L-Tryptophan + Oxygen → N'-Formylkynurenine
Myeloid differentiation primary response protein MyD88 activates Nuclear factor NF-kappa-B p105 subunit
TICAM1-TICAM2-TLR4 complex activates Myeloid differentiation primary response protein MyD88
Aryl hydrocarbon receptor + L-Kynurenine → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens)
TICAM1-TICAM2-TLR4 complex activates Interferon regulatory factor 3 IRF3
Itaconate (→) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytosol
Lipopolysaccharide activates TICAM1-TICAM2-TLR4 complex
Indoleamine 2,3-dioxygenase 1 (→) Transport: Homo sapiens, Cell, Nucleus to Homo sapiens, Cell, Cytosol
Interferon regulatory factor 3 IRF3 activates IFNB1-IFNAR1-IFNAR2- complex
Peroxisome proliferator-activated receptor gamma (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
TICAM1-TICAM2-TLR4 complex activates Signal transducer and activator of transcription 1-alpha/beta
L-Tryptophan (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
Peroxisome proliferator-activated receptor gamma
Myeloid differentiation primary response protein MyD88
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates Nuclear factor NF-kappa-B p105 subunit
L-Tryptophan inhibits Indoleamine 2,3-dioxygenase 1
L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
Kelch-like ECH-associated protein 1 inhibits Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Itaconate inhibits Kelch-like ECH-associated protein 1
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates interleukin 10 receptor
Peroxisome proliferator-activated receptor gamma inhibits Nuclear factor NF-kappa-B p105 subunit
Nuclear factor erythroid 2-related factor 2 (NFE2L2) activates Peroxisome proliferator-activated receptor gamma
Nuclear factor NF-kappa-B p105 subunit activates Interleukin-1 beta
Adrenocorticotropic hormone activates Epinephrine
Corticotropin-releasing hormone activates Adrenocorticotropic hormone
Nuclear factor NF-kappa-B p105 subunit activates Interleukin-6
Nuclear factor NF-kappa-B p105 subunit activates Tumor necrosis factor
Nuclear factor erythroid 2-related factor 2
Large neutral amino acids transporter small subunit 1
TIR domain-containing adapter molecule 2
Signal transducer and activator of transcription 1-alpha/beta
TIR domain-containing adapter molecule 1
Peroxisome proliferator-activated receptor gamma activates Macrophage mannose receptor 1
Peroxisome proliferator-activated receptor gamma activates Interleukin-10
Peroxisome proliferator-activated receptor gamma activates Arginase-1
Solute carrier family 2, facilitated glucose transporter member 1
Solute carrier family 2, facilitated glucose transporter member 2
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
interleukin 10 receptor (→) Transport: Homo sapiens, Cell, Nucleus to Homo sapiens, Cell, Cytosol
Interleukin-1 beta (→) Transport: Homo sapiens, Liver to Homo sapiens, Blood Vessel
L-Kynurenine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Blood Vessel
Epinephrine (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
Cortisol (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
Tumor necrosis factor (→), IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
Interleukin-6 (→), Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
interleukin 10 receptor (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Cell Membrane
Nitric oxide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Interleukin-6 (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Tumor necrosis factor (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Cortisol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
Epinephrine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
Adrenocorticotropic hormone (→) Transport: Homo sapiens, Pituitary Gland to Homo sapiens, Adrenal Cortex
D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Tumor necrosis factor (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Interferon regulatory factor 3 IRF3 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Interleukin-6 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Nuclear factor NF-kappa-B p105 subunit (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
L-Kynurenine + Serum Albumin → L-Kynurenine + Serum Albumin (Homo sapiens)
Adrenocorticotropic hormone activates Cortisol
L-Kynurenine_Serum Albumin (Homo sapiens)