Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/188 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/116 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/145 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/174 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Pyruvate kinase PKM
type: Protein
cellular location: Nucleus
entity reference: Pyruvate kinase PKM

Protein/710 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate kinase PKM
stoichiometric coefficient: 2.0

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P31040
organism: BiologicalState1169

Reference/UniProt Q96KS0
type: UnificationXref
id: Q96KS0
db: UniProt

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Solute carrier family 22 member 5
type: Protein
entity reference: Solute carrier family 22 member 5

Reference/PathWhiz PW127049
type: UnificationXref
id: PW127049
db: PathWhiz

Reference/HMDB HMDB0001072
type: UnificationXref
id: HMDB0001072
db: HMDB

BoundComplex/584 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid_Pyruvate kinase PKM (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/PathWhiz PW127041
type: UnificationXref
id: PW127041
db: PathWhiz

Interaction4175
type: MolecularInteraction
interaction type: direct_interaction
name: Myeloid differentiation primary response protein MyD88 activates Nuclear factor NF-kappa-B p105 subunit
participant: Myeloid differentiation primary response protein MyD88
participant: Nuclear factor NF-kappa-B p105 subunit

Interaction4174
type: MolecularInteraction
interaction type: direct_interaction
name: TICAM1-TICAM2-TLR4 complex activates Myeloid differentiation primary response protein MyD88
participant: TICAM1-TICAM2-TLR4 complex
participant: Myeloid differentiation primary response protein MyD88

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Interaction4177
type: MolecularInteraction
interaction type: direct_interaction
name: TICAM1-TICAM2-TLR4 complex activates Interferon regulatory factor 3 IRF3
participant: Interferon regulatory factor 3
participant: TICAM1-TICAM2-TLR4 complex

Interaction4176
type: MolecularInteraction
interaction type: direct_interaction
name: Lipopolysaccharide activates TICAM1-TICAM2-TLR4 complex
participant: Lipopolysaccharide
participant: TICAM1-TICAM2-TLR4 complex

Interaction4179
type: MolecularInteraction
interaction type: direct_interaction
name: Interferon regulatory factor 3 IRF3 activates IFNB1-IFNAR1-IFNAR2- complex
participant: IFNB1-IFNAR1-IFNAR2- complex
participant: Interferon regulatory factor 3

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/PubChem-compound 16132265
type: UnificationXref
id: 16132265
db: PubChem-compound

Interaction4178
type: MolecularInteraction
interaction type: direct_interaction
name: TICAM1-TICAM2-TLR4 complex activates Signal transducer and activator of transcription 1-alpha/beta
participant: Signal transducer and activator of transcription 1-alpha/beta
participant: TICAM1-TICAM2-TLR4 complex

Reference/UniProt O15427
type: UnificationXref
id: O15427
db: UniProt

Importin-4
type: Protein
entity reference: Importin-4

Low affinity cationic amino acid transporter 2
type: Protein
entity reference: Low affinity cationic amino acid transporter 2

Reference/UniProt Q9Y294
type: UnificationXref
id: Q9Y294
db: UniProt

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

Interleukin-1 beta
type: Protein
cellular location: Nucleus
entity reference: Interleukin-1 beta

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

FAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FAD

Interferon beta precursor
type: Protein
entity reference: Interferon beta precursor

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O14521
organism: BiologicalState1169

Reference/ChEBI CHEBI 30769
type: UnificationXref
id: CHEBI:30769
db: ChEBI

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000174 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/1134 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/23934 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Pyruvate kinase PKM
component: Hypoxia-inducible factor 1-alpha
component: Succinic acid

TransportCatalysis5328
type: Catalysis
controller: Histone H3.1 complex
controlled: Transport14512
control type: ACTIVATION

Interaction4191
type: MolecularInteraction
interaction type: direct_interaction
name: Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) activates Solute carrier family 2, facilitated glucose transporter member 1
participant: Solute carrier family 2, facilitated glucose transporter member 1
participant: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)

Interaction4190
type: MolecularInteraction
interaction type: direct_interaction
name: Prolyl hydroxylase EGLN2 inhibits hypoxia-inducible factor-1α
participant: Egl nine homolog 2
participant: Hypoxia-inducible factor 1-alpha

TransportCatalysis5323
type: Catalysis
controller: Solute carrier family 22 member 8
controlled: Transport14472
control type: ACTIVATION

Compound/PW C000143 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

TransportCatalysis5324
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport14473
control type: ACTIVATION

Interaction4192
type: MolecularInteraction
interaction type: direct_interaction
name: Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) activates Interleukin-1 beta
participant: Interleukin-1 beta
participant: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Interferon alpha/beta receptor 2
type: Protein
entity reference: Interferon alpha/beta receptor 2

Monocarboxylate transporter 4
type: Protein
entity reference: Monocarboxylate transporter 4

Interferon alpha/beta receptor 1
type: Protein
entity reference: Interferon alpha/beta receptor 1

Protein/23930 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cis-aconitate decarboxylase
stoichiometric coefficient: 1.0

TransportCatalysis5321
type: Catalysis
controller: Solute carrier family 22 member 8
controlled: Transport14493
control type: ACTIVATION

TransportCatalysis5322
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport14494
control type: ACTIVATION

TransportCatalysis5320
type: Catalysis
controller: Unknown
controlled: Transport14492
control type: ACTIVATION

Interaction4184
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Cis-aconitate decarboxylase
participant: Nuclear factor NF-kappa-B p105 subunit
participant: Cis-aconitate decarboxylase

Interaction4183
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Interleukin-1 beta
participant: Interleukin-1 beta
participant: Nuclear factor NF-kappa-B p105 subunit

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Interaction4186
type: MolecularInteraction
interaction type: direct_interaction
name: Adrenocorticotropic hormone activates Epinephrine
participant: Epinephrine
participant: Adrenocorticotropic hormone

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Interaction4185
type: MolecularInteraction
interaction type: direct_interaction
name: Corticotropin-releasing hormone activates Adrenocorticotropic hormone
participant: Corticoliberin
participant: Adrenocorticotropic hormone

Interaction4180
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Nitric oxide synthase, inducible
participant: Nitric oxide synthase, inducible
participant: Nuclear factor NF-kappa-B p105 subunit

Reference/PathWhiz PW127080
type: UnificationXref
id: PW127080
db: PathWhiz

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Interaction4182
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Interleukin-6
participant: Interleukin-6
participant: Nuclear factor NF-kappa-B p105 subunit

Interaction4181
type: MolecularInteraction
interaction type: direct_interaction
name: Nuclear factor NF-kappa-B p105 subunit activates Tumor necrosis factor
participant: Nuclear factor NF-kappa-B p105 subunit
participant: Tumor necrosis factor

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt Q09028
type: UnificationXref
id: Q09028
db: UniProt

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99643
organism: BiologicalState1169

Interaction4187
type: MolecularInteraction
interaction type: direct_interaction
name: Cis-aconitate decarboxylase inhibits Succinate dehydrogenase
participant: Cis-aconitate decarboxylase
participant: Succinate dehydrogenase

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Interaction4189
type: MolecularInteraction
interaction type: direct_interaction
name: Succinic acid + Pyruvate kinase PKM (Homo sapiens) inhibits Prolyl hydroxylase EGLN2
participant: Egl nine homolog 2
participant: Succinic acid_Pyruvate kinase PKM (Homo sapiens)

Protein/8956 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon regulatory factor 3
stoichiometric coefficient: 1.0

Reference/KEGG Compound C11378
type: UnificationXref
id: C11378
db: KEGG Compound

Coenzyme Q10
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001072
xref: Reference/BioCyc UBIQUINONE-10
xref: Reference/PubChem-compound 5281915
xref: Reference/ChemSpider 4445197
xref: Reference/CAS 303-98-0
xref: Reference/KEGG Compound C11378
xref: Reference/ChEBI CHEBI 46245
chemical formula: C59H90O4
molecular weight: 862.6839
structure: ChemicalStructure/PW C000846

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

Reference/ChEBI CHEBI 73024
type: UnificationXref
id: CHEBI:73024
db: ChEBI

Solute carrier family 2, facilitated glucose transporter member 1
type: Protein
cellular location: Cytoplasm
entity reference: Solute carrier family 2, facilitated glucose transporter member 1

L-Acetylcarnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Acetylcarnitine
name: SubPathwayInhibition

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

TICAM1-TICAM2-TLR4 complex
type: Complex
component stoichiometry: Protein/9559 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/9558 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/2033 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-like receptor 4
component: TIR domain-containing adapter molecule 2
component: TIR domain-containing adapter molecule 1

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt P05231
type: UnificationXref
id: P05231
db: UniProt

Protein/1766 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Protein/14788 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01352
type: UnificationXref
id: C01352
db: KEGG Compound

Protein/2033 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Tricarboxylic acid cycle
type: Pathway
xref: Reference/PathWhiz PW127080
xref: Reference/SMPDB SMP0125522
name: InhibitorySubPathway

Protein/1766 Nucleus/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Interferon gamma
type: Protein
cellular location: Cytoplasm
entity reference: Interferon gamma

Reference/UniProt O14521
type: UnificationXref
id: O14521
db: UniProt

BiologicalState64
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Pituitary Gland
tissue: Pituitary Gland

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

Signal transducer and activator of transcription 1-alpha/beta
type: Protein
cellular location: Cytoplasm
entity reference: Signal transducer and activator of transcription 1-alpha/beta

Protein/14361 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

L-Kynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Kynurenine

Pyruvate kinase PKM
type: Complex
component stoichiometry: Protein/710 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Pyruvate kinase PKM

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Interaction1289
type: MolecularInteraction
interaction type: direct_interaction
name: Interferon gamma activates Indoleamine 2,3-dioxygenase 1
participant: Indoleamine 2,3-dioxygenase 1
participant: Interferon gamma

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Reference/CELL TYPE ONTOLOGY CL 0000235
type: UnificationXref
id: CL:0000235
db: CELL TYPE ONTOLOGY

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Compound/PW C000932 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: FADH
stoichiometric coefficient: 1.0

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

Protein/3837/Stoichiometry/1.0
type: Stoichiometry
physical entity: Exportin-5
stoichiometric coefficient: 1.0

Protein/20827 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-10
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

BiologicalState847
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

Nitric oxide synthase, inducible
type: Protein
cellular location: Nucleus
entity reference: Nitric oxide synthase, inducible

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

IFNB1-IFNAR1-IFNAR2- complex
type: Complex
component stoichiometry: Protein/2120 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/8911 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/8910 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Interferon alpha/beta receptor 2
component: Interferon beta precursor
component: Interferon alpha/beta receptor 1

Protein/174 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/UniProt P21912
type: UnificationXref
id: P21912
db: UniProt

TransportCatalysis5318
type: Catalysis
controller: Low affinity cationic amino acid transporter 2
controlled: Transport14489
control type: ACTIVATION

TransportCatalysis5316
type: Catalysis
controller: Histone H3.1 complex
controlled: Transport14487
control type: ACTIVATION

TransportCatalysis5317
type: Catalysis
controller: ILF3-XPO5 complex
controlled: Transport14488
control type: ACTIVATION

TransportCatalysis5314
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 1
controlled: Transport14482
control type: ACTIVATION

TransportCatalysis5315
type: Catalysis
controller: Monocarboxylate transporter 4
controlled: Transport14485
control type: ACTIVATION

TransportCatalysis5312
type: Catalysis
controller: Solute carrier family 22 member 5
controlled: Transport14475
control type: ACTIVATION

TransportCatalysis5313
type: Catalysis
controller: Solute carrier family 13 member 3
controlled: Transport14481
control type: ACTIVATION

Reference/UniProt P19838
type: UnificationXref
id: P19838
db: UniProt

ChemicalStructure/PW C001006
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC

Reference/UniProt Q8IUC6
type: UnificationXref
id: Q8IUC6
db: UniProt

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/BioCyc (-)o-acetylcarnitine
type: UnificationXref
id: (-)o-acetylcarnitine
db: BioCyc

Pyruvate kinase PKM
type: Protein
cellular location: Cytoplasm
entity reference: Pyruvate kinase PKM

Serine/threonine-protein kinase mTOR
type: Protein
cellular location: Nucleus
entity reference: Serine/threonine-protein kinase mTOR

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Nucleus
entity reference: Hypoxia-inducible factor 1-alpha

Histone-binding protein RBBP4
type: ProteinReference
xref: Reference/UniProt Q09028

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C105126/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adrenocorticotropic hormone
stoichiometric coefficient: 1.0

Interferon gamma
type: ProteinReference
xref: Reference/UniProt P01579
organism: BiologicalState1169

Reference/BioCyc QH2
type: UnificationXref
id: QH2
db: BioCyc

Tumor necrosis factor
type: ProteinReference
xref: Reference/UniProt P01375
organism: BiologicalState1169

Inflammasome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0097169

Protein/8667/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin enhancer-binding factor 3
stoichiometric coefficient: 1.0

Compound/PW C001006 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: QH2
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Interleukin-10
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-10
name: SubPathwayInput

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt Q63HM1
organism: BiologicalState1169

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Pituitary Gland
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001073

Coenzyme Q10
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme Q10

Tumor necrosis factor
type: Protein
cellular location: Nucleus
entity reference: Tumor necrosis factor

Reference/UniProt P48551
type: UnificationXref
id: P48551
db: UniProt

Protein/8911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 2
stoichiometric coefficient: 1.0

Reference/BioCyc FADH2
type: UnificationXref
id: FADH2
db: BioCyc

Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Protein/8910 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 1
stoichiometric coefficient: 1.0

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

TICAM1-TICAM2-TLR4 complex
type: Complex
component stoichiometry: Protein/9558 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2033 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/9559 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Toll-like receptor 4
component: TIR domain-containing adapter molecule 1
component: TIR domain-containing adapter molecule 2

Protein/188 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

mTOR-signaling complex (mTOR/FRAP1, RAPTOR)
type: Complex
component stoichiometry: Protein/2017 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/9135 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Regulatory-associated protein of mTOR
component: Serine/threonine-protein kinase mTOR
name: SubPathwayInhibition

D-Glucose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Glucose
name: SubPathwayInput

Reference/PubChem-compound 11970143
type: UnificationXref
id: 11970143
db: PubChem-compound

Protein/8260/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone H3.1
stoichiometric coefficient: 1.0

Reference/UniProt O14929
type: UnificationXref
id: O14929
db: UniProt

ProteinComplex/2353/Stoichiometry/1.0
type: Stoichiometry
physical entity: IFNB1-IFNAR1-IFNAR2- complex
stoichiometric coefficient: 1.0

Compound/PW C000048/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 446013
type: UnificationXref
id: 446013
db: PubChem-compound

Protein/23940 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Cytoplasm
entity reference: Hypoxia-inducible factor 1-alpha

Reference/BRENDA TISSUE ONTOLOGY BTO 0001073
type: UnificationXref
id: BTO:0001073
db: BRENDA TISSUE ONTOLOGY

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

Protein/4648/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone acetyltransferase type B catalytic subunit
stoichiometric coefficient: 1.0

T cell Autophagy and Anergy
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118356
pathway component: SubPathwayInteraction118356
name: SubPathway

TIR domain-containing adapter molecule 1
type: Protein
cellular location: Cytoplasm
entity reference: TIR domain-containing adapter molecule 1

Virus Not Cleared
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118357
pathway component: SubPathwayInteraction118357
name: SubPathway

General Control Non-Depressible 2 Kinase (GCN2K) Pathway
type: Pathway
name: InhibitorySubPathway

Protein Kinase C Signaling
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118355
pathway component: SubPathwayInteraction118355
name: SubPathway

Protein/2120 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon beta precursor
stoichiometric coefficient: 1.0

Reference/UniProt P01574
type: UnificationXref
id: P01574
db: UniProt

Solute carrier family 22 member 8
type: ProteinReference
xref: Reference/UniProt Q8TCC7

Epinephrine
type: SmallMolecule
entity reference: Epinephrine

L-Acetylcarnitine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Acetylcarnitine

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

FADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FADH

Cortisol
type: SmallMolecule
entity reference: Cortisol

Cortisol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00735
xref: Reference/CAS 50-23-7
xref: Reference/PubChem-compound 5754
xref: Reference/HMDB HMDB0000063
xref: Reference/ChemSpider 5551
xref: Reference/ChEBI CHEBI 17650
chemical formula: C21H30O5
molecular weight: 362.20932
structure: ChemicalStructure/PW C000045

Reference/UniProt P01579
type: UnificationXref
id: P01579
db: UniProt

Reference/ChEBI CHEBI 46245
type: UnificationXref
id: CHEBI:46245
db: ChEBI

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/UniProt P01584
type: UnificationXref
id: P01584
db: UniProt

Reference/PubChem-compound 5754
type: UnificationXref
id: 5754
db: PubChem-compound

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/UniProt Q8WWT9
type: UnificationXref
id: Q8WWT9
db: UniProt

Interleukin-6
type: Protein
entity reference: Interleukin-6

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/14361 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aryl hydrocarbon receptor
component: L-Kynurenine

Compound/PW C000129 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

ProteinComplex/1023/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 1.0

Solute carrier family 13 member 3
type: Protein
entity reference: Solute carrier family 13 member 3

Reference/CAS 3040-38-8
type: UnificationXref
id: 3040-38-8
db: CAS

Compound/PW C000129/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

L-Kynurenine
type: SmallMolecule
cellular location: Nucleus
entity reference: L-Kynurenine

Protein/8867/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone H4
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Tumor necrosis factor
type: Protein
cellular location: Cytosol
entity reference: Tumor necrosis factor

Interleukin-1 beta
type: Protein
cellular location: Inflammasome
entity reference: Interleukin-1 beta

Interferon regulatory factor 3
type: Protein
cellular location: Cytoplasm
entity reference: Interferon regulatory factor 3

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
right: L-Kynurenine
right: Formic acid
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

ChemicalStructure/PW C104587
type: ChemicalStructure
structure format: SMILES

Pyruvate kinase PKM
type: Complex
component stoichiometry: Protein/710 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Pyruvate kinase PKM

Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Protein/14789/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-1 beta
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Reference/UniProt P14618
type: UnificationXref
id: P14618
db: UniProt

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

TIR domain-containing adapter molecule 1
type: Protein
cellular location: Cell Membrane
entity reference: TIR domain-containing adapter molecule 1

Epinephrine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000068
xref: Reference/KEGG Compound C00788
xref: Reference/PubChem-compound 5816
xref: Reference/ChemSpider 5611
xref: Reference/CAS 51-43-4
xref: Reference/BioCyc L-EPINEPHRINE
xref: Reference/ChEBI CHEBI 28918
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000048

Solute carrier family 22 member 5
type: ProteinReference
xref: Reference/UniProt O76082

Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Protein/23934 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Nucleus
entity reference: Indoleamine 2,3-dioxygenase 1

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Reference/UniProt Q8TEX9
type: UnificationXref
id: Q8TEX9
db: UniProt

Succinic acid_Pyruvate kinase PKM (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000174 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/1134 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Pyruvate kinase PKM
component: Succinic acid

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Reference/PathWhiz PW000630
type: UnificationXref
id: PW000630
db: PathWhiz

Importin-4
type: ProteinReference
xref: Reference/UniProt Q8TEX9

Low affinity cationic amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt P52569

Protein/8956 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon regulatory factor 3
stoichiometric coefficient: 1.0

Reference/UniProt P68431
type: UnificationXref
id: P68431
db: UniProt

ProteinComplex/1023 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Histone-binding protein RBBP4
type: Protein
entity reference: Histone-binding protein RBBP4

Reference/UniProt O76082
type: UnificationXref
id: O76082
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Protein/869 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 2.0

Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Protein/14361 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

Citric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30769
xref: Reference/BioCyc CIT
xref: Reference/HMDB HMDB0000094
xref: Reference/PubChem-compound 19782904
xref: Reference/KEGG Compound C00158
xref: Reference/CAS 77-92-9
xref: Reference/ChemSpider 305
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000063

Compound/PW C000396/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16412
type: UnificationXref
id: CHEBI:16412
db: ChEBI

Protein/145 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Tumor necrosis factor
type: Protein
entity reference: Tumor necrosis factor

ChemicalStructure/PW C000846
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

BoundComplex/583 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Interferon beta precursor
type: ProteinReference
xref: Reference/UniProt P01574
organism: BiologicalState1169

Protein/710 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate kinase PKM
stoichiometric coefficient: 2.0

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

BoundComplex/583 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Monocarboxylate transporter 4
type: ProteinReference
xref: Reference/UniProt O15427

Interferon alpha/beta receptor 1
type: ProteinReference
xref: Reference/UniProt P17181
organism: BiologicalState1169

Interferon alpha/beta receptor 2
type: ProteinReference
xref: Reference/UniProt P48551
organism: BiologicalState1169

Reference/KEGG Compound C00735
type: UnificationXref
id: C00735
db: KEGG Compound

SubPathwayControl118491
type: Interaction
name: InhibitorySubPathwayControl
name: SubPathway118491Control
participant: Nitric oxide
participant: Citric acid
participant: Tricarboxylic acid cycle
participant: L-Acetylcarnitine

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

ProteinComplex/938 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 1.0

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

Transport42
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0125493
type: UnificationXref
id: SMP0125493
db: SMPDB

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Compound/PW C000396 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 2.0

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

Protein/2033 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Protein/428 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleamine 2,3-dioxygenase 1
stoichiometric coefficient: 1.0

Solute carrier family 22 member 2
type: Protein
entity reference: Solute carrier family 22 member 2

Reference/SMPDB SMP0125485
type: UnificationXref
id: SMP0125485
db: SMPDB

L-Arginine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Arginine

Protein/1794 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Solute carrier family 2, facilitated glucose transporter member 1
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Solute carrier family 2, facilitated glucose transporter member 1
type: Protein
cellular location: Nucleus
entity reference: Solute carrier family 2, facilitated glucose transporter member 1

Solute carrier family 2, facilitated glucose transporter member 1
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 1

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P21912
organism: BiologicalState1169

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Interaction3827
type: MolecularInteraction
interaction type: direct_interaction
name: Adrenocorticotropic hormone activates Cortisol
participant: Cortisol
participant: Adrenocorticotropic hormone

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Compound/PW C000846 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Protein/116 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Protein/9558 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 1
stoichiometric coefficient: 1.0

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N'-Formylkynurenine

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: Reference/UniProt P42224
organism: BiologicalState1169

Interferon regulatory factor 3
type: ProteinReference
xref: Reference/UniProt Q14653
organism: BiologicalState1169

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

Protein/9559 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00788
type: UnificationXref
id: C00788
db: KEGG Compound

Protein/9558 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 1
stoichiometric coefficient: 1.0

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

BoundComplex/587 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
stoichiometric coefficient: 1.0

Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reaction213297
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000723 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000396 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001867 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/4.0
right: Citrulline
right: Water
right: Nitric oxide
right: NADP
spontaneous: false
left: Oxygen
left: Hydrogen Ion
left: L-Arginine
left: NADPH
name: Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Egl nine homolog 2
type: Protein
cellular location: Cytoplasm
entity reference: Egl nine homolog 2

Toll-like receptor 4
type: Protein
cellular location: Extracellular Space
entity reference: Toll-like receptor 4

Reference/UniProt P42224
type: UnificationXref
id: P42224
db: UniProt

Interleukin-10
type: Protein
cellular location: Nucleus
entity reference: Interleukin-10

Compound/PW C000174 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Corticoliberin
type: Protein
entity reference: Corticoliberin

Citrulline
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Citrulline

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

direct_interaction
type: InteractionVocabulary

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Histone H4
type: ProteinReference
xref: Reference/UniProt P62805

Unknown
type: ProteinReference

Reference/HMDB HMDB0000094
type: UnificationXref
id: HMDB0000094
db: HMDB

Protein/2033 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Protein/1808 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

Protein/869 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 2.0

Reference/SMPDB SMP0000654
type: UnificationXref
id: SMP0000654
db: SMPDB

Protein/8910/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 1
stoichiometric coefficient: 1.0

Transport14513
type: Transport
participant stoichiometry: Protein/428 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/428 Cytoplasm/Stoichiometry/1.0
right: Indoleamine 2,3-dioxygenase 1
spontaneous: true
left: Indoleamine 2,3-dioxygenase 1
name: Indoleamine 2,3-dioxygenase 1 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

Histone acetyltransferase type B catalytic subunit
type: Protein
entity reference: Histone acetyltransferase type B catalytic subunit

Transport14512
type: Transport
participant stoichiometry: BoundComplex/583 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytoplasm/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis202881
type: Catalysis
controller: Nitric oxide synthase, inducible
controlled: Reaction213297
control type: ACTIVATION

Transport14514
type: Transport
participant stoichiometry: Protein/20827 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/20827 Nucleus/Stoichiometry/1.0
right: Interleukin-10
spontaneous: true
left: Interleukin-10
name: Interleukin-10 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

Interleukin-1 beta
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-1 beta
name: SubPathwayInput

Compound/PW C001065 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0001197
type: UnificationXref
id: HMDB0001197
db: HMDB

Reaction218819
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000174 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/584 Cytoplasm/Stoichiometry/1.0
right: Succinic acid_Pyruvate kinase PKM (Homo sapiens)
spontaneous: false
left: Pyruvate kinase PKM
left: Succinic acid
name: Pyruvate kinase PKM + Succinic acid → Succinic acid + Pyruvate kinase PKM (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

TICAM1-TICAM2-TLR4 complex
type: Complex
component stoichiometry: Protein/9559 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/9558 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/2033 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Toll-like receptor 4
component: TIR domain-containing adapter molecule 1
component: TIR domain-containing adapter molecule 2

Reaction218817
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/14361 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytoplasm/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine
left: Aryl hydrocarbon receptor
name: Aryl hydrocarbon receptor + L-Kynurenine → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Nitric oxide synthase, inducible
type: Complex
component stoichiometry: Protein/869 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Nitric oxide synthase, inducible

Reference/GENE ONTOLOGY GO 0097169
type: UnificationXref
id: GO:0097169
db: GENE ONTOLOGY

Reference/PubChem-compound 5281915
type: UnificationXref
id: 5281915
db: PubChem-compound

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

ProteinComplex/1134 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvate kinase PKM
stoichiometric coefficient: 1.0

FADH
type: SmallMoleculeReference
xref: Reference/PubChem-compound 446013
xref: Reference/ChEBI CHEBI 17877
xref: Reference/BioCyc FADH2
xref: Reference/KEGG Compound C01352
xref: Reference/ChemSpider 393487
xref: Reference/HMDB HMDB0001197
xref: Reference/CAS 1910-41-4
chemical formula: C27H35N9O15P2
molecular weight: 787.1728
structure: ChemicalStructure/PW C000932

Reference/ChemSpider 5611
type: UnificationXref
id: 5611
db: ChemSpider

Reference/SMPDB SMP0125522
type: UnificationXref
id: SMP0125522
db: SMPDB

Interleukin-1 beta
type: Protein
entity reference: Interleukin-1 beta
name: SubPathwayActivator

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reaction218820
type: BiochemicalReaction
participant stoichiometry: BoundComplex/585 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/14788 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/584 Cytoplasm/Stoichiometry/1.0
right: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
spontaneous: false
left: Hypoxia-inducible factor 1-alpha
left: Succinic acid_Pyruvate kinase PKM (Homo sapiens)
name: Succinic acid + Pyruvate kinase PKM (Homo sapiens) + hypoxia-inducible factor-1α → Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cell Membrane
entity reference: Myeloid differentiation primary response protein MyD88

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/14361 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: L-Kynurenine
component: Aryl hydrocarbon receptor

Compound/PW C001867/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Nitric oxide
type: SmallMolecule
entity reference: Nitric oxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Interleukin enhancer-binding factor 3
type: ProteinReference
xref: Reference/UniProt Q12906

Protein/8261/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear autoantigenic sperm protein
stoichiometric coefficient: 1.0

ReactionCatalysis2059
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

ChemicalStructure/PW C000932
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P52569
type: UnificationXref
id: P52569
db: UniProt

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

Reference/CAS 1910-41-4
type: UnificationXref
id: 1910-41-4
db: CAS

Cis-aconitate decarboxylase
type: Protein
cellular location: Cytoplasm
entity reference: Cis-aconitate decarboxylase

ProteinComplex/1134 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvate kinase PKM
stoichiometric coefficient: 1.0

Protein/14789 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-1 beta
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt P19838
organism: BiologicalState1169

Protein/23940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000614
type: UnificationXref
id: BTO:0000614
db: BRENDA TISSUE ONTOLOGY

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Reference/UniProt Q8N122
type: UnificationXref
id: Q8N122
db: UniProt

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/PubChem-compound 1
type: UnificationXref
id: 1
db: PubChem-compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Kynurenine formamidase
type: Protein
cellular location: Cytoplasm
entity reference: Kynurenine formamidase

Reference/UniProt Q8TCC7
type: UnificationXref
id: Q8TCC7
db: UniProt

Reference/UniProt P52789
type: UnificationXref
id: P52789
db: UniProt

Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
type: Complex
component stoichiometry: ProteinComplex/1134 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/23934 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C000174 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Pyruvate kinase PKM
component: Succinic acid
component: Hypoxia-inducible factor 1-alpha

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid

Reference/KEGG Compound C02571
type: UnificationXref
id: C02571
db: KEGG Compound

Reference/KEGG Compound C00390
type: UnificationXref
id: C00390
db: KEGG Compound

TIR domain-containing adapter molecule 2
type: Protein
cellular location: Cytoplasm
entity reference: TIR domain-containing adapter molecule 2

Reference/UniProt P06850
type: UnificationXref
id: P06850
db: UniProt

Indoleamine 2,3-dioxygenase 1
type: ProteinReference
xref: Reference/UniProt P14902
organism: BiologicalState1169

Reference/CAS 56275-39-9
type: UnificationXref
id: 56275-39-9
db: CAS

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

Reference/KEGG Compound C00158
type: UnificationXref
id: C00158
db: KEGG Compound

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

TIR domain-containing adapter molecule 1
type: ProteinReference
xref: Reference/UniProt Q8IUC6
organism: BiologicalState1169

TIR domain-containing adapter molecule 2
type: ProteinReference
xref: Reference/UniProt Q86XR7
organism: BiologicalState1169

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

Reference/UniProt Q12906
type: UnificationXref
id: Q12906
db: UniProt

Hexokinase-2
type: Protein
cellular location: Cytoplasm
entity reference: Hexokinase-2
name: SubPathwayOutput

ProteinComplex/1023 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 1.0

Lipopolysaccharide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lipopolysaccharide

Reference/ChemSpider 4445197
type: UnificationXref
id: 4445197
db: ChemSpider

Reference/CAS 303-98-0
type: UnificationXref
id: 303-98-0
db: CAS

ChemicalStructure/PW C000063
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(O)(CC(O)=O)C(O)=O

ChemicalStructure/PW C105126
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/UniProt O00206
type: UnificationXref
id: O00206
db: UniProt

Solute carrier family 13 member 3
type: ProteinReference
xref: Reference/UniProt Q8WWT9

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: Reference/UniProt Q16665
organism: BiologicalState1169

Hexokinase-2
type: ProteinReference
xref: Reference/UniProt P52789
organism: BiologicalState1169

Citric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Citric acid
name: SubPathwayInhibition

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Cis-aconitate decarboxylase
type: ProteinReference
xref: Reference/UniProt A6NK06
organism: BiologicalState1169

Reference/UniProt P49321
type: UnificationXref
id: P49321
db: UniProt

Interaction4212
type: MolecularInteraction
interaction type: direct_interaction
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates Interleukin-10
participant: Interleukin-10
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)

Interaction4211
type: MolecularInteraction
interaction type: direct_interaction
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit (Homo sapiens) activates Indoleamine 2,3-dioxygenase 1
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
participant: Indoleamine 2,3-dioxygenase 1

Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

Histone H3.1
type: ProteinReference
xref: Reference/UniProt P68431

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Nuclear autoantigenic sperm protein
type: ProteinReference
xref: Reference/UniProt P49321

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

Chromatin assembly factor 1 subunit A
type: ProteinReference
xref: Reference/UniProt Q13111

Reference/ChemSpider 305
type: UnificationXref
id: 305
db: ChemSpider

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Histone chaperone ASF1A
type: ProteinReference
xref: Reference/UniProt Q9Y294

Histone chaperone ASF1B
type: ProteinReference
xref: Reference/UniProt Q9NVP2

Interleukin-6
type: ProteinReference
xref: Reference/UniProt P05231
organism: BiologicalState1169

Chromatin assembly factor 1 subunit B
type: ProteinReference
xref: Reference/UniProt Q13112

Histone H4
type: Protein
entity reference: Histone H4

ChemicalStructure/PW C000048
type: ChemicalStructure
structure format: SMILES
structure data: CNC[C@H](O)C1=CC(O)=C(O)C=C1

ChemicalStructure/PW C000045
type: ChemicalStructure
structure format: SMILES

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Adrenocorticotropic hormone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 16132265
chemical formula: C207H308N56O58S
molecular weight: 4538.2593
structure: ChemicalStructure/PW C105126

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Protein/9559 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 2
stoichiometric coefficient: 1.0

Nitric oxide synthase, inducible
type: ProteinReference
xref: Reference/UniProt P35228
organism: BiologicalState1169

QH2
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: QH2

Reference/UniProt P11166
type: UnificationXref
id: P11166
db: UniProt

Protein/9135 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Regulatory-associated protein of mTOR
stoichiometric coefficient: 1.0

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766 Nucleus/Stoichiometry/3.0
cellular location: Nucleus
component: Tumor necrosis factor

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

Protein/14789 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-1 beta
stoichiometric coefficient: 1.0

Reference/UniProt P01375
type: UnificationXref
id: P01375
db: UniProt

Reference/BioCyc L-EPINEPHRINE
type: UnificationXref
id: L-EPINEPHRINE
db: BioCyc

Protein/3684/Stoichiometry/1.0
type: Stoichiometry
physical entity: Importin-4
stoichiometric coefficient: 1.0

TIR domain-containing adapter molecule 1
type: Protein
cellular location: Extracellular Space
entity reference: TIR domain-containing adapter molecule 1

SubPathwayInteraction118353
type: Interaction
name: SubPathway118353Reaction
name: SubPathwayReaction
participant: Interleukin-10

SubPathwayInteraction118351
type: Interaction
name: SubPathway118351Reaction
name: SubPathwayReaction
participant: Interleukin-1 beta

SubPathwayInteraction118356
type: Interaction
name: SubPathwayReaction
name: SubPathway118356Reaction

SubPathwayInteraction118357
type: Interaction
name: SubPathway118357Reaction
name: SubPathwayReaction

L-Acetylcarnitine
type: SmallMolecule
entity reference: L-Acetylcarnitine

Regulatory-associated protein of mTOR
type: ProteinReference
xref: Reference/UniProt Q8N122
organism: BiologicalState1169

SubPathwayInteraction118355
type: Interaction
name: SubPathway118355Reaction
name: SubPathwayReaction

Reference/HMDB HMDB0000068
type: UnificationXref
id: HMDB0000068
db: HMDB

SubPathwayInteraction118349
type: Interaction
name: SubPathway118349Reaction
name: SubPathwayReaction
participant: Hexokinase-2
participant: L-Lactic acid
participant: D-Glucose

Macrophage
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000235

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Protein/2017 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine/threonine-protein kinase mTOR
stoichiometric coefficient: 1.0

L-Lactic acid
type: SmallMolecule
entity reference: L-Lactic acid

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Reference/HMDB HMDB0000063
type: UnificationXref
id: HMDB0000063
db: HMDB

Exportin-5
type: ProteinReference
xref: Reference/UniProt Q9HAV4

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/9559 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 2
stoichiometric coefficient: 1.0

Interferon alpha/beta receptor 1
type: Protein
cellular location: Nucleus
entity reference: Interferon alpha/beta receptor 1

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/CAS 50-23-7
type: UnificationXref
id: 50-23-7
db: CAS

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Compound/PW C001867 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 1.0

Reference/UniProt Q99643
type: UnificationXref
id: Q99643
db: UniProt

Formic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Formic acid

Interleukin enhancer-binding factor 3
type: Protein
entity reference: Interleukin enhancer-binding factor 3

Protein/1794 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Solute carrier family 2, facilitated glucose transporter member 1
stoichiometric coefficient: 1.0

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/188 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/116 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/145 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/174 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/UniProt Q16665
type: UnificationXref
id: Q16665
db: UniProt

Protein/23934 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxia-inducible factor 1-alpha
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor
type: ProteinReference
xref: Reference/UniProt P35869
organism: BiologicalState1169

Solute carrier family 2, facilitated glucose transporter member 1
type: ProteinReference
xref: Reference/UniProt P11166

Reference/ChEBI CHEBI 28918
type: UnificationXref
id: CHEBI:28918
db: ChEBI

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytoplasm
entity reference: Indoleamine 2,3-dioxygenase 1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Nitric oxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Nitric oxide
name: SubPathwayInhibitor

Reference/BioCyc CIT
type: UnificationXref
id: CIT
db: BioCyc

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Solute carrier family 22 member 2
type: ProteinReference
xref: Reference/UniProt O15244

Interferon alpha/beta receptor 2
type: Protein
cellular location: Nucleus
entity reference: Interferon alpha/beta receptor 2

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

Lipopolysaccharide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16412
xref: Reference/PubChem-compound 11970143
chemical formula: C205H366N3O117P5
molecular weight: 4897.147
structure: ChemicalStructure/PW C104587

QH2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001304
xref: Reference/BioCyc QH2
xref: Reference/PubChem-compound 5280344
xref: Reference/KEGG Compound C00390
xref: Reference/CAS 56275-39-9
xref: Reference/ChemSpider 4444052
chemical formula: (C5H8)nC14H20O4
structure: ChemicalStructure/PW C001006

Pyruvate kinase PKM
type: ProteinReference
xref: Reference/UniProt P14618
organism: BiologicalState1169

Protein/1808 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

Hypothalamus
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000614

Interleukin-10
type: ProteinReference
xref: Reference/UniProt P22301
organism: BiologicalState1169

L-Acetylcarnitine
type: SmallMoleculeReference
xref: Reference/CAS 3040-38-8
xref: Reference/PubChem-compound 1
xref: Reference/ChemSpider 21243783
xref: Reference/HMDB HMDB0000201
xref: Reference/KEGG Compound C02571
xref: Reference/BioCyc (-)o-acetylcarnitine
xref: Reference/ChEBI CHEBI 73024
chemical formula: C9H17NO4
molecular weight: 203.11575
structure: ChemicalStructure/PW C000129

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

IFNB1-IFNAR1-IFNAR2- complex
type: Complex
component stoichiometry: Protein/2120/Stoichiometry/1.0
component stoichiometry: Protein/8911/Stoichiometry/1.0
component stoichiometry: Protein/8910/Stoichiometry/1.0
component: Interferon beta precursor
component: Interferon alpha/beta receptor 2
component: Interferon alpha/beta receptor 1

Reference/UniProt Q9NVP2
type: UnificationXref
id: Q9NVP2
db: UniProt

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C000122/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

L-Arginine
type: SmallMolecule
entity reference: L-Arginine

Reference/UniProt Q99836
type: UnificationXref
id: Q99836
db: UniProt

Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/ChemSpider 393487
type: UnificationXref
id: 393487
db: ChemSpider

Aryl hydrocarbon receptor
type: Protein
cellular location: Cytoplasm
entity reference: Aryl hydrocarbon receptor

ProteinComplex/938 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 1.0

Reference/UniProt P35228
type: UnificationXref
id: P35228
db: UniProt

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4

Compound/PW C000723 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 2.0

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Reference/CAS 77-92-9
type: UnificationXref
id: 77-92-9
db: CAS

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

Reference/HMDB HMDB0000201
type: UnificationXref
id: HMDB0000201
db: HMDB

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766/Stoichiometry/3.0
component: Tumor necrosis factor

L-Lactic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Lactic acid
name: SubPathwayOutput

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Protein/23940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-6
stoichiometric coefficient: 1.0

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ReactionCatalysis1353
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

Adrenocorticotropic hormone
type: SmallMolecule
entity reference: Adrenocorticotropic hormone

Protein/8259/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chromatin assembly factor 1 subunit B
stoichiometric coefficient: 1.0

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Reference/CAS 51-43-4
type: UnificationXref
id: 51-43-4
db: CAS

ChemicalStructure/PW C000129
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Compound/PW C001867 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001304
type: UnificationXref
id: HMDB0001304
db: HMDB

Reference/PubChem-compound 5816
type: UnificationXref
id: 5816
db: PubChem-compound

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Cis-aconitate decarboxylase
type: Protein
cellular location: Nucleus
entity reference: Cis-aconitate decarboxylase

Nitric oxide synthase, inducible
type: Protein
cellular location: Cytoplasm
entity reference: Nitric oxide synthase, inducible

Reference/UniProt P62805
type: UnificationXref
id: P62805
db: UniProt

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

TIR domain-containing adapter molecule 2
type: Protein
cellular location: Cell Membrane
entity reference: TIR domain-containing adapter molecule 2

Protein/8258/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone chaperone ASF1B
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Interleukin-6
type: Protein
cellular location: Nucleus
entity reference: Interleukin-6

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/UniProt P31040
type: UnificationXref
id: P31040
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Protein/23930 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cis-aconitate decarboxylase
stoichiometric coefficient: 1.0

Egl nine homolog 2
type: ProteinReference
xref: Reference/UniProt Q96KS0
organism: BiologicalState1169

Histone acetyltransferase type B catalytic subunit
type: ProteinReference
xref: Reference/UniProt O14929

Regulatory-associated protein of mTOR
type: Protein
cellular location: Nucleus
entity reference: Regulatory-associated protein of mTOR

ReactionCatalysis75
type: Catalysis
controller: Succinate dehydrogenase
controlled: 1.3.5.1
control type: ACTIVATION

Reference/ChemSpider 4444052
type: UnificationXref
id: 4444052
db: ChemSpider

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

Histone chaperone ASF1B
type: Protein
entity reference: Histone chaperone ASF1B

Histone chaperone ASF1A
type: Protein
entity reference: Histone chaperone ASF1A

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Reference/PubChem-compound 5280344
type: UnificationXref
id: 5280344
db: PubChem-compound

Chromatin assembly factor 1 subunit B
type: Protein
entity reference: Chromatin assembly factor 1 subunit B

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Corticoliberin
type: ProteinReference
xref: Reference/UniProt P06850
organism: BiologicalState64

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt Q99836
organism: BiologicalState1169

Compound/PW C000122 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor
type: Protein
cellular location: Nucleus
entity reference: Aryl hydrocarbon receptor

Reference/UniProt Q9HAV4
type: UnificationXref
id: Q9HAV4
db: UniProt

Compound/PW C000174 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Transport14497
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
right: Interleukin-1 beta
spontaneous: true
left: Interleukin-1 beta
name: Interleukin-1 beta (→) Transport: Homo sapiens, Liver to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Protein/428 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleamine 2,3-dioxygenase 1
stoichiometric coefficient: 1.0

Transport14494
type: Transport
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: Epinephrine
spontaneous: false
left: Epinephrine
name: Epinephrine (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Transport14493
type: Transport
participant stoichiometry: Compound/PW C000045/Stoichiometry/1.0
right: Cortisol
spontaneous: false
left: Cortisol
name: Cortisol (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14496
type: Transport
participant stoichiometry: ProteinComplex/1023/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/2353/Stoichiometry/1.0
right: Tumor necrosis factor
right: IFNB1-IFNAR1-IFNAR2- complex
spontaneous: true
left: Tumor necrosis factor
left: IFNB1-IFNAR1-IFNAR2- complex
name: Tumor necrosis factor (→), IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
conversion direction: REVERSIBLE

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

Transport14495
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
participant stoichiometry: Protein/23940/Stoichiometry/1.0
right: Interleukin-1 beta
right: Interleukin-6
spontaneous: true
left: Interleukin-1 beta
left: Interleukin-6
name: Interleukin-6 (→), Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
conversion direction: REVERSIBLE

Nuclear autoantigenic sperm protein
type: Protein
entity reference: Nuclear autoantigenic sperm protein

Histone H3.1
type: Protein
entity reference: Histone H3.1

Transport14492
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
participant stoichiometry: Protein/14789 Inflammasome/Stoichiometry/1.0
right: Interleukin-1 beta
spontaneous: false
left: Interleukin-1 beta
name: Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Inflammasome to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14491
type: Transport
participant stoichiometry: Protein/14789 Inflammasome/Stoichiometry/1.0
participant stoichiometry: Protein/14789 Cytoplasm/Stoichiometry/1.0
right: Interleukin-1 beta
spontaneous: true
left: Interleukin-1 beta
name: Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Inflammasome to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

Histone H3.1 complex
type: Complex
component stoichiometry: Protein/8259/Stoichiometry/1.0
component stoichiometry: Protein/8867/Stoichiometry/1.0
component stoichiometry: Protein/8257/Stoichiometry/1.0
component stoichiometry: Protein/8263/Stoichiometry/1.0
component stoichiometry: Protein/8260/Stoichiometry/1.0
component stoichiometry: Protein/4648/Stoichiometry/1.0
component stoichiometry: Protein/3684/Stoichiometry/1.0
component stoichiometry: Protein/8261/Stoichiometry/1.0
component stoichiometry: Protein/8258/Stoichiometry/1.0
component stoichiometry: Protein/8146/Stoichiometry/1.0
component: Histone chaperone ASF1B
component: Histone chaperone ASF1A
component: Histone-binding protein RBBP4
component: Histone H4
component: Importin-4
component: Chromatin assembly factor 1 subunit B
component: Nuclear autoantigenic sperm protein
component: Histone H3.1
component: Histone acetyltransferase type B catalytic subunit
component: Chromatin assembly factor 1 subunit A

Chromatin assembly factor 1 subunit A
type: Protein
entity reference: Chromatin assembly factor 1 subunit A

Protein/2120/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon beta precursor
stoichiometric coefficient: 1.0

Interferon beta precursor
type: Protein
cellular location: Nucleus
entity reference: Interferon beta precursor

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/PubChem-compound 19782904
type: UnificationXref
id: 19782904
db: PubChem-compound

TransportCatalysis15
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport42
control type: ACTIVATION

Transport14487
type: Transport
participant stoichiometry: BoundComplex/585 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/585 Nucleus/Stoichiometry/1.0
right: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
spontaneous: false
left: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
name: Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: LEFT_TO_RIGHT

Transport14489
type: Transport
participant stoichiometry: Compound/PW C000396/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000396 Cytoplasm/Stoichiometry/1.0
right: L-Arginine
spontaneous: false
left: L-Arginine
name: L-Arginine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport14488
type: Transport
participant stoichiometry: Protein/14789 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1794 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/14789 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/1794 Cytoplasm/Stoichiometry/1.0
right: Interleukin-1 beta
right: Solute carrier family 2, facilitated glucose transporter member 1
spontaneous: false
left: Solute carrier family 2, facilitated glucose transporter member 1
left: Interleukin-1 beta
name: Interleukin-1 beta (→), Solute carrier family 2, facilitated glucose transporter member 1 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Compound/PW C000146 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Transport14482
type: Transport
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport14485
type: Transport
participant stoichiometry: Compound/PW C000122 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000122/Stoichiometry/1.0
right: L-Lactic acid
spontaneous: false
left: L-Lactic acid
name: L-Lactic acid (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Compound/PW C000396 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 1.0

Reference/UniProt P22301
type: UnificationXref
id: P22301
db: UniProt

Reference/UniProt P17181
type: UnificationXref
id: P17181
db: UniProt

Transport14481
type: Transport
participant stoichiometry: Compound/PW C000174 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
spontaneous: false
left: Succinic acid
name: Succinic acid (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Mitochondrial Matrix to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Interferon regulatory factor 3
type: Protein
cellular location: Nucleus
entity reference: Interferon regulatory factor 3

Transport14480
type: Transport
participant stoichiometry: Protein/23930 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/23930 Nucleus/Stoichiometry/1.0
right: Cis-aconitate decarboxylase
spontaneous: true
left: Cis-aconitate decarboxylase
name: Cis-aconitate decarboxylase (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001006 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000932 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: FADH
right: QH2
spontaneous: false
EC number: 1.3.5.1
left: Succinic acid
left: FAD
left: Coenzyme Q10
name: Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
conversion direction: REVERSIBLE

Compound/PW C000538 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Hypoxia-inducible factor 1-alpha
type: Protein
cellular location: Cytoplasm
entity reference: Hypoxia-inducible factor 1-alpha

Reference/UniProt Q14653
type: UnificationXref
id: Q14653
db: UniProt

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: Reference/UniProt P42345
organism: BiologicalState1169

Reference/ChEBI CHEBI 17877
type: UnificationXref
id: CHEBI:17877
db: ChEBI

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/1766 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Tumor necrosis factor

Transport14479
type: Transport
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001867/Stoichiometry/1.0
right: Nitric oxide
spontaneous: true
left: Nitric oxide
name: Nitric oxide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Exportin-5
type: Protein
entity reference: Exportin-5

Reference/ChemSpider 5551
type: UnificationXref
id: 5551
db: ChemSpider

Transport14476
type: Transport
participant stoichiometry: Protein/23940/Stoichiometry/1.0
participant stoichiometry: Protein/23940 Cytosol/Stoichiometry/1.0
right: Interleukin-6
spontaneous: true
left: Interleukin-6
name: Interleukin-6 (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14475
type: Transport
participant stoichiometry: Compound/PW C000129/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000129 Cytosol/Stoichiometry/1.0
right: L-Acetylcarnitine
spontaneous: false
left: L-Acetylcarnitine
name: L-Acetylcarnitine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Transport14478
type: Transport
participant stoichiometry: ProteinComplex/1023/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1023 Cytosol/Stoichiometry/1.0
right: Tumor necrosis factor
spontaneous: true
left: Tumor necrosis factor
name: Tumor necrosis factor (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Transport14472
type: Transport
participant stoichiometry: Compound/PW C000045/Stoichiometry/1.0
right: Cortisol
spontaneous: true
left: Cortisol
name: Cortisol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
conversion direction: REVERSIBLE

Transport14473
type: Transport
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: Epinephrine
spontaneous: false
left: Epinephrine
name: Epinephrine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Transport14470
type: Transport
participant stoichiometry: Compound/PW C105126/Stoichiometry/1.0
right: Adrenocorticotropic hormone
spontaneous: true
left: Adrenocorticotropic hormone
name: Adrenocorticotropic hormone (→) Transport: Homo sapiens, Pituitary Gland to Homo sapiens, Adrenal Cortex
conversion direction: REVERSIBLE

BiologicalState1169
type: BioSource
cell type: Macrophage
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, Macrophage
tissue: Blood Vessel

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: Reference/UniProt Q16665
organism: BiologicalState1169

BiologicalState1180
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Hypothalamus
tissue: Hypothalamus

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Transport14469
type: Transport
participant stoichiometry: ProteinComplex/938 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/938 Nucleus/Stoichiometry/1.0
right: Nitric oxide synthase, inducible
spontaneous: true
left: Nitric oxide synthase, inducible
name: Nitric oxide synthase, inducible (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

Transport14468
type: Transport
participant stoichiometry: ProteinComplex/1023/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1023 Nucleus/Stoichiometry/1.0
right: Tumor necrosis factor
spontaneous: true
left: Tumor necrosis factor
name: Tumor necrosis factor (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Succinic acid
type: SmallMolecule
cellular location: Nucleus
entity reference: Succinic acid

Transport14465
type: Transport
participant stoichiometry: Protein/14789/Stoichiometry/1.0
participant stoichiometry: Protein/14789 Nucleus/Stoichiometry/1.0
right: Interleukin-1 beta
spontaneous: true
left: Interleukin-1 beta
name: Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Transport14464
type: Transport
participant stoichiometry: Protein/8956 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/8956 Nucleus/Stoichiometry/1.0
right: Interferon regulatory factor 3
spontaneous: true
left: Interferon regulatory factor 3
name: Interferon regulatory factor 3 IRF3 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: REVERSIBLE

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Transport14467
type: Transport
participant stoichiometry: ProteinComplex/2353 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/2353/Stoichiometry/1.0
right: IFNB1-IFNAR1-IFNAR2- complex
spontaneous: true
left: IFNB1-IFNAR1-IFNAR2- complex
name: IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14466
type: Transport
participant stoichiometry: Protein/23940 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/23940/Stoichiometry/1.0
right: Interleukin-6
spontaneous: true
left: Interleukin-6
name: Interleukin-6 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Transport14463
type: Transport
participant stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Cytoplasm/Stoichiometry/1.0
right: Nuclear factor NF-kappa-B p105 subunit
spontaneous: true
left: Nuclear factor NF-kappa-B p105 subunit
name: Nuclear factor NF-kappa-B p105 subunit (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: REVERSIBLE

Interleukin-1 beta
type: ProteinReference
xref: Reference/UniProt P01584
organism: BiologicalState1169

BoundComplex/585 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/UniProt P35869
type: UnificationXref
id: P35869
db: UniProt

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/14361 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aryl hydrocarbon receptor
component: Nuclear factor NF-kappa-B p105 subunit
component: L-Kynurenine

Protein/14789 Inflammasome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-1 beta
stoichiometric coefficient: 1.0

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

Reference/UniProt Q86XR7
type: UnificationXref
id: Q86XR7
db: UniProt

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt O00206
organism: BiologicalState1169

Nitric oxide synthase, inducible
type: Complex
component stoichiometry: Protein/869 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Nitric oxide synthase, inducible

ProteinComplex/2353 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: IFNB1-IFNAR1-IFNAR2- complex
stoichiometric coefficient: 1.0

Protein/1766/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide

Reference/UniProt Q13112
type: UnificationXref
id: Q13112
db: UniProt

Compound/PW C000045/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisol
stoichiometric coefficient: 1.0

Reference/UniProt Q13111
type: UnificationXref
id: Q13111
db: UniProt

Reaction218835
type: BiochemicalReaction
participant stoichiometry: BoundComplex/587 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
spontaneous: false
left: Nuclear factor NF-kappa-B p105 subunit
left: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

SubPathwayControl118352
type: Interaction
name: SubPathway118352Control
name: ActivatingSubPathwayControl
participant: Interleukin-1 beta
participant: Aerobic Glycolysis (Warburg Effect)

SubPathwayControl118354
type: Interaction
name: SubPathway118354Control
name: InhibitorySubPathwayControl
participant: mTOR-signaling complex (mTOR/FRAP1, RAPTOR)
participant: L-Tryptophan
participant: General Control Non-Depressible 2 Kinase (GCN2K) Pathway

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Solute carrier family 22 member 8
type: Protein
entity reference: Solute carrier family 22 member 8

Reference/UniProt O15244
type: UnificationXref
id: O15244
db: UniProt

Bacterial Sepsis
type: Pathway
pathway order: PathwayInteraction/4185
pathway order: PathwayInteraction/4184
pathway order: PathwayInteraction/4183
pathway order: PathwayInteraction/4182
pathway order: PathwayTransport/2511242
pathway order: PathwayInteraction/4181
pathway order: PathwayTransport/2511241
pathway order: PathwayInteraction/4180
pathway order: PathwayTransport/2511240
pathway order: PathwayInteraction/4212
pathway order: PathwayInteraction/4179
pathway order: PathwayTransport/2511239
pathway order: PathwayInteraction/4178
pathway order: PathwayInteraction/4211
pathway order: PathwayEnzymeReaction/2511229
pathway order: PathwayTransport/2511238
pathway order: PathwayInteraction/4177
pathway order: PathwayTransport/2511237
pathway order: PathwayInteraction/4176
pathway order: PathwayInteraction/4175
pathway order: PathwayInteraction/4174
pathway order: PathwayTransport/2511253
pathway order: PathwayTransport/2511252
pathway order: PathwayTransport/2511251
pathway order: PathwayTransport/2511250
pathway order: PathwayEnzymeReaction/2511231
pathway order: PathwayEnzymeReaction/2511230
pathway order: PathwayEnzymeReaction/2511236
pathway order: PathwaySubPathway/118491
pathway order: PathwayEnzymeReaction/2511233
pathway order: PathwayEnzymeReaction/2511232
pathway order: PathwayEnzymeReaction/2511235
pathway order: PathwayEnzymeReaction/2511234
pathway order: PathwayTransport/2511246
pathway order: PathwayTransport/2511245
pathway order: PathwayTransport/2511244
pathway order: PathwayTransport/2511243
pathway order: PathwayTransport/2511249
pathway order: PathwayTransport/2511248
pathway order: PathwayTransport/2511247
pathway order: PathwayTransport/2511260
pathway order: PathwayTransport/2511264
pathway order: PathwayTransport/2511263
pathway order: PathwayTransport/2511262
pathway order: PathwayTransport/2511261
pathway order: PathwayInteraction/3827
pathway order: PathwayTransport/2511257
pathway order: PathwayTransport/2511256
pathway order: PathwayInteraction/1289
pathway order: PathwayTransport/2511255
pathway order: PathwayTransport/2511254
pathway order: PathwayTransport/2511259
pathway order: PathwayTransport/2511258
pathway order: PathwaySubPathway/118349
pathway order: PathwayInteraction/4192
pathway order: PathwayInteraction/4191
pathway order: PathwayInteraction/4190
pathway order: PathwaySubPathway/118353
pathway order: PathwaySubPathway/118354
pathway order: PathwaySubPathway/118351
pathway order: PathwaySubPathway/118352
pathway order: PathwayTransport/2511268
pathway order: PathwaySubPathway/118357
pathway order: PathwayTransport/2511267
pathway order: PathwaySubPathway/118355
pathway order: PathwayTransport/2511265
pathway order: PathwaySubPathway/118356
pathway order: PathwayInteraction/4189
pathway order: PathwayInteraction/4187
pathway order: PathwayTransport/2511269
pathway order: PathwayInteraction/4186
pathway component: Reaction218835
pathway component: TransportCatalysis5328
pathway component: Interaction4191
pathway component: SubPathwayControl118352
pathway component: Interaction4190
pathway component: TransportCatalysis5323
pathway component: SubPathwayControl118354
pathway component: TransportCatalysis5324

Compound/PW C001420 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 4.0

Compound/PW C000964 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Reference/UniProt Q63HM1
type: UnificationXref
id: Q63HM1
db: UniProt

Protein/8146/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone-binding protein RBBP4
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

ILF3-XPO5 complex
type: Complex
component stoichiometry: Protein/8667/Stoichiometry/1.0
component stoichiometry: Protein/3837/Stoichiometry/1.0
component: Interleukin enhancer-binding factor 3
component: Exportin-5

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

TIR domain-containing adapter molecule 2
type: Protein
cellular location: Extracellular Space
entity reference: TIR domain-containing adapter molecule 2

Reference/UniProt A6NK06
type: UnificationXref
id: A6NK06
db: UniProt

Protein/8263/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chromatin assembly factor 1 subunit A
stoichiometric coefficient: 1.0

Protein/9558 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain-containing adapter molecule 1
stoichiometric coefficient: 1.0

Protein/20827 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-10
stoichiometric coefficient: 1.0

BoundComplex/585 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
stoichiometric coefficient: 1.0

Interleukin-6
type: Protein
cellular location: Cytosol
entity reference: Interleukin-6

Reference/ChemSpider 21243783
type: UnificationXref
id: 21243783
db: ChemSpider

Protein/8257/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone chaperone ASF1A
stoichiometric coefficient: 1.0

Succinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Succinic acid

L-Tryptophan
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Tryptophan
name: SubPathwayInhibitor

Aerobic Glycolysis (Warburg Effect)
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118349
pathway order: SubPathwayInteractionSteps/SubPathway118351
pathway component: SubPathwayInteraction118349
pathway component: SubPathwayInteraction118351
xref: Reference/SMPDB SMP0000654
xref: Reference/PathWhiz PW000630
name: SubPathway

Compound/PW C000935 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

Anti-inflammatory pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118353
pathway component: SubPathwayInteraction118353
xref: Reference/SMPDB SMP0125485
xref: Reference/PathWhiz PW127041
name: SubPathway

Reference/UniProt P14902
type: UnificationXref
id: P14902
db: UniProt

Reference/ChEBI CHEBI 17650
type: UnificationXref
id: CHEBI:17650
db: ChEBI

Protein/8911 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interferon alpha/beta receptor 2
stoichiometric coefficient: 1.0

Reference/UniProt P42345
type: UnificationXref
id: P42345
db: UniProt

Reference/BioCyc UBIQUINONE-10
type: UnificationXref
id: UBIQUINONE-10
db: BioCyc