Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

direct_interaction
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState39

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

1.14.16.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
EC number: 1.14.16.2
left: L-Tyrosine
name: L-Tyrosine → L-Dopa
conversion direction: LEFT_TO_RIGHT

Cocaine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Cocaine

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Reference/KEGG Compound C01416
type: UnificationXref
id: C01416
db: KEGG Compound

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState52

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState39

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Interaction3526
type: MolecularInteraction
interaction type: direct_interaction
name: Alpha-1A adrenergic receptor activates Gq protein signaling cascade
participant: Guanine nucleotide-binding protein G(q) subunit alpha
participant: Alpha-1A adrenergic receptor

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Transport14066
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Nervous System, Neuron, Synapse to Homo sapiens, Nervous System, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

TransportCatalysis4985
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14003
control type: ACTIVATION

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Pathway
type: Pathway
xref: Reference/SMPDB SMP0125166
xref: Reference/PathWhiz PW126707
name: ActivatingSubPathway

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Extracellular Space
entity reference: Sodium-dependent noradrenaline transporter

Reference/ChemSpider 10194104
type: UnificationXref
id: 10194104
db: ChemSpider

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

TransportCatalysis5032
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14066
control type: ACTIVATION

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

SubPathwayControl121009
type: Interaction
name: SubPathway121009Control
name: ActivatingSubPathwayControl
participant: Guanine nucleotide-binding protein G(q) subunit alpha
participant: Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Pathway

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Reference/UniProt P50148
type: UnificationXref
id: P50148
db: UniProt

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/SMPDB SMP0126544
type: UnificationXref
id: SMP0126544
db: SMPDB

Reference/PathWhiz PW128144
type: UnificationXref
id: PW128144
db: PathWhiz

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/HMDB HMDB0015043
type: UnificationXref
id: HMDB0015043
db: HMDB

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState39

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Interaction3327
type: MolecularInteraction
interaction type: direct_interaction
name: Cocaine inhibits Sodium-dependent noradrenaline transporter
participant: Cocaine
participant: Sodium-dependent noradrenaline transporter

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

BiologicalState52
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Norepinephrine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Norepinephrine

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Reference/UniProt P54289
type: UnificationXref
id: P54289
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Reference/ChEBI CHEBI 27958
type: UnificationXref
id: CHEBI:27958
db: ChEBI

Reference/BRENDA TISSUE ONTOLOGY BTO 0001484
type: UnificationXref
id: BTO:0001484
db: BRENDA TISSUE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Norepinephrine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Norepinephrine

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Transport14128
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Cocaine Norepinephrine Reuptake Inhibitor Action Pathway
type: Pathway
pathway order: PathwayTransport/2532975
pathway order: PathwayInteraction/3140
pathway order: PathwayEnzymeReaction/2532971
pathway order: PathwayEnzymeReaction/2532970
pathway order: PathwayInteraction/3933
pathway order: PathwayInteraction/3526
pathway order: PathwayTransport/2532981
pathway order: PathwayInteraction/3327
pathway order: PathwaySubPathway/121009
pathway order: PathwayEnzymeReaction/2532969
pathway order: PathwayTransport/2532977
pathway order: PathwayTransport/2532976
pathway component: Interaction3140
pathway component: TransportCatalysis4985
pathway component: 1.14.17.1
pathway component: Transport14128
pathway component: Transport14003
pathway component: TransportCatalysis5082
pathway component: Transport14004
pathway component: Interaction3327
pathway component: Interaction3933
pathway component: Interaction3526
pathway component: Transport14066
pathway component: SubPathwayControl121009
pathway component: 4.1.1.28
pathway component: 1.14.16.2
pathway component: ReactionCatalysis118
pathway component: TransportCatalysis5032
pathway component: ReactionCatalysis214
pathway component: ReactionCatalysis115
xref: Reference/SMPDB SMP0126544
xref: Reference/PathWhiz PW128144
organism: Homo sapiens

Transport14003
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron, Cytosol to Homo sapiens, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

TransportCatalysis5082
type: Catalysis
controller: Calcium channel
controlled: Transport14128
control type: ACTIVATION

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Transport14004
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron, Exocytic Vesicle to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

BiologicalState39
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Nervous System, Neuron
tissue: Nervous System

Calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Alpha-1A adrenergic receptor
type: Protein
cellular location: Cytosol
entity reference: Alpha-1A adrenergic receptor

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: ProteinReference
xref: Reference/UniProt P54289

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Alpha-1A adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Alpha-1A adrenergic receptor

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: Reference/UniProt Q00975

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: Reference/UniProt P50148
organism: BiologicalState52

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Cocaine
type: SmallMoleculeReference
xref: Reference/ChemSpider 10194104
xref: Reference/CAS 50-36-2
xref: Reference/KEGG Compound C01416
xref: Reference/PubChem-compound 446220
xref: Reference/ChEBI CHEBI 27958
xref: Reference/HMDB HMDB0015043
chemical formula: C17H21NO4
molecular weight: 303.14706
structure: ChemicalStructure/PW C009355

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 50-36-2
type: UnificationXref
id: 50-36-2
db: CAS

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
name: SubPathwayActivator

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Reference/PubChem-compound 446220
type: UnificationXref
id: 446220
db: PubChem-compound

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/PathWhiz PW126707
type: UnificationXref
id: PW126707
db: PathWhiz

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Interaction3933
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Norepinephrine
participant: Norepinephrine
participant: Calcium

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

ChemicalStructure/PW C009355
type: ChemicalStructure
structure format: SMILES

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/UniProt Q00975
type: UnificationXref
id: Q00975
db: UniProt

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/SMPDB SMP0125166
type: UnificationXref
id: SMP0125166
db: SMPDB

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Nervous System
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001484

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

ReactionCatalysis115
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: 1.14.16.2
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202