: Reduced acceptor
left: Oxygen
name: Oxygen + Pregnenolone + Reduced acceptor → 17a-Hydroxypregnenolone + Acceptor + Water
conversion direction: LEFT_TO_RIGHT

5-Androstenediol
type: SmallMolecule
entity reference: 5-Androstenediol

Glycoprotein hormones alpha chain
type: Protein
entity reference: Glycoprotein hormones alpha chain

5-Androstenediol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04295
xref: Reference/HMDB HMDB0003818
xref: Reference/ChemSpider 10188
xref: Reference/PubChem-compound 10634
xref: Reference/ChEBI CHEBI 2710
xref: Reference/CAS 521-17-5
chemical formula: C19H30O2
molecular weight: 290.22458
structure: ChemicalStructure/PW C001971

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Progesterone
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Progesterone

Reference/BRENDA TISSUE ONTOLOGY BTO 0000975
type: UnificationXref
id: BTO:0000975
db: BRENDA TISSUE ONTOLOGY

Testosterone
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Testosterone

Reference/CAS 57-88-5
type: UnificationXref
id: 57-88-5
db: CAS

Potassium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Potassium

Proto-oncogene c-Fos
type: Protein
cellular location: Extracellular Space
entity reference: Proto-oncogene c-Fos

Reaction217803
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000094/Stoichiometry/1.0
participant stoichiometry: Compound/PW C112789/Stoichiometry/1.0
right: 17β-estradiol
spontaneous: false
left: Estrone
name: Estrone → 17β-estradiol
conversion direction: LEFT_TO_RIGHT

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C112789/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002602/Stoichiometry/1.0
right: 4-Hydroxyestradiol
spontaneous: false
EC number: 1.14.14.1
left: 17β-estradiol
name: 17β-estradiol → 4-Hydroxyestradiol
conversion direction: LEFT_TO_RIGHT

Reaction217801
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000037/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094/Stoichiometry/1.0
right: Estrone
spontaneous: false
left: Androstenedione
name: Androstenedione → Estrone
conversion direction: LEFT_TO_RIGHT

Lutropin-choriogonadotropic hormone receptor
type: ProteinReference
xref: Reference/UniProt P22888
organism: BiologicalState948

Reference/SMPDB SMP0125332
type: UnificationXref
id: SMP0125332
db: SMPDB

Reaction217802
type: BiochemicalReaction
participant stoichiometry: Compound/PW C112789/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157/Stoichiometry/1.0
right: 17β-estradiol
spontaneous: false
left: Testosterone
name: Testosterone → 17β-estradiol
conversion direction: LEFT_TO_RIGHT

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/KEGG Compound C01227
type: UnificationXref
id: C01227
db: KEGG Compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Cholesterol
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Cholesterol

Reaction217805
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000240/Stoichiometry/1.0
participant stoichiometry: Compound/PW C112789/Stoichiometry/1.0
right: 2-Hydroxyestradiol
spontaneous: false
left: 17β-estradiol
name: 17β-estradiol → 2-Hydroxyestradiol
conversion direction: LEFT_TO_RIGHT

Follicle Stimulating Hormone
type: Complex
component: Follitropin subunit beta
component: Glycoprotein hormones alpha chain

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Reference/PubChem-compound 6128
type: UnificationXref
id: 6128
db: PubChem-compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reaction217800
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001971/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157/Stoichiometry/1.0
right: Testosterone
spontaneous: false
left: 5-Androstenediol
name: 5-Androstenediol → Testosterone
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5660
type: UnificationXref
id: 5660
db: ChemSpider

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

Reference/UniProt P05108
type: UnificationXref
id: P05108
db: UniProt

Luteinizing Hormone
type: Complex
component: Lutropin subunit beta
component: Glycoprotein hormones alpha chain

AP1
type: Complex
cellular location: Extracellular Space
component: Transcription factor AP-1
component: Proto-oncogene c-Fos

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Reference/ChemSpider 10188
type: UnificationXref
id: 10188
db: ChemSpider

Reference/UniProt P37058
type: UnificationXref
id: P37058
db: UniProt

Compound/PW C000273/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17-Hydroxyprogesterone
stoichiometric coefficient: 1.0

Inhibin A
type: Complex
component: Inhibin beta A chain
component: Inhibin alpha chain

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ReactionCoupledTransport490
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006075 Cell Membrane/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
left: PIP2(16:0/16:2(9Z,12Z))
name: PIP2(16:0/16:2(9Z,12Z)) + Potassium → Potassium
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P05111
type: UnificationXref
id: P05111
db: UniProt

Catenin beta-1
type: ProteinReference
xref: Reference/UniProt P35222
organism: Homo sapiens

Reference/ChemSpider 5898
type: UnificationXref
id: 5898
db: ChemSpider

Reference/ChemSpider 5773
type: UnificationXref
id: 5773
db: ChemSpider

Reference/ChEBI CHEBI 17252
type: UnificationXref
id: CHEBI:17252
db: ChEBI

Reference/ChemSpider 5775
type: UnificationXref
id: 5775
db: ChemSpider

Granulosa Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000501

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/PubChem-compound 6238
type: UnificationXref
id: 6238
db: PubChem-compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

ChemicalStructure/PW C112789
type: ChemicalStructure
structure format: SMILES

Compound/PW C006075 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/16:2(9Z,12Z))
stoichiometric coefficient: 1.0

Compound/PW C000173/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

ReactionCatalysis999
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction1284
control type: ACTIVATION

Compound/Generic41/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

AP1
type: Complex
cellular location: Nucleus
component: Proto-oncogene c-Fos
component: Transcription factor AP-1

Reference/UniProt P14060
type: UnificationXref
id: P14060
db: UniProt

Reference/UniProt P14061
type: UnificationXref
id: P14061
db: UniProt

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

ReactionCatalysis995
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction1279
control type: ACTIVATION

BiologicalState946
type: BioSource
cell type: Sertoli Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Testis, Sertoli Cell
tissue: Testis

BiologicalState949
type: BioSource
cell type: Granulosa Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Ovary, Granulosa Cell
tissue: Ovary

BiologicalState948
type: BioSource
cell type: Theca Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Ovary, Theca Cell
tissue: Ovary

4-Hydroxyestradiol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14209
xref: Reference/ChemSpider 23205091
xref: Reference/PubChem-compound 44348689
xref: Reference/CAS 5976-61-4
xref: Reference/HMDB HMDB0005896
chemical formula: C18H24O3
molecular weight: 288.17255
structure: ChemicalStructure/PW C002602

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/UniProt P30968
type: UnificationXref
id: P30968
db: UniProt

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000054
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000173
type: ChemicalStructure
structure format: SMILES

Follicle-stimulating hormone receptor
type: Protein
entity reference: Follicle-stimulating hormone receptor

Steroid 17-alpha-hydroxylase/17,20 lyase
type: Protein
entity reference: Steroid 17-alpha-hydroxylase/17,20 lyase

Early growth response protein 1
type: Protein
cellular location: Nucleus
entity reference: Early growth response protein 1

Compound/Generic40/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00280
type: UnificationXref
id: C00280
db: KEGG Compound

Reference/UniProt P04798
type: UnificationXref
id: P04798
db: UniProt

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Reference/HMDB HMDB0000253
type: UnificationXref
id: HMDB0000253
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0000374
type: UnificationXref
id: HMDB0000374
db: HMDB

Interaction3691
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A activates Cytochrome P450 19A1
participant: Protein kinase A
participant: Cytochrome P450 19A1

Reference/UniProt P05412
type: UnificationXref
id: P05412
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState949

Reference/UniProt P18847
type: UnificationXref
id: P18847
db: UniProt

Interaction3696
type: MolecularInteraction
interaction type: direct_interaction
name: Inhibin A inhibits Follicle Stimulating Hormone
participant: Inhibin A
participant: Follicle Stimulating Hormone

Compound/PW C000054/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroepiandrosterone
stoichiometric coefficient: 1.0

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000145
type: UnificationXref
id: HMDB0000145
db: HMDB

Reference/KEGG Compound C14209
type: UnificationXref
id: C14209
db: KEGG Compound

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: BiologicalState946

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q969F8
type: UnificationXref
id: Q969F8
db: UniProt

Estradiol 17-beta-dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P14061
organism: BiologicalState949

Testosterone 17-beta-dehydrogenase 3
type: ProteinReference
xref: Reference/UniProt P37058
organism: BiologicalState949

Reference/PubChem-compound 44348689
type: UnificationXref
id: 44348689
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Cholesterol side-chain cleavage enzyme, mitochondrial
type: ProteinReference
xref: Reference/UniProt P05108
organism: BiologicalState948

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Cholesterol
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Cholesterol

Protein/1990/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000273
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000037
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000157
type: ChemicalStructure
structure format: SMILES

Reference/CELL TYPE ONTOLOGY CL 0000216
type: UnificationXref
id: CL:0000216
db: CELL TYPE ONTOLOGY

Compound/PW C000047/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

PIP2(16:0/16:2(9Z,12Z))
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/ChemSpider 24767911
xref: Reference/PubChem-compound 53480225
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010034
chemical formula: C41H77O19P3
molecular weight: 966.4272
structure: ChemicalStructure/PW C006075

Erk1/Erk2 Mapk Signaling pathway
type: Pathway
xref: Reference/SMPDB SMP0063779
xref: Reference/PathWhiz PW064771
name: ActivatingSubPathway

Androgen receptor
type: ProteinReference
xref: Reference/UniProt P10275
organism: BiologicalState789

Reaction24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000037/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273/Stoichiometry/1.0
right: Androstenedione
spontaneous: false
left: 17-Hydroxyprogesterone
name: 17-Hydroxyprogesterone → Androstenedione
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Follitropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01225
organism: Homo sapiens

Compound/PW C006075 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/16:2(9Z,12Z))
stoichiometric coefficient: 1.0

Glycoprotein hormones alpha chain
type: ProteinReference
xref: Reference/UniProt P01215
organism: Homo sapiens

Reference/CAS 68-96-2
type: UnificationXref
id: 68-96-2
db: CAS

ATP-sensitive inward rectifier potassium channel 12
type: ProteinReference
xref: Reference/UniProt Q14500
organism: BiologicalState789

Reference/KEGG Compound C00187
type: UnificationXref
id: C00187
db: KEGG Compound

Gonadotropin-releasing hormone receptor
type: ProteinReference
xref: Reference/UniProt P30968
organism: BiologicalState789

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: Reference/UniProt P18847
organism: Homo sapiens

Splicing factor 1
type: ProteinReference
xref: Reference/UniProt Q15637
organism: Homo sapiens

KiSS-1 receptor
type: ProteinReference
xref: Reference/UniProt Q969F8
organism: BiologicalState789

Reaction21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000054/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263/Stoichiometry/1.0
right: Dehydroepiandrosterone
spontaneous: false
left: 17a-Hydroxypregnenolone
name: 17a-Hydroxypregnenolone → Dehydroepiandrosterone
conversion direction: LEFT_TO_RIGHT

Metastasis-suppressor KiSS-1
type: ProteinReference
xref: Reference/UniProt Q15726
organism: BiologicalState789

4-Hydroxyestradiol
type: SmallMolecule
entity reference: 4-Hydroxyestradiol

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000047
type: ChemicalStructure
structure format: SMILES

Follitropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Follitropin subunit beta

Theca Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000503

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Interaction4230
type: MolecularInteraction
interaction type: direct_interaction
name: Levonorgestrel activates Androgen Receptor
participant: Levonorgestrel
participant: Androgen receptor

Transcription factor Sp1
type: ProteinReference
xref: Reference/UniProt P08047

Follicle-stimulating hormone receptor bound to G protein complex
type: Complex
component stoichiometry: Protein/3625/Stoichiometry/1.0
component stoichiometry: Protein/3618/Stoichiometry/1.0
component stoichiometry: Protein/1601/Stoichiometry/1.0
component stoichiometry: Protein/2055/Stoichiometry/1.0
component: Gβ
component: Follicle-stimulating hormone receptor
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState949

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Interaction4231
type: MolecularInteraction
interaction type: direct_interaction
name: Levonorgestrel activates Membrane-associated progesterone receptor component 1
participant: Levonorgestrel
participant: Membrane-associated progesterone receptor component 1

Reference/PathWhiz PW064771
type: UnificationXref
id: PW064771
db: PathWhiz

Steroid 17-alpha-hydroxylase/17,20 lyase
type: ProteinReference
xref: Reference/UniProt P05093
organism: BiologicalState948

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reaction219491
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000263/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273/Stoichiometry/1.0
right: 17-Hydroxyprogesterone
spontaneous: false
left: 17a-Hydroxypregnenolone
name: 17a-Hydroxypregnenolone → 17-Hydroxyprogesterone
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Testis
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001363

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000053
type: UnificationXref
id: HMDB0000053
db: HMDB

Compound/PW C043143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000094
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P49675
type: UnificationXref
id: P49675
db: UniProt

Reference/KEGG Compound C01176
type: UnificationXref
id: C01176
db: KEGG Compound

Reference/CAS 53-43-0
type: UnificationXref
id: 53-43-0
db: CAS

Progesterone
type: SmallMolecule
entity reference: Progesterone

2-Hydroxyestradiol
type: SmallMolecule
entity reference: 2-Hydroxyestradiol

Reference/HMDB HMDB0000067
type: UnificationXref
id: HMDB0000067
db: HMDB

KiSS-1 receptor
type: Protein
cellular location: Cell Membrane
entity reference: KiSS-1 receptor

2-Hydroxyestradiol
type: SmallMoleculeReference
xref: Reference/ChemSpider 216475
xref: Reference/ChEBI CHEBI 28744
xref: Reference/CAS 362-05-0
xref: Reference/PubChem-compound 247304
xref: Reference/HMDB HMDB0000338
xref: Reference/BioCyc 2-HYDROXY-ESTRADIOL
xref: Reference/KEGG Compound C05301
chemical formula: C18H24O3
molecular weight: 288.17255
structure: ChemicalStructure/PW C000240

Glycoprotein hormones alpha chain
type: Protein
cellular location: Nucleus
entity reference: Glycoprotein hormones alpha chain

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/CAS 362-05-0
type: UnificationXref
id: 362-05-0
db: CAS

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cell Membrane
entity reference: Gonadotropin-releasing hormone receptor
name: SubPathwayActivator

Reference/KEGG Compound C05301
type: UnificationXref
id: C05301
db: KEGG Compound

Reference/BioCyc CPD-272
type: UnificationXref
id: CPD-272
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Membrane-associated progesterone receptor component 1
type: Protein
cellular location: Extracellular Space
entity reference: Membrane-associated progesterone receptor component 1

Reference/UniProt P01148
type: UnificationXref
id: P01148
db: UniProt

1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)
type: SmallMoleculeReference
chemical formula: C39H76O5
molecular weight: 624.5693
structure: ChemicalStructure/PW C043143

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/HMDB HMDB0000077
type: UnificationXref
id: HMDB0000077
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

ATP-sensitive inward rectifier potassium channel 12
type: Protein
cellular location: Cell Membrane
entity reference: ATP-sensitive inward rectifier potassium channel 12

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Compound/PW C000041/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/CAS 5976-61-4
type: UnificationXref
id: 5976-61-4
db: CAS

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Protein/3618/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0005896
type: UnificationXref
id: HMDB0005896
db: HMDB

Protein/2055/Stoichiometry/1.0
type: Stoichiometry
physical entity: Follicle-stimulating hormone receptor
stoichiometric coefficient: 1.0

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState949

Protein/1134/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

Cytochrome P450 1B1
type: ProteinReference
xref: Reference/UniProt Q16678
organism: BiologicalState949

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState948

Pregnenolone
type: SmallMolecule
entity reference: Pregnenolone

NADH
type: SmallMolecule
entity reference: NADH

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Dehydroepiandrosterone
type: SmallMolecule
entity reference: Dehydroepiandrosterone

Testosterone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17347
xref: Reference/PubChem-compound 6013
xref: Reference/KEGG Compound C00535
xref: Reference/HMDB HMDB0000234
xref: Reference/CAS 58-22-0
xref: Reference/ChemSpider 5791
chemical formula: C19H28O2
molecular weight: 288.20892
structure: ChemicalStructure/PW C000157

Reference/UniProt P10275
type: UnificationXref
id: P10275
db: UniProt

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Metastasis-suppressor KiSS-1
type: Protein
cellular location: Cell Membrane
entity reference: Metastasis-suppressor KiSS-1

17-Hydroxyprogesterone
type: SmallMoleculeReference
xref: Reference/CAS 68-96-2
xref: Reference/ChEBI CHEBI 17252
xref: Reference/KEGG Compound C01176
xref: Reference/PubChem-compound 6238
xref: Reference/ChemSpider 6002
xref: Reference/HMDB HMDB0000374
chemical formula: C21H30O3
molecular weight: 330.21948
structure: ChemicalStructure/PW C000273

Protein/3359/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Acceptor
type: SmallMolecule
entity reference: Acceptor

Cytochrome P450 19A1
type: ProteinReference
xref: Reference/UniProt P11511
organism: BiologicalState949

Reference/UniProt Q16678
type: UnificationXref
id: Q16678
db: UniProt

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState948

Reduced acceptor
type: SmallMolecule
entity reference: Reduced acceptor

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
type: ProteinReference
xref: Reference/UniProt P14060
organism: BiologicalState948

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState949

Androstenedione
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16422
xref: Reference/ChemSpider 5898
xref: Reference/KEGG Compound C00280
xref: Reference/PubChem-compound 6128
xref: Reference/HMDB HMDB0000053
xref: Reference/BioCyc ANDROST4ENE
xref: Reference/CAS 63-05-8
chemical formula: C19H26O2
molecular weight: 286.19327
structure: ChemicalStructure/PW C000037

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/UniProt P0CP74
type: UnificationXref
id: P0CP74
db: UniProt

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Androgen receptor
type: Protein
cellular location: Cytosol
entity reference: Androgen receptor

Cholesterol
type: SmallMolecule
entity reference: Cholesterol

Cytochrome P450 1A1
type: ProteinReference
xref: Reference/UniProt P04798
organism: BiologicalState949

Reference/PubChem-compound 10634
type: UnificationXref
id: 10634
db: PubChem-compound

Progonadoliberin-1
type: Protein
cellular location: Cell Membrane
entity reference: Progonadoliberin-1

Reference/ChemSpider 6002
type: UnificationXref
id: 6002
db: ChemSpider

ReactionCatalysis24
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction24
control type: ACTIVATION

Lutropin-choriogonadotropic hormone receptor
type: Protein
entity reference: Lutropin-choriogonadotropic hormone receptor

ReactionCatalysis22
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction21
control type: ACTIVATION

Follitropin subunit beta
type: Protein
entity reference: Follitropin subunit beta

Reference/PathWhiz PW126879
type: UnificationXref
id: PW126879
db: PathWhiz

cAMP
type: SmallMolecule
entity reference: cAMP

Lutropin subunit beta
type: Protein
entity reference: Lutropin subunit beta

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Splicing factor 1
type: Protein
cellular location: Nucleus
entity reference: Splicing factor 1

Protein/3358/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Inhibin beta A chain
type: Protein
entity reference: Inhibin beta A chain

Inhibin alpha chain
type: Protein
entity reference: Inhibin alpha chain

Cholesterol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000067
xref: Reference/ChEBI CHEBI 16113
xref: Reference/BioCyc CHOLESTEROL
xref: Reference/KEGG Compound C00187
xref: Reference/ChemSpider 5775
xref: Reference/PubChem-compound 5997
xref: Reference/CAS 57-88-5
chemical formula: C27H46O
molecular weight: 386.35486
structure: ChemicalStructure/PW C000047

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/UniProt P01215
type: UnificationXref
id: P01215
db: UniProt

Protein/1601/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0063779
type: UnificationXref
id: SMP0063779
db: SMPDB

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/PubChem-compound 5870
type: UnificationXref
id: 5870
db: PubChem-compound

Reference/UniProt P01100
type: UnificationXref
id: P01100
db: UniProt

Protein/3357/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5757
type: UnificationXref
id: 5757
db: PubChem-compound

Reference/HMDB HMDB0003818
type: UnificationXref
id: HMDB0003818
db: HMDB

Progesterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001830
xref: Reference/ChEBI CHEBI 17026
xref: Reference/CAS 57-83-0
xref: Reference/ChemSpider 5773
xref: Reference/PubChem-compound 5994
xref: Reference/BioCyc CPD-272
xref: Reference/KEGG Compound C00410
chemical formula: C21H30O2
molecular weight: 314.22458
structure: ChemicalStructure/PW C001216

Androstenedione
type: SmallMolecule
entity reference: Androstenedione

Reference/PubChem-compound 5997
type: UnificationXref
id: 5997
db: PubChem-compound

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Testosterone
type: SmallMolecule
entity reference: Testosterone

Reference/PubChem-compound 5994
type: UnificationXref
id: 5994
db: PubChem-compound

ChemicalStructure/PW C002602
type: ChemicalStructure
structure format: SMILES

17-Hydroxyprogesterone
type: SmallMolecule
entity reference: 17-Hydroxyprogesterone

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/UniProt P01225
type: UnificationXref
id: P01225
db: UniProt

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/UniProt P01229
type: UnificationXref
id: P01229
db: UniProt

Membrane-associated progesterone receptor component 1
type: ProteinReference
xref: Reference/UniProt O00264
organism: BiologicalState789

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

SubPathwayControl120967
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway120967Control
participant: Catenin beta-1
participant: Gonadotropin-releasing hormone receptor
participant: Erk1/Erk2 Mapk Signaling pathway
participant: Transcription factor Sp1

17a-Hydroxypregnenolone
type: SmallMolecule
entity reference: 17a-Hydroxypregnenolone

Reference/UniProt P35222
type: UnificationXref
id: P35222
db: UniProt

17a-Hydroxypregnenolone
type: SmallMoleculeReference
xref: Reference/ChemSpider 82579
xref: Reference/PubChem-compound 91451
xref: Reference/CAS 387-79-1
xref: Reference/HMDB HMDB0000363
xref: Reference/KEGG Compound C05138
xref: Reference/ChEBI CHEBI 28750
chemical formula: C21H32O3
molecular weight: 332.23514
structure: ChemicalStructure/PW C000263

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState948

ReactionCatalysis207329
type: Catalysis
controller: Phospholipase B
controlled: Reaction217794
control type: ACTIVATION

ChemicalStructure/PW C001216
type: ChemicalStructure
structure format: SMILES

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Androgen receptor
type: Protein
cellular location: Extracellular Space
entity reference: Androgen receptor

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Reference/BioCyc ANDROST4ENE
type: UnificationXref
id: ANDROST4ENE
db: BioCyc

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState948

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Estrone
type: SmallMolecule
entity reference: Estrone

ReactionCatalysis208891
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction219491
control type: ACTIVATION

Interaction3668
type: MolecularInteraction
interaction type: direct_interaction
name: KISS1 activates KISS1R
participant: KiSS-1 receptor
participant: Metastasis-suppressor KiSS-1

Reference/HMDB HMDB0000338
type: UnificationXref
id: HMDB0000338
db: HMDB

Interaction3669
type: MolecularInteraction
interaction type: direct_interaction
name: KISS1R activates PLC-beta
participant: Phospholipase B
participant: KiSS-1 receptor

Levonorgestrel
type: SmallMolecule
cellular location: Synapse
entity reference: Levonorgestrel

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

ChemicalStructure/PW C043143
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/1315/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Follitropin subunit beta
type: Protein
cellular location: Extracellular Space
entity reference: Follitropin subunit beta

Compound/PW C000263/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a-Hydroxypregnenolone
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: Protein
cellular location: Extracellular Space
entity reference: Transcription factor AP-1

Reference/UniProt P08047
type: UnificationXref
id: P08047
db: UniProt

Reference/PubChem-compound 53480225
type: UnificationXref
id: 53480225
db: PubChem-compound

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/CAS 58-22-0
type: UnificationXref
id: 58-22-0
db: CAS

ReactionCatalysis207337
type: Catalysis
controller: Cytochrome P450 1A1
controlled: Reaction217805
control type: ACTIVATION

Compound/PW C000157/Stoichiometry/1.0
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

ReactionCatalysis207336
type: Catalysis
controller: Cytochrome P450 1B1
controlled: 1.14.14.1
control type: ACTIVATION

Reference/KEGG Compound C05138
type: UnificationXref
id: C05138
db: KEGG Compound

ReactionCatalysis207335
type: Catalysis
controller: Estradiol 17-beta-dehydrogenase 1
controlled: Reaction217803
control type: ACTIVATION

ReactionCatalysis207334
type: Catalysis
controller: Cytochrome P450 19A1
controlled: Reaction217802
control type: ACTIVATION

ReactionCatalysis207333
type: Catalysis
controller: Cytochrome P450 19A1
controlled: Reaction217801
control type: ACTIVATION

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000263
type: ChemicalStructure
structure format: SMILES

Catenin beta-1
type: Protein
cellular location: Nucleus
entity reference: Catenin beta-1
name: SubPathwayActivation

Reference/KEGG Compound C04295
type: UnificationXref
id: C04295
db: KEGG Compound

ReactionCatalysis207332
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction217800
control type: ACTIVATION

ReactionCatalysis207331
type: Catalysis
controller: Estradiol 17-beta-dehydrogenase 1
controlled: Reaction217799
control type: ACTIVATION

Adenylate cyclase type 1
type: Protein
entity reference: Adenylate cyclase type 1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Testosterone 17-beta-dehydrogenase 3
type: Protein
entity reference: Testosterone 17-beta-dehydrogenase 3

Estradiol 17-beta-dehydrogenase 1
type: Protein
entity reference: Estradiol 17-beta-dehydrogenase 1

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/PubChem-compound 91451
type: UnificationXref
id: 91451
db: PubChem-compound

Compound/PW C112789/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17β-estradiol
stoichiometric coefficient: 1.0

ReactionCatalysis169348
type: Catalysis
controller: Cholesterol side-chain cleavage enzyme, mitochondrial
controlled: Reaction179451
control type: ACTIVATION

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Interaction3685
type: MolecularInteraction
interaction type: direct_interaction
name: Follicle-stimulating hormone receptor bound to G protein complex activates Adenylate cyclase type 1
participant: Adenylate cyclase type 1
participant: Follicle-stimulating hormone receptor bound to G protein complex

Reaction51
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000037/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000054/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Androstenedione
spontaneous: false
left: Dehydroepiandrosterone
left: NAD
name: Dehydroepiandrosterone + NAD → Androstenedione + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState948

Interaction3681
type: MolecularInteraction
interaction type: direct_interaction
name: G protein complex activates Adenylate cyclase type 1
participant: Adenylate cyclase type 1
participant: G protein complex

Reference/HMDB HMDB0010034
type: UnificationXref
id: HMDB0010034
db: HMDB

Interaction3683
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Protein kinase A catalytic subunit
participant: cAMP
participant: Protein kinase A catalytic subunit

Reaction52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000173/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Progesterone
spontaneous: false
left: Pregnenolone
left: NAD
name: NAD + Pregnenolone → Hydrogen Ion + NADH + Progesterone
conversion direction: LEFT_TO_RIGHT

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Cholesterol side-chain cleavage enzyme, mitochondrial
type: Protein
entity reference: Cholesterol side-chain cleavage enzyme, mitochondrial

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Reference/HMDB HMDB0000234
type: UnificationXref
id: HMDB0000234
db: HMDB

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Interaction3689
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A catalytic subunit activates StAR
participant: Steroidogenic acute regulatory protein, mitochondrial
participant: Protein kinase A catalytic subunit

Sertoli Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000216

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Dehydroepiandrosterone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5881
xref: Reference/KEGG Compound C01227
xref: Reference/ChEBI CHEBI 28689
xref: Reference/BioCyc 3-BETA-HYDROXYANDROST-5-EN-17-ONE
xref: Reference/CAS 53-43-0
xref: Reference/ChemSpider 5670
xref: Reference/HMDB HMDB0000077
chemical formula: C19H28O2
molecular weight: 288.20892
structure: ChemicalStructure/PW C000054

Pregnenolone
type: SmallMoleculeReference
xref: Reference/CAS 145-13-1
xref: Reference/KEGG Compound C01953
xref: Reference/PubChem-compound 53477678
xref: Reference/ChEBI CHEBI 16581
xref: Reference/BioCyc PREGNENOLONE
xref: Reference/HMDB HMDB0000253
chemical formula: C21H32O2
molecular weight: 316.24023
structure: ChemicalStructure/PW C000173

Interaction3674
type: MolecularInteraction
interaction type: direct_interaction
name: Catenin beta-1 (CTNNB1) activates AP1
participant: Catenin beta-1
participant: AP1

Interaction3675
type: MolecularInteraction
interaction type: direct_interaction
name: AP1 activates FSH Beta
participant: AP1
participant: Follitropin subunit beta

Interaction3676
type: MolecularInteraction
interaction type: direct_interaction
name: Luteinizing Hormone activates Lutropin-choriogonadotropic hormone receptor
participant: Luteinizing Hormone
participant: Lutropin-choriogonadotropic hormone receptor

Interaction3677
type: MolecularInteraction
interaction type: direct_interaction
name: Follicle Stimulating Hormone activates Follicle-stimulating hormone receptor bound to G protein complex
participant: Follicle Stimulating Hormone
participant: Follicle-stimulating hormone receptor bound to G protein complex

Interaction3670
type: MolecularInteraction
interaction type: direct_interaction
name: Progonadoliberin-1 activates GNRHR
participant: Gonadotropin-releasing hormone receptor
participant: Progonadoliberin-1

Interaction3671
type: MolecularInteraction
interaction type: direct_interaction
name: Early growth response protein 1 activates ATF3
participant: Early growth response protein 1
participant: Cyclic AMP-dependent transcription factor ATF-3

TransportCatalysis4825
type: Catalysis
controller: Steroidogenic acute regulatory protein, mitochondrial
controlled: Transport13777
control type: ACTIVATION

Interaction3672
type: MolecularInteraction
interaction type: direct_interaction
name: SF1 activates FSH Beta
participant: Splicing factor 1
participant: Follitropin subunit beta

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState948

Interaction3673
type: MolecularInteraction
interaction type: direct_interaction
name: ATF3 activates CGA
participant: Cyclic AMP-dependent transcription factor ATF-3
participant: Glycoprotein hormones alpha chain

Transcription factor Sp1
type: Protein
entity reference: Transcription factor Sp1
name: SubPathwayActivation

Reference/BRENDA TISSUE ONTOLOGY BTO 0001363
type: UnificationXref
id: BTO:0001363
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000240
type: ChemicalStructure
structure format: SMILES

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Interaction3678
type: MolecularInteraction
interaction type: direct_interaction
name: Lutropin-choriogonadotropic hormone receptor activates G protein complex
participant: G protein complex
participant: Lutropin-choriogonadotropic hormone receptor

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/HMDB HMDB0000363
type: UnificationXref
id: HMDB0000363
db: HMDB

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Progonadoliberin-1
type: ProteinReference
xref: Reference/UniProt P01148
organism: BiologicalState789

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/UniProt P08476
type: UnificationXref
id: P08476
db: UniProt

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Levonorgestrel Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2512070
pathway order: PathwayEnzymeReaction/2512075
pathway order: PathwayEnzymeReaction/2512072
pathway order: PathwayEnzymeReaction/2512071
pathway order: PathwayEnzymeReaction/2512074
pathway order: PathwayInteraction/2835
pathway order: PathwayInteraction/3689
pathway order: PathwayInteraction/3685
pathway order: PathwayInteraction/3683
pathway order: PathwayInteraction/3681
pathway order: PathwayInteraction/4173
pathway order: PathwayEnzymeReaction/2512081
pathway order: PathwayInteraction/4172
pathway order: PathwayInteraction/4171
pathway order: PathwayInteraction/4170
pathway order: PathwayInteraction/637
pathway order: PathwaySubPathway/120967
pathway order: PathwayInteraction/3678
pathway order: PathwayInteraction/3677
pathway order: PathwayInteraction/3676
pathway order: PathwayInteraction/3675
pathway order: PathwayInteraction/3674
pathway order: PathwayInteraction/3673
pathway order: PathwayInteraction/3672
pathway order: PathwayInteraction/3671
pathway order: PathwayInteraction/3670
pathway order: PathwayTransport/2532240
pathway order: PathwayEnzymeReaction/2512056
pathway order: PathwayEnzymeReaction/2512055
pathway order: PathwayInteraction/3669
pathway order: PathwayEnzymeReaction/2512057
pathway order: PathwayInteraction/3668
pathway order: PathwayEnzymeReaction/2512059
pathway order: PathwayInteraction/4231
pathway order: PathwayInteraction/4230
pathway order: PathwayTransport/2512084
pathway order: PathwayTransport/2512083
pathway order: PathwayTransport/2512082
pathway order: PathwayEnzymeReaction/2512067
pathway order: PathwayEnzymeReaction/2532252
pathway order: PathwayEnzymeReaction/2532251
pathway order: PathwayEnzymeReaction/2532254
pathway order: PathwayEnzymeReaction/2532253
pathway order: PathwayEnzymeReaction/2532256
pathway order: PathwayEnzymeReaction/2532255
pathway order: PathwayEnzymeReaction/2512069
pathway order: PathwayEnzymeReaction/2532258
pathway order: PathwayEnzymeReaction/2512068
pathway order: PathwayEnzymeReaction/2532257
pathway order: PathwayInteraction/3696
pathway order: PathwayInteraction/3691
pathway component: Interaction4230
pathway component: ReactionCoupledTransportCatalysis533
pathway component: ReactionCatalysis207329
pathway component: Transport15617
pathway component: Interaction4231
pathway component: Reaction219491
pathway component: ReactionCatalysis208891
pathway component: Interaction3668
pathway component: Interaction3669
pathway component: ReactionCatalysis946
pathway component: ReactionCatalysis944
pathway component: ReactionCatalysis981
pathway component: Interaction3691
pathway component: ReactionCatalysis101095
pathway component: Interaction3696
pathway component: Reaction217794
pathway component: ReactionCatalysis207337
pathway component: Reaction217799
pathway component: ReactionCatalysis207336
pathway component: ReactionCatalysis24
pathway component: ReactionCatalysis207335
pathway component: Reaction179451
pathway component: ReactionCatalysis207334
pathway component: ReactionCatalysis22
pathway component: ReactionCatalysis207333
pathway component: ReactionCatalysis207332
pathway component: Reaction1284
pathway component: ReactionCatalysis207331

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

PIP2(16:0/16:2(9Z,12Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2(16:0/16:2(9Z,12Z))

Compound/PW C002602/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyestradiol
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

KiSS-1 receptor
type: Protein
cellular location: Cytosol
entity reference: KiSS-1 receptor

Reference/ChEBI CHEBI 16422
type: UnificationXref
id: CHEBI:16422
db: ChEBI

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Compound/PW C000047 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Reference/UniProt P05093
type: UnificationXref
id: P05093
db: UniProt

ReactionCatalysis101095
type: Catalysis
controller: Adenylate cyclase type 1
controlled: 4.6.1.1
control type: ACTIVATION

Reaction217794
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006075 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043143 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
right: 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)
spontaneous: false
left: PIP2(16:0/16:2(9Z,12Z))
left: Water
name: PIP2(16:0/16:2(9Z,12Z)) + Water → 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0) + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Phospholipase B
type: Protein
cellular location: Cytosol
entity reference: Phospholipase B

Reference/ChemSpider 5791
type: UnificationXref
id: 5791
db: ChemSpider

Reference/ChemSpider 5670
type: UnificationXref
id: 5670
db: ChemSpider

Reaction217799
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001971/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000054/Stoichiometry/1.0
right: 5-Androstenediol
spontaneous: false
left: Dehydroepiandrosterone
name: Dehydroepiandrosterone → 5-Androstenediol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Protein/1262/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Reference/ChemSpider 23205091
type: UnificationXref
id: 23205091
db: ChemSpider

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Reference/ChEBI CHEBI 28750
type: UnificationXref
id: CHEBI:28750
db: ChEBI

Reference/UniProt Q14500
type: UnificationXref
id: Q14500
db: UniProt

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState949

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState949

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Glycoprotein hormones alpha chain
type: ProteinReference
xref: Reference/UniProt P01215
organism: BiologicalState948

Reference/BioCyc ESTRONE
type: UnificationXref
id: ESTRONE
db: BioCyc

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState949

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Interaction637
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Calcium
participant: Inositol 1,4,5-trisphosphate
participant: Calcium

Estrone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000145
xref: Reference/PubChem-compound 5870
xref: Reference/KEGG Compound C00468
xref: Reference/CAS 53-16-7
xref: Reference/ChEBI CHEBI 17263
xref: Reference/BioCyc ESTRONE
xref: Reference/ChemSpider 5660
chemical formula: C18H22O2
molecular weight: 270.162
structure: ChemicalStructure/PW C000094

Interaction2835
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Protein kinase A
participant: Protein kinase A
participant: cAMP

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reference/ChEBI CHEBI 28744
type: UnificationXref
id: CHEBI:28744
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 521-17-5
type: UnificationXref
id: 521-17-5
db: CAS

Gβ
type: Protein
entity reference: Gβ

Reference/KEGG Compound C01953
type: UnificationXref
id: C01953
db: KEGG Compound

Levonorgestrel
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Levonorgestrel

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Cytochrome P450 1B1
type: Protein
entity reference: Cytochrome P450 1B1

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

ChemicalStructure/PW C113316
type: ChemicalStructure
structure format: SMILES

Membrane-associated progesterone receptor component 1
type: Protein
cellular location: Cell Membrane
entity reference: Membrane-associated progesterone receptor component 1

Reference/UniProt Q15726
type: UnificationXref
id: Q15726
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

ReactionCoupledTransportCatalysis533
type: Catalysis
controller: ATP-sensitive inward rectifier potassium channel 12
controlled: ReactionCoupledTransport490
control type: ACTIVATION

Reference/CAS 57-83-0
type: UnificationXref
id: 57-83-0
db: CAS

Reference/CAS 53-16-7
type: UnificationXref
id: 53-16-7
db: CAS

Reference/BioCyc 2-HYDROXY-ESTRADIOL
type: UnificationXref
id: 2-HYDROXY-ESTRADIOL
db: BioCyc

Cytochrome P450 1A1
type: Protein
entity reference: Cytochrome P450 1A1

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
type: Protein
entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Cytochrome P450 19A1
type: Protein
entity reference: Cytochrome P450 19A1

Steroidogenic acute regulatory protein, mitochondrial
type: Protein
entity reference: Steroidogenic acute regulatory protein, mitochondrial

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Phospholipase B
type: ProteinReference
xref: Reference/UniProt P0CP74
organism: BiologicalState789

Reference/ChEBI CHEBI 28689
type: UnificationXref
id: CHEBI:28689
db: ChEBI

ChemicalStructure/PW C006075
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/PubChem-compound 5881
type: UnificationXref
id: 5881
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C001971/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Androstenediol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16469
type: UnificationXref
id: CHEBI:16469
db: ChEBI

Protein kinase A catalytic subunit
type: Complex
component stoichiometry: Protein/1262/Stoichiometry/1.0
component stoichiometry: Protein/1134/Stoichiometry/1.0
component stoichiometry: Protein/1315/Stoichiometry/1.0
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16581
type: UnificationXref
id: CHEBI:16581
db: ChEBI

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Follicle-stimulating hormone receptor
type: ProteinReference
xref: Reference/UniProt P23945
organism: BiologicalState949

Protein kinase A
type: Complex
component stoichiometry: Protein/1990/Stoichiometry/1.0
component stoichiometry: Protein/1262/Stoichiometry/1.0
component stoichiometry: Protein/3358/Stoichiometry/1.0
component stoichiometry: Protein/1134/Stoichiometry/1.0
component stoichiometry: Protein/3357/Stoichiometry/1.0
component stoichiometry: Protein/1315/Stoichiometry/1.0
component stoichiometry: Protein/3359/Stoichiometry/1.0
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt P23945
type: UnificationXref
id: P23945
db: UniProt

Reference/CAS 145-13-1
type: UnificationXref
id: 145-13-1
db: CAS

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001830
type: UnificationXref
id: HMDB0001830
db: HMDB

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Reference/CAS 387-79-1
type: UnificationXref
id: 387-79-1
db: CAS

1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)

Reference/KEGG Compound C00535
type: UnificationXref
id: C00535
db: KEGG Compound

17β-estradiol
type: SmallMolecule
entity reference: 17β-estradiol

Reference/KEGG Compound C00410
type: UnificationXref
id: C00410
db: KEGG Compound

Reference/UniProt P22888
type: UnificationXref
id: P22888
db: UniProt

Androgen receptor
type: Protein
cellular location: Cell Membrane
entity reference: Androgen receptor

Reference/UniProt Q15637
type: UnificationXref
id: Q15637
db: UniProt

Reference/CAS 63-05-8
type: UnificationXref
id: 63-05-8
db: CAS

1.1.1.64
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000037/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Androstenedione
spontaneous: false
EC number: 1.1.1.64
left: NAD
left: Testosterone
name: NAD + Testosterone ↔ Androstenedione + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/UniProt P11511
type: UnificationXref
id: P11511
db: UniProt

Cyclic AMP-dependent transcription factor ATF-3
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-dependent transcription factor ATF-3

Reference/UniProt P18146
type: UnificationXref
id: P18146
db: UniProt

Early growth response protein 1
type: ProteinReference
xref: Reference/UniProt P18146
organism: Homo sapiens

Gγ
type: Protein
entity reference: Gγ

ChemicalStructure/PW C001971
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202