Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Vanylglycol
type: SmallMolecule
cellular location: Cytosol
entity reference: Vanylglycol

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Melanosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000968 Melanosome/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001065 Melanosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002045 Melanosome/Stoichiometry/1.0
right: Water
right: Melanin
spontaneous: false
EC number: 1.14.18.1
left: Oxygen
left: 5,6-Dihydroxyindole-2-carboxylic acid
name: 2 5,6-Dihydroxyindole-2-carboxylic acid + Oxygen → Melanin + Water
conversion direction: LEFT_TO_RIGHT

Reaction1130
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002926 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002045 Cytosol/Stoichiometry/1.0
right: Melanin
spontaneous: false
left: Indole-5,6-quinone
name: Indole-5,6-quinone → Melanin
conversion direction: LEFT_TO_RIGHT

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Ammonia

5.3.3.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000968 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001105 Cytosol/Stoichiometry/1.0
right: 5,6-Dihydroxyindole-2-carboxylic acid
spontaneous: false
EC number: 5.3.3.12
left: L-Dopachrome
name: L-Dopachrome → 5,6-Dihydroxyindole-2-carboxylic acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Amiloride-sensitive amine oxidase [copper-containing]
type: ProteinReference
xref: Reference/UniProt P19801
organism: Homo sapiens

ReactionCatalysis825
type: Catalysis
controller: L-dopachrome tautomerase
controlled: 5.3.3.12
control type: ACTIVATION

ReactionCatalysis826
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

ReactionCatalysis823
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

ReactionCatalysis824
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000764 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001081 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074 Cytoplasm/Stoichiometry/1.0
right: Homovanillic acid
right: Pyrocatechol
spontaneous: false
EC number: 2.1.1.6
left: 3,4-Dihydroxybenzeneacetic acid
left: Guaiacol
name: 3,4-Dihydroxybenzeneacetic acid + Guaiacol → Homovanillic acid + Pyrocatechol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

ReactionCatalysis822
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

Reference/BioCyc 56-DIHYDROXYINDOLE-2-CARBOXYLATE
type: UnificationXref
id: 56-DIHYDROXYINDOLE-2-CARBOXYLATE
db: BioCyc

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/CAS 775-01-9
type: UnificationXref
id: 775-01-9
db: CAS

Indole-5,6-quinone
type: SmallMolecule
cellular location: Cytosol
entity reference: Indole-5,6-quinone

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Phenylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt P11086
organism: Homo sapiens

1.4.3.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000210 Cytosol/Stoichiometry/1.0
right: Homovanillin
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.22
left: Oxygen
left: Tyramine
left: Water
name: Oxygen + Tyramine + Water → Ammonia + Homovanillin + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000210 Cytosol/Stoichiometry/1.0
right: Homovanillin
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Tyramine
left: Water
name: Oxygen + Tyramine + Water → Ammonia + Homovanillin + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000210 Cytosol/Stoichiometry/1.0
right: Tyramine
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.28
left: L-Tyrosine
name: L-Tyrosine → Carbon dioxide + Tyramine
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P21964
type: UnificationXref
id: P21964
db: UniProt

ReactionCatalysis818
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

Reference/ChEBI CHEBI 846276
type: UnificationXref
id: CHEBI:846276
db: ChEBI

ReactionCatalysis819
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

ReactionCatalysis816
type: Catalysis
controller: Amiloride-sensitive amine oxidase [copper-containing]
controlled: 1.4.3.22
control type: ACTIVATION

ReactionCatalysis817
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002040 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002926 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Indole-5,6-quinone
right: Water
spontaneous: false
EC number: 1.14.18.1
left: Oxygen
left: 5,6-Dihydroxyindole
name: 5,6-Dihydroxyindole + Oxygen → Indole-5,6-quinone + Water
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis814
type: Catalysis
controller: Macrophage migration inhibitory factor
controlled: Reaction392
control type: ACTIVATION

ReactionCatalysis815
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

ReactionCatalysis812
type: Catalysis
controller: Aspartate aminotransferase, cytoplasmic
controlled: Reaction1118
control type: ACTIVATION

Reaction1127
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002044 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001105 Cytosol/Stoichiometry/1.0
right: L-Dopachrome
spontaneous: false
left: Leucodopachrome
name: Leucodopachrome → L-Dopachrome
conversion direction: LEFT_TO_RIGHT

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002040 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 5,6-Dihydroxyindole
right: Water
spontaneous: false
EC number: 1.14.18.1
left: Oxygen
left: L-Dopachrome
name: L-Dopachrome + Oxygen → 5,6-Dihydroxyindole + Water
conversion direction: LEFT_TO_RIGHT

Reaction1126
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002044/Stoichiometry/1.0
right: Leucodopachrome
spontaneous: false
left: Dopaquinone
name: Dopaquinone → Leucodopachrome
conversion direction: LEFT_TO_RIGHT

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000013 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: NADPH
right: p-Hydroxyphenylacetic acid
spontaneous: false
EC number: 1.2.1.5
left: Homovanillin
left: NADP
left: Water
name: Homovanillin + NADP + Water → NADPH + p-Hydroxyphenylacetic acid
conversion direction: LEFT_TO_RIGHT

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000052 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000210 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Melanosome Membrane/Stoichiometry/1.0
right: Water
right: Dopamine
spontaneous: false
EC number: 1.14.18.1
left: Tyramine
left: Oxygen
name: Oxygen + Tyramine → Dopamine + Water
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00218
type: UnificationXref
id: C00218
db: KEGG Compound

ReactionCatalysis850
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

ReactionCatalysis851
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Tyrosine aminotransferase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine aminotransferase

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChEBI CHEBI 44747
type: UnificationXref
id: CHEBI:44747
db: ChEBI

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/PubChem-compound 736172
type: UnificationXref
id: 736172
db: PubChem-compound

Aspartate aminotransferase, cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Aspartate aminotransferase, cytoplasmic

Reference/HMDB HMDB0006779
type: UnificationXref
id: HMDB0006779
db: HMDB

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: Homo sapiens

ReactionCatalysis847
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

ChemicalStructure/PW C001081
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC=C1

ReactionCatalysis848
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000197 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001240 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000764 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001081 Cytosol/Stoichiometry/1.0
right: Pyrocatechol
right: Vanillylmandelic acid
spontaneous: false
EC number: 2.1.1.6
left: 3,4-Dihydroxymandelic acid
left: Guaiacol
name: 3,4-Dihydroxymandelic acid + Guaiacol → Pyrocatechol + Vanillylmandelic acid
conversion direction: LEFT_TO_RIGHT

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000197 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002041 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Vanillylmandelic acid
right: NADPH
spontaneous: false
EC number: 1.2.1.5
left: NADP
left: 3-Methoxy-4-hydroxyphenylglycolaldehyde
left: Water
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water → NADPH + Vanillylmandelic acid
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000654 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002041 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 3-Methoxy-4-hydroxyphenylglycolaldehyde
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Normetanephrine
left: Water
name: Normetanephrine + Oxygen + Water → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002043 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002041 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 3-Methoxy-4-hydroxyphenylglycolaldehyde
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Metanephrine
left: Water
name: Metanephrine + Oxygen + Water → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/UniProt O43708
type: UnificationXref
id: O43708
db: UniProt

Reference/PubChem-compound 119219
type: UnificationXref
id: 119219
db: PubChem-compound

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Transport14600
type: Transport
participant stoichiometry: Compound/PW C000558/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558 Cytosol/Stoichiometry/1.0
right: 4-Hydroxyphenylpyruvic acid
spontaneous: false
left: 4-Hydroxyphenylpyruvic acid
name: 4-Hydroxyphenylpyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reaction392
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558 Cytosol/Stoichiometry/1.0
right: 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
spontaneous: false
left: 4-Hydroxyphenylpyruvic acid
name: 4-Hydroxyphenylpyruvic acid → 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001969 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: 3,4-Dihydroxyphenylacetaldehyde
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Dopamine
left: Water
name: Dopamine + Oxygen + Water → 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Maleylacetoacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Maleylacetoacetic acid

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000015 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: Homovanillin
spontaneous: false
EC number: 1.4.3.4
left: 3-Methoxytyramine
left: Oxygen
left: Water
name: 3-Methoxytyramine + Oxygen + Water → Ammonia + Homovanillin + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000108 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: Methylamine
right: Hydrogen peroxide
right: 3,4-Dihydroxymandelaldehyde
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Epinephrine
left: Water
name: Epinephrine + Oxygen + Water → 3,4-Dihydroxymandelaldehyde + Hydrogen peroxide + Methylamine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

ReactionCatalysis866
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

Compound/PW C000210 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyramine
stoichiometric coefficient: 1.0

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 3,4-Dihydroxymandelaldehyde
spontaneous: false
EC number: 1.4.3.4
left: Norepinephrine
left: Oxygen
left: Water
name: Norepinephrine + Oxygen + Water → 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis863
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

ReactionCatalysis861
type: Catalysis
controller: 3,4-Dihydroxyphenylacetaldehyde
controlled: 1.13.11.6
control type: ACTIVATION

Reference/ChemSpider 388447
type: UnificationXref
id: 388447
db: ChemSpider

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

ReactionCatalysis860
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/CAS 17592-23-3
type: UnificationXref
id: 17592-23-3
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00483
type: UnificationXref
id: C00483
db: KEGG Compound

Compound/PW C001065 Melanosome Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChemSpider 82648
type: UnificationXref
id: 82648
db: ChemSpider

Pyrocatechol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrocatechol

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

3,4-Dihydroxyphenylacetaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04043
xref: Reference/ChemSpider 106504
xref: Reference/PubChem-compound 119219
xref: Reference/ChEBI CHEBI 27978
xref: Reference/CAS 5707-55-1
xref: Reference/HMDB HMDB0003791
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C001969

Homovanillin
type: SmallMolecule
cellular location: Cytosol
entity reference: Homovanillin

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002043 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000764 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001081 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048 Cytosol/Stoichiometry/1.0
right: Pyrocatechol
right: Metanephrine
spontaneous: false
EC number: 2.1.1.6
left: Epinephrine
left: Guaiacol
name: Epinephrine + Guaiacol → Metanephrine + Pyrocatechol
conversion direction: LEFT_TO_RIGHT

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000052 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000764 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001081 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000015 Cytoplasm/Stoichiometry/1.0
right: 3-Methoxytyramine
right: Pyrocatechol
spontaneous: false
EC number: 2.1.1.6
left: Dopamine
left: Guaiacol
name: Dopamine + Guaiacol → 3-Methoxytyramine + Pyrocatechol
conversion direction: LEFT_TO_RIGHT

1.1.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000222 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: 3,4-Dihydroxyphenylglycol
right: NADH
spontaneous: false
EC number: 1.1.1.1
left: NAD
left: 3,4-Dihydroxymandelaldehyde
name: 3,4-Dihydroxymandelaldehyde + NAD → 3,4-Dihydroxyphenylglycol + NADH
conversion direction: LEFT_TO_RIGHT

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000210 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Melanosome Membrane/Stoichiometry/1.0
right: Water
right: L-Dopa
spontaneous: false
EC number: 1.14.18.1
left: Tyramine
left: Oxygen
name: Oxygen + Tyramine → L-Dopa + Water
conversion direction: LEFT_TO_RIGHT

4-hydroxyphenylpyruvate dioxygenase
type: Protein
cellular location: Cytosol
entity reference: 4-hydroxyphenylpyruvate dioxygenase

Compound/PW C000210 Melanosome Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyramine
stoichiometric coefficient: 1.0

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000654 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000764 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001081 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Normetanephrine
right: Pyrocatechol
spontaneous: false
EC number: 2.1.1.6
left: Norepinephrine
left: Guaiacol
name: Guaiacol + Norepinephrine → Normetanephrine + Pyrocatechol
conversion direction: LEFT_TO_RIGHT

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000222 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000764 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001081 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001147 Cytosol/Stoichiometry/1.0
right: Vanylglycol
right: Pyrocatechol
spontaneous: false
EC number: 2.1.1.6
left: 3,4-Dihydroxyphenylglycol
left: Guaiacol
name: 3,4-Dihydroxyphenylglycol + Guaiacol → Pyrocatechol + Vanylglycol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

ReactionCatalysis858
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

ReactionCatalysis859
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

ReactionCatalysis856
type: Catalysis
controller: Alcohol dehydrogenase 1A
controlled: 1.1.1.1
control type: ACTIVATION

ReactionCatalysis857
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

ReactionCatalysis854
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

Reference/CAS 8049-97-6
type: UnificationXref
id: 8049-97-6
db: CAS

Compound/PW C002045 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Melanin
stoichiometric coefficient: 1.0

ReactionCatalysis852
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

Leucodopachrome
type: SmallMolecule
cellular location: Cytosol
entity reference: Leucodopachrome

ReactionCatalysis853
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Oxygen

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/UniProt P14174
type: UnificationXref
id: P14174
db: UniProt

Compound/PW C002044 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leucodopachrome
stoichiometric coefficient: 1.0

Compound/PW C000048 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

Fumarylacetoacetase
type: Protein
cellular location: Cytosol
entity reference: Fumarylacetoacetase

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C002043 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Metanephrine
stoichiometric coefficient: 1.0

Compound/PW C003007 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

3-Methoxy-4-hydroxyphenylglycolaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Methoxy-4-hydroxyphenylglycolaldehyde

Compound/PW C000074 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillic acid
stoichiometric coefficient: 1.0

Dopaquinone
type: SmallMolecule
cellular location: Melanosome
entity reference: Dopaquinone

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

L-Dopachrome
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopachrome

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Oxygen
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Oxygen

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Reference/BioCyc 4-HYDROXYPHENYLACETATE
type: UnificationXref
id: 4-HYDROXYPHENYLACETATE
db: BioCyc

Homogentisate 1,2-dioxygenase
type: ProteinReference
xref: Reference/UniProt Q93099
organism: Homo sapiens

4-hydroxyphenylpyruvate dioxygenase
type: ProteinReference
xref: Reference/UniProt P32754
organism: Homo sapiens

Compound/PW C000052 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Dopamine beta-hydroxylase
type: Protein
cellular location: Cell Membrane
entity reference: Dopamine beta-hydroxylase

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/HMDB HMDB0006915
type: UnificationXref
id: HMDB0006915
db: HMDB

Reference/UniProt P19801
type: UnificationXref
id: P19801
db: UniProt

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/HMDB HMDB0001229
type: UnificationXref
id: HMDB0001229
db: HMDB

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

Reference/UniProt P11086
type: UnificationXref
id: P11086
db: UniProt

Reference/HMDB HMDB0000130
type: UnificationXref
id: HMDB0000130
db: HMDB

Compound/PW C001065 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001029
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC(O)=C(O)C=C1

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/UniProt P30838
type: UnificationXref
id: P30838
db: UniProt

Epinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Epinephrine

Compound/PW C002926 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indole-5,6-quinone
stoichiometric coefficient: 1.0

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

3,4-Dihydroxyphenylacetaldehyde
type: Complex
component stoichiometry: Protein/1061 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: 3-hydroxyanthranilate 3,4-dioxygenase

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Dopamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dopamine

Reference/PubChem-compound 547
type: UnificationXref
id: 547
db: PubChem-compound

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/PubChem-compound 780
type: UnificationXref
id: 780
db: PubChem-compound

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

4-Hydroxyphenylpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Hydroxyphenylpyruvic acid

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

ChemicalStructure/PW C001240
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(O)=O)C1=CC=C(O)C(O)=C1

3-Methoxytyramine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 3-Methoxytyramine

Reference/SMPDB SMP0000716
type: UnificationXref
id: SMP0000716
db: SMPDB

5,6-Dihydroxyindole-2-carboxylic acid
type: SmallMolecule
cellular location: Melanosome
entity reference: 5,6-Dihydroxyindole-2-carboxylic acid

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Normetanephrine
type: SmallMoleculeReference
xref: Reference/CAS 97-31-4
xref: Reference/ChemSpider 1200
xref: Reference/PubChem-compound 1237
xref: Reference/ChEBI CHEBI 144308
xref: Reference/HMDB HMDB0000819
xref: Reference/KEGG Compound C05589
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000654

3,4-Dihydroxyphenylglycol
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxyphenylglycol

Reference/PubChem-compound 21100
type: UnificationXref
id: 21100
db: PubChem-compound

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Reference/KEGG Compound C01161
type: UnificationXref
id: C01161
db: KEGG Compound

Reference/HMDB HMDB0001490
type: UnificationXref
id: HMDB0001490
db: HMDB

Amiloride-sensitive amine oxidase [copper-containing]
type: Complex
component stoichiometry: Protein/382 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Amiloride-sensitive amine oxidase [copper-containing]

Reference/HMDB HMDB0001253
type: UnificationXref
id: HMDB0001253
db: HMDB

Reference/HMDB HMDB0000164
type: UnificationXref
id: HMDB0000164
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/CAS 5703-24-2
type: UnificationXref
id: 5703-24-2
db: CAS

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 306-08-1
type: UnificationXref
id: 306-08-1
db: CAS

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/PubChem-compound 1738
type: UnificationXref
id: 1738
db: PubChem-compound

Reference/HMDB HMDB0001268
type: UnificationXref
id: HMDB0001268
db: HMDB

ChemicalStructure/PW C003007
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(\O)=C\C1=CC=C(O)C=C1

Homovanillin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 151276
xref: Reference/CAS 5703-24-2
xref: Reference/KEGG Compound C05581
xref: Reference/HMDB HMDB0005175
xref: Reference/ChEBI CHEBI 28111
xref: Reference/ChemSpider 133331
chemical formula: C9H10O3
molecular weight: 166.06299
structure: ChemicalStructure/PW C002411

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Reference/CAS 102-32-9
type: UnificationXref
id: 102-32-9
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Compound/PW C000052 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Macrophage migration inhibitory factor
type: Protein
cellular location: Cytosol
entity reference: Macrophage migration inhibitory factor

Reference/KEGG Compound C01179
type: UnificationXref
id: C01179
db: KEGG Compound

Reference/PubChem-compound 636708
type: UnificationXref
id: 636708
db: PubChem-compound

Reference/KEGG Compound C00090
type: UnificationXref
id: C00090
db: KEGG Compound

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Homogentisic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Homogentisic acid

Reference/CAS 156-39-8
type: UnificationXref
id: 156-39-8
db: CAS

Acetoacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetoacetic acid

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChemSpider 133725
type: UnificationXref
id: 133725
db: ChemSpider

ChemicalStructure/PW C000197
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(=C1)[C@H](O)C(O)=O

Maleylacetoacetate isomerase
type: ProteinReference
xref: Reference/UniProt O43708
organism: Homo sapiens

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Tyramine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5408
xref: Reference/CAS 51-67-2
xref: Reference/BioCyc CPD-7650
xref: Reference/HMDB HMDB0000306
xref: Reference/KEGG Compound C00483
xref: Reference/PubChem-compound 5610
xref: Reference/ChEBI CHEBI 15760
chemical formula: C8H11NO
molecular weight: 137.08406
structure: ChemicalStructure/PW C000210

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C000558 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylpyruvic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Compound/PW C000108 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylamine
stoichiometric coefficient: 1.0

Compound/PW C000013 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Hydroxyphenylacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 55-10-7
type: UnificationXref
id: 55-10-7
db: CAS

3,4-Dihydroxyphenylglycol
type: SmallMoleculeReference
xref: Reference/CAS 3343-19-9
xref: Reference/ChEBI CHEBI 1387
xref: Reference/HMDB HMDB0000318
xref: Reference/KEGG Compound C05576
xref: Reference/ChemSpider 82648
xref: Reference/PubChem-compound 91528
chemical formula: C8H10O4
molecular weight: 170.0579
structure: ChemicalStructure/PW C000222

Reference/PubChem-compound 979
type: UnificationXref
id: 979
db: PubChem-compound

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reference/ChemSpider 19844
type: UnificationXref
id: 19844
db: ChemSpider

Reference/PubChem-compound 127
type: UnificationXref
id: 127
db: PubChem-compound

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Compound/PW C001240 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 90-05-1
type: UnificationXref
id: 90-05-1
db: CAS

Reference/PubChem-compound 91528
type: UnificationXref
id: 91528
db: PubChem-compound

Reference/CAS 3131-52-0
type: UnificationXref
id: 3131-52-0
db: CAS

Dopamine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Dopamine

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C000210
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC=C(O)C=C1

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/HMDB HMDB0001866
type: UnificationXref
id: HMDB0001866
db: HMDB

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Compound/PW C000764 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrocatechol
stoichiometric coefficient: 1.0

Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05579
type: UnificationXref
id: C05579
db: KEGG Compound

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Reference/KEGG Compound C05576
type: UnificationXref
id: C05576
db: KEGG Compound

Dopamine
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Dopamine

Reference/KEGG Compound C05578
type: UnificationXref
id: C05578
db: KEGG Compound

Reference/KEGG Compound C05577
type: UnificationXref
id: C05577
db: KEGG Compound

Reference/KEGG Compound C05583
type: UnificationXref
id: C05583
db: KEGG Compound

Reference/KEGG Compound C05582
type: UnificationXref
id: C05582
db: KEGG Compound

Reference/KEGG Compound C05584
type: UnificationXref
id: C05584
db: KEGG Compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Maleylacetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 47904
xref: Reference/ChemSpider 4444078
xref: Reference/CAS 5698-52-2
xref: Reference/HMDB HMDB0002052
xref: Reference/PubChem-compound 5280393
xref: Reference/KEGG Compound C01036
xref: Reference/BioCyc 4-MALEYL-ACETOACETATE
chemical formula: C8H8O6
molecular weight: 200.03209
structure: ChemicalStructure/PW C001376

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/KEGG Compound C05581
type: UnificationXref
id: C05581
db: KEGG Compound

ChemicalStructure/PW C000222
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C1=CC(O)=C(O)C=C1

Reference/KEGG Compound C05580
type: UnificationXref
id: C05580
db: KEGG Compound

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Guaiacol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guaiacol

Compound/PW C000952 Melanosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dopaquinone
stoichiometric coefficient: 2.0

Reference/PubChem-compound 440729
type: UnificationXref
id: 440729
db: PubChem-compound

Reference/PubChem-compound 440728
type: UnificationXref
id: 440728
db: PubChem-compound

Protein/271 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Tyrosine aminotransferase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000306
type: UnificationXref
id: HMDB0000306
db: HMDB

Reference/KEGG Compound C05587
type: UnificationXref
id: C05587
db: KEGG Compound

Reference/KEGG Compound C05589
type: UnificationXref
id: C05589
db: KEGG Compound

Reference/KEGG Compound C05588
type: UnificationXref
id: C05588
db: KEGG Compound

Tyramine
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Tyramine

Reference/KEGG Compound C05594
type: UnificationXref
id: C05594
db: KEGG Compound

L-Dopa
type: SmallMolecule
cellular location: Melanosome
entity reference: L-Dopa

Reference/KEGG Compound C05350
type: UnificationXref
id: C05350
db: KEGG Compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

p-Hydroxyphenylacetic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 127
xref: Reference/ChemSpider 124
xref: Reference/CAS 156-38-7
xref: Reference/HMDB HMDB0000020
xref: Reference/BioCyc 4-HYDROXYPHENYLACETATE
xref: Reference/KEGG Compound C00642
xref: Reference/ChEBI CHEBI 18101
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C000013

Compound/PW C000117 Melanosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 2.0

Compound/PW C000088 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Water
type: SmallMolecule
cellular location: Melanosome
entity reference: Water

Reference/BioCyc CPD-400
type: UnificationXref
id: CPD-400
db: BioCyc

3-Methoxytyramine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Methoxytyramine

3-Methoxytyramine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 742324
xref: Reference/PubChem-compound 1669
xref: Reference/CAS 554-52-9
xref: Reference/KEGG Compound C05587
xref: Reference/HMDB HMDB0000022
xref: Reference/ChemSpider 1606
chemical formula: C9H13NO2
molecular weight: 167.09464
structure: ChemicalStructure/PW C000015

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Reference/HMDB HMDB0000318
type: UnificationXref
id: HMDB0000318
db: HMDB

L-Dopachrome
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15772
xref: Reference/CAS 89762-39-0
xref: Reference/PubChem-compound 5459802
xref: Reference/ChemSpider 4573572
xref: Reference/KEGG Compound C01693
xref: Reference/HMDB HMDB0001430
chemical formula: C9H7NO4
molecular weight: 193.0375
structure: ChemicalStructure/PW C001105

Reference/PubChem-compound 114683
type: UnificationXref
id: 114683
db: PubChem-compound

3,4-Dihydroxymandelaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27852
xref: Reference/PubChem-compound 151725
xref: Reference/ChemSpider 133725
xref: Reference/CAS 13023-73-9
xref: Reference/HMDB HMDB0006242
xref: Reference/KEGG Compound C05577
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C002683

Reference/CAS 18766-67-1
type: UnificationXref
id: 18766-67-1
db: CAS

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000952 Melanosome/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Melanosome/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000117 Melanosome/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001065 Melanosome/Stoichiometry/1.0
right: Dopaquinone
right: Water
spontaneous: false
EC number: 1.14.18.1
left: Oxygen
left: L-Dopa
name: 2 L-Dopa + Oxygen → 2 Dopaquinone + 2 Water
conversion direction: LEFT_TO_RIGHT

Tyramine
type: SmallMolecule
cellular location: Cytosol
entity reference: Tyramine

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Amine oxidase [flavin-containing] A

Reference/ChEBI CHEBI 16852
type: UnificationXref
id: CHEBI:16852
db: ChEBI

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Fumaric acid

Reference/GENE ONTOLOGY GO 0033162
type: UnificationXref
id: GO:0033162
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Protein/1061 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-hydroxyanthranilate 3,4-dioxygenase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15760
type: UnificationXref
id: CHEBI:15760
db: ChEBI

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/KEGG Compound C04043
type: UnificationXref
id: C04043
db: KEGG Compound

Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C001029 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxybenzeneacetic acid
stoichiometric coefficient: 1.0

Compound/PW C002040 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,6-Dihydroxyindole
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000015
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CCN)=C1

ChemicalStructure/PW C000013
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC=C(O)C=C1

5,6-Dihydroxyindole-2-carboxylic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5,6-Dihydroxyindole-2-carboxylic acid

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Compound/PW C002044/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leucodopachrome
stoichiometric coefficient: 1.0

Vanillylmandelic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Vanillylmandelic acid

Homovanillic acid
type: SmallMoleculeReference
xref: Reference/CAS 306-08-1
xref: Reference/KEGG Compound C05582
xref: Reference/PubChem-compound 1738
xref: Reference/HMDB HMDB0000118
xref: Reference/ChemSpider 1675
xref: Reference/ChEBI CHEBI 545959
chemical formula: C9H10O4
molecular weight: 182.0579
structure: ChemicalStructure/PW C000074

Reference/ChEBI CHEBI 15772
type: UnificationXref
id: CHEBI:15772
db: ChEBI

Reference/ChEBI CHEBI 144308
type: UnificationXref
id: CHEBI:144308
db: ChEBI

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001105
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CC2=CC(=O)C(=O)C=C2N1

Reference/PubChem-compound 161255
type: UnificationXref
id: 161255
db: PubChem-compound

Reference/ChemSpider 447
type: UnificationXref
id: 447
db: ChemSpider

Reference/ChemSpider 13837760
type: UnificationXref
id: 13837760
db: ChemSpider

ChemicalStructure/PW C002683
type: ChemicalStructure
structure format: SMILES
structure data: OC(C=O)C1=CC(O)=C(O)C=C1

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/ChEBI CHEBI 30907
type: UnificationXref
id: CHEBI:30907
db: ChEBI

Reference/HMDB HMDB0001430
type: UnificationXref
id: HMDB0001430
db: HMDB

Homogentisic acid
type: SmallMoleculeReference
xref: Reference/CAS 451-13-8
xref: Reference/ChEBI CHEBI 44747
xref: Reference/ChemSpider 759
xref: Reference/HMDB HMDB0000130
xref: Reference/KEGG Compound C00544
xref: Reference/PubChem-compound 780
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C000084

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Reference/ChEBI CHEBI 16830
type: UnificationXref
id: CHEBI:16830
db: ChEBI

Epinephrine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000068
xref: Reference/KEGG Compound C00788
xref: Reference/PubChem-compound 5816
xref: Reference/ChemSpider 5611
xref: Reference/CAS 51-43-4
xref: Reference/BioCyc L-EPINEPHRINE
xref: Reference/ChEBI CHEBI 28918
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000048

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

4-hydroxyphenylpyruvate dioxygenase
type: Complex
component stoichiometry: Protein/786 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 4-hydroxyphenylpyruvate dioxygenase

Homovanillic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Homovanillic acid

ChemicalStructure/PW C002411
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CC=O)=C1

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000118
type: UnificationXref
id: HMDB0000118
db: HMDB

Reference/ChEBI CHEBI 1387
type: UnificationXref
id: CHEBI:1387
db: ChEBI

Vanylglycol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05594
xref: Reference/ChemSpider 10348
xref: Reference/CAS 534-82-7
xref: Reference/ChEBI CHEBI 846276
xref: Reference/PubChem-compound 10805
xref: Reference/HMDB HMDB0001490
chemical formula: C9H12O4
molecular weight: 184.07356
structure: ChemicalStructure/PW C001147

Reference/ChEBI CHEBI 27978
type: UnificationXref
id: CHEBI:27978
db: ChEBI

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/ChEBI CHEBI 15999
type: UnificationXref
id: CHEBI:15999
db: ChEBI

Compound/PW C001147 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vanylglycol
stoichiometric coefficient: 1.0

3,4-Dihydroxyphenylacetaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3,4-Dihydroxyphenylacetaldehyde

3,4-Dihydroxyphenylacetaldehyde
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 3,4-Dihydroxyphenylacetaldehyde

Protein/786 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 4-hydroxyphenylpyruvate dioxygenase
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 2003
type: UnificationXref
id: CHEBI:2003
db: ChEBI

Compound/PW C001420 Melanosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 133331
type: UnificationXref
id: 133331
db: ChemSpider

Norepinephrine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Norepinephrine

3,4-Dihydroxybenzeneacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3,4-Dihydroxybenzeneacetic acid

Reference/ChemSpider 106648
type: UnificationXref
id: 106648
db: ChemSpider

Reference/SMPDB SMP0000008
type: UnificationXref
id: SMP0000008
db: SMPDB

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Maleylacetoacetate isomerase
type: Protein
cellular location: Cytosol
entity reference: Maleylacetoacetate isomerase

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Catechol O-methyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Catechol O-methyltransferase

Reference/PubChem-compound 10805
type: UnificationXref
id: 10805
db: PubChem-compound

Reference/PubChem-compound 439316
type: UnificationXref
id: 439316
db: PubChem-compound

Compound/PW C000117 Melanosome Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004058
type: UnificationXref
id: HMDB0004058
db: HMDB

Reference/PathWhiz PW000693
type: UnificationXref
id: PW000693
db: PathWhiz

Reference/HMDB HMDB0004061
type: UnificationXref
id: HMDB0004061
db: HMDB

Compound/PW C000764 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrocatechol
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Compound/PW C000222 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylglycol
stoichiometric coefficient: 1.0

Reference/CAS 3343-19-9
type: UnificationXref
id: 3343-19-9
db: CAS

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002411 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074 Cytoplasm/Stoichiometry/1.0
right: Homovanillic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.2.1.5
left: Water
left: Homovanillin
left: NAD
name: Homovanillin + NAD + Water → Homovanillic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0004063
type: UnificationXref
id: HMDB0004063
db: HMDB

1.13.11.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001969 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: 3,4-Dihydroxybenzeneacetic acid
right: NADH
spontaneous: false
EC number: 1.13.11.6
left: Water
left: NAD
left: 3,4-Dihydroxyphenylacetaldehyde
name: 3,4-Dihydroxyphenylacetaldehyde + NAD + Water → 3,4-Dihydroxybenzeneacetic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0006242
type: UnificationXref
id: HMDB0006242
db: HMDB

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001240 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: 3,4-Dihydroxymandelic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.2.1.5
left: NAD
left: 3,4-Dihydroxymandelaldehyde
left: Water
name: 3,4-Dihydroxymandelaldehyde + NAD + Water → 3,4-Dihydroxymandelic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0004068
type: UnificationXref
id: HMDB0004068
db: HMDB

Reference/HMDB HMDB0004067
type: UnificationXref
id: HMDB0004067
db: HMDB

Compound/PW C001081 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guaiacol
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000707
type: UnificationXref
id: HMDB0000707
db: HMDB

3-hydroxyanthranilate 3,4-dioxygenase
type: ProteinReference
xref: Reference/UniProt P46952
organism: Homo sapiens

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Hydrogen peroxide

Maleylacetoacetate isomerase
type: Complex
component stoichiometry: Protein/762 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Maleylacetoacetate isomerase

ReactionCatalysis447
type: Catalysis
controller: Fumarylacetoacetase
controlled: 3.7.1.2
control type: ACTIVATION

Compound/PW C002045 Melanosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Melanin
stoichiometric coefficient: 1.0

ReactionCatalysis445
type: Catalysis
controller: Homogentisate 1,2-dioxygenase
controlled: 1.13.11.5
control type: ACTIVATION

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

ReactionCatalysis446
type: Catalysis
controller: Maleylacetoacetate isomerase
controlled: Reaction386
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

ReactionCatalysis444
type: Catalysis
controller: 4-hydroxyphenylpyruvate dioxygenase
controlled: 1.13.11.27
control type: ACTIVATION

ReactionCatalysis440
type: Catalysis
controller: Tyrosine aminotransferase
controlled: 2.6.1.5
control type: ACTIVATION

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Dehydroascorbic acid

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Reference/HMDB HMDB0000957
type: UnificationXref
id: HMDB0000957
db: HMDB

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Metanephrine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 144365
xref: Reference/PubChem-compound 21100
xref: Reference/HMDB HMDB0004063
xref: Reference/CAS 5001-33-2
xref: Reference/KEGG Compound C05588
xref: Reference/ChemSpider 19844
chemical formula: C10H15NO3
molecular weight: 197.1052
structure: ChemicalStructure/PW C002043

Leucodopachrome
type: SmallMoleculeReference
xref: Reference/CAS 18766-67-1
xref: Reference/KEGG Compound C05604
xref: Reference/ChemSpider 141655
xref: Reference/PubChem-compound 161255
xref: Reference/ChEBI CHEBI 60872
xref: Reference/HMDB HMDB0004067
chemical formula: C9H9NO4
molecular weight: 195.05316
structure: ChemicalStructure/PW C002044

Melanin
type: SmallMoleculeReference
xref: Reference/BioCyc MELANIN
xref: Reference/KEGG Compound C05606
xref: Reference/PubChem-compound 6325610
xref: Reference/ChemSpider 4884931
xref: Reference/HMDB HMDB0004068
xref: Reference/CAS 8049-97-6
chemical formula: C18H10N2O4
molecular weight: 318.06406
structure: ChemicalStructure/PW C002045

Compound/PW C000981 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Fumarylacetoacetic acid
stoichiometric coefficient: 1.0

Leucodopachrome
type: SmallMolecule
entity reference: Leucodopachrome

Protein/382 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Amiloride-sensitive amine oxidase [copper-containing]
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0005175
type: UnificationXref
id: HMDB0005175
db: HMDB

Reaction386
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000981 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001376 Cytosol/Stoichiometry/1.0
right: 4-Fumarylacetoacetic acid
spontaneous: false
left: Maleylacetoacetic acid
name: Maleylacetoacetic acid → 4-Fumarylacetoacetic acid
conversion direction: LEFT_TO_RIGHT

5,6-Dihydroxyindole
type: SmallMoleculeReference
xref: Reference/PubChem-compound 114683
xref: Reference/BioCyc 56-DIHYDROXYINDOLE-2-CARBOXYLATE
xref: Reference/CAS 3131-52-0
xref: Reference/ChEBI CHEBI 27404
xref: Reference/ChemSpider 102690
xref: Reference/HMDB HMDB0004058
xref: Reference/KEGG Compound C05578
chemical formula: C8H7NO2
molecular weight: 149.04768
structure: ChemicalStructure/PW C002040

3-Methoxy-4-hydroxyphenylglycolaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05583
xref: Reference/ChemSpider 389601
xref: Reference/HMDB HMDB0004061
xref: Reference/PubChem-compound 440729
xref: Reference/CAS 17592-23-3
chemical formula: C9H10O4
molecular weight: 182.0579
structure: ChemicalStructure/PW C002041

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Compound/PW C000052 Melanosome Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

1.13.11.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000084 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001376 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
right: Maleylacetoacetic acid
spontaneous: false
EC number: 1.13.11.5
left: Oxygen
left: Homogentisic acid
name: Homogentisic acid + Oxygen → Maleylacetoacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 4790-08-3
type: UnificationXref
id: 4790-08-3
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000654
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=CC=C1O)C(O)CN

Catechol O-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Catechol O-methyltransferase

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/CAS 97-31-4
type: UnificationXref
id: 97-31-4
db: CAS

Compound/PW C000015 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

ReactionCatalysis218
type: Catalysis
controller: Phenylethanolamine N-methyltransferase
controlled: 2.1.1.28
control type: ACTIVATION

1.13.11.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000084 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Homogentisic acid
spontaneous: false
EC number: 1.13.11.27
left: 4-Hydroxyphenylpyruvic acid
left: Oxygen
name: 4-Hydroxyphenylpyruvic acid + Oxygen → Carbon dioxide + Homogentisic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C001969 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChemSpider 10348
type: UnificationXref
id: 10348
db: ChemSpider

Normetanephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Normetanephrine

Tyrosinase
type: ProteinReference
xref: Reference/UniProt P14679
organism: Homo sapiens

Compound/PW C000968 Melanosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: 5,6-Dihydroxyindole-2-carboxylic acid
stoichiometric coefficient: 2.0

ReactionCatalysis2116
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

Reference/ChEBI CHEBI 144365
type: UnificationXref
id: CHEBI:144365
db: ChEBI

ReactionCatalysis2115
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

ReactionCatalysis2117
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

Hawkinsinuria
type: Pathway
pathway order: PathwayEnzymeReaction/2512692
pathway order: PathwayEnzymeReaction/2512691
pathway order: PathwayEnzymeReaction/2512694
pathway order: PathwayEnzymeReaction/2512693
pathway order: PathwayEnzymeReaction/2512690
pathway order: PathwayEnzymeReaction/2512678
pathway order: PathwayEnzymeReaction/2512711
pathway order: PathwayEnzymeReaction/2512677
pathway order: PathwayEnzymeReaction/2512699
pathway order: PathwayEnzymeReaction/2512710
pathway order: PathwayEnzymeReaction/2512713
pathway order: PathwayEnzymeReaction/2512679
pathway order: PathwayEnzymeReaction/2512712
pathway order: PathwayEnzymeReaction/2512674
pathway order: PathwayEnzymeReaction/2512696
pathway order: PathwayEnzymeReaction/2512695
pathway order: PathwayEnzymeReaction/2512676
pathway order: PathwayEnzymeReaction/2512698
pathway order: PathwayEnzymeReaction/2512675
pathway order: PathwayEnzymeReaction/2512697
pathway order: PathwayEnzymeReaction/2512714
pathway order: PathwayEnzymeReaction/2512681
pathway order: PathwayEnzymeReaction/2512680
pathway order: PathwayEnzymeReaction/2512683
pathway order: PathwayEnzymeReaction/2512682
pathway order: PathwayEnzymeReaction/2512689
pathway order: PathwayEnzymeReaction/2512700
pathway order: PathwayEnzymeReaction/2512688
pathway order: PathwayEnzymeReaction/2512702
pathway order: PathwayTransport/2512715
pathway order: PathwayEnzymeReaction/2512701
pathway order: PathwayEnzymeReaction/2512685
pathway order: PathwayEnzymeReaction/2512684
pathway order: PathwayEnzymeReaction/2512687
pathway order: PathwayEnzymeReaction/2512686
pathway order: PathwayEnzymeReaction/2512708
pathway order: PathwayEnzymeReaction/2512707
pathway order: PathwaySubPathway/118533
pathway order: PathwaySubPathway/118532
pathway order: PathwayEnzymeReaction/2512709
pathway order: PathwayEnzymeReaction/2512704
pathway order: PathwayEnzymeReaction/2512703
pathway order: PathwayEnzymeReaction/2512706
pathway order: PathwayEnzymeReaction/2512705
pathway component: 1.14.17.1
pathway component: Transport14600
pathway component: 1.14.18.1
pathway component: Reaction1130
pathway component: 5.3.3.12
pathway component: Reaction392
pathway component: 1.4.3.4
pathway component: 2.6.1.5
pathway component: ReactionCatalysis825
pathway component: 4.1.1.28
pathway component: ReactionCatalysis826
pathway component: ReactionCatalysis823
pathway component: ReactionCatalysis824
pathway component: 2.1.1.6
pathway component: ReactionCatalysis822
pathway component: 1.13.11.5
pathway component: ReactionCatalysis866
pathway component: ReactionCatalysis863
pathway component: ReactionCatalysis861
pathway component: ReactionCatalysis860
pathway component: TransportCatalysis5416
pathway component: Thyroid Hormone Synthesis
pathway component: 1.4.3.22
pathway component: ReactionCatalysis818
pathway component: 1.1.1.1
pathway component: ReactionCatalysis819

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/KEGG Compound C00788
type: UnificationXref
id: C00788
db: KEGG Compound

Reference/CAS 5698-52-2
type: UnificationXref
id: 5698-52-2
db: CAS

Macrophage migration inhibitory factor
type: ProteinReference
xref: Reference/UniProt P14174
organism: Homo sapiens

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/KEGG Compound C00544
type: UnificationXref
id: C00544
db: KEGG Compound

Reference/ChemSpider 102690
type: UnificationXref
id: 102690
db: ChemSpider

ChemicalStructure/PW C001969
type: ChemicalStructure
structure format: SMILES
structure data: OC1=C(O)C=C(CC=O)C=C1

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Oxygen
type: SmallMolecule
cellular location: Melanosome
entity reference: Oxygen

Dopamine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Dopamine

2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Catechol O-methyltransferase
type: ProteinReference
xref: Reference/UniProt P21964
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0042470
type: UnificationXref
id: GO:0042470
db: GENE ONTOLOGY

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Unknown
type: ProteinReference

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine
name: SubPathwayInput

Reference/PathWhiz PW127154
type: UnificationXref
id: PW127154
db: PathWhiz

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Compound/PW C000654 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Normetanephrine
stoichiometric coefficient: 1.0

Dopaquinone
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00822
xref: Reference/ChemSpider 388447
xref: Reference/CAS 4430-97-1 25520-73-4
xref: Reference/ChEBI CHEBI 16852
xref: Reference/HMDB HMDB0001229
xref: Reference/BioCyc DOPAQUINONE
xref: Reference/PubChem-compound 439316
chemical formula: C9H9NO4
molecular weight: 195.05316
structure: ChemicalStructure/PW C000952

Thyroid Hormone Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118533
pathway component: SubPathwayInteraction118533
xref: Reference/SMPDB SMP0000716
xref: Reference/PathWhiz PW000693
name: SubPathway

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Reference/CAS 554-52-9
type: UnificationXref
id: 554-52-9
db: CAS

Melanosome Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0033162

Aspartate aminotransferase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P17174
organism: Homo sapiens

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: Homo sapiens

Aspartate aminotransferase, cytoplasmic
type: Complex
component stoichiometry: Protein/277 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Aspartate aminotransferase, cytoplasmic

Reference/ChEBI CHEBI 28591
type: UnificationXref
id: CHEBI:28591
db: ChEBI

Tyrosine aminotransferase
type: ProteinReference
xref: Reference/UniProt P17735
organism: Homo sapiens

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

4-Fumarylacetoacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Fumarylacetoacetic acid

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Reference/ChEBI CHEBI 28111
type: UnificationXref
id: CHEBI:28111
db: ChEBI

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/UniProt P07327
type: UnificationXref
id: P07327
db: UniProt

Reference/CAS 534-82-7
type: UnificationXref
id: 534-82-7
db: CAS

Dopaquinone
type: SmallMolecule
entity reference: Dopaquinone

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000042
type: UnificationXref
id: PW000042
db: PathWhiz

Reference/ChemSpider 954
type: UnificationXref
id: 954
db: ChemSpider

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Aldehyde dehydrogenase, dimeric NADP-preferring
type: ProteinReference
xref: Reference/UniProt P30838
organism: Homo sapiens

Reference/HMDB HMDB0002052
type: UnificationXref
id: HMDB0002052
db: HMDB

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Reference/ChEBI CHEBI 47904
type: UnificationXref
id: CHEBI:47904
db: ChEBI

Reference/UniProt P32754
type: UnificationXref
id: P32754
db: UniProt

Reference/ChemSpider 5611
type: UnificationXref
id: 5611
db: ChemSpider

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/UniProt P40126
type: UnificationXref
id: P40126
db: UniProt

Compound/PW C001420 Melanosome Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/ChemSpider 5408
type: UnificationXref
id: 5408
db: ChemSpider

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0125590
type: UnificationXref
id: SMP0125590
db: SMPDB

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Indole-5,6-quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 389600
xref: Reference/HMDB HMDB0006779
xref: Reference/PubChem-compound 440728
xref: Reference/ChEBI CHEBI 27406
xref: Reference/KEGG Compound C05579
chemical formula: C8H5NO2
molecular weight: 147.03203
structure: ChemicalStructure/PW C002926

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Alcohol dehydrogenase 1A
type: Complex
component stoichiometry: Protein/729 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Alcohol dehydrogenase 1A

Compound/PW C000052 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Compound/PW C000084 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homogentisic acid
stoichiometric coefficient: 1.0

Reference/CAS 451-13-8
type: UnificationXref
id: 451-13-8
db: CAS

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/BioCyc DOPAQUINONE
type: UnificationXref
id: DOPAQUINONE
db: BioCyc

Reference/KEGG Compound C01693
type: UnificationXref
id: C01693
db: KEGG Compound

Compound/PW C000148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc CATECHOL
type: UnificationXref
id: CATECHOL
db: BioCyc

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

5,6-Dihydroxyindole-2-carboxylic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 119405
xref: Reference/KEGG Compound C04185
xref: Reference/BioCyc 56-DIHYDROXYINDOLE-2-CARBOXYLATE
xref: Reference/ChemSpider 106648
xref: Reference/ChEBI CHEBI 2003
xref: Reference/CAS 4790-08-3
xref: Reference/HMDB HMDB0001253
chemical formula: C9H7NO4
molecular weight: 193.0375
structure: ChemicalStructure/PW C000968

Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/PubChem-compound 85782
type: UnificationXref
id: 85782
db: PubChem-compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Compound/PW C000142 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: Homo sapiens

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C001065 Melanosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChemSpider 552441
type: UnificationXref
id: 552441
db: ChemSpider

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Protein/677 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Fumarylacetoacetase
stoichiometric coefficient: 2.0

Reference/PubChem-compound 6325610
type: UnificationXref
id: 6325610
db: PubChem-compound

Tyrosine aminotransferase
type: Complex
component stoichiometry: Protein/271 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Tyrosine aminotransferase

SubPathwayInteraction118532
type: Interaction
name: SubPathwayReaction
name: SubPathway118532Reaction
participant: L-Tyrosine

SubPathwayInteraction118533
type: Interaction
name: SubPathwayReaction
name: SubPathway118533Reaction
participant: L-Tyrosine

Reference/ChEBI CHEBI 18101
type: UnificationXref
id: CHEBI:18101
db: ChEBI

4-Fumarylacetoacetic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 4-FUMARYL-ACETOACETATE
xref: Reference/HMDB HMDB0001268
xref: Reference/PubChem-compound 5280398
xref: Reference/KEGG Compound C01061
xref: Reference/ChemSpider 4444081
xref: Reference/ChEBI CHEBI 30907
xref: Reference/CAS 28613-33-4
chemical formula: C8H8O6
molecular weight: 200.03209
structure: ChemicalStructure/PW C000981

Tyrosinase
type: Protein
cellular location: Cytosol
entity reference: Tyrosinase

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxymandelaldehyde

Reference/ChemSpider 389601
type: UnificationXref
id: 389601
db: ChemSpider

Reference/ChemSpider 389600
type: UnificationXref
id: 389600
db: ChemSpider

Reference/KEGG Compound C05606
type: UnificationXref
id: C05606
db: KEGG Compound

Reference/KEGG Compound C05604
type: UnificationXref
id: C05604
db: KEGG Compound

Reference/ChemSpider 141655
type: UnificationXref
id: 141655
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Protein/762 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Maleylacetoacetate isomerase
stoichiometric coefficient: 2.0

Reference/BioCyc MELANIN
type: UnificationXref
id: MELANIN
db: BioCyc

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Melanosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042470

Reference/ChemSpider 532
type: UnificationXref
id: 532
db: ChemSpider

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Oxalacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalacetic acid

ChemicalStructure/PW C001147
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=CC=C1O)C(O)CO

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

p-Hydroxyphenylacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: p-Hydroxyphenylacetic acid

4-Hydroxyphenylpyruvic acid
type: SmallMoleculeReference
xref: Reference/BioCyc P-HYDROXY-PHENYLPYRUVATE
xref: Reference/CAS 156-39-8
xref: Reference/ChEBI CHEBI 15999
xref: Reference/PubChem-compound 979
xref: Reference/HMDB HMDB0000707
xref: Reference/ChemSpider 954
xref: Reference/KEGG Compound C01179
chemical formula: C9H8O4
molecular weight: 180.04225
structure: ChemicalStructure/PW C000558

TransportCatalysis5416
type: Catalysis
controller: Unknown
controlled: Transport14600
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Water

Compound/PW C002411 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

L-Dopa
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: L-Dopa

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Fumarylacetoacetase
type: ProteinReference
xref: Reference/UniProt P16930
organism: Homo sapiens

Reference/ChemSpider 6089
type: UnificationXref
id: 6089
db: ChemSpider

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000020
type: UnificationXref
id: HMDB0000020
db: HMDB

Reference/HMDB HMDB0000022
type: UnificationXref
id: HMDB0000022
db: HMDB

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Pyrocatechol
type: SmallMoleculeReference
xref: Reference/BioCyc CATECHOL
xref: Reference/KEGG Compound C00090
xref: Reference/PubChem-compound 289
xref: Reference/CAS 120-80-9
xref: Reference/HMDB HMDB0000957
xref: Reference/ChEBI CHEBI 18135
xref: Reference/ChemSpider 13837760
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C000764

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 18135
type: UnificationXref
id: CHEBI:18135
db: ChEBI

L-dopachrome tautomerase
type: ProteinReference
xref: Reference/UniProt P40126
organism: Homo sapiens

4-Hydroxyphenylpyruvic acid
type: SmallMolecule
entity reference: 4-Hydroxyphenylpyruvic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 13023-73-9
type: UnificationXref
id: 13023-73-9
db: CAS

Compound/PW C000031 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Macrophage migration inhibitory factor
type: Complex
component stoichiometry: Protein/97 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Macrophage migration inhibitory factor

Reference/PubChem-compound 151276
type: UnificationXref
id: 151276
db: PubChem-compound

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

L-dopachrome tautomerase
type: Protein
cellular location: Cytosol
entity reference: L-dopachrome tautomerase

Compound/PW C000952/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopaquinone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/ChemSpider 4444081
type: UnificationXref
id: 4444081
db: ChemSpider

Reference/KEGG Compound C01036
type: UnificationXref
id: C01036
db: KEGG Compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C000197 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vanillylmandelic acid
stoichiometric coefficient: 1.0

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

ChemicalStructure/PW C000048
type: ChemicalStructure
structure format: SMILES
structure data: CNC[C@H](O)C1=CC(O)=C(O)C=C1

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001376
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)CC(=O)\C=C/C(O)=O

Reference/PubChem-compound 1669
type: UnificationXref
id: 1669
db: PubChem-compound

Reference/HMDB HMDB0003791
type: UnificationXref
id: HMDB0003791
db: HMDB

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Cytosol
entity reference: Amine oxidase [flavin-containing] A

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Guaiacol
type: SmallMolecule
cellular location: Cytosol
entity reference: Guaiacol

Methylamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00218
xref: Reference/BioCyc CPD-4521
xref: Reference/ChEBI CHEBI 16830
xref: Reference/CAS 74-89-5
xref: Reference/PubChem-compound 6329
xref: Reference/ChemSpider 6089
xref: Reference/HMDB HMDB0000164
chemical formula: CH5N
molecular weight: 31.0422
structure: ChemicalStructure/PW C000108

Reference/ChemSpider 643307
type: UnificationXref
id: 643307
db: ChemSpider

Reference/ChemSpider 1200
type: UnificationXref
id: 1200
db: ChemSpider

Reference/CAS 156-38-7
type: UnificationXref
id: 156-38-7
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Reference/UniProt P14679
type: UnificationXref
id: P14679
db: UniProt

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Phenylethanolamine N-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Phenylethanolamine N-methyltransferase

Reference/HMDB HMDB0000291
type: UnificationXref
id: HMDB0000291
db: HMDB

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

5,6-Dihydroxyindole
type: SmallMolecule
cellular location: Cytosol
entity reference: 5,6-Dihydroxyindole

Reference/ChemSpider 1675
type: UnificationXref
id: 1675
db: ChemSpider

Reference/BioCyc L-EPINEPHRINE
type: UnificationXref
id: L-EPINEPHRINE
db: BioCyc

Reference/PubChem-compound 5280393
type: UnificationXref
id: 5280393
db: PubChem-compound

Reference/UniProt Q93099
type: UnificationXref
id: Q93099
db: UniProt

Reference/HMDB HMDB0000068
type: UnificationXref
id: HMDB0000068
db: HMDB

Reference/HMDB HMDB0001398
type: UnificationXref
id: HMDB0001398
db: HMDB

Reference/PubChem-compound 5280398
type: UnificationXref
id: 5280398
db: PubChem-compound

ChemicalStructure/PW C002043
type: ChemicalStructure
structure format: SMILES
structure data: CNCC(O)C1=CC(OC)=C(O)C=C1

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

ChemicalStructure/PW C002044
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CC2=CC(O)=C(O)C=C2N1

Aldehyde dehydrogenase, dimeric NADP-preferring
type: Protein
cellular location: Cytoplasm
entity reference: Aldehyde dehydrogenase, dimeric NADP-preferring

ChemicalStructure/PW C002045
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01061
type: UnificationXref
id: C01061
db: KEGG Compound

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

ChemicalStructure/PW C002040
type: ChemicalStructure
structure format: SMILES
structure data: OC1=C(O)C=C2C=CNC2=C1

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

ChemicalStructure/PW C002041
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(=C1)C(O)C=O

Reference/CAS 28613-33-4
type: UnificationXref
id: 28613-33-4
db: CAS

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/ChemSpider 4884931
type: UnificationXref
id: 4884931
db: ChemSpider

Reference/ChemSpider 759
type: UnificationXref
id: 759
db: ChemSpider

3-hydroxyanthranilate 3,4-dioxygenase
type: Protein
cellular location: Cytoplasm
entity reference: 3-hydroxyanthranilate 3,4-dioxygenase

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

ChemicalStructure/PW C000074
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(CC(O)=O)=CC=C1O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Alcohol dehydrogenase 1A
type: Protein
cellular location: Cytosol
entity reference: Alcohol dehydrogenase 1A

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/UniProt P17735
type: UnificationXref
id: P17735
db: UniProt

Melanin
type: SmallMolecule
cellular location: Melanosome
entity reference: Melanin

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Melanin
type: SmallMolecule
cellular location: Cytosol
entity reference: Melanin

ChemicalStructure/PW C000084
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=C(O)C=CC(O)=C1

Compound/PW C000968 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,6-Dihydroxyindole-2-carboxylic acid
stoichiometric coefficient: 1.0

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000052 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000977 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Oxygen
left: Ascorbic acid
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C002041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxy-4-hydroxyphenylglycolaldehyde
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-7650
type: UnificationXref
id: CPD-7650
db: BioCyc

Reference/ChEBI CHEBI 28918
type: UnificationXref
id: CHEBI:28918
db: ChEBI

Reference/PubChem-compound 5610
type: UnificationXref
id: 5610
db: PubChem-compound

Reference/BioCyc P-HYDROXY-PHENYLPYRUVATE
type: UnificationXref
id: P-HYDROXY-PHENYLPYRUVATE
db: BioCyc

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

3,4-Dihydroxymandelic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 85782
xref: Reference/HMDB HMDB0001866
xref: Reference/KEGG Compound C05580
xref: Reference/ChEBI CHEBI 27637
xref: Reference/CAS 775-01-9
xref: Reference/ChemSpider 77371
chemical formula: C8H8O5
molecular weight: 184.03717
structure: ChemicalStructure/PW C001240

Tyrosinase
type: Protein
cellular location: Melanosome Membrane
entity reference: Tyrosinase

Reference/UniProt P16930
type: UnificationXref
id: P16930
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: Oxygen
left: L-Dopa
left: Tetrahydrobiopterin
name: L-Dopa + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + Dopamine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 4573572
type: UnificationXref
id: 4573572
db: ChemSpider

Homovanillin
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Homovanillin

Reference/BioCyc CPD-782
type: UnificationXref
id: CPD-782
db: BioCyc

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Reference/ChemSpider 124
type: UnificationXref
id: 124
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Compound/PW C001420 Melanosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/PW C002683 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Alcohol dehydrogenase 1A
type: ProteinReference
xref: Reference/UniProt P07327
organism: Homo sapiens

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/CAS 4430-97-1 25520-73-4
type: UnificationXref
id: 4430-97-1 25520-73-4
db: CAS

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

ChemicalStructure/PW C000558
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)CC1=CC=C(O)C=C1

Compound/PW C001969 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Aldehyde dehydrogenase, dimeric NADP-preferring
type: Protein
cellular location: Cytosol
entity reference: Aldehyde dehydrogenase, dimeric NADP-preferring

Compound/PW C000558/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylpyruvic acid
stoichiometric coefficient: 1.0

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Compound/PW C002411 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444078
type: UnificationXref
id: 4444078
db: ChemSpider

Compound/PW C001376 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Maleylacetoacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 51-43-4
type: UnificationXref
id: 51-43-4
db: CAS

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

2.6.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558 Cytosol/Stoichiometry/1.0
right: 4-Hydroxyphenylpyruvic acid
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.5
left: Oxoglutaric acid
left: L-Tyrosine
name: L-Tyrosine + Oxoglutaric acid ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamic acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 742324
type: UnificationXref
id: CHEBI:742324
db: ChEBI

Reference/PubChem-compound 5816
type: UnificationXref
id: 5816
db: PubChem-compound

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/ChEBI CHEBI 27637
type: UnificationXref
id: CHEBI:27637
db: ChEBI

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Vanillylmandelic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 643307
xref: Reference/KEGG Compound C05584
xref: Reference/CAS 55-10-7
xref: Reference/HMDB HMDB0000291
xref: Reference/ChEBI CHEBI 1127735
xref: Reference/PubChem-compound 736172
chemical formula: C9H10O5
molecular weight: 198.05283
structure: ChemicalStructure/PW C000197

Fumarylacetoacetase
type: Complex
component stoichiometry: Protein/677 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Fumarylacetoacetase

Reference/ChemSpider 1606
type: UnificationXref
id: 1606
db: ChemSpider

Tyrosinase
type: Protein
cellular location: Melanosome
entity reference: Tyrosinase

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/BioCyc 4-FUMARYL-ACETOACETATE
type: UnificationXref
id: 4-FUMARYL-ACETOACETATE
db: BioCyc

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Phenylalanine and Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118532
pathway component: SubPathwayInteraction118532
xref: Reference/SMPDB SMP0000008
xref: Reference/PathWhiz PW000042
name: SubPathway

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 51-67-2
type: UnificationXref
id: 51-67-2
db: CAS

Compound/PW C002411 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/PubChem-compound 460
type: UnificationXref
id: 460
db: PubChem-compound

Reference/ChEBI CHEBI 1127735
type: UnificationXref
id: CHEBI:1127735
db: ChEBI

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

ChemicalStructure/PW C000108
type: ChemicalStructure
structure format: SMILES
structure data: CN

Reference/KEGG Compound C04185
type: UnificationXref
id: C04185
db: KEGG Compound

Reference/ChEBI CHEBI 27852
type: UnificationXref
id: CHEBI:27852
db: ChEBI

Reference/PubChem-compound 1237
type: UnificationXref
id: 1237
db: PubChem-compound

Compound/PW C000977 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00822
type: UnificationXref
id: C00822
db: KEGG Compound

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

3,4-Dihydroxybenzeneacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 41941
xref: Reference/ChemSpider 532
xref: Reference/HMDB HMDB0001336
xref: Reference/KEGG Compound C01161
xref: Reference/PubChem-compound 547
xref: Reference/CAS 102-32-9
xref: Reference/BioCyc CPD-782
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C001029

Reference/CAS 5001-33-2
type: UnificationXref
id: 5001-33-2
db: CAS

Amiloride-sensitive amine oxidase [copper-containing]
type: Protein
cellular location: Cytosol
entity reference: Amiloride-sensitive amine oxidase [copper-containing]

Ascorbic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Ascorbic acid

Reference/HMDB HMDB0001336
type: UnificationXref
id: HMDB0001336
db: HMDB

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Pyrocatechol
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrocatechol

Compound/PW C000015 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 60872
type: UnificationXref
id: CHEBI:60872
db: ChEBI

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Reference/CAS 74-89-5
type: UnificationXref
id: 74-89-5
db: CAS

Reference/CAS 5707-55-1
type: UnificationXref
id: 5707-55-1
db: CAS

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000968
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC2=C(N1)C=C(O)C(O)=C2

Reference/PubChem-compound 119405
type: UnificationXref
id: 119405
db: PubChem-compound

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Protein/729 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Alcohol dehydrogenase 1A
stoichiometric coefficient: 2.0

Guaiacol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001398
xref: Reference/KEGG Compound C01502
xref: Reference/BioCyc CPD-400
xref: Reference/PubChem-compound 460
xref: Reference/ChEBI CHEBI 28591
xref: Reference/CAS 90-05-1
xref: Reference/ChemSpider 447
chemical formula: C7H8O2
molecular weight: 124.05243
structure: ChemicalStructure/PW C001081

Reference/PubChem-compound 5459802
type: UnificationXref
id: 5459802
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Water

Protein/277 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate aminotransferase, cytoplasmic
stoichiometric coefficient: 2.0

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0000819
type: UnificationXref
id: HMDB0000819
db: HMDB

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Reference/ChemSpider 77371
type: UnificationXref
id: 77371
db: ChemSpider

ChemicalStructure/PW C000981
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)CC(=O)\C=C\C(O)=O

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/CAS 120-80-9
type: UnificationXref
id: 120-80-9
db: CAS

Reference/ChemSpider 106504
type: UnificationXref
id: 106504
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/PubChem-compound 6329
type: UnificationXref
id: 6329
db: PubChem-compound

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 151725
type: UnificationXref
id: 151725
db: PubChem-compound

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 552441
xref: Reference/HMDB HMDB0006915
xref: Reference/KEGG Compound C05350
xref: Reference/ChEBI CHEBI 27683
xref: Reference/PubChem-compound 636708
chemical formula: C9H8O4
molecular weight: 180.04225
structure: ChemicalStructure/PW C003007

ChemicalStructure/PW C000952
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC(=O)C(=O)C=C1)C(O)=O

Reference/ChEBI CHEBI 27404
type: UnificationXref
id: CHEBI:27404
db: ChEBI

Reference/ChEBI CHEBI 27406
type: UnificationXref
id: CHEBI:27406
db: ChEBI

Metanephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Metanephrine

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

3.7.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000088 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000981 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Cytosol/Stoichiometry/1.0
right: Acetoacetic acid
right: Fumaric acid
spontaneous: false
EC number: 3.7.1.2
left: 4-Fumarylacetoacetic acid
left: Water
name: 4-Fumarylacetoacetic acid + Water → Acetoacetic acid + Fumaric acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 89762-39-0
type: UnificationXref
id: 89762-39-0
db: CAS

Reference/PubChem-compound 289
type: UnificationXref
id: 289
db: PubChem-compound

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000764
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=CC=C1O

Compound/PW C000042 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/UniProt P46952
type: UnificationXref
id: P46952
db: UniProt

Oxygen
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Oxygen

Reference/ChEBI CHEBI 41941
type: UnificationXref
id: CHEBI:41941
db: ChEBI

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C00642
type: UnificationXref
id: C00642
db: KEGG Compound

Homovanillin
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Homovanillin

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Methylamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Methylamine

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01502
type: UnificationXref
id: C01502
db: KEGG Compound

Reference/ChEBI CHEBI 545959
type: UnificationXref
id: CHEBI:545959
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

ChemicalStructure/PW C002926
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=C2NC=CC2=CC1=O

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Protein/97 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Macrophage migration inhibitory factor
stoichiometric coefficient: 2.0

3,4-Dihydroxymandelic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxymandelic acid

Compound/PW C001081 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guaiacol
stoichiometric coefficient: 1.0

Reaction1118
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
right: Oxalacetic acid
right: L-Glutamic acid
spontaneous: false
left: L-Aspartic acid
left: Oxoglutaric acid
name: L-Aspartic acid + Oxoglutaric acid → L-Glutamic acid + Oxalacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Compound/PW C001105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopachrome
stoichiometric coefficient: 1.0

2.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Epinephrine
spontaneous: false
EC number: 2.1.1.28
left: Norepinephrine
left: S-Adenosylmethionine
name: Norepinephrine + S-Adenosylmethionine → Epinephrine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P17174
type: UnificationXref
id: P17174
db: UniProt

ReactionCatalysis117
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Reference/ChEBI CHEBI 27683
type: UnificationXref
id: CHEBI:27683
db: ChEBI

Reference/BioCyc 4-MALEYL-ACETOACETATE
type: UnificationXref
id: 4-MALEYL-ACETOACETATE
db: BioCyc

Homogentisate 1,2-dioxygenase
type: Protein
cellular location: Cytosol
entity reference: Homogentisate 1,2-dioxygenase