Corticoliberin
type: Protein
entity reference: Corticoliberin

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Compound/PW C000935 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

Compound/PW C000741 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Mitochondrial dicarboxylate carrier
type: Protein
entity reference: Mitochondrial dicarboxylate carrier

Unknown
type: ProteinReference

Protein/2033 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Protein/1808 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Protein/428 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleamine 2,3-dioxygenase 1
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000654
type: UnificationXref
id: SMP0000654
db: SMPDB

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

Protein/8910/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 1
stoichiometric coefficient: 1.0

SubPathwayInteraction118311
type: Interaction
name: SubPathway118311Reaction
name: SubPathwayReaction
participant: L-Tryptophan

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

SubPathwayInteraction118309
type: Interaction
name: SubPathway118309Reaction
name: SubPathwayReaction
participant: L-Kynurenine

Protein/292 Nucleus/Stoichiometry/3.0
type: Stoichiometry
physical entity: Arginase-1
stoichiometric coefficient: 3.0

Reference/PathWhiz PW127041
type: UnificationXref
id: PW127041
db: PathWhiz

L-Tryptophan
type: SmallMolecule
cellular location: Nucleus
entity reference: L-Tryptophan

Interaction4175
type: MolecularInteraction
interaction type: direct_interaction
name: Myeloid differentiation primary response protein MyD88 activates Nuclear factor NF-kappa-B p105 subunit
participant: Myeloid differentiation primary response protein MyD88
participant: Nuclear factor NF-kappa-B p105 subunit

Interaction4174
type: MolecularInteraction
interaction type: direct_interaction
name: TICAM1-TICAM2-TLR4 complex activates Myeloid differentiation primary response protein MyD88
participant: TICAM1-TICAM2-TLR4 complex
participant: Myeloid differentiation primary response protein MyD88

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

TICAM1-TICAM2-TLR4 complex
type: Complex
component stoichiometry: Protein/9559 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/9558 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/2033 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Toll-like receptor 4
component: TIR domain-containing adapter molecule 1
component: TIR domain-containing adapter molecule 2

TCA cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118345
pathway component: SubPathwayInteraction118345
xref: Reference/PathWhiz PW122533
xref: Reference/SMPDB SMP0121238
name: SubPathway

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reaction218817
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/14361 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytosol/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine
left: Aryl hydrocarbon receptor
name: Aryl hydrocarbon receptor + L-Kynurenine → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Interleukin-10 receptor subunit alpha
type: Protein
cellular location: Nucleus
entity reference: Interleukin-10 receptor subunit alpha

SubPathwayInteraction118341
type: Interaction
name: SubPathwayReaction
name: SubPathway118341Reaction
participant: Fatty acids
participant: Peroxisome proliferator-activated receptor gamma

Interaction4177
type: MolecularInteraction
interaction type: direct_interaction
name: TICAM1-TICAM2-TLR4 complex activates Interferon regulatory factor 3 IRF3
participant: Interferon regulatory factor 3
participant: TICAM1-TICAM2-TLR4 complex

Transport14502
type: Transport
participant stoichiometry: Compound/PW C113278 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113278 Cytosol/Stoichiometry/1.0
right: Itaconate
spontaneous: false
left: Itaconate
name: Itaconate (→) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction118345
type: Interaction
name: SubPathwayReaction
name: SubPathway118345Reaction
participant: Itaconate
participant: Fatty acids
participant: L-Glutamine

Interaction4176
type: MolecularInteraction
interaction type: direct_interaction
name: Lipopolysaccharide activates TICAM1-TICAM2-TLR4 complex
participant: Lipopolysaccharide
participant: TICAM1-TICAM2-TLR4 complex

Transport14501
type: Transport
participant stoichiometry: Protein/428 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/428 Cytosol/Stoichiometry/1.0
right: Indoleamine 2,3-dioxygenase 1
spontaneous: false
left: Indoleamine 2,3-dioxygenase 1
name: Indoleamine 2,3-dioxygenase 1 (→) Transport: Homo sapiens, Cell, Nucleus to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Interaction4179
type: MolecularInteraction
interaction type: direct_interaction
name: Interferon regulatory factor 3 IRF3 activates IFNB1-IFNAR1-IFNAR2- complex
participant: IFNB1-IFNAR1-IFNAR2- complex
participant: Interferon regulatory factor 3

Transport14504
type: Transport
participant stoichiometry: Protein/1825 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1825 Cytosol/Stoichiometry/1.0
right: Peroxisome proliferator-activated receptor gamma
spontaneous: false
left: Peroxisome proliferator-activated receptor gamma
name: Peroxisome proliferator-activated receptor gamma (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 16132265
type: UnificationXref
id: 16132265
db: PubChem-compound

Interaction4178
type: MolecularInteraction
interaction type: direct_interaction
name: TICAM1-TICAM2-TLR4 complex activates Signal transducer and activator of transcription 1-alpha/beta
participant: Signal transducer and activator of transcription 1-alpha/beta
participant: TICAM1-TICAM2-TLR4 complex

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

SubPathwayInteraction118338
type: Interaction
name: SubPathwayReaction
name: SubPathway118338Reaction
participant: L-Lactic acid
participant: D-Glucose

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Transport14500
type: Transport
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Nucleus/Stoichiometry/1.0
right: L-Tryptophan
spontaneous: false
left: L-Tryptophan
name: L-Tryptophan (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Interleukin-10 receptor subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: Interleukin-10 receptor subunit beta

Interleukin-10 receptor subunit beta
type: Protein
cellular location: Cytosol
entity reference: Interleukin-10 receptor subunit beta

ProteinComplex/12010 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: interleukin 10 receptor
stoichiometric coefficient: 1.0

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

Reference/ChemSpider 5611
type: UnificationXref
id: 5611
db: ChemSpider

Interleukin-1 beta
type: Protein
cellular location: Nucleus
entity reference: Interleukin-1 beta

L-Kynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Kynurenine
name: SubPathwayOutput
name: SubPathwayInput

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

Interleukin-1 beta
type: Protein
entity reference: Interleukin-1 beta

SubPathwayInteraction118334
type: Interaction
name: SubPathwayReaction
name: SubPathway118334Reaction
participant: L-Glutamine
participant: Peroxisome proliferator-activated receptor gamma

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Peroxisome proliferator-activated receptor gamma
type: Protein
cellular location: Nucleus
entity reference: Peroxisome proliferator-activated receptor gamma

Interferon beta precursor
type: Protein
entity reference: Interferon beta precursor

Interleukin-10 receptor subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Interleukin-10 receptor subunit alpha

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cell Membrane
entity reference: Myeloid differentiation primary response protein MyD88

Arginase-1
type: ProteinReference
xref: Reference/UniProt P05089
organism: Homo sapiens

Interaction4195
type: MolecularInteraction
interaction type: direct_interaction
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates Nuclear factor NF-kappa-B p105 subunit
participant: Nuclear factor NF-kappa-B p105 subunit
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)

Compound/PW C001867/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 1.0

Interaction4194
type: MolecularInteraction
interaction type: direct_interaction
name: L-Tryptophan inhibits Indoleamine 2,3-dioxygenase 1
participant: L-Tryptophan
participant: Indoleamine 2,3-dioxygenase 1

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/14361 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: L-Kynurenine
component: Aryl hydrocarbon receptor

TransportCatalysis5327
type: Catalysis
controller: Mitochondrial dicarboxylate carrier
controlled: Transport14502
control type: ACTIVATION

Interaction4197
type: MolecularInteraction
interaction type: direct_interaction
name: Kelch-like ECH-associated protein 1 inhibits Nuclear factor erythroid 2-related factor 2 (NFE2L2)
participant: Kelch-like ECH-associated protein 1
participant: Nuclear factor erythroid 2-related factor 2

Interaction4196
type: MolecularInteraction
interaction type: direct_interaction
name: Itaconate inhibits Kelch-like ECH-associated protein 1
participant: Kelch-like ECH-associated protein 1
participant: Itaconate

TransportCatalysis5325
type: Catalysis
controller: Large neutral amino acids transporter small subunit 1
controlled: Transport14499
control type: ACTIVATION

TransportCatalysis5326
type: Catalysis
controller: Unknown
controlled: Transport14500
control type: ACTIVATION

TransportCatalysis5323
type: Catalysis
controller: Solute carrier family 22 member 8
controlled: Transport14472
control type: ACTIVATION

Interaction4193
type: MolecularInteraction
interaction type: direct_interaction
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates interleukin 10 receptor
participant: interleukin 10 receptor
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

TransportCatalysis5324
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport14473
control type: ACTIVATION

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Nitric oxide
type: SmallMolecule
entity reference: Nitric oxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

L-Kynurenine
type: SmallMolecule
entity reference: L-Kynurenine

Interaction4199
type: MolecularInteraction
interaction type: direct_interaction
name: Peroxisome proliferator-activated receptor gamma inhibits Nuclear factor NF-kappa-B p105 subunit
participant: Peroxisome proliferator-activated receptor gamma
participant: Nuclear factor NF-kappa-B p105 subunit

Interaction4198
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor erythroid 2-related factor 2 (NFE2L2) activates Peroxisome proliferator-activated receptor gamma
participant: Peroxisome proliferator-activated receptor gamma
participant: Nuclear factor erythroid 2-related factor 2

Reference/PathWhiz PW123952
type: UnificationXref
id: PW123952
db: PathWhiz

Interferon alpha/beta receptor 2
type: Protein
entity reference: Interferon alpha/beta receptor 2

Interferon alpha/beta receptor 1
type: Protein
entity reference: Interferon alpha/beta receptor 1

BoundComplex/586/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Serum Albumin (Homo sapiens)
stoichiometric coefficient: 1.0

TransportCatalysis5321
type: Catalysis
controller: Solute carrier family 22 member 8
controlled: Transport14493
control type: ACTIVATION

TransportCatalysis5322
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport14494
control type: ACTIVATION

ReactionCatalysis2059
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Interaction4183
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Interleukin-1 beta
participant: Interleukin-1 beta
participant: Nuclear factor NF-kappa-B p105 subunit

Interaction4186
type: MolecularInteraction
interaction type: direct_interaction
name: Adrenocorticotropic hormone activates Epinephrine
participant: Epinephrine
participant: Adrenocorticotropic hormone

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Interaction4185
type: MolecularInteraction
interaction type: direct_interaction
name: Corticotropin-releasing hormone activates Adrenocorticotropic hormone
participant: Corticoliberin
participant: Adrenocorticotropic hormone

Interaction4182
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Interleukin-6
participant: Interleukin-6
participant: Nuclear factor NF-kappa-B p105 subunit

Interaction4181
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Tumor necrosis factor
participant: Nuclear factor NF-kappa-B p105 subunit
participant: Tumor necrosis factor

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

Nuclear factor erythroid 2-related factor 2
type: Protein
cellular location: Cytosol
entity reference: Nuclear factor erythroid 2-related factor 2

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

Reference/KEGG Compound C00490
type: UnificationXref
id: C00490
db: KEGG Compound

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt P19838
organism: BiologicalState1169

Protein/23940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

Protein/8956 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon regulatory factor 3
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000614
type: UnificationXref
id: BTO:0000614
db: BRENDA TISSUE ONTOLOGY

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

Large neutral amino acids transporter small subunit 1
type: Protein
entity reference: Large neutral amino acids transporter small subunit 1

TICAM1-TICAM2-TLR4 complex
type: Complex
component stoichiometry: Protein/9559 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/9558 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/2033 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-like receptor 4
component: TIR domain-containing adapter molecule 2
component: TIR domain-containing adapter molecule 1

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Kelch-like ECH-associated protein 1
type: Protein
cellular location: Cytosol
entity reference: Kelch-like ECH-associated protein 1

Compound/PW C113278 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconate
stoichiometric coefficient: 1.0

Reference/UniProt P05231
type: UnificationXref
id: P05231
db: UniProt

Protein/1766 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Peroxisome proliferator-activated receptor gamma
type: ProteinReference
xref: Reference/UniProt P37231
organism: Homo sapiens

Reference/UniProt Q8TCC7
type: UnificationXref
id: Q8TCC7
db: UniProt

Protein/2033 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Protein/1766 Nucleus/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Reference/UniProt Q01650
type: UnificationXref
id: Q01650
db: UniProt

TIR domain-containing adapter molecule 2
type: Protein
cellular location: Cytoplasm
entity reference: TIR domain-containing adapter molecule 2

BiologicalState64
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Pituitary Gland
tissue: Pituitary Gland

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

Signal transducer and activator of transcription 1-alpha/beta
type: Protein
cellular location: Cytoplasm
entity reference: Signal transducer and activator of transcription 1-alpha/beta

Reference/UniProt P06850
type: UnificationXref
id: P06850
db: UniProt

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Protein/14361 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

Indoleamine 2,3-dioxygenase 1
type: ProteinReference
xref: Reference/UniProt P14902
organism: Homo sapiens

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

TIR domain-containing adapter molecule 1
type: ProteinReference
xref: Reference/UniProt Q8IUC6
organism: BiologicalState1169

L-Lactic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Lactic acid
name: SubPathwayOutput

Reference/CELL TYPE ONTOLOGY CL 0000235
type: UnificationXref
id: CL:0000235
db: CELL TYPE ONTOLOGY

TIR domain-containing adapter molecule 2
type: ProteinReference
xref: Reference/UniProt Q86XR7
organism: BiologicalState1169

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayInput

Reference/SMPDB SMP0121238
type: UnificationXref
id: SMP0121238
db: SMPDB

Reference/UniProt P37231
type: UnificationXref
id: P37231
db: UniProt

Peroxisome proliferator-activated receptor gamma
type: Protein
cellular location: Mitochondrion
entity reference: Peroxisome proliferator-activated receptor gamma
name: SubPathwayInput

ProteinComplex/1023 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 1.0

Arginase-1
type: Protein
cellular location: Nucleus
entity reference: Arginase-1

Lipopolysaccharide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lipopolysaccharide

Kynurenine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118309
pathway component: SubPathwayInteraction118309
xref: Reference/PathWhiz PW123952
xref: Reference/SMPDB SMP0122637
name: SubPathway

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

ChemicalStructure/PW C105126
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

BiologicalState847
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Reference/UniProt O00206
type: UnificationXref
id: O00206
db: UniProt

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Kelch-like ECH-associated protein 1
type: ProteinReference
xref: Reference/UniProt Q14145
organism: Homo sapiens

IFNB1-IFNAR1-IFNAR2- complex
type: Complex
component stoichiometry: Protein/2120 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/8911 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/8910 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Interferon alpha/beta receptor 2
component: Interferon beta precursor
component: Interferon alpha/beta receptor 1

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

TransportCatalysis5314
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 1
controlled: Transport14482
control type: ACTIVATION

Peroxisome proliferator-activated receptor gamma
type: Protein
cellular location: Cytosol
entity reference: Peroxisome proliferator-activated receptor gamma
name: SubPathwayInput

Reference/UniProt P19838
type: UnificationXref
id: P19838
db: UniProt

Interaction4202
type: MolecularInteraction
interaction type: direct_interaction
name: Peroxisome proliferator-activated receptor gamma activates Macrophage mannose receptor 1
participant: Peroxisome proliferator-activated receptor gamma
participant: Macrophage mannose receptor 1

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Kynurenine formamidase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine formamidase

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

Protein/1825 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peroxisome proliferator-activated receptor gamma
stoichiometric coefficient: 1.0

Reference/UniProt Q8IUC6
type: UnificationXref
id: Q8IUC6
db: UniProt

Interaction4201
type: MolecularInteraction
interaction type: direct_interaction
name: Peroxisome proliferator-activated receptor gamma activates Interleukin-10
participant: Peroxisome proliferator-activated receptor gamma
participant: Interleukin-10

Interaction4200
type: MolecularInteraction
interaction type: direct_interaction
name: Peroxisome proliferator-activated receptor gamma activates Arginase-1
participant: Peroxisome proliferator-activated receptor gamma
participant: Arginase-1

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/PathWhiz PW122533
type: UnificationXref
id: PW122533
db: PathWhiz

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

Interleukin-6
type: ProteinReference
xref: Reference/UniProt P05231
organism: BiologicalState1169

Compound/PW C000538/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000048
type: ChemicalStructure
structure format: SMILES
structure data: CNC[C@H](O)C1=CC(O)=C(O)C=C1

ChemicalStructure/PW C000045
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Adrenocorticotropic hormone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 16132265
chemical formula: C207H308N56O58S
molecular weight: 4538.2593
structure: ChemicalStructure/PW C105126

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Protein/9559 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Itaconate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00490
chemical formula: C5H6O4
molecular weight: 130.02661
structure: ChemicalStructure/PW C113278

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/UniProt P11166
type: UnificationXref
id: P11166
db: UniProt

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766 Nucleus/Stoichiometry/3.0
cellular location: Nucleus
component: Tumor necrosis factor

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Compound/PW C105126/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adrenocorticotropic hormone
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamine
name: SubPathwayOutput
name: SubPathwayInput

Protein/14789 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-1 beta
stoichiometric coefficient: 1.0

Tumor necrosis factor
type: ProteinReference
xref: Reference/UniProt P01375
organism: BiologicalState1169

Reference/UniProt P01375
type: UnificationXref
id: P01375
db: UniProt

Reference/BioCyc L-EPINEPHRINE
type: UnificationXref
id: L-EPINEPHRINE
db: BioCyc

Reference/UniProt Q08334
type: UnificationXref
id: Q08334
db: UniProt

TIR domain-containing adapter molecule 1
type: Protein
cellular location: Extracellular Space
entity reference: TIR domain-containing adapter molecule 1

BoundComplex/583 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000068
type: UnificationXref
id: HMDB0000068
db: HMDB

Macrophage
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000235

Compound/PW C000538 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Fatty acids
type: SmallMoleculeReference
chemical formula: C16H32O2
molecular weight: 256.24023
structure: ChemicalStructure/PW C113283

Reference/HMDB HMDB0000063
type: UnificationXref
id: HMDB0000063
db: HMDB

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt Q63HM1
organism: Homo sapiens

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Serum albumin
type: ProteinReference
xref: Reference/UniProt P02768
organism: BiologicalState51

Pituitary Gland
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001073

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Tumor necrosis factor
type: Protein
cellular location: Nucleus
entity reference: Tumor necrosis factor

Reference/UniProt P48551
type: UnificationXref
id: P48551
db: UniProt

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Protein/8911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 2
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/8910 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 1
stoichiometric coefficient: 1.0

Protein/9559 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 2
stoichiometric coefficient: 1.0

Interferon alpha/beta receptor 1
type: Protein
cellular location: Nucleus
entity reference: Interferon alpha/beta receptor 1

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

TICAM1-TICAM2-TLR4 complex
type: Complex
component stoichiometry: Protein/9558 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2033 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/9559 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Toll-like receptor 4
component: TIR domain-containing adapter molecule 1
component: TIR domain-containing adapter molecule 2

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Protein/1771/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serum albumin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/CAS 50-23-7
type: UnificationXref
id: 50-23-7
db: CAS

D-Glucose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Glucose

Compound/PW C001867 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 11970143
type: UnificationXref
id: 11970143
db: PubChem-compound

ProteinComplex/2353/Stoichiometry/1.0
type: Stoichiometry
physical entity: IFNB1-IFNAR1-IFNAR2- complex
stoichiometric coefficient: 1.0

Compound/PW C000048/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

Protein/23940 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor
type: ProteinReference
xref: Reference/UniProt P35869
organism: Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 1
type: ProteinReference
xref: Reference/UniProt P11166

Nuclear factor erythroid 2-related factor 2
type: ProteinReference
xref: Reference/UniProt Q16236
organism: Homo sapiens

Reference/ChEBI CHEBI 28918
type: UnificationXref
id: CHEBI:28918
db: ChEBI

Compound/PW C113278 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconate
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0001073
type: UnificationXref
id: BTO:0001073
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

TIR domain-containing adapter molecule 1
type: Protein
cellular location: Cytoplasm
entity reference: TIR domain-containing adapter molecule 1

Solute carrier family 22 member 2
type: ProteinReference
xref: Reference/UniProt O15244

Interferon alpha/beta receptor 2
type: Protein
cellular location: Nucleus
entity reference: Interferon alpha/beta receptor 2

Protein/2120 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon beta precursor
stoichiometric coefficient: 1.0

Lipopolysaccharide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16412
xref: Reference/PubChem-compound 11970143
chemical formula: C205H366N3O117P5
molecular weight: 4897.147
structure: ChemicalStructure/PW C104587

Reference/UniProt P01574
type: UnificationXref
id: P01574
db: UniProt

Solute carrier family 22 member 8
type: ProteinReference
xref: Reference/UniProt Q8TCC7

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Epinephrine
type: SmallMolecule
entity reference: Epinephrine

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Protein/1808 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

Hypothalamus
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000614

Reference/UniProt Q9UBX3
type: UnificationXref
id: Q9UBX3
db: UniProt

Cortisol
type: SmallMolecule
entity reference: Cortisol

Cortisol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00735
xref: Reference/CAS 50-23-7
xref: Reference/PubChem-compound 5754
xref: Reference/HMDB HMDB0000063
xref: Reference/ChemSpider 5551
xref: Reference/ChEBI CHEBI 17650
chemical formula: C21H30O5
molecular weight: 362.20932
structure: ChemicalStructure/PW C000045

Interleukin-10 receptor subunit alpha
type: ProteinReference
xref: Reference/UniProt Q13651
organism: Homo sapiens

Interleukin-10
type: ProteinReference
xref: Reference/UniProt P22301
organism: Homo sapiens

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/UniProt P01584
type: UnificationXref
id: P01584
db: UniProt

Interleukin-10 receptor subunit beta
type: ProteinReference
xref: Reference/UniProt Q08334
organism: Homo sapiens

IFNB1-IFNAR1-IFNAR2- complex
type: Complex
component stoichiometry: Protein/2120/Stoichiometry/1.0
component stoichiometry: Protein/8911/Stoichiometry/1.0
component stoichiometry: Protein/8910/Stoichiometry/1.0
component: Interferon beta precursor
component: Interferon alpha/beta receptor 2
component: Interferon alpha/beta receptor 1

Reference/PubChem-compound 5754
type: UnificationXref
id: 5754
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

interleukin 10 receptor
type: Complex
cellular location: Cell Membrane
component: Interleukin-10 receptor subunit beta
component: Interleukin-10 receptor subunit alpha

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

ChemicalStructure/PW C113278
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=C)C(O)=O

Reference/UniProt Q99836
type: UnificationXref
id: Q99836
db: UniProt

Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Interleukin-6
type: Protein
entity reference: Interleukin-6

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/14361 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aryl hydrocarbon receptor
component: L-Kynurenine

ProteinComplex/1023/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 1.0

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

ProteinComplex/12010 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: interleukin 10 receptor
stoichiometric coefficient: 1.0

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766/Stoichiometry/3.0
component: Tumor necrosis factor

Protein/23940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

L-Kynurenine
type: SmallMolecule
cellular location: Nucleus
entity reference: L-Kynurenine

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

ChemicalStructure/PW C113283
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(O)=O

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

ReactionCatalysis1353
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

Adrenocorticotropic hormone
type: SmallMolecule
entity reference: Adrenocorticotropic hormone

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Interleukin-10 receptor subunit beta
type: Protein
cellular location: Nucleus
entity reference: Interleukin-10 receptor subunit beta

Reference/CAS 51-43-4
type: UnificationXref
id: 51-43-4
db: CAS

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

ProteinComplex/12010 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: interleukin 10 receptor
stoichiometric coefficient: 1.0

Tumor necrosis factor
type: Protein
cellular location: Cytosol
entity reference: Tumor necrosis factor

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Interferon regulatory factor 3
type: Protein
cellular location: Cytoplasm
entity reference: Interferon regulatory factor 3

Reference/PubChem-compound 5816
type: UnificationXref
id: 5816
db: PubChem-compound

Protein/14361 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formic acid
right: L-Kynurenine
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

Arginase-1
type: Complex
component stoichiometry: Protein/292 Nucleus/Stoichiometry/3.0
cellular location: Nucleus
component: Arginase-1

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

ChemicalStructure/PW C104587
type: ChemicalStructure
structure format: SMILES

Tryptophan biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118311
pathway component: SubPathwayInteraction118311
name: SubPathway

Itaconate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Itaconate
name: SubPathwayOutput

Reference/UniProt Q16236
type: UnificationXref
id: Q16236
db: UniProt

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Mitochondrial dicarboxylate carrier
type: ProteinReference
xref: Reference/UniProt Q9UBX3

TIR domain-containing adapter molecule 2
type: Protein
cellular location: Cell Membrane
entity reference: TIR domain-containing adapter molecule 2

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Interleukin-6
type: Protein
cellular location: Nucleus
entity reference: Interleukin-6

Protein/14789/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-1 beta
stoichiometric coefficient: 1.0

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/SMPDB SMP0122637
type: UnificationXref
id: SMP0122637
db: SMPDB

Reference/UniProt Q14145
type: UnificationXref
id: Q14145
db: UniProt

TIR domain-containing adapter molecule 1
type: Protein
cellular location: Cell Membrane
entity reference: TIR domain-containing adapter molecule 1

Epinephrine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000068
xref: Reference/KEGG Compound C00788
xref: Reference/PubChem-compound 5816
xref: Reference/ChemSpider 5611
xref: Reference/CAS 51-43-4
xref: Reference/BioCyc L-EPINEPHRINE
xref: Reference/ChEBI CHEBI 28918
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000048

Macrophage mannose receptor 1
type: Protein
cellular location: Nucleus
entity reference: Macrophage mannose receptor 1

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

Itaconate
type: SmallMolecule
cellular location: Cytosol
entity reference: Itaconate

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Nucleus
entity reference: Indoleamine 2,3-dioxygenase 1

Macrophage mannose receptor 1
type: ProteinReference
xref: Reference/UniProt P22897
organism: Homo sapiens

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Glutaminolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118334
pathway component: SubPathwayInteraction118334
name: SubPathway

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Corticoliberin
type: ProteinReference
xref: Reference/UniProt P06850
organism: BiologicalState64

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt Q99836
organism: BiologicalState1169

Aryl hydrocarbon receptor
type: Protein
cellular location: Nucleus
entity reference: Aryl hydrocarbon receptor

Reference/PathWhiz PW000630
type: UnificationXref
id: PW000630
db: PathWhiz

interleukin 10 receptor
type: Complex
cellular location: Cytosol
component: Interleukin-10 receptor subunit alpha
component: Interleukin-10 receptor subunit beta

Protein/8956 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon regulatory factor 3
stoichiometric coefficient: 1.0

ProteinComplex/1023 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 1.0

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Transport14498
type: Transport
participant stoichiometry: ProteinComplex/12010 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/12010 Cytosol/Stoichiometry/1.0
right: interleukin 10 receptor
spontaneous: false
left: interleukin 10 receptor
name: interleukin 10 receptor (→) Transport: Homo sapiens, Cell, Nucleus to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Transport14497
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
right: Interleukin-1 beta
spontaneous: true
left: Interleukin-1 beta
name: Interleukin-1 beta (→) Transport: Homo sapiens, Liver to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14499
type: Transport
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538/Stoichiometry/1.0
right: L-Kynurenine
spontaneous: false
left: L-Kynurenine
name: L-Kynurenine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Protein/428 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleamine 2,3-dioxygenase 1
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Transport14494
type: Transport
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: Epinephrine
spontaneous: false
left: Epinephrine
name: Epinephrine (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Transport14493
type: Transport
participant stoichiometry: Compound/PW C000045/Stoichiometry/1.0
right: Cortisol
spontaneous: false
left: Cortisol
name: Cortisol (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14496
type: Transport
participant stoichiometry: ProteinComplex/1023/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/2353/Stoichiometry/1.0
right: Tumor necrosis factor
right: IFNB1-IFNAR1-IFNAR2- complex
spontaneous: true
left: Tumor necrosis factor
left: IFNB1-IFNAR1-IFNAR2- complex
name: Tumor necrosis factor (→), IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
conversion direction: REVERSIBLE

Transport14495
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
participant stoichiometry: Protein/23940/Stoichiometry/1.0
right: Interleukin-1 beta
right: Interleukin-6
spontaneous: true
left: Interleukin-1 beta
left: Interleukin-6
name: Interleukin-6 (→), Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
conversion direction: REVERSIBLE

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

Reference/UniProt P02768
type: UnificationXref
id: P02768
db: UniProt

Fatty-acid beta oxidation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118341
pathway component: SubPathwayInteraction118341
name: SubPathway

Reference/UniProt P05089
type: UnificationXref
id: P05089
db: UniProt

Protein/2120/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon beta precursor
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16412
type: UnificationXref
id: CHEBI:16412
db: ChEBI

Interferon beta precursor
type: Protein
cellular location: Nucleus
entity reference: Interferon beta precursor

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Tumor necrosis factor
type: Protein
entity reference: Tumor necrosis factor

TransportCatalysis15
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport42
control type: ACTIVATION

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Interferon beta precursor
type: ProteinReference
xref: Reference/UniProt P01574
organism: BiologicalState1169

Interleukin-10 receptor subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Interleukin-10 receptor subunit alpha

Transport14483
type: Transport
participant stoichiometry: BoundComplex/583 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytosol/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan
name: SubPathwayOutput

Transport14482
type: Transport
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport14484
type: Transport
participant stoichiometry: ProteinComplex/12010 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/12010 Cell Membrane/Stoichiometry/1.0
right: interleukin 10 receptor
spontaneous: false
left: interleukin 10 receptor
name: interleukin 10 receptor (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Cell Membrane
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P22301
type: UnificationXref
id: P22301
db: UniProt

Reference/UniProt P17181
type: UnificationXref
id: P17181
db: UniProt

Interferon regulatory factor 3
type: Protein
cellular location: Nucleus
entity reference: Interferon regulatory factor 3

Compound/PW C000538 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Reference/UniProt Q14653
type: UnificationXref
id: Q14653
db: UniProt

BoundComplex/583 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Tumor necrosis factor

Transport14479
type: Transport
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001867/Stoichiometry/1.0
right: Nitric oxide
spontaneous: true
left: Nitric oxide
name: Nitric oxide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Reference/ChemSpider 5551
type: UnificationXref
id: 5551
db: ChemSpider

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: N'-Formylkynurenine

Transport14476
type: Transport
participant stoichiometry: Protein/23940/Stoichiometry/1.0
participant stoichiometry: Protein/23940 Cytosol/Stoichiometry/1.0
right: Interleukin-6
spontaneous: true
left: Interleukin-6
name: Interleukin-6 (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Transport14478
type: Transport
participant stoichiometry: ProteinComplex/1023/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1023 Cytosol/Stoichiometry/1.0
right: Tumor necrosis factor
spontaneous: true
left: Tumor necrosis factor
name: Tumor necrosis factor (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Reference/UniProt P22897
type: UnificationXref
id: P22897
db: UniProt

Transport14472
type: Transport
participant stoichiometry: Compound/PW C000045/Stoichiometry/1.0
right: Cortisol
spontaneous: true
left: Cortisol
name: Cortisol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
conversion direction: REVERSIBLE

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Interferon alpha/beta receptor 1
type: ProteinReference
xref: Reference/UniProt P17181
organism: BiologicalState1169

Interferon alpha/beta receptor 2
type: ProteinReference
xref: Reference/UniProt P48551
organism: BiologicalState1169

Serum albumin
type: Protein
entity reference: Serum albumin

Transport14473
type: Transport
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: Epinephrine
spontaneous: false
left: Epinephrine
name: Epinephrine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Transport14470
type: Transport
participant stoichiometry: Compound/PW C105126/Stoichiometry/1.0
right: Adrenocorticotropic hormone
spontaneous: true
left: Adrenocorticotropic hormone
name: Adrenocorticotropic hormone (→) Transport: Homo sapiens, Pituitary Gland to Homo sapiens, Adrenal Cortex
conversion direction: REVERSIBLE

BiologicalState1169
type: BioSource
cell type: Macrophage
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, Macrophage
tissue: Blood Vessel

Reference/KEGG Compound C00735
type: UnificationXref
id: C00735
db: KEGG Compound

Reference/UniProt Q13651
type: UnificationXref
id: Q13651
db: UniProt

BiologicalState1180
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Hypothalamus
tissue: Hypothalamus

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Transport42
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14468
type: Transport
participant stoichiometry: ProteinComplex/1023/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1023 Nucleus/Stoichiometry/1.0
right: Tumor necrosis factor
spontaneous: true
left: Tumor necrosis factor
name: Tumor necrosis factor (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14465
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
participant stoichiometry: Protein/14789 Nucleus/Stoichiometry/1.0
right: Interleukin-1 beta
spontaneous: true
left: Interleukin-1 beta
name: Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14464
type: Transport
participant stoichiometry: Protein/8956 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/8956 Nucleus/Stoichiometry/1.0
right: Interferon regulatory factor 3
spontaneous: true
left: Interferon regulatory factor 3
name: Interferon regulatory factor 3 IRF3 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: REVERSIBLE

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Transport14467
type: Transport
participant stoichiometry: ProteinComplex/2353 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/2353/Stoichiometry/1.0
right: IFNB1-IFNAR1-IFNAR2- complex
spontaneous: true
left: IFNB1-IFNAR1-IFNAR2- complex
name: IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Fatty acids
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Fatty acids
name: SubPathwayOutput
name: SubPathwayInput

Transport14466
type: Transport
participant stoichiometry: Protein/23940 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/23940/Stoichiometry/1.0
right: Interleukin-6
spontaneous: true
left: Interleukin-6
name: Interleukin-6 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14463
type: Transport
participant stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Cytoplasm/Stoichiometry/1.0
right: Nuclear factor NF-kappa-B p105 subunit
spontaneous: true
left: Nuclear factor NF-kappa-B p105 subunit
name: Nuclear factor NF-kappa-B p105 subunit (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: REVERSIBLE

Protein/2033 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Interleukin-1 beta
type: ProteinReference
xref: Reference/UniProt P01584
organism: BiologicalState1169

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Solute carrier family 22 member 2
type: Protein
entity reference: Solute carrier family 22 member 2

Reference/SMPDB SMP0125485
type: UnificationXref
id: SMP0125485
db: SMPDB

Reference/UniProt P35869
type: UnificationXref
id: P35869
db: UniProt

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

Large neutral amino acids transporter small subunit 1
type: ProteinReference
xref: Reference/UniProt Q01650

Reference/UniProt Q86XR7
type: UnificationXref
id: Q86XR7
db: UniProt

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt O00206
organism: BiologicalState1169

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Protein/1825 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peroxisome proliferator-activated receptor gamma
stoichiometric coefficient: 1.0

ProteinComplex/2353 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: IFNB1-IFNAR1-IFNAR2- complex
stoichiometric coefficient: 1.0

Solute carrier family 2, facilitated glucose transporter member 1
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 1

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/1766/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Compound/PW C000045/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Solute carrier family 22 member 8
type: Protein
entity reference: Solute carrier family 22 member 8

Reference/UniProt O15244
type: UnificationXref
id: O15244
db: UniProt

Reaction218833
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538/Stoichiometry/1.0
participant stoichiometry: Protein/1771/Stoichiometry/1.0
participant stoichiometry: BoundComplex/586/Stoichiometry/1.0
right: L-Kynurenine_Serum Albumin (Homo sapiens)
spontaneous: false
left: Serum albumin
left: L-Kynurenine
name: L-Kynurenine + Serum Albumin → L-Kynurenine + Serum Albumin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

Interaction3827
type: MolecularInteraction
interaction type: direct_interaction
name: Adrenocorticotropic hormone activates Cortisol
participant: Cortisol
participant: Adrenocorticotropic hormone

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytosol
entity reference: Indoleamine 2,3-dioxygenase 1

L-Kynurenine_Serum Albumin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538/Stoichiometry/1.0
component stoichiometry: Protein/1771/Stoichiometry/1.0
component: Serum albumin
component: L-Kynurenine

Reference/UniProt Q63HM1
type: UnificationXref
id: Q63HM1
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Protein/9558 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 1
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

TIR domain-containing adapter molecule 2
type: Protein
cellular location: Extracellular Space
entity reference: TIR domain-containing adapter molecule 2

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: Reference/UniProt P42224
organism: BiologicalState1169

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Interferon regulatory factor 3
type: ProteinReference
xref: Reference/UniProt Q14653
organism: BiologicalState1169

Protein/9558 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Interleukin-6
type: Protein
cellular location: Cytosol
entity reference: Interleukin-6

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

Aerobic Glycolysis (Warburg Effect)
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118338
pathway component: SubPathwayInteraction118338
xref: Reference/SMPDB SMP0000654
xref: Reference/PathWhiz PW000630
name: SubPathway

Protein/9559 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 2
stoichiometric coefficient: 1.0

interleukin 10 receptor
type: Complex
cellular location: Nucleus
component: Interleukin-10 receptor subunit beta
component: Interleukin-10 receptor subunit alpha

Reference/KEGG Compound C00788
type: UnificationXref
id: C00788
db: KEGG Compound

Protein/9558 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 1
stoichiometric coefficient: 1.0

Anti-inflammatory pathway
type: Pathway
pathway order: PathwayInteraction/4185
pathway order: PathwayInteraction/4183
pathway order: PathwayInteraction/4182
pathway order: PathwayInteraction/4181
pathway order: PathwayTransport/2510945
pathway order: PathwayTransport/2510989
pathway order: PathwayTransport/2510944
pathway order: PathwayTransport/2510988
pathway order: PathwayTransport/2510947
pathway order: PathwayInteraction/4179
pathway order: PathwayTransport/2510941
pathway order: PathwayInteraction/4178
pathway order: PathwayTransport/2510942
pathway order: PathwayInteraction/4177
pathway order: PathwayTransport/2510986
pathway order: PathwayInteraction/4176
pathway order: PathwayTransport/2510940
pathway order: PathwayInteraction/4175
pathway order: PathwayInteraction/4174
pathway order: PathwayTransport/2510956
pathway order: PathwayTransport/2510957
pathway order: PathwayEnzymeReaction/2510985
pathway order: PathwayTransport/2510999
pathway order: PathwayTransport/2510958
pathway order: PathwayTransport/2510959
pathway order: PathwayTransport/2510990
pathway order: PathwayInteraction/4202
pathway order: PathwayInteraction/4201
pathway order: PathwaySubPathway/118334
pathway order: PathwayInteraction/4200
pathway order: PathwayTransport/2510997
pathway order: PathwayTransport/2511007
pathway order: PathwayTransport/2510950
pathway order: PathwayTransport/2510995
pathway order: PathwaySubPathway/118338
pathway order: PathwayInteraction/3827
pathway order: PathwayEnzymeReaction/2510994
pathway order: PathwayTransport/2510965
pathway order: PathwayEnzymeReaction/2510991
pathway order: PathwayEnzymeReaction/2510993
pathway order: PathwaySubPathway/118341
pathway order: PathwaySubPathway/118345
pathway order: PathwayTransport/2510963
pathway order: PathwayTransport/2510964
pathway order: PathwayInteraction/4199
pathway order: PathwayTransport/2510961
pathway order: PathwayInteraction/4198
pathway order: PathwayTransport/2510962
pathway order: PathwayInteraction/4197
pathway order: PathwayInteraction/4196
pathway order: PathwayInteraction/4195
pathway order: PathwayInteraction/4194
pathway order: PathwayInteraction/4193
pathway order: PathwaySubPathway/118309
pathway order: PathwayTransport/2510938
pathway order: PathwayTransport/2510939
pathway order: PathwayTransport/2510937
pathway order: PathwaySubPathway/118311
pathway order: PathwayInteraction/4186
pathway component: Interaction4195
pathway component: Interaction4194
pathway component: TransportCatalysis5327
pathway component: Interaction4197
pathway component: Interaction4196
pathway component: TransportCatalysis5325
pathway component: TransportCatalysis5326
pathway component: TransportCatalysis5323
pathway component: Interaction4193
pathway component: TransportCatalysis5324
pathway component: Interaction4199
pathway component: Reaction218833
pathway component: Interaction4198
pathway component: TransportCatalysis15
pathway component: Interaction3827
pathway component: Transport14483
pathway component: Transport14482
pathway component: Transport14484
pathway component: TransportCatalysis5321
pathway component: TransportCatalysis5322

Aryl hydrocarbon receptor
type: Protein
cellular location: Cytosol
entity reference: Aryl hydrocarbon receptor

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Reference/UniProt P14902
type: UnificationXref
id: P14902
db: UniProt

Reference/ChEBI CHEBI 17650
type: UnificationXref
id: CHEBI:17650
db: ChEBI

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Protein/8911 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 2
stoichiometric coefficient: 1.0

Toll-like receptor 4
type: Protein
cellular location: Extracellular Space
entity reference: Toll-like receptor 4

Reference/UniProt P42224
type: UnificationXref
id: P42224
db: UniProt

Interleukin-10
type: Protein
cellular location: Nucleus
entity reference: Interleukin-10