Protein/23969/Stoichiometry/4.0
type: Stoichiometry
physical entity: Intermediate conductance calcium-activated potassium channel protein 4
stoichiometric coefficient: 4.0

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

ATP-binding cassette sub-family C member 9
type: Protein
entity reference: ATP-binding cassette sub-family C member 9

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Gastrointestinal Tract
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000511

Domperidone
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Domperidone

Protein kinase A
type: Complex
component stoichiometry: Protein/1315 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3359 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3358 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1990 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1134 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3357 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

direct_interaction
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt O15554
type: UnificationXref
id: O15554
db: UniProt

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

ATP-sensitive inward rectifier potassium channel (IKATP)
type: Complex
component: ATP-sensitive inward rectifier potassium channel 8
component: ATP-binding cassette sub-family C member 8
component: ATP-sensitive inward rectifier potassium channel 11
component: ATP-binding cassette sub-family C member 9

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Reference/ChEBI CHEBI 31515
type: UnificationXref
id: CHEBI:31515
db: ChEBI

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

BiologicalState791
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Gastrointestinal Tract
tissue: Gastrointestinal Tract

Compound/PW C000353/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Reference/CAS 57808-66-9
type: UnificationXref
id: 57808-66-9
db: CAS

ReactionCatalysis202856
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: 2.7.11.18
control type: ACTIVATION

Intermediate conductance calcium-activated potassium channel protein 4
type: Complex
component stoichiometry: Protein/23969/Stoichiometry/4.0
component: Intermediate conductance calcium-activated potassium channel protein 4

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Transport13772
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Transport13773
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Compound/Generic402 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate
stoichiometric coefficient: 1.0

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

L-type calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Protein/2126/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 1.0

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Reference/BRENDA TISSUE ONTOLOGY BTO 0000511
type: UnificationXref
id: BTO:0000511
db: BRENDA TISSUE ONTOLOGY

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Protein/3359 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Intermediate conductance calcium-activated potassium channel protein 4
type: ProteinReference
xref: Reference/UniProt O15554

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

D(2) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P14416
organism: BiologicalState789

Transport15801
type: Transport
participant stoichiometry: Compound/PW C009597/Stoichiometry/1.0
right: Domperidone
spontaneous: true
left: Domperidone
name: Domperidone (→) Transport: Homo sapiens, Gastrointestinal Tract to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Gi Protein Signaling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121166
pathway component: SubPathwayInteraction121166
name: SubPathway

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Domperidone Mechanism of Action Action Pathway
type: Pathway
pathway order: PathwayTransport/2534220
pathway order: PathwayTransport/2534221
pathway order: PathwayInteraction/509
pathway order: PathwaySubPathway/121149
pathway order: PathwayTransport/2534219
pathway order: PathwayInteraction/3988
pathway order: PathwayTransport/2534234
pathway order: PathwayEnzymeReaction/2534208
pathway order: PathwayTransport/2534235
pathway order: PathwayEnzymeReaction/2534209
pathway order: PathwayTransport/2534236
pathway order: PathwayInteraction/4971
pathway order: PathwayTransport/2534237
pathway order: PathwayTransport/2534218
pathway order: PathwayTransport/2534250
pathway order: PathwayEnzymeReaction/2536196
pathway order: PathwayEnzymeReaction/2534210
pathway order: PathwayEnzymeReaction/2534232
pathway order: PathwayInteraction/2849
pathway order: PathwayEnzymeReaction/2534213
pathway order: PathwaySubPathway/121143
pathway order: PathwayEnzymeReaction/2534214
pathway order: PathwayEnzymeReaction/2534211
pathway order: PathwayEnzymeReaction/2534233
pathway order: PathwayEnzymeReaction/2534212
pathway order: PathwayInteraction/3912
pathway order: PathwaySubPathway/121144
pathway order: PathwaySubPathway/121166
pathway order: PathwayEnzymeReaction/2534217
pathway order: PathwayEnzymeReaction/2534215
pathway order: PathwayEnzymeReaction/2534216
pathway order: PathwayTransport/2534222
pathway order: PathwayInteraction/3231
pathway order: PathwayInteraction/4
pathway order: PathwayInteraction/3374
pathway component: ReactionCatalysis207629
pathway component: ReactionCatalysis202856
pathway component: Reaction219325
pathway component: Transport14925
pathway component: Transport10963
pathway component: Transport14926
pathway component: Reaction218277
pathway component: 2.7.11.18
pathway component: Interaction4971
pathway component: ReactionCatalysis203360
pathway component: Transport13772
pathway component: Transport14002
pathway component: Transport13773
pathway component: Reaction219552
pathway component: Interaction3988
pathway component: TransportCatalysis4991
pathway component: Interaction4
pathway component: Reaction213775
pathway component: TransportCatalysis4823
pathway component: 3.1.3.16
pathway component: Reaction110955
pathway component: TransportCatalysis4984
pathway component: TransportCatalysis2122
pathway component: TransportCatalysis5632
pathway component: Reaction219314
pathway component: Reaction219313
pathway component: Gi Signaling Cascade
pathway component: Reaction219312
pathway component: Transport3328
pathway component: Transport15801
pathway component: Transport14933
pathway component: Interaction3231
pathway component: Interaction3374
pathway component: Muscle Relaxation
pathway component: Gi Protein Signaling Cascade
pathway component: Muscle Contraction
pathway component: Interaction2849
pathway component: Interaction509
pathway component: Transport14010
pathway component: Interaction3912
pathway component: Reaction115846
pathway component: 4.1.1.28
pathway component: Reaction2159
pathway component: ReactionCatalysis214

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: BiologicalState1056

ProteinComplex/7708/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Protein/216 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
stoichiometric coefficient: 1.0

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ATP-sensitive inward rectifier potassium channel 11
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 11

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Transport14933
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reaction2159
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

ProteinComplex/15522/Stoichiometry/1.0
type: Stoichiometry
physical entity: Intermediate conductance calcium-activated potassium channel protein 4
stoichiometric coefficient: 1.0

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Transport14925
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Lung
conversion direction: LEFT_TO_RIGHT

Transport14926
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Dopamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Dopamine

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Diacylglycerol
type: SmallMoleculeReference

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Dopamine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Dopamine

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: ProteinReference
xref: Reference/UniProt P54289

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Protein/1990/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Gi Signaling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121149
pathway component: SubPathwayInteraction121149
name: SubPathway

Interaction3231
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: cAMP
participant: PKA complex

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121144
pathway component: SubPathwayInteraction121144
name: SubPathway

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: BiologicalState1056

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121143
pathway component: SubPathwayInteraction121143
name: SubPathway

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Domperidone
type: SmallMolecule
entity reference: Domperidone

Domperidone
type: SmallMoleculeReference
xref: Reference/CAS 57808-66-9
xref: Reference/PubChem-compound 3151
xref: Reference/HMDB HMDB0015315
xref: Reference/ChEBI CHEBI 31515
xref: Reference/ChemSpider 3039
chemical formula: C22H24ClN5O2
molecular weight: 425.16187
structure: ChemicalStructure/PW C009597

Calcium
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Calcium

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reaction218277
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: Tetrahydrobiopterin
name: L-Tyrosine + Oxygen + Tetrahydrobiopterin ↔ Dihydrobiopterin + L-Dopa + Water
conversion direction: REVERSIBLE

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

TransportCatalysis4991
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport14010
control type: ACTIVATION

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/SMPDB SMP0126605
type: UnificationXref
id: SMP0126605
db: SMPDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reaction110955
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic402 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate
name: Phosphatidylinositol-4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0015315
type: UnificationXref
id: HMDB0015315
db: HMDB

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Interaction3374
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(2) dopamine receptor
participant: D(2) dopamine receptor
participant: Dopamine

Reference/UniProt Q09428
type: UnificationXref
id: Q09428
db: UniProt

Sodium
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Sodium

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Calcium
type: SmallMolecule
entity reference: Calcium

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

TransportCatalysis2122
type: Catalysis
controller: L type Calcium channel
controlled: Transport10963
control type: ACTIVATION

TransportCatalysis5632
type: Catalysis
controller: L-type calcium channel
controlled: Transport14925
control type: ACTIVATION

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C000041/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Protein/1262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

ATP-sensitive inward rectifier potassium channel 8
type: ProteinReference
xref: Reference/UniProt Q15842

Phosphatidylinositol-4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate

Transport3328
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: BiologicalState1056

Protein/1134/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694

Reaction219325
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/681/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7708/Stoichiometry/1.0
right: ATP-sensitive inward rectifier potassium channel (IKATP)
spontaneous: false
left: Protein kinase A
name: Protein kinase A → ATP-sensitive inward rectifier potassium channel (IKATP)
conversion direction: LEFT_TO_RIGHT

Transport10963
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Intermediate conductance calcium-activated potassium channel protein 4
type: Protein
entity reference: Intermediate conductance calcium-activated potassium channel protein 4

Interaction3988
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates L-type calcium channel
participant: L-type calcium channel
participant: Protein kinase C alpha type

Protein/1134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

D(2) dopamine receptor
type: Protein
entity reference: D(2) dopamine receptor

Protein/3359/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

SubPathwayInteraction121166
type: Interaction
name: SubPathwayReaction
name: SubPathway121166Reaction

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Phosphatidylinositol-4,5-bisphosphate
type: SmallMoleculeReference

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

cAMP
type: SmallMolecule
entity reference: cAMP

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Protein/3358/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

ReactionCatalysis207629
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: Reaction218277
control type: ACTIVATION

Protein/3357/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/UniProt O60706
type: UnificationXref
id: O60706
db: UniProt

Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

ATP-binding cassette sub-family C member 8
type: ProteinReference
xref: Reference/UniProt Q09428

Reference/UniProt P14416
type: UnificationXref
id: P14416
db: UniProt

Interaction4971
type: MolecularInteraction
interaction type: direct_interaction
name: Domperidone inhibits D(2) dopamine receptor
participant: D(2) dopamine receptor
participant: Domperidone

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Compound/PW C009597/Stoichiometry/1.0
type: Stoichiometry
physical entity: Domperidone
stoichiometric coefficient: 1.0

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

TransportCatalysis4984
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport14002
control type: ACTIVATION

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

ProteinComplex/7708 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: BiologicalState1056

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Protein/1315/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Protein/1315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

ATP-binding cassette sub-family C member 9
type: ProteinReference
xref: Reference/UniProt O60706

Protein/3357 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reaction219552
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium ↔ Sodium
conversion direction: REVERSIBLE

SubPathwayInteraction121149
type: Interaction
name: SubPathwayReaction
name: SubPathway121149Reaction

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Interaction4
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

SubPathwayInteraction121144
type: Interaction
name: SubPathwayReaction
name: SubPathway121144Reaction
participant: Myosin light chain 3

SubPathwayInteraction121143
type: Interaction
name: SubPathwayReaction
name: SubPathway121143Reaction
participant: Myosin light chain 3

TransportCatalysis4823
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport13773
control type: ACTIVATION

Reference/UniProt P54289
type: UnificationXref
id: P54289
db: UniProt

Reaction219314
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/7708 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/216 Cytosol/Stoichiometry/1.0
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Phospholipase C
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Reaction219313
type: BiochemicalReaction
participant stoichiometry: Protein/2126/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7708/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate receptor type 1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Inositol 1,4,5-trisphosphate receptor
conversion direction: LEFT_TO_RIGHT

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Reaction219312
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/15522/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7708/Stoichiometry/1.0
right: Intermediate conductance calcium-activated potassium channel protein 4
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Intermediate conductance calcium-activated potassium channel protein 4
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Inositol 1,4,5-trisphosphate
type: SmallMolecule
entity reference: Inositol 1,4,5-trisphosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Transport14010
type: Transport
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C097908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3151
type: UnificationXref
id: 3151
db: PubChem-compound

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643

Compound/PW C000052 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Protein/1990 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

ProteinComplex/681/Stoichiometry/1.0
type: Stoichiometry
physical entity: ATP-sensitive inward rectifier potassium channel (IKATP)
stoichiometric coefficient: 1.0

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Transport14002
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Sarcoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/UniProt Q14654
type: UnificationXref
id: Q14654
db: UniProt

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Protein/1262/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Interaction509
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Protein/3358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

ATP-sensitive inward rectifier potassium channel 8
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 8

BiologicalState1056
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/UniProt Q15842
type: UnificationXref
id: Q15842
db: UniProt

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMolecule
entity reference: Diacylglycerol

Reference/ChemSpider 3039
type: UnificationXref
id: 3039
db: ChemSpider

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

L-type calcium channel
type: Complex
cellular location: Cytosol
component: Voltage-dependent calcium channel subunit alpha-2/delta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1

ATP-sensitive inward rectifier potassium channel 11
type: ProteinReference
xref: Reference/UniProt Q14654

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Dopamine
type: SmallMolecule
cellular location: Synapse
entity reference: Dopamine

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Interaction3912
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Dopamine
participant: Dopamine
participant: Calcium

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

Potassium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Potassium

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Reference/PathWhiz PW128207
type: UnificationXref
id: PW128207
db: PathWhiz

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Adenosine triphosphate
left: Myosin light chain 3
name: Adenosine triphosphate + Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

D(2) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(2) dopamine receptor

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

PKA complex
type: Complex
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Protein kinase A
type: Complex
component stoichiometry: Protein/1990/Stoichiometry/1.0
component stoichiometry: Protein/1262/Stoichiometry/1.0
component stoichiometry: Protein/3358/Stoichiometry/1.0
component stoichiometry: Protein/1134/Stoichiometry/1.0
component stoichiometry: Protein/3357/Stoichiometry/1.0
component stoichiometry: Protein/1315/Stoichiometry/1.0
component stoichiometry: Protein/3359/Stoichiometry/1.0
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ATP-binding cassette sub-family C member 8
type: Protein
entity reference: ATP-binding cassette sub-family C member 8

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097908 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C009597
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

Protein kinase C alpha type
type: Protein
entity reference: Protein kinase C alpha type

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: BiologicalState1056

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202