Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C000146 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Reference/PubChem-compound 6262
type: UnificationXref
id: 6262
db: PubChem-compound

ReactionCatalysis18
type: Catalysis
controller: Argininosuccinate lyase
controlled: 4.3.2.1
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

ReactionCatalysis12
type: Catalysis
controller: Argininosuccinate synthase
controlled: 6.3.4.5
control type: ACTIVATION

Reference/CELL TYPE ONTOLOGY CL 0000084
type: UnificationXref
id: CL:0000084
db: CELL TYPE ONTOLOGY

Compound/PW C000935 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Argininosuccinic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03406
xref: Reference/ChemSpider 16059
xref: Reference/HMDB HMDB0000052
xref: Reference/PubChem-compound 16950
xref: Reference/CAS 2387-71-5
xref: Reference/ChEBI CHEBI 15682
chemical formula: C10H18N4O6
molecular weight: 290.12262
structure: ChemicalStructure/PW C000036

Compound/PW C000723 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 2.0

Reference/CAS 57-13-6
type: UnificationXref
id: 57-13-6
db: CAS

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Nitric oxide synthase, inducible
type: Protein
cellular location: Cytosol
entity reference: Nitric oxide synthase, inducible

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

Reference/ChEBI CHEBI 15611
type: UnificationXref
id: CHEBI:15611
db: ChEBI

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Sarcosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Sarcosine
name: SubPathwayInput
name: SubPathwayInhibitor

Arginase-1
type: Protein
cellular location: Cytosol
entity reference: Arginase-1

ReactionCatalysis202881
type: Catalysis
controller: Nitric oxide synthase, inducible
controlled: Reaction213297
control type: ACTIVATION

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15729
type: UnificationXref
id: CHEBI:15729
db: ChEBI

Compound/PW C001867 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 2.0

ReactionCatalysis137
type: Catalysis
controller: Arginase-1
controlled: 3.5.3.1
control type: ACTIVATION

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Arginase-1
type: Complex
component stoichiometry: Protein/292 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Arginase-1

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Argininosuccinate synthase
type: Protein
cellular location: Cytosol
entity reference: Argininosuccinate synthase

Reference/ChemSpider 1143
type: UnificationXref
id: 1143
db: ChemSpider

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/KEGG Compound C00213
type: UnificationXref
id: C00213
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/BioCyc UREA
type: UnificationXref
id: UREA
db: BioCyc

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/UniProt P35228
type: UnificationXref
id: P35228
db: UniProt

Compound/PW C000088 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/CAS 70-26-8
type: UnificationXref
id: 70-26-8
db: CAS

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

L-Kynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Kynurenine

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

Reference/ChemSpider 6026
type: UnificationXref
id: 6026
db: ChemSpider

Reference/PubChem-compound 16950
type: UnificationXref
id: 16950
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

ChemicalStructure/PW C000200
type: ChemicalStructure
structure format: SMILES
structure data: NC(N)=O

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Arginase-1
type: ProteinReference
xref: Reference/UniProt P05089
organism: BiologicalState1164

Reference/PathWhiz PW127022
type: UnificationXref
id: PW127022
db: PathWhiz

ReactionCatalysis1353
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

Ornithine
type: SmallMoleculeReference
xref: Reference/CAS 70-26-8
xref: Reference/HMDB HMDB0000214
xref: Reference/PubChem-compound 6262
xref: Reference/KEGG Compound C00077
xref: Reference/BioCyc L-ORNITHINE
xref: Reference/ChemSpider 6026
xref: Reference/ChEBI CHEBI 15729
chemical formula: C5H12N2O2
molecular weight: 132.08987
structure: ChemicalStructure/PW C000140

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Fumaric acid

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Reference/BioCyc SARCOSINE
type: UnificationXref
id: SARCOSINE
db: BioCyc

Reference/HMDB HMDB0000214
type: UnificationXref
id: HMDB0000214
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formic acid
right: L-Kynurenine
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

L-Arginine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Arginine

Compound/PW C000396 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 2.0

ReactionCatalysis2059
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/SMPDB SMP0125467
type: UnificationXref
id: SMP0125467
db: SMPDB

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Urea
type: SmallMolecule
cellular location: Cytosol
entity reference: Urea

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Protein/869 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000140
type: ChemicalStructure
structure format: SMILES
structure data: NCCC[C@H](N)C(O)=O

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 4.0

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

3.5.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000140 Cytosol/Stoichiometry/1.0
right: Urea
right: Ornithine
spontaneous: false
EC number: 3.5.3.1
left: L-Arginine
left: Water
name: L-Arginine + Water → Ornithine + Urea
conversion direction: LEFT_TO_RIGHT

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

Reference/KEGG Compound C03406
type: UnificationXref
id: C03406
db: KEGG Compound

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Compound/PW C000723 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000396 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 1.0

Reference/ChemSpider 1057
type: UnificationXref
id: 1057
db: ChemSpider

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChemSpider 16059
type: UnificationXref
id: 16059
db: ChemSpider

Sarcosine
type: SmallMoleculeReference
xref: Reference/CAS 107-97-1
xref: Reference/BioCyc SARCOSINE
xref: Reference/ChemSpider 1057
xref: Reference/ChEBI CHEBI 15611
xref: Reference/HMDB HMDB0000271
xref: Reference/KEGG Compound C00213
xref: Reference/PubChem-compound 1088
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000185

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

Reference/UniProt P05089
type: UnificationXref
id: P05089
db: UniProt

BiologicalState1164
type: BioSource
cell type: T Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, T Cell
tissue: Blood Vessel

Indoleamine 2,3-dioxygenase 1
type: ProteinReference
xref: Reference/UniProt P14902
organism: BiologicalState1164

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/ChEBI CHEBI 15682
type: UnificationXref
id: CHEBI:15682
db: ChEBI

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

Argininosuccinate lyase
type: ProteinReference
xref: Reference/UniProt P04424
organism: BiologicalState1164

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan
name: SubPathwayOutput

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

SubPathwayControl118280
type: Interaction
name: SubPathway118280Control
name: InhibitorySubPathwayControl
participant: Excessive Inflamation
participant: Sarcosine

Nitric oxide synthase, inducible
type: Complex
component stoichiometry: Protein/869 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Nitric oxide synthase, inducible

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Argininosuccinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Argininosuccinic acid

T Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000084

Argininosuccinate synthase
type: Complex
component stoichiometry: Protein/622 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Argininosuccinate synthase

SubPathwayInteraction118275
type: Interaction
name: SubPathway118275Reaction
name: SubPathwayReaction
participant: L-Tryptophan

Protein/622 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Argininosuccinate synthase
stoichiometric coefficient: 4.0

SubPathwayInteraction118276
type: Interaction
name: SubPathwayReaction
name: SubPathway118276Reaction
participant: Nitric oxide

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C000200 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

SubPathwayInteraction118279
type: Interaction
name: SubPathway118279Reaction
name: SubPathwayReaction
participant: Sarcosine

T Cell Exhaustion
type: Pathway
pathway order: PathwayEnzymeReaction/2510693
pathway order: PathwaySubPathway/118276
pathway order: PathwayEnzymeReaction/2510694
pathway order: PathwaySubPathway/118277
pathway order: PathwaySubPathway/118275
pathway order: PathwayEnzymeReaction/2510716
pathway order: PathwayEnzymeReaction/2510727
pathway order: PathwaySubPathway/118279
pathway order: PathwaySubPathway/118280
pathway order: PathwayEnzymeReaction/2510714
pathway order: PathwayEnzymeReaction/2510726
pathway component: 4.3.2.1
pathway component: ReactionCatalysis18
pathway component: Reaction213297
pathway component: 6.3.4.5
pathway component: ReactionCatalysis12
pathway component: ReactionCatalysis202881
pathway component: 1.13.11.52
pathway component: Viral antigens
pathway component: 3.5.1.9
pathway component: ReactionCatalysis1353
pathway component: Immune Response
pathway component: Tissue Repair
pathway component: ReactionCatalysis2059
pathway component: 3.5.3.1
pathway component: ReactionCatalysis137
pathway component: Elimination of virus
pathway component: SubPathwayControl118280
xref: Reference/SMPDB SMP0125467
xref: Reference/PathWhiz PW127022
organism: Homo sapiens

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: N'-Formylkynurenine

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Ornithine
type: SmallMolecule
cellular location: Cytosol
entity reference: Ornithine

SubPathwayInteraction118277
type: Interaction
name: SubPathwayReaction
name: SubPathway118277Reaction
participant: Sarcosine

Reference/PubChem-compound 1088
type: UnificationXref
id: 1088
db: PubChem-compound

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

Reference/CAS 107-97-1
type: UnificationXref
id: 107-97-1
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000185
type: ChemicalStructure
structure format: SMILES
structure data: CNCC(O)=O

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Urea
type: SmallMoleculeReference
xref: Reference/BioCyc UREA
xref: Reference/CAS 57-13-6
xref: Reference/KEGG Compound C00086
xref: Reference/HMDB HMDB0000294
xref: Reference/ChemSpider 1143
xref: Reference/PubChem-compound 1176
xref: Reference/ChEBI CHEBI 16199
chemical formula: CH4N2O
molecular weight: 60.032364
structure: ChemicalStructure/PW C000200

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/PW C000036 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Argininosuccinic acid
stoichiometric coefficient: 1.0

4.3.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000088 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000036 Cytosol/Stoichiometry/2.0
right: Fumaric acid
right: L-Arginine
spontaneous: false
EC number: 4.3.2.1
left: Argininosuccinic acid
name: 2 Argininosuccinic acid → Fumaric acid + L-Arginine
conversion direction: LEFT_TO_RIGHT

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

6.3.4.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000036 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000723 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Argininosuccinic acid
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.3.4.5
left: L-Aspartic acid
left: Adenosine triphosphate
left: Citrulline
name: Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/ChEBI CHEBI 16199
type: UnificationXref
id: CHEBI:16199
db: ChEBI

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Compound/PW C001065 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 4.0

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

ChemicalStructure/PW C000036
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/HMDB HMDB0000271
type: UnificationXref
id: HMDB0000271
db: HMDB

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Kynurenine formamidase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine formamidase

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/CAS 2387-71-5
type: UnificationXref
id: 2387-71-5
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide
name: SubPathwayInput

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000036 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Argininosuccinic acid
stoichiometric coefficient: 2.0

Excessive Inflamation
type: Pathway
name: InhibitorySubPathway

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Reference/KEGG Compound C00077
type: UnificationXref
id: C00077
db: KEGG Compound

Nitric oxide synthase, inducible
type: ProteinReference
xref: Reference/UniProt P35228
organism: BiologicalState1164

Argininosuccinate synthase
type: ProteinReference
xref: Reference/UniProt P00966
organism: BiologicalState1164

Reference/PubChem-compound 1176
type: UnificationXref
id: 1176
db: PubChem-compound

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Viral antigens
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118279
pathway component: SubPathwayInteraction118279
name: SubPathway

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytosol
entity reference: Indoleamine 2,3-dioxygenase 1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Immune Response
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118275
pathway component: SubPathwayInteraction118275
name: SubPathway

Protein/292 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Arginase-1
stoichiometric coefficient: 3.0

Reference/HMDB HMDB0000294
type: UnificationXref
id: HMDB0000294
db: HMDB

Reference/HMDB HMDB0000052
type: UnificationXref
id: HMDB0000052
db: HMDB

Tissue Repair
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118276
pathway component: SubPathwayInteraction118276
name: SubPathway

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

Elimination of virus
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118277
pathway component: SubPathwayInteraction118277
name: SubPathway

Reference/UniProt Q63HM1
type: UnificationXref
id: Q63HM1
db: UniProt

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C00086
type: UnificationXref
id: C00086
db: KEGG Compound

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Compound/PW C000538 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Argininosuccinate lyase
type: Complex
component stoichiometry: Protein/661 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Argininosuccinate lyase

Reference/UniProt P00966
type: UnificationXref
id: P00966
db: UniProt

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt Q63HM1
organism: BiologicalState1164

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C000143 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Compound/PW C000140 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ornithine
stoichiometric coefficient: 1.0

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

Argininosuccinate lyase
type: Protein
cellular location: Cytosol
entity reference: Argininosuccinate lyase

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reaction213297
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000723 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/2.0
right: NADP
right: Nitric oxide
right: Citrulline
right: Water
spontaneous: false
left: Oxygen
left: Hydrogen Ion
left: L-Arginine
left: NADPH
name: Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Reference/UniProt P14902
type: UnificationXref
id: P14902
db: UniProt

Citrulline
type: SmallMolecule
cellular location: Cytosol
entity reference: Citrulline

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/BioCyc L-ORNITHINE
type: UnificationXref
id: L-ORNITHINE
db: BioCyc

Reference/UniProt P04424
type: UnificationXref
id: P04424
db: UniProt

Protein/661 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Argininosuccinate lyase
stoichiometric coefficient: 4.0