Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

L-Glutamic acid
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: L-Glutamic acid

Substance P
type: SmallMolecule
cellular location: Cytosol
entity reference: Substance P

Reference/CAS 33507-63-0
type: UnificationXref
id: 33507-63-0
db: CAS

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit zeta-1

direct_interaction
type: InteractionVocabulary

Transport15179
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Spinal cord, Neuron, Extracellular Space to Homo sapiens, Spinal cord, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Calcitonin gene-related peptide type 1 receptor
type: ProteinReference
xref: Reference/UniProt Q16602
organism: BiologicalState1442

Receptor activity-modifying protein 1
type: ProteinReference
xref: Reference/UniProt O60894
organism: BiologicalState1442

Transport15178
type: Transport
participant stoichiometry: Compound/PW C001265 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001265 Synapse/Stoichiometry/1.0
right: Substance P
spontaneous: false
left: Substance P
name: Substance P (→) Transport: Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle to Homo sapiens, Spinal cord, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

SubPathwayInteraction120750
type: Interaction
name: SubPathway120750Reaction
name: SubPathwayReaction
participant: Calcium

Exocytic Vesicle membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0012506

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

SubPathwayControl120751
type: Interaction
name: SubPathway120751Control
name: ActivatingSubPathwayControl
participant: Substance-P receptor
participant: Pain

TransportCatalysis5019
type: Catalysis
controller: NMDA Receptor
controlled: Transport14050
control type: ACTIVATION

Interaction3971
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates L-Glutamic acid
participant: Calcium
participant: L-Glutamic acid

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayInput

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5

Interaction4708
type: MolecularInteraction
interaction type: direct_interaction
name: Ziconotide inhibits N-type calcium channel
participant: Ziconotide
participant: N-type calcium channel

SubPathwayInteraction120749
type: Interaction
name: SubPathwayReaction
name: SubPathway120749Reaction
participant: CRLR-RAMP1 complex

BiologicalState1442
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Spinal cord, Neuron
tissue: Spinal cord

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

Glutamate [NMDA] receptor subunit 3A
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit 3A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Calcitonin gene-related peptide 1
type: Protein
cellular location: Exocytic Vesicle membrane
entity reference: Calcitonin gene-related peptide 1

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt O60391
type: UnificationXref
id: O60391
db: UniProt

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

TransportCatalysis5715
type: Catalysis
controller: Vesicular glutamate transporter 2
controlled: Transport15185
control type: ACTIVATION

TransportCatalysis5714
type: Catalysis
controller: Vesicular glutamate transporter 3
controlled: Transport15180
control type: ACTIVATION

TransportCatalysis5713
type: Catalysis
controller: N-type calcium channel
controlled: Transport15179
control type: ACTIVATION

Substance P
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Substance P

N-type calcium channel
type: Complex
cellular location: Presynaptic membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-4
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Interaction4722
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calcitonin gene-related peptide 1
participant: Calcitonin gene-related peptide 1
participant: Calcium

Interaction4046
type: MolecularInteraction
interaction type: direct_interaction
name: Substance P activates Substance P receptor
participant: Substance P
participant: Substance-P receptor

Reference/UniProt Q9P2U8
type: UnificationXref
id: Q9P2U8
db: UniProt

Reference/ChemSpider 23215821
type: UnificationXref
id: 23215821
db: ChemSpider

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Interaction4723
type: MolecularInteraction
interaction type: direct_interaction
name: Calcitonin gene-related peptide 1 activates CRLR-RAMP1 complex
participant: CRLR-RAMP1 complex
participant: Calcitonin gene-related peptide 1

Reference/HMDB HMDB0001897
type: UnificationXref
id: HMDB0001897
db: HMDB

Transport14050
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Calcitonin gene-related peptide 1
type: Protein
cellular location: Synapse
entity reference: Calcitonin gene-related peptide 1

Reference/SMPDB SMP0126445
type: UnificationXref
id: SMP0126445
db: SMPDB

Reference/PathWhiz PW128043
type: UnificationXref
id: PW128043
db: PathWhiz

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Substance-P receptor
type: ProteinReference
xref: Reference/UniProt P25103
organism: BiologicalState1442

Ziconotide
type: SmallMoleculeReference
xref: Reference/ChemSpider 17291932
xref: Reference/KEGG Compound D06363
xref: Reference/PubChem-compound 347910345
chemical formula: C102H172N36O32S7
molecular weight: 2637.0984
structure: ChemicalStructure/PW C113554

Calcitonin gene-related peptide type 1 receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Calcitonin gene-related peptide type 1 receptor

Reference/BRENDA TISSUE ONTOLOGY BTO 0001279
type: UnificationXref
id: BTO:0001279
db: BRENDA TISSUE ONTOLOGY

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Calcium
type: SmallMolecule
cellular location: Exocytic Vesicle membrane
entity reference: Calcium

NMDA Receptor
type: Complex
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit zeta-1

Pain
type: Pathway
name: ActivatingSubPathway

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Hyperpolarization
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120750
pathway component: SubPathwayInteraction120750
name: SubPathway

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Vesicular glutamate transporter 3
type: Protein
entity reference: Vesicular glutamate transporter 3

Vesicular glutamate transporter 2
type: Protein
entity reference: Vesicular glutamate transporter 2

Reference/KEGG Compound D06363
type: UnificationXref
id: D06363
db: KEGG Compound

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

CRLR-RAMP1 complex
type: Complex
component stoichiometry: Protein/8621 post-synaptic membrane/Stoichiometry/1.0
component stoichiometry: Protein/8622 post-synaptic membrane/Stoichiometry/1.0
cellular location: post-synaptic membrane
component: Calcitonin gene-related peptide type 1 receptor
component: Receptor activity-modifying protein 1
name: SubPathwayInput

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Compound/PW C001265 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Substance P
stoichiometric coefficient: 1.0

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/PubChem-compound 44359816
type: UnificationXref
id: 44359816
db: PubChem-compound

Substance P
type: SmallMoleculeReference
xref: Reference/ChemSpider 23215821
xref: Reference/HMDB HMDB0001897
xref: Reference/ChEBI CHEBI 332416
xref: Reference/CAS 33507-63-0
xref: Reference/PubChem-compound 44359816
chemical formula: C63H98N18O13S
molecular weight: 1346.7281
structure: ChemicalStructure/PW C001265

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Calcitonin gene-related peptide 1
type: Protein
cellular location: Exocytic Vesicle
entity reference: Calcitonin gene-related peptide 1

Reference/UniProt Q8NDX2
type: UnificationXref
id: Q8NDX2
db: UniProt

Compound/PW C001265 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Substance P
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit 3B
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3B

NMDA Receptor
type: Complex
cellular location: Synapse
component: Glutamate [NMDA] receptor subunit zeta-1
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit 3A

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Voltage-dependent L-type calcium channel subunit beta-4
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-4

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/UniProt Q14957
type: UnificationXref
id: Q14957
db: UniProt

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Reference/UniProt O60894
type: UnificationXref
id: O60894
db: UniProt

ChemicalStructure/PW C001265
type: ChemicalStructure
structure format: SMILES

Voltage-dependent L-type calcium channel subunit beta-4
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-4

Protein/1785 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcitonin gene-related peptide 1
stoichiometric coefficient: 1.0

N-type calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit beta-4
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Substance P
type: SmallMolecule
cellular location: Synapse
entity reference: Substance P

Reference/ChEBI CHEBI 332416
type: UnificationXref
id: CHEBI:332416
db: ChEBI

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMolecule
cellular location: Exocytic Vesicle membrane
entity reference: L-Glutamic acid

Reference/UniProt O15399
type: UnificationXref
id: O15399
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Calcitonin gene-related peptide 1
type: Protein
cellular location: post-synaptic membrane
entity reference: Calcitonin gene-related peptide 1

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Protein/8621 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcitonin gene-related peptide type 1 receptor
stoichiometric coefficient: 1.0

Vesicular glutamate transporter 2
type: ProteinReference
xref: Reference/UniProt Q9P2U8

Vesicular glutamate transporter 3
type: ProteinReference
xref: Reference/UniProt Q8NDX2

Ziconotide
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Ziconotide

ChemicalStructure/PW C113554
type: ChemicalStructure
structure format: SMILES

Hyperalgesia
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120749
pathway component: SubPathwayInteraction120749
name: SubPathway

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: Reference/UniProt Q00975

Reference/UniProt P06881
type: UnificationXref
id: P06881
db: UniProt

Glutamate [NMDA] receptor subunit 3B
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit 3B

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Interaction3357
type: MolecularInteraction
interaction type: direct_interaction
name: L-Glutamic acid activates NMDA Receptor
participant: NMDA Receptor
participant: L-Glutamic acid

Compound/PW C001265 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Substance P
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Substance P
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Substance P

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586

TransportCatalysis5724
type: Catalysis
controller: Vesicular glutamate transporter 3
controlled: Transport15197
control type: ACTIVATION

Reference/UniProt O00305
type: UnificationXref
id: O00305
db: UniProt

Calcitonin gene-related peptide 1
type: Protein
cellular location: Cytosol
entity reference: Calcitonin gene-related peptide 1

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/GENE ONTOLOGY GO 0012506
type: UnificationXref
id: GO:0012506
db: GENE ONTOLOGY

Voltage-dependent L-type calcium channel subunit beta-4
type: ProteinReference
xref: Reference/UniProt O00305

Substance-P receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Substance-P receptor
name: SubPathwayActivator

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Protein/8622 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Receptor activity-modifying protein 1
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
cellular location: Synapse
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/PubChem-compound 347910345
type: UnificationXref
id: 347910345
db: PubChem-compound

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Glutamate [NMDA] receptor subunit 3B
type: ProteinReference
xref: Reference/UniProt O60391

Glutamate [NMDA] receptor subunit epsilon-3
type: ProteinReference
xref: Reference/UniProt Q14957

Glutamate [NMDA] receptor subunit epsilon-2
type: ProteinReference
xref: Reference/UniProt Q13224

Glutamate [NMDA] receptor subunit epsilon-4
type: ProteinReference
xref: Reference/UniProt O15399

Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879

Protein/1785 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcitonin gene-related peptide 1
stoichiometric coefficient: 1.0

Compound/PW C000095 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 17291932
type: UnificationXref
id: 17291932
db: ChemSpider

Reference/UniProt Q00975
type: UnificationXref
id: Q00975
db: UniProt

Spinal cord
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001279

Ziconotide Analgesia Action Pathway
type: Pathway
pathway order: PathwaySubPathway/120749
pathway order: PathwayTransport/2530470
pathway order: PathwaySubPathway/120751
pathway order: PathwaySubPathway/120750
pathway order: PathwayInteraction/4708
pathway order: PathwayTransport/2530432
pathway order: PathwayInteraction/4723
pathway order: PathwayTransport/2530471
pathway order: PathwayInteraction/4722
pathway order: PathwayTransport/2530472
pathway order: PathwayInteraction/3357
pathway order: PathwayInteraction/3971
pathway order: PathwayTransport/2530437
pathway order: PathwayInteraction/4046
pathway order: PathwayTransport/2530468
pathway order: PathwayTransport/2530436
pathway order: PathwayTransport/2530469
pathway component: TransportCatalysis5715
pathway component: TransportCatalysis5714
pathway component: TransportCatalysis5713
pathway component: TransportCatalysis5724
pathway component: TransportCatalysis5019
pathway component: Interaction3971
pathway component: Interaction4722
pathway component: Interaction3357
pathway component: Hyperpolarization
pathway component: Interaction4046
pathway component: Transport15179
pathway component: Interaction4708
pathway component: Hyperalgesia
pathway component: Interaction4723
pathway component: Transport15178
pathway component: Transport15197
pathway component: Transport15195
pathway component: Transport14050
pathway component: Transport15185
pathway component: Transport15180
pathway component: Transport15181
pathway component: SubPathwayControl120751
xref: Reference/SMPDB SMP0126445
xref: Reference/PathWhiz PW128043
organism: Homo sapiens

Protein/1785 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcitonin gene-related peptide 1
stoichiometric coefficient: 1.0

Transport15197
type: Transport
participant stoichiometry: Protein/1785 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Protein/1785 Cytosol/Stoichiometry/1.0
right: Calcitonin gene-related peptide 1
spontaneous: false
left: Calcitonin gene-related peptide 1
name: Calcitonin gene-related peptide 1 (→) Transport: Homo sapiens, Spinal cord, Neuron, Cytosol to Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport15195
type: Transport
participant stoichiometry: Protein/1785 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Protein/1785 Synapse/Stoichiometry/1.0
right: Calcitonin gene-related peptide 1
spontaneous: true
left: Calcitonin gene-related peptide 1
name: Calcitonin gene-related peptide 1 (→) Transport: Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle to Homo sapiens, Spinal cord, Neuron, Synapse
conversion direction: REVERSIBLE

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/UniProt Q16602
type: UnificationXref
id: Q16602
db: UniProt

Reference/UniProt Q13224
type: UnificationXref
id: Q13224
db: UniProt

Calcitonin gene-related peptide 1
type: ProteinReference
xref: Reference/UniProt P06881
organism: BiologicalState1442

Reference/UniProt P25103
type: UnificationXref
id: P25103
db: UniProt

Transport15185
type: Transport
participant stoichiometry: Compound/PW C001265 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001265 Exocytic Vesicle/Stoichiometry/1.0
right: Substance P
spontaneous: false
left: Substance P
name: Substance P (→) Transport: Homo sapiens, Spinal cord, Neuron, Cytosol to Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Receptor activity-modifying protein 1
type: Protein
cellular location: post-synaptic membrane
entity reference: Receptor activity-modifying protein 1

Transport15180
type: Transport
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: false
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Spinal cord, Neuron, Cytosol to Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport15181
type: Transport
participant stoichiometry: Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Synapse/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: true
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle to Homo sapiens, Spinal cord, Neuron, Synapse
conversion direction: REVERSIBLE

L-Glutamic acid
type: SmallMolecule
cellular location: Synapse
entity reference: L-Glutamic acid

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202