Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Solute carrier family 22 member 11
type: Protein
entity reference: Solute carrier family 22 member 11

BiologicalState788
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

direct_interaction
type: InteractionVocabulary

TransportCatalysis2099
type: Catalysis
controller: AMPA
controlled: Transport10937
control type: ACTIVATION

TransportCatalysis2098
type: Catalysis
controller: NMDA Receptor
controlled: Transport10936
control type: ACTIVATION

Sodium channel protein type 10 subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel protein type 10 subunit alpha

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Oxcarbazepine Action Pathway (New)
type: Pathway
pathway order: PathwayTransport/2530939
pathway order: PathwayTransport/2530938
pathway order: PathwayTransport/2527276
pathway order: PathwayTransport/2527284
pathway order: PathwayTransport/2527279
pathway order: PathwayEnzymeReaction/2527290
pathway order: PathwayTransport/2527278
pathway order: PathwayInteraction/3425
pathway order: PathwayTransport/2527277
pathway order: PathwayInteraction/3424
pathway order: PathwayInteraction/4599
pathway order: PathwayTransport/2527281
pathway order: PathwayTransport/2527292
pathway order: PathwayTransport/2527280
pathway order: PathwayTransport/2527291
pathway component: Transport10938
pathway component: Transport10939
pathway component: TransportCatalysis2101
pathway component: Transport10978
pathway component: TransportCatalysis2134
pathway component: TransportCatalysis2100
pathway component: Transport10936
pathway component: Transport10937
pathway component: Interaction4599
pathway component: Interaction3424
pathway component: Transport11098
pathway component: ReactionCatalysis208862
pathway component: Transport15465
pathway component: Transport15466
pathway component: Interaction3425
pathway component: Transport15100
pathway component: Reaction219463
pathway component: Transport15099
pathway component: TransportCatalysis5685
pathway component: TransportCatalysis5684
pathway component: TransportCatalysis2099
pathway component: TransportCatalysis2098
pathway component: Transport15091
xref: Reference/SMPDB SMP0126277
xref: Reference/PathWhiz PW127866
organism: Homo sapiens

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5

ReactionCatalysis208862
type: Catalysis
controller: Aldo-keto reductase family 1 member C3
controlled: Reaction219463
control type: ACTIVATION

Reference/UniProt O15439
type: UnificationXref
id: O15439
db: UniProt

Reaction219463
type: BiochemicalReaction
participant stoichiometry: Compound/PW C113528 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009243 Endoplasmic Reticulum/Stoichiometry/1.0
right: Licarbazepine
spontaneous: false
left: Oxcarbazepine
name: Oxcarbazepine → Licarbazepine
conversion direction: LEFT_TO_RIGHT

Glutamate receptor 1
type: Protein
entity reference: Glutamate receptor 1

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

Compound/PW C113528/Stoichiometry/1.0
type: Stoichiometry
physical entity: Licarbazepine
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 104746-03-4
type: UnificationXref
id: 104746-03-4
db: CAS

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Licarbazepine
type: SmallMoleculeReference
xref: Reference/CAS 104746-03-4
xref: Reference/PubChem-compound 9816485
xref: Reference/ChemSpider 7992235
chemical formula: C15H14N2O2
molecular weight: 254.10553
structure: ChemicalStructure/PW C113528

Sodium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q07699
organism: BiologicalState788

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Licarbazepine
type: SmallMolecule
entity reference: Licarbazepine

Reference/UniProt O60391
type: UnificationXref
id: O60391
db: UniProt

ChemicalStructure/PW C009243
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)N1C2=CC=CC=C2CC(=O)C2=CC=CC=C12

Reference/UniProt O43497
type: UnificationXref
id: O43497
db: UniProt

Glutamate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glutamate

Transport10938
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: true
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport10939
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: true
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Transport10936
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10937
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: true
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: REVERSIBLE

Sodium channel protein type 10 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9Y5Y9
organism: BiologicalState788

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/ChemSpider 7992235
type: UnificationXref
id: 7992235
db: ChemSpider

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Glutamate receptor 2
type: Protein
entity reference: Glutamate receptor 2

Sodium channel
type: Complex
component stoichiometry: Protein/4288 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/4299 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Sodium channel subunit beta-1
component: Sodium channel protein type 10 subunit alpha

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Interaction3424
type: MolecularInteraction
interaction type: direct_interaction
name: Glutamate activates AMPA
participant: AMPA
participant: Glutamate

Glutamate [NMDA] receptor subunit 3A
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit 3A

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Interaction3425
type: MolecularInteraction
interaction type: direct_interaction
name: Glutamate activates NMDA Receptor
participant: Glutamate
participant: NMDA Receptor

TransportCatalysis5685
type: Catalysis
controller: Solute carrier family 22 member 11
controlled: Transport15100
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

TransportCatalysis5684
type: Catalysis
controller: Multidrug resistance-associated protein 4
controlled: Transport15099
control type: ACTIVATION

Reference/ChEBI CHEBI 7824
type: UnificationXref
id: CHEBI:7824
db: ChEBI

ChemicalStructure/PW C109119
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](N)(CCC(O)=O)C(O)=O

Solute carrier family 22 member 11
type: ProteinReference
xref: Reference/UniProt Q9NSA0

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

NMDA Receptor
type: Complex
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit zeta-1

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Licarbazepine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Licarbazepine

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Aldo-keto reductase family 1 member C3
type: ProteinReference
xref: Reference/UniProt P42330
organism: BiologicalState996

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Multidrug resistance-associated protein 4
type: Protein
entity reference: Multidrug resistance-associated protein 4

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

BiologicalState84
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain
tissue: Brain

Oxcarbazepine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxcarbazepine

Compound/PW C113528 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Licarbazepine
stoichiometric coefficient: 1.0

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

Protein/4288 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel subunit beta-1
stoichiometric coefficient: 1.0

NMDA Receptor
type: Complex
cellular location: Extracellular Space
component: Glutamate [NMDA] receptor subunit zeta-1
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit 3A

Glutamate receptor 1
type: ProteinReference
xref: Reference/UniProt P42261

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/PubChem-compound 34312
type: UnificationXref
id: 34312
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Compound/PW C109119 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Glutamate [NMDA] receptor subunit 3B
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3B

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Transport15465
type: Transport
participant stoichiometry: Compound/PW C009243/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009243 Endoplasmic Reticulum/Stoichiometry/1.0
right: Oxcarbazepine
spontaneous: false
left: Oxcarbazepine
name: Oxcarbazepine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum
conversion direction: LEFT_TO_RIGHT

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Transport15466
type: Transport
participant stoichiometry: Compound/PW C009243 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009243/Stoichiometry/1.0
right: Oxcarbazepine
spontaneous: false
left: Oxcarbazepine
name: Oxcarbazepine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW127866
type: UnificationXref
id: PW127866
db: PathWhiz

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

AMPA
type: Complex
cellular location: Extracellular Space
component: Glutamate receptor 2
component: Glutamate receptor 1

Transport15100
type: Transport
participant stoichiometry: Compound/PW C113528 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113528/Stoichiometry/1.0
right: Licarbazepine
spontaneous: false
left: Licarbazepine
name: Licarbazepine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Glutamate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Glutamate

Reference/UniProt Q14957
type: UnificationXref
id: Q14957
db: UniProt

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

TransportCatalysis2134
type: Catalysis
controller: L type Calcium channel
controlled: Transport10978
control type: ACTIVATION

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Compound/PW C009243/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxcarbazepine
stoichiometric coefficient: 1.0

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Oxcarbazepine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Oxcarbazepine

ChemicalStructure/PW C113528
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Transport11098
type: Transport
participant stoichiometry: Compound/PW C109119 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109119 Cytosol/Stoichiometry/1.0
right: Glutamate
spontaneous: false
left: Glutamate
name: Glutamate (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt Q9Y5Y9
type: UnificationXref
id: Q9Y5Y9
db: UniProt

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Oxcarbazepine
type: SmallMoleculeReference
xref: Reference/CAS 28721-07-5
xref: Reference/KEGG Compound C07492
xref: Reference/ChemSpider 31608
xref: Reference/HMDB HMDB0014914
xref: Reference/ChEBI CHEBI 7824
xref: Reference/PubChem-compound 34312
chemical formula: C15H12N2O2
molecular weight: 252.08987
structure: ChemicalStructure/PW C009243

Compound/PW C009243 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxcarbazepine
stoichiometric coefficient: 1.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

Reference/UniProt O15399
type: UnificationXref
id: O15399
db: UniProt

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Compound/PW C009243 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxcarbazepine
stoichiometric coefficient: 1.0

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Compound/PW C113528 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Licarbazepine
stoichiometric coefficient: 1.0

Licarbazepine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Licarbazepine

Reference/PubChem-compound 9816485
type: UnificationXref
id: 9816485
db: PubChem-compound

Glutamate receptor 2
type: ProteinReference
xref: Reference/UniProt P42262

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Glutamate [NMDA] receptor subunit 3B
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit 3B

Aldo-keto reductase family 1 member C3
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Aldo-keto reductase family 1 member C3

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Multidrug resistance-associated protein 4
type: ProteinReference
xref: Reference/UniProt O15439

Reference/CAS 28721-07-5
type: UnificationXref
id: 28721-07-5
db: CAS

Reference/KEGG Compound C07492
type: UnificationXref
id: C07492
db: KEGG Compound

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

AMPA
type: Complex
component: Glutamate receptor 2
component: Glutamate receptor 1

Oxcarbazepine
type: SmallMolecule
entity reference: Oxcarbazepine

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt O43497

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/UniProt P42262
type: UnificationXref
id: P42262
db: UniProt

Reference/UniProt P42261
type: UnificationXref
id: P42261
db: UniProt

Reference/UniProt O95180
type: UnificationXref
id: O95180
db: UniProt

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt O95180

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Interaction4599
type: MolecularInteraction
interaction type: direct_interaction
name: Licarbazepine inhibits Sodium channel
participant: Sodium channel
participant: Licarbazepine

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Glutamate receptor 2
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate receptor 2

Compound/PW C109119 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Transport15099
type: Transport
participant stoichiometry: Compound/PW C113528 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113528/Stoichiometry/1.0
right: Licarbazepine
spontaneous: false
left: Licarbazepine
name: Licarbazepine (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Glutamate receptor 1
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate receptor 1

Glutamate [NMDA] receptor subunit 3B
type: ProteinReference
xref: Reference/UniProt O60391

Transport15091
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
cellular location: Extracellular Space
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Reference/UniProt Q9NSA0
type: UnificationXref
id: Q9NSA0
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/SMPDB SMP0126277
type: UnificationXref
id: SMP0126277
db: SMPDB

TransportCatalysis2101
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport10939
control type: ACTIVATION

Glutamate [NMDA] receptor subunit epsilon-3
type: ProteinReference
xref: Reference/UniProt Q14957

Glutamate [NMDA] receptor subunit epsilon-2
type: ProteinReference
xref: Reference/UniProt Q13224

TransportCatalysis2100
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport10938
control type: ACTIVATION

Licarbazepine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Licarbazepine

Glutamate [NMDA] receptor subunit epsilon-4
type: ProteinReference
xref: Reference/UniProt O15399

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879

BiologicalState996
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8

Reference/UniProt Q07699
type: UnificationXref
id: Q07699
db: UniProt

Reference/UniProt P42330
type: UnificationXref
id: P42330
db: UniProt

Reference/ChemSpider 31608
type: UnificationXref
id: 31608
db: ChemSpider

Glutamate
type: SmallMoleculeReference
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C109119

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Reference/UniProt Q13224
type: UnificationXref
id: Q13224
db: UniProt

Transport10978
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Sodium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel subunit beta-1

Protein/4299 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel protein type 10 subunit alpha
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0014914
type: UnificationXref
id: HMDB0014914
db: HMDB