Reference/SMPDB SMP0125795
type: UnificationXref
id: SMP0125795
db: SMPDB

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Mitochondrial pyruvate carrier 1
type: ProteinReference
xref: Reference/UniProt Q9Y5U8

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Water

Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Glucose-6-phosphatase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphatase

Reference/PubChem-compound 439278
type: UnificationXref
id: 439278
db: PubChem-compound

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Phosphoglycerate mutase 2
type: ProteinReference
xref: Reference/UniProt P15259
organism: Homo sapiens

Phosphoglycerate mutase 1
type: ProteinReference
xref: Reference/UniProt P18669
organism: Homo sapiens

Bisphosphoglycerate mutase
type: ProteinReference
xref: Reference/UniProt P07738
organism: Homo sapiens

ReactionCatalysis942
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

ReactionCatalysis940
type: Catalysis
controller: Hexokinase-2
controlled: 2.7.1.1
control type: ACTIVATION

Reference/ChemSpider 58238
type: UnificationXref
id: 58238
db: ChemSpider

Reference/PathWhiz PW000055
type: UnificationXref
id: PW000055
db: PathWhiz

Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001058
xref: Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
xref: Reference/CAS 488-69-7
xref: Reference/ChEBI CHEBI 16905
xref: Reference/ChemSpider 393165
xref: Reference/KEGG Compound C00354
xref: Reference/PubChem-compound 445557
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000833

Reference/PathWhiz PW000054
type: UnificationXref
id: PW000054
db: PathWhiz

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reaction1242
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000998 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: 3-Phosphoglyceric acid
spontaneous: false
left: 2,3-Diphosphoglyceric acid
left: Water
name: 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate
conversion direction: REVERSIBLE

Reaction1243
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000998 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: 3-Phosphoglyceric acid
spontaneous: false
left: 2,3-Diphosphoglyceric acid
left: Water
name: 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate
conversion direction: REVERSIBLE

Reaction1240
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000998 Cytosol/Stoichiometry/1.0
right: 2,3-Diphosphoglyceric acid
spontaneous: false
left: Glyceric acid 1,3-biphosphate
name: Glyceric acid 1,3-biphosphate ↔ 2,3-Diphosphoglyceric acid
conversion direction: REVERSIBLE

ReactionCatalysis939
type: Catalysis
controller: Aldose 1-epimerase
controlled: 5.1.3.3
control type: ACTIVATION

ReactionCatalysis937
type: Catalysis
controller: Hexokinase-2
controlled: 2.7.1.1
control type: ACTIVATION

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Oxoglutaric acid

Reaction1246
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001870 Cytosol/Stoichiometry/1.0
right: 2-Phospho-D-glyceric acid
spontaneous: false
left: 3-Phosphoglyceric acid
name: 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0003498
type: UnificationXref
id: HMDB0003498
db: HMDB

Malic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Malic acid

Reference/ChemSpider 5743
type: UnificationXref
id: 5743
db: ChemSpider

Compound/PW C000592 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malic acid
stoichiometric coefficient: 1.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/PathWhiz PW000042
type: UnificationXref
id: PW000042
db: PathWhiz

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Compound/PW C000592 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malic acid
stoichiometric coefficient: 1.0

ReactionCatalysis965
type: Catalysis
controller: Glucose-6-phosphatase
controlled: 3.1.3.9
control type: ACTIVATION

ChemicalStructure/PW C001083
type: ChemicalStructure
structure format: SMILES

Malate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/803 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Malate dehydrogenase, mitochondrial

ReactionCatalysis960
type: Catalysis
controller: Alpha-enolase
controlled: 4.2.1.11
control type: ACTIVATION

β-D-Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 388538
xref: Reference/KEGG Compound C01172
xref: Reference/ChEBI CHEBI 17719
xref: Reference/HMDB HMDB0003498
xref: Reference/PubChem-compound 439427
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001906

Reference/PathWhiz PW000032
type: UnificationXref
id: PW000032
db: PathWhiz

Reference/HMDB HMDB0003391
type: UnificationXref
id: HMDB0003391
db: HMDB

Reference/PathWhiz PW000159
type: UnificationXref
id: PW000159
db: PathWhiz

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/PathWhiz PW000036
type: UnificationXref
id: PW000036
db: PathWhiz

Reference/KEGG Compound C00221
type: UnificationXref
id: C00221
db: KEGG Compound

2,3-Diphosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2,3-Diphosphoglyceric acid

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

Compound/PW C001083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/PathWhiz PW000031
type: UnificationXref
id: PW000031
db: PathWhiz

Reference/KEGG Compound C00103
type: UnificationXref
id: C00103
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/PathWhiz PW000150
type: UnificationXref
id: PW000150
db: PathWhiz

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/UniProt O43826
type: UnificationXref
id: O43826
db: UniProt

Reference/PubChem-compound 439165
type: UnificationXref
id: 439165
db: PubChem-compound

Reference/CAS 488-69-7
type: UnificationXref
id: 488-69-7
db: CAS

D-Glucose
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: D-Glucose

ReactionCatalysis958
type: Catalysis
controller: Phosphoglycerate mutase 2
controlled: Reaction1246
control type: ACTIVATION

ReactionCatalysis713
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

ReactionCatalysis955
type: Catalysis
controller: Bisphosphoglycerate mutase
controlled: Reaction1243
control type: ACTIVATION

ReactionCatalysis954
type: Catalysis
controller: Phosphoglycerate mutase 1
controlled: Reaction1242
control type: ACTIVATION

Protein/803 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Malate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

ReactionCatalysis952
type: Catalysis
controller: Bisphosphoglycerate mutase
controlled: Reaction1240
control type: ACTIVATION

Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C001083 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 59-56-3
type: UnificationXref
id: 59-56-3
db: CAS

Glyceric acid 1,3-biphosphate
type: SmallMoleculeReference
xref: Reference/CAS 1981-49-3
xref: Reference/ChemSpider 663
xref: Reference/BioCyc DPG
xref: Reference/HMDB HMDB0001270
xref: Reference/KEGG Compound C00236
xref: Reference/PubChem-compound 683
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000983

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Transport67
type: Transport
participant stoichiometry: Compound/PW C001104 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
spontaneous: false
left: Phosphate
name: Phosphate (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Alpha-enolase
type: Protein
cellular location: Cytosol
entity reference: Alpha-enolase

Reference/UniProt Q02978
type: UnificationXref
id: Q02978
db: UniProt

Reference/KEGG Compound C00236
type: UnificationXref
id: C00236
db: KEGG Compound

Reference/ChemSpider 388311
type: UnificationXref
id: 388311
db: ChemSpider

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000122 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Reference/KEGG Compound C00354
type: UnificationXref
id: C00354
db: KEGG Compound

Reference/UniProt P60174
type: UnificationXref
id: P60174
db: UniProt

Transport70
type: Transport
participant stoichiometry: Compound/PW C000180 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
right: Phosphoenolpyruvic acid
spontaneous: false
left: Phosphoenolpyruvic acid
name: Phosphoenolpyruvic acid (?) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Aldose 1-epimerase
type: Protein
cellular location: Cytosol
entity reference: Aldose 1-epimerase

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glyceraldehyde-3-phosphate dehydrogenase

Monocarboxylate transporter 1
type: Protein
entity reference: Monocarboxylate transporter 1

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Fructose 1,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 1,6-bisphosphate

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: Fructose 6-phosphate
name: Fructose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

5.1.3.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000395 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001851 Cytosol/Stoichiometry/1.0
right: β-D-Glucose
spontaneous: false
EC number: 5.1.3.3
left: α-D-Glucose
name: α-D-Glucose ↔ β-D-Glucose
conversion direction: REVERSIBLE

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

ChemicalStructure/PW C001906
type: ChemicalStructure
structure format: SMILES

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

2,3-Diphosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17720
xref: Reference/CAS 138-81-8
xref: Reference/HMDB HMDB0001294
xref: Reference/ChemSpider 161681
xref: Reference/PubChem-compound 186004
xref: Reference/KEGG Compound C01159
xref: Reference/BioCyc 23-DIPHOSPHOGLYCERATE
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000998

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt P15259
type: UnificationXref
id: P15259
db: UniProt

Transport280
type: Transport
participant stoichiometry: Compound/PW C000122 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000122 Extracellular Space/Stoichiometry/1.0
right: L-Lactic acid
spontaneous: false
left: L-Lactic acid
name: L-Lactic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 6-phosphate
name: SubPathwayInput

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyruvic acid
name: SubPathwayOutput

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Compound/PW C000148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Transport14710
type: Transport
participant stoichiometry: Compound/PW C001083 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
left: Glucose 6-phosphate
name: Glucose 6-phosphate (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum Lumen to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Mitochondrial 2-oxoglutarate/malate carrier protein
type: Protein
entity reference: Mitochondrial 2-oxoglutarate/malate carrier protein

Reference/BioCyc GLC-1-P
type: UnificationXref
id: GLC-1-P
db: BioCyc

α-D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003345
xref: Reference/ChemSpider 71358
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/PubChem-compound 79025
xref: Reference/ChEBI CHEBI 17925
xref: Reference/CAS 492-62-6
xref: Reference/KEGG Compound C00267
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C001851

Phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphate

Reference/ChemSpider 388411
type: UnificationXref
id: 388411
db: ChemSpider

Reference/ChemSpider 388538
type: UnificationXref
id: 388538
db: ChemSpider

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid
name: SubPathwayOutput

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

Reference/UniProt P53985
type: UnificationXref
id: P53985
db: UniProt

Protein/260 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Bisphosphoglycerate mutase
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChemSpider 161681
type: UnificationXref
id: 161681
db: ChemSpider

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

SubPathwayInteraction119512
type: Interaction
name: SubPathway119512Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Glucose-6-phosphatase
type: ProteinReference
xref: Reference/UniProt P35575
organism: Homo sapiens

SubPathwayInteraction119511
type: Interaction
name: SubPathwayReaction
name: SubPathway119511Reaction
participant: D-Glyceraldehyde 3-phosphate
participant: 3-Phosphoglyceric acid

SubPathwayInteraction119510
type: Interaction
name: SubPathway119510Reaction
name: SubPathwayReaction
participant: L-Lactic acid

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

SubPathwayInteraction119505
type: Interaction
name: SubPathwayReaction
name: SubPathway119505Reaction
participant: Phosphoenolpyruvic acid

SubPathwayInteraction119504
type: Interaction
name: SubPathway119504Reaction
name: SubPathwayReaction
participant: D-Glyceraldehyde 3-phosphate
participant: Phosphoenolpyruvic acid

SubPathwayInteraction119503
type: Interaction
name: SubPathway119503Reaction
name: SubPathwayReaction
participant: D-Glyceraldehyde 3-phosphate

SubPathwayInteraction119502
type: Interaction
name: SubPathwayReaction
name: SubPathway119502Reaction
participant: D-Glyceraldehyde 3-phosphate
participant: Fructose 6-phosphate

SubPathwayInteraction119509
type: Interaction
name: SubPathway119509Reaction
name: SubPathwayReaction
participant: Pyruvic acid

SubPathwayInteraction119508
type: Interaction
name: SubPathway119508Reaction
name: SubPathwayReaction
participant: Pyruvic acid

SubPathwayInteraction119507
type: Interaction
name: SubPathway119507Reaction
name: SubPathwayReaction
participant: Pyruvic acid

SubPathwayInteraction119506
type: Interaction
name: SubPathway119506Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000463 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/UniProt P52789
type: UnificationXref
id: P52789
db: UniProt

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P18669
type: UnificationXref
id: P18669
db: UniProt

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11498
organism: Homo sapiens

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

SubPathwayInteraction119501
type: Interaction
name: SubPathway119501Reaction
name: SubPathwayReaction
participant: D-Glucose
participant: D-Glyceraldehyde 3-phosphate

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

SubPathwayInteraction119500
type: Interaction
name: SubPathwayReaction
name: SubPathway119500Reaction
participant: Glucose 1-phosphate

Reference/KEGG Compound C00267
type: UnificationXref
id: C00267
db: KEGG Compound

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Compound/PW C000395 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose
stoichiometric coefficient: 1.0

ReactionCatalysis513
type: Catalysis
controller: Glucose-6-phosphatase
controlled: 3.1.3.9
control type: ACTIVATION

Reference/UniProt P06733
type: UnificationXref
id: P06733
db: UniProt

Glucose-6-phosphatase
type: Protein
cellular location: Endoplasmic Reticulum Lumen
entity reference: Glucose-6-phosphatase

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/PubChem-compound 525
type: UnificationXref
id: 525
db: PubChem-compound

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/PubChem-compound 186004
type: UnificationXref
id: 186004
db: PubChem-compound

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Transport1
type: Transport
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction119499
type: Interaction
name: SubPathway119499Reaction
name: SubPathwayReaction
participant: Glucose 1-phosphate

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

SubPathwayInteraction119498
type: Interaction
name: SubPathwayReaction
name: SubPathway119498Reaction
participant: D-Glucose

Reference/HMDB HMDB0001586
type: UnificationXref
id: HMDB0001586
db: HMDB

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

L-Lactic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Lactic acid
name: SubPathwayOutput

Oxalacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalacetic acid

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayOutput
name: SubPathwayInput

TransportCatalysis5520
type: Catalysis
controller: Glucose-6-phosphate translocase
controlled: Transport14710
control type: ACTIVATION

L-Lactic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Lactic acid

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine diphosphate

Reference/CAS 492-61-5
type: UnificationXref
id: 492-61-5
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Protein/659 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 4.0

3.1.3.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001207 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: D-Glucose
spontaneous: false
EC number: 3.1.3.9
left: Glucose 1-phosphate
left: Water
name: Glucose 1-phosphate + Water → D-Glucose + Phosphate
conversion direction: LEFT_TO_RIGHT

3.1.3.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Fructose 6-phosphate
spontaneous: false
EC number: 3.1.3.11
left: Fructose 1,6-bisphosphate
left: Water
name: Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P06744
type: UnificationXref
id: P06744
db: UniProt

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

4.1.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 4.1.2.13
left: Fructose 1,6-bisphosphate
name: Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

3.1.3.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
right: D-Glucose
right: Phosphate
spontaneous: false
EC number: 3.1.3.9
left: Water
left: Glucose 6-phosphate
name: Glucose 6-phosphate + Water ↔ D-Glucose + Phosphate
conversion direction: REVERSIBLE

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Phosphate

Protein/19 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase, mitochondrial
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/PubChem-compound 64689
type: UnificationXref
id: 64689
db: PubChem-compound

Reaction812
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: NADH
right: Glyceric acid 1,3-biphosphate
spontaneous: false
left: NAD
left: Phosphoric acid
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH
conversion direction: REVERSIBLE

Compound/PW C000592 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malic acid
stoichiometric coefficient: 1.0

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

5.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 5.3.1.1
left: Dihydroxyacetone phosphate
name: Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate
conversion direction: REVERSIBLE

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Hexokinase-2
type: ProteinReference
xref: Reference/UniProt P52789
organism: Homo sapiens

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 16077
type: UnificationXref
id: CHEBI:16077
db: ChEBI

Reference/ChEBI CHEBI 4170
type: UnificationXref
id: CHEBI:4170
db: ChEBI

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

ChemicalStructure/PW C000395
type: ChemicalStructure
structure format: SMILES

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvic acid

Compound/PW C001104 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/CAS 492-62-6
type: UnificationXref
id: 492-62-6
db: CAS

Compound/PW C001851 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-D-Glucose
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

5.4.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001207 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.4.2.2
left: Glucose 1-phosphate
name: Glucose 1-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

Malic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Malic acid

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/BioCyc DPG
type: UnificationXref
id: DPG
db: BioCyc

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Reference/BioCyc MAL
type: UnificationXref
id: MAL
db: BioCyc

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Reference/KEGG Compound C01159
type: UnificationXref
id: C01159
db: KEGG Compound

Reference/PubChem-compound 445557
type: UnificationXref
id: 445557
db: PubChem-compound

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/ChemSpider 663
type: UnificationXref
id: 663
db: ChemSpider

α-D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: α-D-Glucose

2-Phospho-D-glyceric acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439278
xref: Reference/ChemSpider 388411
xref: Reference/ChEBI CHEBI 17835
xref: Reference/HMDB HMDB0003391
xref: Reference/BioCyc 2-PG
xref: Reference/KEGG Compound C00631
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C001870

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

Mitochondrial pyruvate carrier 1
type: Protein
entity reference: Mitochondrial pyruvate carrier 1

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Oxalacetic acid
spontaneous: false
EC number: 6.4.1.1
left: Adenosine triphosphate
left: Hydrogen carbonate
left: Pyruvic acid
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

3-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Phosphoglyceric acid
name: SubPathwayInput

Reference/UniProt P07738
type: UnificationXref
id: P07738
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Endoplasmic Reticulum Lumen
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005788

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: Protein
cellular location: Cytosol
entity reference: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Compound/PW C001420 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Malate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Malate dehydrogenase, mitochondrial

Fructose-bisphosphate aldolase A
type: Protein
cellular location: Cytosol
entity reference: Fructose-bisphosphate aldolase A

Fructose-1,6-bisphosphatase 1
type: ProteinReference
xref: Reference/UniProt P09467
organism: Homo sapiens

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Thiamine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119504
pathway component: SubPathwayInteraction119504
xref: Reference/PathWhiz PW000036
xref: Reference/SMPDB SMP0000076
name: SubPathway

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/KEGG Compound C01172
type: UnificationXref
id: C01172
db: KEGG Compound

Protein/1472 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Triosephosphate isomerase
stoichiometric coefficient: 2.0

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Phosphoglycerate mutase 1
type: Protein
cellular location: Cytosol
entity reference: Phosphoglycerate mutase 1

Reference/UniProt Q9Y5U8
type: UnificationXref
id: Q9Y5U8
db: UniProt

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Malic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00711
xref: Reference/ChEBI CHEBI 6650
xref: Reference/ChemSpider 510
xref: Reference/CAS 6915-15-7
xref: Reference/BioCyc MAL
xref: Reference/HMDB HMDB0000744
xref: Reference/PubChem-compound 525
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000592

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Glucose-6-phosphate isomerase
type: Complex
component stoichiometry: Protein/751 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glucose-6-phosphate isomerase

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Glucose 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001586
xref: Reference/PubChem-compound 439165
xref: Reference/CAS 59-56-3
xref: Reference/BioCyc GLC-1-P
xref: Reference/ChEBI CHEBI 16077
xref: Reference/KEGG Compound C00103
xref: Reference/ChemSpider 388311
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001207

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/KEGG Compound C00092
type: UnificationXref
id: C00092
db: KEGG Compound

Reference/ChemSpider 71358
type: UnificationXref
id: 71358
db: ChemSpider

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt P06744
organism: Homo sapiens

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/HMDB HMDB0001270
type: UnificationXref
id: HMDB0001270
db: HMDB

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxalacetic acid

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/UniProt P04406
type: UnificationXref
id: P04406
db: UniProt

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Reference/CAS 56-73-5
type: UnificationXref
id: 56-73-5
db: CAS

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc 23-DIPHOSPHOGLYCERATE
type: UnificationXref
id: 23-DIPHOSPHOGLYCERATE
db: BioCyc

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Phosphoglucomutase-1
type: Protein
cellular location: Cytosol
entity reference: Phosphoglucomutase-1

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Pantothenate kinase 1
type: Complex
component stoichiometry: Protein/963 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Pantothenate kinase 1

Malate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/803 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Malate dehydrogenase, mitochondrial

Reference/HMDB HMDB0003345
type: UnificationXref
id: HMDB0003345
db: HMDB

Reference/ChemSpider 510
type: UnificationXref
id: 510
db: ChemSpider

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/CAS 138-81-8
type: UnificationXref
id: 138-81-8
db: CAS

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

Compound/PW C000998 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-Diphosphoglyceric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 393165
type: UnificationXref
id: 393165
db: ChemSpider

Triosephosphate isomerase
type: Complex
component stoichiometry: Protein/1472 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Triosephosphate isomerase

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

β-D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Glucose

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Compound/PW C000122 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Malic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Malic acid

Glucose-6-phosphate translocase
type: ProteinReference
xref: Reference/UniProt O43826

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: Reference/UniProt P04406
organism: Homo sapiens

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Protein/748 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-1,6-bisphosphatase 1
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0001058
type: UnificationXref
id: HMDB0001058
db: HMDB

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Compound/PW C001207 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Reference/HMDB HMDB0001294
type: UnificationXref
id: HMDB0001294
db: HMDB

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/ChEBI CHEBI 15903
type: UnificationXref
id: CHEBI:15903
db: ChEBI

Aldose 1-epimerase
type: ProteinReference
xref: Reference/UniProt Q96C23
organism: Homo sapiens

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

2-Phospho-D-glyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Phospho-D-glyceric acid

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Protein/916 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-bisphosphate aldolase A
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 6650
type: UnificationXref
id: CHEBI:6650
db: ChEBI

Glyceraldehyde-3-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/659 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glyceraldehyde-3-phosphate dehydrogenase

Pentose Phosphate Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119501
pathway component: SubPathwayInteraction119501
xref: Reference/PathWhiz PW000055
xref: Reference/SMPDB SMP0000031
name: SubPathway

Compound/PW C000983 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid 1,3-biphosphate
stoichiometric coefficient: 1.0

Compound/PW C000833 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt P35575
type: UnificationXref
id: P35575
db: UniProt

Reference/UniProt Q96C23
type: UnificationXref
id: Q96C23
db: UniProt

Glycerolipid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119511
pathway component: SubPathwayInteraction119511
xref: Reference/PathWhiz PW000144
xref: Reference/SMPDB SMP0000039
name: SubPathway

β-D-Glucose
type: SmallMoleculeReference
xref: Reference/PubChem-compound 64689
xref: Reference/ChemSpider 58238
xref: Reference/HMDB HMDB0000516
xref: Reference/KEGG Compound C00221
xref: Reference/CAS 492-61-5
xref: Reference/ChEBI CHEBI 15903
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000395

Compound/PW C000180 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Glucose 6-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Glucose 6-phosphate

Triosephosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Triosephosphate isomerase

Reference/UniProt P11498
type: UnificationXref
id: P11498
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: ProteinReference
xref: Reference/UniProt P35558
organism: Homo sapiens

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

TransportCatalysis6
type: Catalysis
controller: Mitochondrial pyruvate carrier 1
controlled: Transport1
control type: ACTIVATION

TransportCatalysis8
type: Catalysis
controller: Mitochondrial 2-oxoglutarate/malate carrier protein
controlled: Transport32
control type: ACTIVATION

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Reference/CAS 1981-49-3
type: UnificationXref
id: 1981-49-3
db: CAS

Galactose Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119498
pathway order: SubPathwayInteractionSteps/SubPathway119503
pathway component: SubPathwayInteraction119503
pathway component: SubPathwayInteraction119498
xref: Reference/PathWhiz PW000159
xref: Reference/SMPDB SMP0000043
name: SubPathway

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Pantothenate kinase 1
type: ProteinReference
xref: Reference/UniProt Q8TE04
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Alanine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119512
pathway component: SubPathwayInteraction119512
xref: Reference/PathWhiz PW000001
xref: Reference/SMPDB SMP0000055
name: SubPathway

Reference/HMDB HMDB0001401
type: UnificationXref
id: HMDB0001401
db: HMDB

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16905
type: UnificationXref
id: CHEBI:16905
db: ChEBI

Fructose-1,6-bisphosphatase 1
type: Protein
cellular location: Cytosol
entity reference: Fructose-1,6-bisphosphatase 1

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Starch and Sucrose Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119500
pathway component: SubPathwayInteraction119500
xref: Reference/SMPDB SMP0000058
xref: Reference/PathWhiz PW000150
name: SubPathway

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/PW C000644 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119508
pathway component: SubPathwayInteraction119508
xref: Reference/PathWhiz PW000002
xref: Reference/SMPDB SMP0000067
name: SubPathway

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

Fructose and Mannose Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119502
pathway component: SubPathwayInteraction119502
xref: Reference/PathWhiz PW000025
xref: Reference/SMPDB SMP0000064
name: SubPathway

Pyruvate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119506
pathway component: SubPathwayInteraction119506
xref: Reference/SMPDB SMP0000060
xref: Reference/PathWhiz PW000054
name: SubPathway

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

TransportCatalysis228
type: Catalysis
controller: Monocarboxylate transporter 1
controlled: Transport280
control type: ACTIVATION

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/UniProt P40926
type: UnificationXref
id: P40926
db: UniProt

Hexokinase-2
type: Protein
cellular location: Cytosol
entity reference: Hexokinase-2

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Glucose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 1-phosphate
name: SubPathwayOutput

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/PubChem-compound 683
type: UnificationXref
id: 683
db: PubChem-compound

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvic acid
name: SubPathwayInput

Triosephosphate isomerase
type: ProteinReference
xref: Reference/UniProt P60174
organism: Homo sapiens

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Pantothenate kinase 1
type: Protein
cellular location: Cytosol
entity reference: Pantothenate kinase 1

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Compound/PW C000180 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Reference/SMPDB SMP0000043
type: UnificationXref
id: SMP0000043
db: SMPDB

Protein/803 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Malate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Fructose-bisphosphate aldolase A
type: ProteinReference
xref: Reference/UniProt P04075
organism: Homo sapiens

Reference/ChEBI CHEBI 17835
type: UnificationXref
id: CHEBI:17835
db: ChEBI

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphoenolpyruvic acid

ReactionCatalysis4
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: 6.4.1.1
control type: ACTIVATION

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Malate dehydrogenase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Malate dehydrogenase, mitochondrial

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/SMPDB SMP0000058
type: UnificationXref
id: SMP0000058
db: SMPDB

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Phenylalanine and Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119505
pathway component: SubPathwayInteraction119505
xref: Reference/SMPDB SMP0000008
xref: Reference/PathWhiz PW000042
name: SubPathway

Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119509
pathway component: SubPathwayInteraction119509
xref: Reference/PathWhiz PW000142
xref: Reference/SMPDB SMP0000006
name: SubPathway

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Reference/SMPDB SMP0000055
type: UnificationXref
id: SMP0000055
db: SMPDB

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Pyruvate carboxylase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Pyruvate carboxylase, mitochondrial

Reference/UniProt P35558
type: UnificationXref
id: P35558
db: UniProt

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Malate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P40926
organism: Homo sapiens

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

ChemicalStructure/PW C000592
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC(O)=O)C(O)=O

Nucleotide Sugars Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119499
pathway component: SubPathwayInteraction119499
xref: Reference/SMPDB SMP0000010
xref: Reference/PathWhiz PW000031
name: SubPathway

Reference/SMPDB SMP0000060
type: UnificationXref
id: SMP0000060
db: SMPDB

Reference/PubChem-compound 5958
type: UnificationXref
id: 5958
db: PubChem-compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Malic acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Malic acid

Reference/SMPDB SMP0000067
type: UnificationXref
id: SMP0000067
db: SMPDB

Propanoate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119510
pathway component: SubPathwayInteraction119510
xref: Reference/PathWhiz PW000149
xref: Reference/SMPDB SMP0000016
name: SubPathway

Reference/UniProt P00338
type: UnificationXref
id: P00338
db: UniProt

Reference/SMPDB SMP0000064
type: UnificationXref
id: SMP0000064
db: SMPDB

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

ChemicalStructure/PW C001207
type: ChemicalStructure
structure format: SMILES

L-lactate dehydrogenase A chain
type: ProteinReference
xref: Reference/UniProt P00338
organism: Homo sapiens

Alpha-enolase
type: ProteinReference
xref: Reference/UniProt P06733
organism: Homo sapiens

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Compound/PW C000592 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

Reference/UniProt P36871
type: UnificationXref
id: P36871
db: UniProt

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate
name: SubPathwayOutput
name: SubPathwayInput

Reference/ChEBI CHEBI 17925
type: UnificationXref
id: CHEBI:17925
db: ChEBI

Reference/SMPDB SMP0000076
type: UnificationXref
id: SMP0000076
db: SMPDB

Pantothenate and CoA Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119507
pathway component: SubPathwayInteraction119507
xref: Reference/PathWhiz PW000032
xref: Reference/SMPDB SMP0000027
name: SubPathway

Reference/KEGG Compound C00711
type: UnificationXref
id: C00711
db: KEGG Compound

Reference/SMPDB SMP0000008
type: UnificationXref
id: SMP0000008
db: SMPDB

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Compound/PW C000134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000006
type: UnificationXref
id: SMP0000006
db: SMPDB

L-lactate dehydrogenase A chain
type: Protein
cellular location: Cytosol
entity reference: L-lactate dehydrogenase A chain

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C000077 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

TransportCatalysis15
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport42
control type: ACTIVATION

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00092
xref: Reference/BioCyc GLC-6-P
xref: Reference/HMDB HMDB0001401
xref: Reference/PubChem-compound 5958
xref: Reference/ChemSpider 5743
xref: Reference/CAS 56-73-5
xref: Reference/ChEBI CHEBI 4170
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001083

Protein/751 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

ReactionCatalysis661
type: Catalysis
controller: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
controlled: 4.1.1.32
control type: ACTIVATION

Reference/SMPDB SMP0000016
type: UnificationXref
id: SMP0000016
db: SMPDB

Monocarboxylate transporter 1
type: ProteinReference
xref: Reference/UniProt P53985

Phosphoglucomutase-1
type: ProteinReference
xref: Reference/UniProt P36871
organism: Homo sapiens

Phosphoglycerate mutase 2
type: Protein
cellular location: Cytosol
entity reference: Phosphoglycerate mutase 2

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/19 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Pyruvate carboxylase, mitochondrial

Compound/PW C001104 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Mitochondrial 2-oxoglutarate/malate carrier protein
type: ProteinReference
xref: Reference/UniProt Q02978

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C000983
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)C(=O)OP(O)(O)=O

Reference/UniProt Q8TE04
type: UnificationXref
id: Q8TE04
db: UniProt

Reference/CAS 6915-15-7
type: UnificationXref
id: 6915-15-7
db: CAS

ReactionCatalysis658
type: Catalysis
controller: L-lactate dehydrogenase A chain
controlled: 1.1.1.27
control type: ACTIVATION

ReactionCatalysis1053
type: Catalysis
controller: Pantothenate kinase 1
controlled: 2.7.1.33
control type: ACTIVATION

4.2.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001870 Cytosol/Stoichiometry/1.0
right: Phosphoenolpyruvic acid
right: Water
spontaneous: false
EC number: 4.2.1.11
left: 2-Phospho-D-glyceric acid
name: 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water
conversion direction: REVERSIBLE

Reference/SMPDB SMP0000010
type: UnificationXref
id: SMP0000010
db: SMPDB

Reference/PubChem-compound 439427
type: UnificationXref
id: 439427
db: PubChem-compound

Compound/PW C001906 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChEBI CHEBI 17720
type: UnificationXref
id: CHEBI:17720
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/UniProt P09467
type: UnificationXref
id: P09467
db: UniProt

Reference/SMPDB SMP0000027
type: UnificationXref
id: SMP0000027
db: SMPDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Glucose-6-phosphate translocase
type: Protein
entity reference: Glucose-6-phosphate translocase

Hydrogen carbonate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen carbonate

β-D-Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Glucose 6-phosphate

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Transport42
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Glycogenosis, Type IC
type: Pathway
pathway order: PathwayEnzymeReaction/2519364
pathway order: PathwayEnzymeReaction/2519365
pathway order: PathwaySubPathway/119509
pathway order: PathwayEnzymeReaction/2519366
pathway order: PathwayTransport/2519368
pathway order: PathwaySubPathway/119508
pathway order: PathwayEnzymeReaction/2519345
pathway order: PathwayEnzymeReaction/2519367
pathway order: PathwayTransport/2519369
pathway order: PathwaySubPathway/119507
pathway order: PathwayEnzymeReaction/2519346
pathway order: PathwayEnzymeReaction/2519347
pathway order: PathwayEnzymeReaction/2519348
pathway order: PathwayEnzymeReaction/2519349
pathway order: PathwayEnzymeReaction/2519360
pathway order: PathwayEnzymeReaction/2519361
pathway order: PathwayEnzymeReaction/2519362
pathway order: PathwayEnzymeReaction/2519363
pathway order: PathwaySubPathway/119498
pathway order: PathwaySubPathway/119512
pathway order: PathwaySubPathway/119511
pathway order: PathwaySubPathway/119499
pathway order: PathwaySubPathway/119510
pathway order: PathwayEnzymeReaction/2519353
pathway order: PathwayEnzymeReaction/2519354
pathway order: PathwayEnzymeReaction/2519355
pathway order: PathwayEnzymeReaction/2519356
pathway order: PathwayEnzymeReaction/2519357
pathway order: PathwayEnzymeReaction/2519358
pathway order: PathwayEnzymeReaction/2519359
pathway order: PathwayTransport/2519373
pathway order: PathwayTransport/2519374
pathway order: PathwayTransport/2519371
pathway order: PathwayTransport/2519372
pathway order: PathwayEnzymeReaction/2519350
pathway order: PathwayTransport/2519370
pathway order: PathwayEnzymeReaction/2519351
pathway order: PathwayEnzymeReaction/2519352
pathway order: PathwaySubPathway/119502
pathway order: PathwaySubPathway/119501
pathway order: PathwaySubPathway/119500
pathway order: PathwaySubPathway/119506
pathway order: PathwaySubPathway/119505
pathway order: PathwaySubPathway/119504
pathway order: PathwaySubPathway/119503
pathway component: Transport67
pathway component: TransportCatalysis15
pathway component: Transport1
pathway component: Transport70
pathway component: Thiamine Metabolism
pathway component: Pentose Phosphate Pathway
pathway component: 2.7.1.33
pathway component: TransportCatalysis5520
pathway component: 2.7.1.1
pathway component: Glycerolipid Metabolism
pathway component: ReactionCatalysis942
pathway component: ReactionCatalysis349
pathway component: 5.3.1.9
pathway component: ReactionCatalysis940
pathway component: 5.1.3.3
pathway component: ReactionCatalysis347
pathway component: ReactionCatalysis344
pathway component: 3.1.3.9
pathway component: 3.1.3.11
pathway component: ReactionCatalysis661
pathway component: ReactionCatalysis343
pathway component: ReactionCatalysis4
pathway component: Transport280
pathway component: TransportCatalysis6
pathway component: 4.1.2.13
pathway component: TransportCatalysis8
pathway component: Transport14710
pathway component: Reaction1242
pathway component: Reaction1243
pathway component: Reaction1240
pathway component: Galactose Metabolism
pathway component: ReactionCatalysis939
pathway component: ReactionCatalysis937

Compound/PW C001870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Phospho-D-glyceric acid
stoichiometric coefficient: 1.0

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Fructose-1,6-bisphosphatase 1
type: Complex
component stoichiometry: Protein/748 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Fructose-1,6-bisphosphatase 1

Reference/GENE ONTOLOGY GO 0005788
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 17719
type: UnificationXref
id: CHEBI:17719
db: ChEBI

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

1.1.1.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000122 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Pyruvic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.27
left: NAD
left: L-Lactic acid
name: L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid
conversion direction: REVERSIBLE

Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
type: UnificationXref
id: FRUCTOSE-16-DIPHOSPHATE
db: BioCyc

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/SMPDB SMP0000039
type: UnificationXref
id: SMP0000039
db: SMPDB

ChemicalStructure/PW C000833
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Transport32
type: Transport
participant stoichiometry: Compound/PW C000592 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000592 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
right: Malic acid
right: Oxoglutaric acid
spontaneous: false
left: Malic acid
left: Oxoglutaric acid
name: Oxoglutaric acid (←), Malic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc GLC-6-P
type: UnificationXref
id: GLC-6-P
db: BioCyc

1.1.1.37
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000592 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000592 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
right: Oxalacetic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.37
left: NAD
left: Malic acid
name: Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Compound/PW C000079 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000031
type: UnificationXref
id: SMP0000031
db: SMPDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PathWhiz PW000144
type: UnificationXref
id: PW000144
db: PathWhiz

Reference/UniProt P04075
type: UnificationXref
id: P04075
db: UniProt

Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 6-phosphate

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/PathWhiz PW000142
type: UnificationXref
id: PW000142
db: PathWhiz

Reference/PathWhiz PW000149
type: UnificationXref
id: PW000149
db: PathWhiz

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/PathWhiz PW000025
type: UnificationXref
id: PW000025
db: PathWhiz

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/KEGG Compound C00631
type: UnificationXref
id: C00631
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

2.7.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Glyceric acid 1,3-biphosphate
spontaneous: false
EC number: 2.7.1.33
left: Adenosine triphosphate
left: 3-Phosphoglyceric acid
name: 3-Phosphoglyceric acid + Adenosine triphosphate → Adenosine diphosphate + Glyceric acid 1,3-biphosphate
conversion direction: LEFT_TO_RIGHT

Fructose-bisphosphate aldolase A
type: Complex
component stoichiometry: Protein/916 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Fructose-bisphosphate aldolase A

2.7.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000395 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: β-D-Glucose 6-phosphate
spontaneous: false
EC number: 2.7.1.1
left: Adenosine triphosphate
left: β-D-Glucose
name: Adenosine triphosphate + β-D-Glucose → Adenosine diphosphate + β-D-Glucose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

ReactionCatalysis349
type: Catalysis
controller: Glyceraldehyde-3-phosphate dehydrogenase
controlled: Reaction812
control type: ACTIVATION

ReactionCatalysis347
type: Catalysis
controller: Triosephosphate isomerase
controlled: 5.3.1.1
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ReactionCatalysis344
type: Catalysis
controller: Fructose-bisphosphate aldolase A
controlled: 4.1.2.13
control type: ACTIVATION

ReactionCatalysis343
type: Catalysis
controller: Fructose-1,6-bisphosphatase 1
controlled: 3.1.3.11
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Glucose-6-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate isomerase

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Glyceric acid 1,3-biphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceric acid 1,3-biphosphate

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

ChemicalStructure/PW C001870
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](OP(O)(O)=O)C(O)=O

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Reference/HMDB HMDB0000744
type: UnificationXref
id: HMDB0000744
db: HMDB

Reference/PubChem-compound 79025
type: UnificationXref
id: 79025
db: PubChem-compound

Reference/PathWhiz PW127362
type: UnificationXref
id: PW127362
db: PathWhiz

Phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Phosphate

4.1.1.32
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Carbon dioxide
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 4.1.1.32
left: Oxalacetic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Oxalacetic acid ↔ Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

Reference/PathWhiz PW000002
type: UnificationXref
id: PW000002
db: PathWhiz

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/PathWhiz PW000001
type: UnificationXref
id: PW000001
db: PathWhiz

ReactionCatalysis375
type: Catalysis
controller: Phosphoglucomutase-1
controlled: 5.4.2.2
control type: ACTIVATION

ReactionCatalysis373
type: Catalysis
controller: Malate dehydrogenase, mitochondrial
controlled: 1.1.1.37
control type: ACTIVATION

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

2.7.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001851 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.1
left: Adenosine triphosphate
left: α-D-Glucose
name: Adenosine triphosphate + α-D-Glucose → Adenosine diphosphate + Glucose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Fructose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: β-D-Glucose 6-phosphate
name: β-D-Glucose 6-phosphate ↔ Fructose 6-phosphate
conversion direction: REVERSIBLE

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Protein/963 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pantothenate kinase 1
stoichiometric coefficient: 2.0

Bisphosphoglycerate mutase
type: Complex
component stoichiometry: Protein/260 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Bisphosphoglycerate mutase

Reference/HMDB HMDB0000516
type: UnificationXref
id: HMDB0000516
db: HMDB

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

ChemicalStructure/PW C000998
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H](COP(O)(O)=O)OP(O)(O)=O

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Bisphosphoglycerate mutase
type: Protein
cellular location: Cytosol
entity reference: Bisphosphoglycerate mutase

ChemicalStructure/PW C001851
type: ChemicalStructure
structure format: SMILES

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0