Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
L-Tryptophan + Oxygen → N'-Formylkynurenine
Myeloid differentiation primary response protein MyD88 activates Nuclear factor NF-kappa-B p105 subunit
TICAM1-TICAM2-TLR4 complex activates Myeloid differentiation primary response protein MyD88
TICAM1-TICAM2-TLR4 complex activates Interferon regulatory factor 3 IRF3
Lipopolysaccharide activates TICAM1-TICAM2-TLR4 complex
Interferon regulatory factor 3 IRF3 activates IFNB1-IFNAR1-IFNAR2- complex
TICAM1-TICAM2-TLR4 complex activates Signal transducer and activator of transcription 1-alpha/beta
Low affinity cationic amino acid transporter 2
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) activates Solute carrier family 2, facilitated glucose transporter member 1
Prolyl hydroxylase EGLN2 inhibits hypoxia-inducible factor-1α
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) activates Interleukin-1 beta
Nuclear factor NF-kappa-B p105 subunit activates Cis-aconitate decarboxylase
Nuclear factor NF-kappa-B p105 subunit activates Interleukin-1 beta
Adrenocorticotropic hormone activates Epinephrine
Corticotropin-releasing hormone activates Adrenocorticotropic hormone
Nuclear factor NF-kappa-B p105 subunit activates Nitric oxide synthase, inducible
Nuclear factor NF-kappa-B p105 subunit activates Interleukin-6
Nuclear factor NF-kappa-B p105 subunit activates Tumor necrosis factor
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Cis-aconitate decarboxylase inhibits Succinate dehydrogenase
Succinic acid + Pyruvate kinase PKM (Homo sapiens) inhibits Prolyl hydroxylase EGLN2
Solute carrier family 2, facilitated glucose transporter member 1
Signal transducer and activator of transcription 1-alpha/beta
Interferon gamma activates Indoleamine 2,3-dioxygenase 1
mTOR-signaling complex (mTOR/FRAP1, RAPTOR)
TIR domain-containing adapter molecule 1
General Control Non-Depressible 2 Kinase (GCN2K) Pathway
L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
Succinic acid_Pyruvate kinase PKM (Homo sapiens)
Myeloid differentiation primary response protein MyD88
D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Adrenocorticotropic hormone activates Cortisol
Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
Solute carrier family 2, facilitated glucose transporter member 2
Indoleamine 2,3-dioxygenase 1 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Histone acetyltransferase type B catalytic subunit
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
Interleukin-10 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Pyruvate kinase PKM + Succinic acid → Succinic acid + Pyruvate kinase PKM (Homo sapiens)
Aryl hydrocarbon receptor + L-Kynurenine → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens)
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + hypoxia-inducible factor-1α → Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens)
TIR domain-containing adapter molecule 2
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates Interleukin-10
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit (Homo sapiens) activates Indoleamine 2,3-dioxygenase 1
Interleukin-1 beta (→) Transport: Homo sapiens, Liver to Homo sapiens, Blood Vessel
Epinephrine (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
Cortisol (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
Tumor necrosis factor (→), IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
Interleukin-6 (→), Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Inflammasome to Homo sapiens, Blood Vessel
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Inflammasome to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
L-Arginine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Interleukin-1 beta (→), Solute carrier family 2, facilitated glucose transporter member 1 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
L-Lactic acid (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel
Succinic acid (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Mitochondrial Matrix to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Cis-aconitate decarboxylase (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
Nitric oxide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Interleukin-6 (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
L-Acetylcarnitine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Tumor necrosis factor (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
Cortisol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
Epinephrine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
Adrenocorticotropic hormone (→) Transport: Homo sapiens, Pituitary Gland to Homo sapiens, Adrenal Cortex
Nitric oxide synthase, inducible (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
Tumor necrosis factor (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Interferon regulatory factor 3 IRF3 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Interleukin-6 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
Nuclear factor NF-kappa-B p105 subunit (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)