Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

L-Glutamic acid
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: L-Glutamic acid

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

direct_interaction
type: InteractionVocabulary

Transport14087
type: Transport
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: false
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

TransportCatalysis4725
type: Catalysis
controller: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
controlled: Transport13624
control type: ACTIVATION

TransportCatalysis5019
type: Catalysis
controller: NMDA Receptor
controlled: Transport14050
control type: ACTIVATION

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Interaction3971
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates L-Glutamic acid
participant: L-Glutamic acid
participant: Calcium

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayInput

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

TransportCatalysis4976
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport13994
control type: ACTIVATION

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/PathWhiz PW127815
type: UnificationXref
id: PW127815
db: PathWhiz

Interaction3528
type: MolecularInteraction
interaction type: direct_interaction
name: Gq protein signaling cascade activates Phospholipase C
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Reference/UniProt O60391
type: UnificationXref
id: O60391
db: UniProt

Reference/ChEBI CHEBI 313639
type: UnificationXref
id: CHEBI:313639
db: ChEBI

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Compound/Generic369 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Interaction242
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reference/UniProt O94925
type: UnificationXref
id: O94925
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Glutamate [NMDA] receptor subunit 3B
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit 3B

Transport14050
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis207193
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Inositol 1,4,5-trisphosphate receptor type 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Ethopropazine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3290
xref: Reference/HMDB HMDB0014536
xref: Reference/CAS 522-00-9
xref: Reference/ChEBI CHEBI 313639
xref: Reference/ChemSpider 3174
chemical formula: C19H24N2S
molecular weight: 312.16602
structure: ChemicalStructure/PW C008908

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Transport14046
type: Transport
participant stoichiometry: Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Synapse/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: false
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Transport13994
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Endoplasmic Reticulum to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Protein/2126 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Compound/PW C000500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: Reference/UniProt P11229
organism: BiologicalState789

NMDA Receptor
type: Complex
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit zeta-1

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Transport13624
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Transport15368
type: Transport
participant stoichiometry: Compound/PW C008908 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008908/Stoichiometry/1.0
right: Ethopropazine
spontaneous: true
left: Ethopropazine
name: Ethopropazine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, Synapse
conversion direction: REVERSIBLE

Vesicular glutamate transporter 3
type: Protein
entity reference: Vesicular glutamate transporter 3

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit 3A

Reference/UniProt P50148
type: UnificationXref
id: P50148
db: UniProt

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/UniProt P11229
type: UnificationXref
id: P11229
db: UniProt

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Glutaminase kidney isoform, mitochondrial
type: ProteinReference
xref: Reference/UniProt O94925
organism: BiologicalState789

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt Q8NDX2
type: UnificationXref
id: Q8NDX2
db: UniProt

Glutamate [NMDA] receptor subunit 3B
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3B

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Ethopropazine
type: SmallMolecule
entity reference: Ethopropazine

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/UniProt Q14957
type: UnificationXref
id: Q14957
db: UniProt

Compound/PW C008908 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethopropazine
stoichiometric coefficient: 1.0

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Reference/HMDB HMDB0014536
type: UnificationXref
id: HMDB0014536
db: HMDB

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

L-Glutamic acid
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: L-Glutamic acid

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

NMDA Receptor
type: Complex
cellular location: post-synaptic membrane
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit zeta-1
component: Glutamate [NMDA] receptor subunit epsilon-1

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference

Reference/UniProt O15399
type: UnificationXref
id: O15399
db: UniProt

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Ethopropazine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Ethopropazine

Interaction4571
type: MolecularInteraction
interaction type: direct_interaction
name: Ethopropazine inhibits NMDA Receptor
participant: NMDA Receptor
participant: Ethopropazine

Reference/PubChem-compound 3290
type: UnificationXref
id: 3290
db: PubChem-compound

Reference/SMPDB SMP0126229
type: UnificationXref
id: SMP0126229
db: SMPDB

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: L-Glutamic acid
spontaneous: false
EC number: 3.5.1.2
left: L-Glutamine
left: Water
name: L-Glutamine + Water → Ammonia + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Interaction4573
type: MolecularInteraction
interaction type: direct_interaction
name: Ethopropazine inhibits Muscarinic acetylcholine receptor M1
participant: Muscarinic acetylcholine receptor M1
participant: Ethopropazine

Vesicular glutamate transporter 3
type: ProteinReference
xref: Reference/UniProt Q8NDX2

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Interaction3921
type: MolecularInteraction
interaction type: direct_interaction
name: Muscarinic acetylcholine receptor M1 activates Gq protein signaling cascade
participant: Guanine nucleotide-binding protein G(q) subunit alpha
participant: Muscarinic acetylcholine receptor M1

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Interaction3357
type: MolecularInteraction
interaction type: direct_interaction
name: L-Glutamic acid activates NMDA Receptor
participant: NMDA Receptor
participant: L-Glutamic acid

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: Reference/UniProt P50148
organism: BiologicalState789

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: BiologicalState789

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

SubPathwayInteraction120246
type: Interaction
name: SubPathway120246Reaction
name: SubPathwayReaction
participant: L-Glutamine

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

SubPathwayInteraction120245
type: Interaction
name: SubPathway120245Reaction
name: SubPathwayReaction
participant: Calcium

Ethopropazine
type: SmallMolecule
cellular location: Synapse
entity reference: Ethopropazine

Calcium
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Calcium

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Profenamine Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2526804
pathway order: PathwayTransport/2526689
pathway order: PathwaySubPathway/120245
pathway order: PathwaySubPathway/120246
pathway order: PathwayTransport/2526044
pathway order: PathwayInteraction/3528
pathway order: PathwayTransport/2530495
pathway order: PathwayTransport/2526047
pathway order: PathwayInteraction/3921
pathway order: PathwayTransport/2526046
pathway order: PathwayTransport/2526045
pathway order: PathwayInteraction/3357
pathway order: PathwayInteraction/3971
pathway order: PathwayInteraction/242
pathway order: PathwayInteraction/4573
pathway order: PathwayEnzymeReaction/2526043
pathway order: PathwayInteraction/4571
pathway component: TransportCatalysis4725
pathway component: TransportCatalysis5019
pathway component: Interaction4571
pathway component: TransportCatalysis4976
pathway component: Interaction242
pathway component: TransportCatalysis5048
pathway component: Interaction3971
pathway component: 3.5.1.2
pathway component: Interaction3357
pathway component: Depolarization
pathway component: 3.1.4.11
pathway component: Interaction4573
pathway component: ReactionCatalysis207831
pathway component: Transport13624
pathway component: Interaction3528
pathway component: Transport15368
pathway component: Transport14046
pathway component: Transport13994
pathway component: Transport14087
pathway component: Interaction3921
pathway component: Glutamate Metabolism
pathway component: Transport14050
pathway component: ReactionCatalysis207193
xref: Reference/PathWhiz PW127815
xref: Reference/SMPDB SMP0126229
organism: Homo sapiens

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586

TransportCatalysis5048
type: Catalysis
controller: Vesicular glutamate transporter 3
controlled: Transport14087
control type: ACTIVATION

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Depolarization
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120245
pathway component: SubPathwayInteraction120245
name: SubPathway

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic369 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120246
pathway component: SubPathwayInteraction120246
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

Muscarinic acetylcholine receptor M1
type: Protein
cellular location: post-synaptic membrane
entity reference: Muscarinic acetylcholine receptor M1

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Glutamate [NMDA] receptor subunit 3B
type: ProteinReference
xref: Reference/UniProt O60391

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Glutamate [NMDA] receptor subunit epsilon-3
type: ProteinReference
xref: Reference/UniProt Q14957

Glutamate [NMDA] receptor subunit epsilon-2
type: ProteinReference
xref: Reference/UniProt Q13224

Glutamate [NMDA] receptor subunit epsilon-4
type: ProteinReference
xref: Reference/UniProt O15399

Glutaminase kidney isoform, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Glutaminase kidney isoform, mitochondrial

Reference/CAS 522-00-9
type: UnificationXref
id: 522-00-9
db: CAS

Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChemSpider 3174
type: UnificationXref
id: 3174
db: ChemSpider

Compound/PW C000095 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine
name: SubPathwayOutput

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit zeta-1

ChemicalStructure/PW C008908
type: ChemicalStructure
structure format: SMILES
structure data: CCN(CC)C(C)CN1C2=CC=CC=C2SC2=CC=CC=C12

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Compound/PW C008908/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethopropazine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/UniProt Q13224
type: UnificationXref
id: Q13224
db: UniProt

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

ReactionCatalysis207831
type: Catalysis
controller: Glutaminase kidney isoform, mitochondrial
controlled: 3.5.1.2
control type: ACTIVATION

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

L-Glutamic acid
type: SmallMolecule
cellular location: Synapse
entity reference: L-Glutamic acid

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202