Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

Transport10963
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Pimozide
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Pimozide

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

direct_interaction
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Pimozide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 8212
xref: Reference/CAS 2062-78-4
xref: Reference/PubChem-compound 16362
xref: Reference/ChemSpider 15520
xref: Reference/HMDB HMDB0015232
xref: Reference/KEGG Compound C07566
chemical formula: C28H29F2N3O
molecular weight: 461.22787
structure: ChemicalStructure/PW C009522

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

SubPathwayInteraction120990
type: Interaction
name: SubPathwayReaction
name: SubPathway120990Reaction
participant: D(2) dopamine receptor

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/PathWhiz PW128131
type: UnificationXref
id: PW128131
db: PathWhiz

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/HMDB HMDB0015232
type: UnificationXref
id: HMDB0015232
db: HMDB

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Compound/PW C009522/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pimozide
stoichiometric coefficient: 1.0

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

ReactionCatalysis207629
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: Reaction218277
control type: ACTIVATION

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P14416
type: UnificationXref
id: P14416
db: UniProt

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Transport13772
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
right: Dopamine
spontaneous: true
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Transport13773
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Pimozide
type: SmallMolecule
entity reference: Pimozide

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/CAS 2062-78-4
type: UnificationXref
id: 2062-78-4
db: CAS

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

D(2) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P14416
organism: BiologicalState789

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Gi signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120990
pathway component: SubPathwayInteraction120990
name: SubPathway

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Interaction4892
type: MolecularInteraction
interaction type: direct_interaction
name: Pimozide inhibits D(2) dopamine receptor
participant: D(2) dopamine receptor
participant: Pimozide

Reference/KEGG Compound C07566
type: UnificationXref
id: C07566
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 8212
type: UnificationXref
id: CHEBI:8212
db: ChEBI

Reaction219552
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium ↔ Sodium
conversion direction: REVERSIBLE

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/SMPDB SMP0126532
type: UnificationXref
id: SMP0126532
db: SMPDB

TransportCatalysis4823
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport13773
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Transport14010
type: Transport
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

D(2) dopamine receptor
type: Protein
cellular location: Cytosol
entity reference: D(2) dopamine receptor
name: SubPathwayInput

Reference/PubChem-compound 16362
type: UnificationXref
id: 16362
db: PubChem-compound

Reference/ChemSpider 15520
type: UnificationXref
id: 15520
db: ChemSpider

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Compound/PW C000052 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Dopamine

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Dopamine

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

ChemicalStructure/PW C009522
type: ChemicalStructure
structure format: SMILES

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Pimozide Mechanism of Action Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2532550
pathway order: PathwayTransport/2532886
pathway order: PathwayTransport/2532554
pathway order: PathwayInteraction/3912
pathway order: PathwaySubPathway/120990
pathway order: PathwayTransport/2532553
pathway order: PathwayTransport/2532552
pathway order: PathwayTransport/2532551
pathway order: PathwayEnzymeReaction/2536834
pathway order: PathwayEnzymeReaction/2532549
pathway order: PathwayInteraction/3374
pathway order: PathwayInteraction/4892
pathway component: TransportCatalysis4823
pathway component: TransportCatalysis2122
pathway component: ReactionCatalysis207629
pathway component: Transport10963
pathway component: Reaction218277
pathway component: Interaction4892
pathway component: Interaction3374
pathway component: Gi signaling cascade
pathway component: Transport13772
pathway component: Transport15633
pathway component: Transport13773
pathway component: Transport14010
pathway component: Reaction219552
pathway component: Interaction3912
pathway component: TransportCatalysis4991
pathway component: 4.1.1.28
pathway component: ReactionCatalysis214
xref: Reference/SMPDB SMP0126532
xref: Reference/PathWhiz PW128131
organism: Homo sapiens

Dopamine
type: SmallMolecule
cellular location: Synapse
entity reference: Dopamine

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Interaction3912
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Dopamine
participant: Dopamine
participant: Calcium

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Calcium

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reaction218277
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: Tetrahydrobiopterin
name: L-Tyrosine + Oxygen + Tetrahydrobiopterin ↔ Dihydrobiopterin + L-Dopa + Water
conversion direction: REVERSIBLE

D(2) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(2) dopamine receptor

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

TransportCatalysis4991
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport14010
control type: ACTIVATION

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Interaction3374
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(2) dopamine receptor
participant: D(2) dopamine receptor
participant: Dopamine

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Sodium

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Transport15633
type: Transport
participant stoichiometry: Compound/PW C009522/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009522 post-synaptic membrane/Stoichiometry/1.0
right: Pimozide
spontaneous: true
left: Pimozide
name: Pimozide (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, post-synaptic membrane
conversion direction: REVERSIBLE

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

TransportCatalysis2122
type: Catalysis
controller: L type Calcium channel
controlled: Transport10963
control type: ACTIVATION

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C009522 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pimozide
stoichiometric coefficient: 1.0

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202