Myosin light chain kinase, smooth muscle
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Voltage-dependent calcium channel subunit alpha-2/delta-2
Gq protein signaling cascade activates Phospholipase C
Nitric oxide activates Myosin light chain phosphatase
Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
Inositol 1,4,5-trisphosphate receptor type 1
Protein kinase C activates L type Calcium channel
Histamine H1 receptor activates Gq protein signaling cascade
Clemastine inhibits Histamine H1 receptor
Voltage-dependent L-type calcium channel subunit beta-1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Clemastine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel, Endothelial cell, Cell Membrane
Homo sapiens, Blood Vessel, Endothelial cell
Calcium (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Endothelial cell, Cytosol
Calcium (→) Transport: Homo sapiens, Blood Vessel, Endothelial cell, Endoplasmic Reticulum Lumen to Homo sapiens, Blood Vessel, Endothelial cell, Cytosol
Clemastine H1-Antihistamine Blood Vessel Constriction Action Pathway
Guanine nucleotide-binding protein G(q) subunit alpha
Diacylglycerol activates Protein kinase C
Nitric oxide (→) Transport: Homo sapiens, Blood Vessel, Endothelial cell, Cytosol to Homo sapiens, Muscle, Myocyte, Cytosol
Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
Calcium + Calmodulin (Homo sapiens) activates Nitric-oxide synthase, endothelial
Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + Inositol 1,4,5-trisphosphate
Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
Histamine activates Histamine H1 receptor