Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Adenylate cyclase type 10
type: ProteinReference
xref: Reference/UniProt Q96PN6
organism: BiologicalState86

Cytochrome P450 2D6
type: ProteinReference
xref: Reference/UniProt P10635
organism: BiologicalState996

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Interaction2891
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Plasma membrane Ca-ADPase
participant: Unknown
participant: cAMP

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Unknown
type: ProteinReference

Cytochrome P450 1A2
type: ProteinReference
xref: Reference/UniProt P05177
organism: BiologicalState996

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState86

Compound/PW C008752/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ticlopidine
stoichiometric coefficient: 1.0

Endothelium
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000393

Cytochrome P450 3A4
type: ProteinReference
xref: Reference/UniProt P08684
organism: BiologicalState996

Cytochrome P450 2B6
type: ProteinReference
xref: Reference/UniProt P20813
organism: BiologicalState996

Reference/ChemSpider 5273
type: UnificationXref
id: 5273
db: ChemSpider

cAMP
type: SmallMolecule
entity reference: cAMP

Interaction2889
type: MolecularInteraction
interaction type: direct_interaction
name: Gαi inhibits Adenylate Cyclase
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1
participant: Adenylate cyclase type 10

ChemicalStructure/PW C104795
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C1\CN(CC2=CC=CC=C2Cl)CCC1S

Reference/ChemSpider 118335
type: UnificationXref
id: 118335
db: ChemSpider

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P33261
type: UnificationXref
id: P33261
db: UniProt

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/CAS 55142-85-3
type: UnificationXref
id: 55142-85-3
db: CAS

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

2-Oxoticlopidine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 134227
xref: Reference/HMDB HMDB0013923
xref: Reference/ChemSpider 118335
chemical formula: C14H14ClNOS
molecular weight: 279.04846
structure: ChemicalStructure/PW C008653

Reference/ChEBI CHEBI 9588
type: UnificationXref
id: CHEBI:9588
db: ChEBI

Cytochrome P450 2B6
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 2B6

Reference/UniProt Q96PN6
type: UnificationXref
id: Q96PN6
db: UniProt

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C008653 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxoticlopidine
stoichiometric coefficient: 1.0

Cytochrome P450 2C19
type: ProteinReference
xref: Reference/UniProt P33261
organism: BiologicalState996

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Hydrogen Ion

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

UR-4501
type: SmallMoleculeReference
chemical formula: C14H16ClNO2S
molecular weight: 297.05902
structure: ChemicalStructure/PW C104795

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

2-Oxoticlopidine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 2-Oxoticlopidine

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C008653
type: ChemicalStructure
structure format: SMILES
structure data: ClC1=CC=CC=C1CN1CCC2SC(=O)C=C2C1

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

UR-4501
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: UR-4501

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADP

P2Y purinoceptor 12
type: Protein
entity reference: P2Y purinoceptor 12

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADPH

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Cytochrome P450 1A2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 1A2

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

BiologicalState86
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Transport15481
type: Transport
participant stoichiometry: Compound/PW C104795/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104795 Endoplasmic Reticulum/Stoichiometry/1.0
right: UR-4501
spontaneous: true
left: UR-4501
name: UR-4501 (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxygen

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/PubChem-compound 134227
type: UnificationXref
id: 134227
db: PubChem-compound

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Compound/PW C008752 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ticlopidine
stoichiometric coefficient: 1.0

Ticlopidine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Ticlopidine

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Transport15476
type: Transport
participant stoichiometry: Compound/PW C008752/Stoichiometry/1.0
right: Ticlopidine
spontaneous: true
left: Ticlopidine
name: Ticlopidine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Liver
conversion direction: REVERSIBLE

Transport15477
type: Transport
participant stoichiometry: Compound/PW C008752/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008752 Endoplasmic Reticulum/Stoichiometry/1.0
right: Ticlopidine
spontaneous: true
left: Ticlopidine
name: Ticlopidine (→) Transport: Homo sapiens, Liver to Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum
conversion direction: REVERSIBLE

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

ChemicalStructure/PW C008752
type: ChemicalStructure
structure format: SMILES
structure data: ClC1=CC=CC=C1CN1CCC2=C(C1)C=CS2

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

P2Y purinoceptor 12
type: Protein
cellular location: Extracellular Space
entity reference: P2Y purinoceptor 12

Transport10336
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Endothelium , Platelet , Cytoplasm to Homo sapiens, Endothelium , Platelet , Extracellular Space
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate
name: SubPathwayActivation

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Cytochrome P450 2D6
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 2D6

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000393
type: UnificationXref
id: BTO:0000393
db: BRENDA TISSUE ONTOLOGY

SubPathwayControl120805
type: Interaction
name: SubPathway120805Control
name: ActivatingSubPathwayControl
participant: Blood Vessel or Cell Damage
participant: Adenosine diphosphate

Reference/UniProt Q9H244
type: UnificationXref
id: Q9H244
db: UniProt

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Platelet
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000233

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008752 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008653 Endoplasmic Reticulum/Stoichiometry/1.0
right: Water
right: NADP
right: 2-Oxoticlopidine
spontaneous: false
EC number: 1.14.14.1
left: Hydrogen Ion
left: Oxygen
left: NADPH
left: Ticlopidine
name: Hydrogen Ion + NADPH + Oxygen + Ticlopidine → 2-Oxoticlopidine + NADP + Water
conversion direction: LEFT_TO_RIGHT

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reaction180291
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104795 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008653 Endoplasmic Reticulum/Stoichiometry/1.0
right: UR-4501
spontaneous: false
left: 2-Oxoticlopidine
name: 2-Oxoticlopidine → UR-4501
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Adenosine diphosphate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Adenosine diphosphate

Reference/SMPDB SMP0126467
type: UnificationXref
id: SMP0126467
db: SMPDB

Reference/PathWhiz PW128066
type: UnificationXref
id: PW128066
db: PathWhiz

Reference/PubChem-compound 5472
type: UnificationXref
id: 5472
db: PubChem-compound

P2Y purinoceptor 12
type: ProteinReference
xref: Reference/UniProt Q9H244
organism: BiologicalState86

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

TransportCatalysis1505
type: Catalysis
controller: Unknown
controlled: Transport10336
control type: ACTIVATION

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Interaction2834
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylate Cyclase activates cAMP
participant: cAMP
participant: Adenylate cyclase type 10

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

BiologicalState16
type: BioSource
cell type: Platelet
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Endothelium , Platelet
tissue: Endothelium

Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000233
type: UnificationXref
id: CL:0000233
db: CELL TYPE ONTOLOGY

Adenylate cyclase type 10
type: Protein
entity reference: Adenylate cyclase type 10

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C07140
type: UnificationXref
id: C07140
db: KEGG Compound

UR-4501
type: SmallMolecule
entity reference: UR-4501

Reference/UniProt P20813
type: UnificationXref
id: P20813
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt P10635
type: UnificationXref
id: P10635
db: UniProt

Cytochrome P450 2C19
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 2C19

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0013923
type: UnificationXref
id: HMDB0013923
db: HMDB

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Ticlopidine Action Pathway (new)
type: Pathway
pathway order: PathwaySubPathway/120805
pathway order: PathwayEnzymeReaction/2531020
pathway order: PathwayInteraction/4818
pathway order: PathwayEnzymeReaction/2531021
pathway order: PathwayInteraction/2889
pathway order: PathwayInteraction/2834
pathway order: PathwayEnzymeReaction/2531013
pathway order: PathwayEnzymeReaction/2531012
pathway order: PathwayTransport/2531025
pathway order: PathwayInteraction/2865
pathway order: PathwayEnzymeReaction/2531015
pathway order: PathwayEnzymeReaction/2531014
pathway order: PathwayTransport/2531000
pathway order: PathwayTransport/2531011
pathway order: PathwayEnzymeReaction/2531017
pathway order: PathwayInteraction/2864
pathway order: PathwayTransport/2531010
pathway order: PathwayEnzymeReaction/2531016
pathway order: PathwayEnzymeReaction/2531019
pathway order: PathwayEnzymeReaction/2531018
pathway order: PathwayInteraction/2891
pathway component: Transport10336
pathway component: ReactionCatalysis170138
pathway component: ReactionCatalysis170137
pathway component: ReactionCatalysis170139
pathway component: Interaction2891
pathway component: TransportCatalysis1505
pathway component: ReactionCatalysis170141
pathway component: ReactionCatalysis170140
pathway component: Transport15476
pathway component: 1.14.14.1
pathway component: ReactionCatalysis170143
pathway component: Interaction4818
pathway component: Transport15477
pathway component: ReactionCatalysis170142
pathway component: Interaction2864
pathway component: ReactionCatalysis170145
pathway component: Interaction2865
pathway component: ReactionCatalysis170144
pathway component: Interaction2889
pathway component: Interaction2834
pathway component: ReactionCatalysis170146
pathway component: SubPathwayControl120805
pathway component: Transport15481
pathway component: Reaction180291
xref: Reference/SMPDB SMP0126467
xref: Reference/PathWhiz PW128066
organism: Homo sapiens

Blood Vessel or Cell Damage
type: Pathway
name: ActivatingSubPathway

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Ticlopidine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5472
xref: Reference/CAS 55142-85-3
xref: Reference/KEGG Compound C07140
xref: Reference/ChEBI CHEBI 9588
xref: Reference/HMDB HMDB0014353
xref: Reference/ChemSpider 5273
chemical formula: C14H14ClNS
molecular weight: 263.05356
structure: ChemicalStructure/PW C008752

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt P05177
type: UnificationXref
id: P05177
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/UniProt P08684
type: UnificationXref
id: P08684
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

BiologicalState996
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Compound/PW C104795 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: UR-4501
stoichiometric coefficient: 1.0

ReactionCatalysis170138
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis170137
type: Catalysis
controller: Cytochrome P450 1A2
controlled: 1.14.14.1
control type: ACTIVATION

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis170139
type: Catalysis
controller: Cytochrome P450 2C19
controlled: 1.14.14.1
control type: ACTIVATION

Reference/HMDB HMDB0014353
type: UnificationXref
id: HMDB0014353
db: HMDB

Compound/PW C104795/Stoichiometry/1.0
type: Stoichiometry
physical entity: UR-4501
stoichiometric coefficient: 1.0

ReactionCatalysis170141
type: Catalysis
controller: Cytochrome P450 3A4
controlled: 1.14.14.1
control type: ACTIVATION

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ReactionCatalysis170140
type: Catalysis
controller: Cytochrome P450 2D6
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis170143
type: Catalysis
controller: Cytochrome P450 2B6
controlled: Reaction180291
control type: ACTIVATION

Interaction4818
type: MolecularInteraction
interaction type: direct_interaction
name: UR-4501 inhibits P2Y purinoceptor 12
participant: UR-4501
participant: P2Y purinoceptor 12

ReactionCatalysis170142
type: Catalysis
controller: Cytochrome P450 1A2
controlled: Reaction180291
control type: ACTIVATION

Cytochrome P450 3A4
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 3A4

ReactionCatalysis170145
type: Catalysis
controller: Cytochrome P450 2D6
controlled: Reaction180291
control type: ACTIVATION

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ReactionCatalysis170144
type: Catalysis
controller: Cytochrome P450 2C19
controlled: Reaction180291
control type: ACTIVATION

Ticlopidine
type: SmallMolecule
entity reference: Ticlopidine

ReactionCatalysis170146
type: Catalysis
controller: Cytochrome P450 3A4
controlled: Reaction180291
control type: ACTIVATION

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Interaction2864
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine diphosphate activates P2Y purinoceptor 12
participant: Adenosine diphosphate
participant: P2Y purinoceptor 12

Interaction2865
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine diphosphate activates Gαi
participant: Adenosine diphosphate
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0