Protein/3291 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Voltage-gated slow delayed rectifying potassium channel (IK5)
type: Complex
component: Potassium voltage-gated channel subfamily KQT member 1
component: Potassium voltage-gated channel subfamily E member 1

Voltage-gated ultra rapid delayed rectifying potassium channel
type: Complex
component: Disks large homolog 1
component: Potassium voltage-gated channel subfamily A member 5

Disks large homolog 1
type: Protein
entity reference: Disks large homolog 1

Compound/PW C009485/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tocainide
stoichiometric coefficient: 1.0

Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
type: Complex
component: Kv channel-interacting protein 2
component: Potassium voltage-gated channel subfamily D member 3

ATP-binding cassette sub-family C member 9
type: Protein
entity reference: ATP-binding cassette sub-family C member 9

Acetylcholine-activated potassium channel (IKACh)
type: Complex
component: G protein-activated inward rectifier potassium channel 4
component: G protein-activated inward rectifier potassium channel 1

Transport15616
type: Transport
participant stoichiometry: Compound/PW C009485 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009485/Stoichiometry/1.0
right: Tocainide
spontaneous: false
left: Tocainide
name: Tocainide (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Heart, Cardiomyocyte, Cell Membrane
conversion direction: LEFT_TO_RIGHT

Inward rectifier potassium channel (IK1)
type: Complex
component: Inward rectifier potassium channel 2
component: Inward rectifier potassium channel 4

Potassium voltage-gated channel subfamily A member 5
type: Protein
entity reference: Potassium voltage-gated channel subfamily A member 5

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

direct_interaction
type: InteractionVocabulary

TransportCatalysis91
type: Catalysis
controller: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
controlled: Transport120
control type: ACTIVATION

Reference/UniProt O00180
type: UnificationXref
id: O00180
db: UniProt

Transport116
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic536 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytosol/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Calcium
left: Troponin
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

Transport120
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Voltage-gated sodium channel (INa)
type: Complex
component: Sodium channel protein type 5 subunit alpha
component: Beta-1-syntrophin
component: Beta-2-syntrophin
component: Alpha-1-syntrophin

Reference/UniProt P48544
type: UnificationXref
id: P48544
db: UniProt

Reference/UniProt P63252
type: UnificationXref
id: P63252
db: UniProt

Inward rectifier potassium channel 2
type: Protein
entity reference: Inward rectifier potassium channel 2

ATP-sensitive inward rectifier potassium channel (IKATP)
type: Complex
component: ATP-sensitive inward rectifier potassium channel 8
component: ATP-binding cassette sub-family C member 8
component: ATP-sensitive inward rectifier potassium channel 11
component: ATP-binding cassette sub-family C member 9

Reference/UniProt P48549
type: UnificationXref
id: P48549
db: UniProt

Voltage-gated rapid delayed rectifying potassium channel (IKr)
type: Complex
component: Potassium voltage-gated channel subfamily E member 2
component: Potassium voltage-gated channel subfamily H member 2
component: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736

Reference/UniProt Q5I7T1
type: UnificationXref
id: Q5I7T1
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Ryanodine receptor 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Ryanodine receptor 2

Reference/SMPDB SMP0126519
type: UnificationXref
id: SMP0126519
db: SMPDB

Calcium_Troponin
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/Generic536 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Troponin

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Transport13658
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O60706
type: UnificationXref
id: O60706
db: UniProt

ATP-binding cassette sub-family C member 8
type: ProteinReference
xref: Reference/UniProt Q09428

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sodium channel protein type 5 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q14524

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytosol
entity reference: Tropomyosin alpha-1 chain

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

ChemicalStructure/PW C009485
type: ChemicalStructure
structure format: SMILES
structure data: CC(N)C(=O)NC1=C(C)C=CC=C1C

Reference/UniProt O43497
type: UnificationXref
id: O43497
db: UniProt

TransportCatalysis4744
type: Catalysis
controller: Voltage-gated sodium channel (INa)
controlled: Transport13658
control type: ACTIVATION

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/PathWhiz PW128118
type: UnificationXref
id: PW128118
db: PathWhiz

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Beta-1-syntrophin
type: Protein
cellular location: Cell Membrane
entity reference: Beta-1-syntrophin

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

SubPathwayControl120965
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway120965Control
participant: Muscle Contraction

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Voltage-gated sodium channel (INa)
type: Complex
cellular location: Cell Membrane
component: Alpha-1-syntrophin
component: Beta-2-syntrophin
component: Sodium channel protein type 5 subunit alpha
component: Beta-1-syntrophin

Reference/UniProt P48050
type: UnificationXref
id: P48050
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

Protein/2706 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Potassium voltage-gated channel subfamily H member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily H member 2

Reference/UniProt P22460
type: UnificationXref
id: P22460
db: UniProt

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Beta-1-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13884

Troponin
type: ProteinReference
organism: Homo sapiens

Sodium channel protein type 5 subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel protein type 5 subunit alpha

Protein/1262 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Tropomyosin beta chain
type: Protein
cellular location: Cytosol
entity reference: Tropomyosin beta chain

Beta-2-syntrophin
type: Protein
entity reference: Beta-2-syntrophin

Protein/3290 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Alpha-1-syntrophin
type: Protein
entity reference: Alpha-1-syntrophin

Interaction3306
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates cAMP-dependent protein kinase type I-alpha regulatory subunit (Homo sapiens) + cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens)
participant: cAMP
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit (Homo sapiens)_cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens)

cAMP-dependent protein kinase type I-alpha regulatory subunit (Homo sapiens)_cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens)
type: Complex
component stoichiometry: Protein/1262 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1990 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/UniProt Q13884
type: UnificationXref
id: Q13884
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

ATP-binding cassette sub-family C member 9
type: ProteinReference
xref: Reference/UniProt O60706

Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway
type: Pathway
pathway order: PathwaySubPathway/120965
pathway order: PathwayInteraction/2905
pathway order: PathwayTransport/2532205
pathway order: PathwayTransport/2532216
pathway order: PathwayTransport/2532238
pathway order: PathwayTransport/2532204
pathway order: PathwayTransport/2532215
pathway order: PathwayTransport/2532214
pathway order: PathwayTransport/2532213
pathway order: PathwayEnzymeReaction/2532203
pathway order: PathwayTransport/2532212
pathway order: PathwayInteraction/3306
pathway order: PathwayTransport/2532211
pathway order: PathwayTransport/2532210
pathway order: PathwayInteraction/3312
pathway order: PathwayInteraction/2851
pathway order: PathwayInteraction/4586
pathway order: PathwayTransport/2532209
pathway order: PathwayTransport/2532208
pathway order: PathwayTransport/2532207
pathway order: PathwayTransport/2532206
pathway order: PathwayTransport/2532239
pathway component: Transport13658
pathway component: Interaction2851
pathway component: Transport15616
pathway component: TransportCatalysis10
pathway component: Transport10981
pathway component: Transport15535
pathway component: TransportCatalysis91
pathway component: Interaction3306
pathway component: Transport11091
pathway component: TransportCatalysis2231
pathway component: Transport116
pathway component: Reaction179579
pathway component: Transport120
pathway component: TransportCatalysis4744
pathway component: TransportCatalysis89
pathway component: Interaction3312
pathway component: TransportCatalysis88
pathway component: Transport36
pathway component: TransportCatalysis87
pathway component: Interaction4586
pathway component: TransportCatalysis82
pathway component: TransportCatalysis86
pathway component: TransportCatalysis85
pathway component: TransportCatalysis84
pathway component: TransportCatalysis83
pathway component: SubPathwayControl120965
pathway component: Interaction2905
xref: Reference/SMPDB SMP0126519
xref: Reference/PathWhiz PW128118
organism: Homo sapiens

Potassium voltage-gated channel subfamily A member 5
type: ProteinReference
xref: Reference/UniProt P22460

Tropomyosin
type: Complex
component stoichiometry: Protein/3290 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3291 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Tropomyosin beta chain
component: Tropomyosin alpha-1 chain

Disks large homolog 1
type: ProteinReference
xref: Reference/UniProt Q12959

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Protein/Generic536 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

Troponin
type: Protein
cellular location: Cytosol
entity reference: Troponin

Potassium voltage-gated channel subfamily KQT member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily KQT member 1

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/UniProt P09493
type: UnificationXref
id: P09493
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: Protein
entity reference: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Inward rectifier potassium channel 2
type: ProteinReference
xref: Reference/UniProt P63252

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

ATP-sensitive inward rectifier potassium channel 11
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 11

BiologicalState1014
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Heart, Cardiomyocyte
tissue: Heart

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Reference/UniProt P15382
type: UnificationXref
id: P15382
db: UniProt

Reference/UniProt Q9UK17
type: UnificationXref
id: Q9UK17
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C009485 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tocainide
stoichiometric coefficient: 1.0

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Interaction3312
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP-dependent protein kinase type I-alpha regulatory subunit (Homo sapiens) + cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens) activates L type Calcium channel
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit (Homo sapiens)_cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens)
participant: L type Calcium channel

Compound/PW C009485 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tocainide
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: Homo sapiens

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Interaction2905
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Ryanodine receptor 2
participant: Calcium
participant: Ryanodine receptor 2

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Potassium voltage-gated channel subfamily E member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 2

Protein/1990 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

TransportCatalysis10
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport36
control type: ACTIVATION

Reference/HMDB HMDB0015189
type: UnificationXref
id: HMDB0015189
db: HMDB

Potassium voltage-gated channel subfamily E member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 1

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/UniProt P51787
type: UnificationXref
id: P51787
db: UniProt

Muscle Contraction
type: Pathway
name: ActivatingSubPathway

Tocainide
type: SmallMoleculeReference
xref: Reference/CAS 41708-72-9
xref: Reference/KEGG Compound C07142
xref: Reference/ChEBI CHEBI 9611
xref: Reference/HMDB HMDB0015189
xref: Reference/PubChem-compound 38945
xref: Reference/ChemSpider 35632
chemical formula: C11H16N2O
molecular weight: 192.12627
structure: ChemicalStructure/PW C009485

Transport11091
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q14524
type: UnificationXref
id: Q14524
db: UniProt

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

cAMP-dependent protein kinase type I-alpha regulatory subunit (Homo sapiens)_cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens)
type: Complex
component stoichiometry: Protein/1990 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit

Potassium channel subfamily K member 1
type: Protein
entity reference: Potassium channel subfamily K member 1

Reference/UniProt P07951
type: UnificationXref
id: P07951
db: UniProt

G protein-activated inward rectifier potassium channel 4
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 4

Reference/UniProt Q14654
type: UnificationXref
id: Q14654
db: UniProt

Potassium voltage-gated channel subfamily H member 2
type: ProteinReference
xref: Reference/UniProt Q12809

BiologicalState35
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, cardiocyte, Cardiomyocyte
tissue: cardiocyte

Reference/CAS 41708-72-9
type: UnificationXref
id: 41708-72-9
db: CAS

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Heart
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000562

Beta-2-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13425

Potassium voltage-gated channel subfamily D member 3
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 3

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Protein/2712 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/PubChem-compound 38945
type: UnificationXref
id: 38945
db: PubChem-compound

Inward rectifier potassium channel 4
type: Protein
entity reference: Inward rectifier potassium channel 4

Alpha-1-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13424

G protein-activated inward rectifier potassium channel 1
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 1

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

L type Calcium channel
type: Complex
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/2.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2712 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Potassium voltage-gated channel subfamily KQT member 1
type: ProteinReference
xref: Reference/UniProt P51787

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: ProteinReference
xref: Reference/UniProt Q9Y3Q4

Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

ATP-sensitive inward rectifier potassium channel 8
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 8

cardiocyte
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001539

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Tocainide
type: SmallMolecule
entity reference: Tocainide

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47
organism: Homo sapiens

Reference/UniProt Q15842
type: UnificationXref
id: Q15842
db: UniProt

Tocainide
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Tocainide

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt O43497

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555
organism: Homo sapiens

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
cellular location: Sarcoplasmic Reticulum
component: Ryanodine receptor 2

Transport36
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Homo sapiens, Cardiomyocyte, Sarcoplasmic Reticulum to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

ATP-sensitive inward rectifier potassium channel 11
type: ProteinReference
xref: Reference/UniProt Q14654

Reference/UniProt Q9Y6J6
type: UnificationXref
id: Q9Y6J6
db: UniProt

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C07142
type: UnificationXref
id: C07142
db: KEGG Compound

Reference/UniProt O95180
type: UnificationXref
id: O95180
db: UniProt

BoundComplex/507 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Reference/UniProt Q13424
type: UnificationXref
id: Q13424
db: UniProt

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt O95180

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
type: Protein
entity reference: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Reference/UniProt Q13425
type: UnificationXref
id: Q13425
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641
organism: Homo sapiens

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: Homo sapiens

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Interaction2851
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Troponin activates Tropomyosin
participant: Tropomyosin
participant: Calcium_Troponin

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Protein/1990 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Transport15535
type: Transport
participant stoichiometry: Compound/PW C009485/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009485 Extracellular Space/Stoichiometry/1.0
right: Tocainide
spontaneous: false
left: Tocainide
name: Tocainide (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/UniProt Q9Y3Q4
type: UnificationXref
id: Q9Y3Q4
db: UniProt

Potassium voltage-gated channel subfamily E member 1
type: ProteinReference
xref: Reference/UniProt P15382

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Interaction4586
type: MolecularInteraction
interaction type: direct_interaction
name: Tocainide inhibits Voltage-gated sodium channel (INa)
participant: Tocainide
participant: Voltage-gated sodium channel (INa)

Reference/UniProt Q09428
type: UnificationXref
id: Q09428
db: UniProt

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Reference/UniProt Q12959
type: UnificationXref
id: Q12959
db: UniProt

ATP-binding cassette sub-family C member 8
type: Protein
entity reference: ATP-binding cassette sub-family C member 8

Reference/ChEBI CHEBI 9611
type: UnificationXref
id: CHEBI:9611
db: ChEBI

Potassium voltage-gated channel subfamily E member 2
type: ProteinReference
xref: Reference/UniProt Q9Y6J6

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: Reference/UniProt P48549

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48544

Inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48050

Alpha-1-syntrophin
type: Protein
cellular location: Cell Membrane
entity reference: Alpha-1-syntrophin

Potassium voltage-gated channel subfamily D member 3
type: ProteinReference
xref: Reference/UniProt Q9UK17

Transport10981
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q12809
type: UnificationXref
id: Q12809
db: UniProt

Sodium channel protein type 5 subunit alpha
type: Protein
entity reference: Sodium channel protein type 5 subunit alpha

Reference/BRENDA TISSUE ONTOLOGY BTO 0000562
type: UnificationXref
id: BTO:0000562
db: BRENDA TISSUE ONTOLOGY

TransportCatalysis2231
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport11091
control type: ACTIVATION

Reference/BRENDA TISSUE ONTOLOGY BTO 0001539
type: UnificationXref
id: BTO:0001539
db: BRENDA TISSUE ONTOLOGY

Potassium channel subfamily K member 1
type: ProteinReference
xref: Reference/UniProt O00180

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

TransportCatalysis89
type: Catalysis
controller: Potassium channel subfamily K member 1
controlled: Transport116
control type: ACTIVATION

TransportCatalysis88
type: Catalysis
controller: ATP-sensitive inward rectifier potassium channel (IKATP)
controlled: Transport116
control type: ACTIVATION

Protein/1262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

TransportCatalysis87
type: Catalysis
controller: Voltage-gated rapid delayed rectifying potassium channel (IKr)
controlled: Transport116
control type: ACTIVATION

ATP-sensitive inward rectifier potassium channel 8
type: ProteinReference
xref: Reference/UniProt Q15842

Beta-2-syntrophin
type: Protein
cellular location: Cell Membrane
entity reference: Beta-2-syntrophin

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
type: ProteinReference
xref: Reference/UniProt Q5I7T1

TransportCatalysis82
type: Catalysis
controller: Inward rectifier potassium channel (IK1)
controlled: Transport116
control type: ACTIVATION

Beta-1-syntrophin
type: Protein
entity reference: Beta-1-syntrophin

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P07951
organism: Homo sapiens

TransportCatalysis86
type: Catalysis
controller: Voltage-gated slow delayed rectifying potassium channel (IK5)
controlled: Transport116
control type: ACTIVATION

TransportCatalysis85
type: Catalysis
controller: Voltage-gated ultra rapid delayed rectifying potassium channel
controlled: Transport116
control type: ACTIVATION

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

TransportCatalysis84
type: Catalysis
controller: Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
controlled: Transport116
control type: ACTIVATION

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt P09493
organism: Homo sapiens

TransportCatalysis83
type: Catalysis
controller: Acetylcholine-activated potassium channel (IKACh)
controlled: Transport116
control type: ACTIVATION

Reference/ChemSpider 35632
type: UnificationXref
id: 35632
db: ChemSpider

Tocainide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Tocainide