Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 439280
type: UnificationXref
id: 439280
db: PubChem-compound

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Compound/PW C000178 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

5-hydroxytryptamine receptor 2A
type: ProteinReference
xref: Reference/UniProt P28223
organism: BiologicalState39

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Chromaffin granule amine transporter
type: Protein
entity reference: Chromaffin granule amine transporter

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/UniProt P31645
type: UnificationXref
id: P31645
db: UniProt

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState39

Reference/ChEBI CHEBI 27823
type: UnificationXref
id: CHEBI:27823
db: ChEBI

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

SubPathwayInteraction121195
type: Interaction
name: SubPathway121195Reaction
name: SubPathwayReaction
participant: 5-hydroxytryptamine receptor 2A

Reference/PathWhiz PW128221
type: UnificationXref
id: PW128221
db: PathWhiz

Sodium-dependent serotonin transporter
type: Protein
entity reference: Sodium-dependent serotonin transporter

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Transport14185
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Nervous System, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: BiologicalState39

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Methamphetamine
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Methamphetamine

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Reference/PubChem-compound 1826
type: UnificationXref
id: 1826
db: PubChem-compound

Transport14170
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: true
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14173
type: Transport
participant stoichiometry: Protein/1822 Presynaptic membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1822 Cytosol/Stoichiometry/1.0
right: Sodium-dependent serotonin transporter
spontaneous: true
left: Sodium-dependent serotonin transporter
name: Sodium-dependent serotonin transporter (→) Transport: Homo sapiens, Brain, Neuron, Presynaptic membrane to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14172
type: Transport
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0126619
type: UnificationXref
id: SMP0126619
db: SMPDB

Compound/PW C000358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-L-tryptophan
stoichiometric coefficient: 1.0

Sodium-dependent serotonin transporter
type: Protein
cellular location: Extracellular Space
entity reference: Sodium-dependent serotonin transporter

Interaction4073
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Amine oxidase [flavin-containing] A
participant: Amine oxidase [flavin-containing] A
participant: Methamphetamine

Interaction4076
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Sodium-dependent serotonin transporter
participant: Methamphetamine
participant: Sodium-dependent serotonin transporter

Interaction4075
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Chromaffin granule amine transporter
participant: Chromaffin granule amine transporter
participant: Methamphetamine

Interaction4072
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine activates Trace amine-associated receptor 1
participant: Trace amine-associated receptor 1
participant: Methamphetamine

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Compound/PW C000609 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxyindoleacetic acid
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Interaction4077
type: MolecularInteraction
interaction type: direct_interaction
name: Trace amine-associated receptor 1 inhibits Sodium-dependent serotonin transporter
participant: Trace amine-associated receptor 1
participant: Sodium-dependent serotonin transporter

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Transport14169
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport14164
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: true
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14163
type: Transport
participant stoichiometry: Compound/PW C009782 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Serotonin
type: SmallMolecule
cellular location: Synapse
entity reference: Serotonin

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Protein/1822 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent serotonin transporter
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Trace amine-associated receptor 1
type: Protein
cellular location: Presynaptic membrane
entity reference: Trace amine-associated receptor 1

Chromaffin granule amine transporter
type: ProteinReference
xref: Reference/UniProt P54219

Trace amine-associated receptor 1
type: ProteinReference
xref: Reference/UniProt Q96RJ0
organism: BiologicalState1033

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Reference/PathWhiz PW126797
type: UnificationXref
id: PW126797
db: PathWhiz

Reference/PubChem-compound 10836
type: UnificationXref
id: 10836
db: PubChem-compound

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C009782 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Reference/ChemSpider 388413
type: UnificationXref
id: 388413
db: ChemSpider

TransportCatalysis5109
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14185
control type: ACTIVATION

Serotonin
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Serotonin

Gq Signalling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121196
pathway component: SubPathwayInteraction121196
name: SubPathway

5-Hydroxyindoleacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxyindoleacetic acid

Reference/UniProt P28223
type: UnificationXref
id: P28223
db: UniProt

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Methamphetamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Methamphetamine

5-Hydroxyindoleacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000763
xref: Reference/PubChem-compound 1826
xref: Reference/BioCyc 5-HYDROXYINDOLE ACETATE
xref: Reference/ChEBI CHEBI 27823
xref: Reference/KEGG Compound C05635
xref: Reference/CAS 54-16-0
xref: Reference/ChemSpider 1760
chemical formula: C10H9NO3
molecular weight: 191.05824
structure: ChemicalStructure/PW C000609

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Methamphetamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 6809
xref: Reference/KEGG Compound C07164
xref: Reference/HMDB HMDB0015517
xref: Reference/CAS 537-46-2
xref: Reference/PubChem-compound 10836
xref: Reference/ChemSpider 10379
chemical formula: C10H15N
molecular weight: 149.12045
structure: ChemicalStructure/PW C009782

Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
type: UnificationXref
id: 5-HYDROXY-TRYPTOPHAN
db: BioCyc

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

TransportCatalysis5100
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14172
control type: ACTIVATION

Reference/HMDB HMDB0000472
type: UnificationXref
id: HMDB0000472
db: HMDB

Sodium-dependent serotonin transporter
type: ProteinReference
xref: Reference/UniProt P31645

Methamphetamine Serotonin Reuptake Inhibitor Action Pathway
type: Pathway
pathway order: PathwayInteraction/4075
pathway order: PathwayInteraction/4073
pathway order: PathwayInteraction/4072
pathway order: PathwayTransport/2534560
pathway order: PathwayTransport/2534561
pathway order: PathwayEnzymeReaction/2534540
pathway order: PathwayTransport/2534549
pathway order: PathwayEnzymeReaction/2534541
pathway order: PathwaySubPathway/121196
pathway order: PathwaySubPathway/121195
pathway order: PathwayEnzymeReaction/2534539
pathway order: PathwayTransport/2534556
pathway order: PathwayTransport/2534557
pathway order: PathwayInteraction/3143
pathway order: PathwayTransport/2534558
pathway order: PathwayInteraction/4077
pathway order: PathwayTransport/2534548
pathway order: PathwayTransport/2534559
pathway order: PathwayInteraction/4076
pathway component: TransportCatalysis5109
pathway component: Interaction4073
pathway component: Gq Signalling cascade
pathway component: Interaction4076
pathway component: Interaction4075
pathway component: Interaction4072
pathway component: Intestinal Serotonin pathway
pathway component: Interaction4077
pathway component: Interaction3143
pathway component: Transport14169
pathway component: Transport14164
pathway component: Transport14163
pathway component: Transport14185
pathway component: TransportCatalysis5100
pathway component: ReactionCatalysis1364
pathway component: ReactionCatalysis1363
pathway component: Transport14119
pathway component: ReactionCatalysis207970
pathway component: Reaction218550
pathway component: 1.14.16.4
pathway component: 4.1.1.28
pathway component: Transport14170
pathway component: Transport14173
pathway component: Transport14172
pathway component: TransportCatalysis5098
pathway component: TransportCatalysis5095
pathway component: TransportCatalysis5074
xref: Reference/PathWhiz PW128221
xref: Reference/SMPDB SMP0126619
organism: Homo sapiens

ChemicalStructure/PW C000358
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0001484
type: UnificationXref
id: BTO:0001484
db: BRENDA TISSUE ONTOLOGY

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

1.14.16.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: 5-Hydroxy-L-tryptophan
spontaneous: false
EC number: 1.14.16.4
left: Oxygen
left: L-Tryptophan
left: Tetrahydrobiopterin
name: L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Serotonin
spontaneous: false
EC number: 4.1.1.28
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
conversion direction: LEFT_TO_RIGHT

Methamphetamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Methamphetamine

ChemicalStructure/PW C000609
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CNC2=C1C=C(O)C=C2

Reference/ChEBI CHEBI 6809
type: UnificationXref
id: CHEBI:6809
db: ChEBI

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/ChemSpider 1760
type: UnificationXref
id: 1760
db: ChemSpider

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

BiologicalState1033
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

ChemicalStructure/PW C009782
type: ChemicalStructure
structure format: SMILES
structure data: CN[C@@H](C)CC1=CC=CC=C1

Sodium-dependent serotonin transporter
type: Protein
cellular location: Presynaptic membrane
entity reference: Sodium-dependent serotonin transporter

BiologicalState39
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Nervous System, Neuron
tissue: Nervous System

Sodium-dependent serotonin transporter
type: Protein
cellular location: Cytosol
entity reference: Sodium-dependent serotonin transporter

Reference/CAS 4350-09-8
type: UnificationXref
id: 4350-09-8
db: CAS

Reference/HMDB HMDB0015517
type: UnificationXref
id: HMDB0015517
db: HMDB

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Transport14119
type: Transport
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Protein/1822 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent serotonin transporter
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/UniProt P17752
type: UnificationXref
id: P17752
db: UniProt

Compound/PW C000178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

TransportCatalysis5098
type: Catalysis
controller: Chromaffin granule amine transporter
controlled: Transport14169
control type: ACTIVATION

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

TransportCatalysis5095
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14163
control type: ACTIVATION

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/SMPDB SMP0125254
type: UnificationXref
id: SMP0125254
db: SMPDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

Reference/UniProt Q96RJ0
type: UnificationXref
id: Q96RJ0
db: UniProt

Reference/KEGG Compound C05635
type: UnificationXref
id: C05635
db: KEGG Compound

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Compound/PW C009782 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: Reference/UniProt P17752
organism: BiologicalState39

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Tryptophan 5-hydroxylase 1
type: Protein
cellular location: Cytosol
entity reference: Tryptophan 5-hydroxylase 1

Reaction218550
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000609 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: 5-Hydroxyindoleacetic acid
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: Serotonin
left: Water
name: Oxygen + Serotonin + Water → 5-Hydroxyindoleacetic acid + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Chromaffin granule amine transporter
type: Protein
cellular location: Exocytic Vesicle
entity reference: Chromaffin granule amine transporter

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Cytosol
entity reference: Amine oxidase [flavin-containing] A

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

Reference/CAS 537-46-2
type: UnificationXref
id: 537-46-2
db: CAS

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Reference/UniProt P54219
type: UnificationXref
id: P54219
db: UniProt

Reference/ChEBI CHEBI 17780
type: UnificationXref
id: CHEBI:17780
db: ChEBI

Intestinal Serotonin pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121195
pathway component: SubPathwayInteraction121195
xref: Reference/SMPDB SMP0125254
xref: Reference/PathWhiz PW126797
name: SubPathway

Serotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: Serotonin

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Interaction3143
type: MolecularInteraction
interaction type: direct_interaction
name: Serotonin activates 5-hydroxytryptamine receptor 2A
participant: Serotonin
participant: 5-hydroxytryptamine receptor 2A

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc 5-HYDROXYINDOLE ACETATE
type: UnificationXref
id: 5-HYDROXYINDOLE_ACETATE
db: BioCyc

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/CAS 54-16-0
type: UnificationXref
id: 54-16-0
db: CAS

ReactionCatalysis1364
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ReactionCatalysis1363
type: Catalysis
controller: Tryptophan 5-hydroxylase 1
controlled: 1.14.16.4
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

5-Hydroxy-L-tryptophan
type: SmallMoleculeReference
xref: Reference/ChemSpider 388413
xref: Reference/CAS 4350-09-8
xref: Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
xref: Reference/ChEBI CHEBI 17780
xref: Reference/KEGG Compound C00643
xref: Reference/PubChem-compound 439280
xref: Reference/HMDB HMDB0000472
chemical formula: C11H12N2O3
molecular weight: 220.0848
structure: ChemicalStructure/PW C000358

Reference/KEGG Compound C00643
type: UnificationXref
id: C00643
db: KEGG Compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

ReactionCatalysis207970
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: Reaction218550
control type: ACTIVATION

Reference/KEGG Compound C07164
type: UnificationXref
id: C07164
db: KEGG Compound

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

Reference/ChemSpider 10379
type: UnificationXref
id: 10379
db: ChemSpider

SubPathwayInteraction121196
type: Interaction
name: SubPathway121196Reaction
name: SubPathwayReaction
participant: 5-hydroxytryptamine receptor 2A

Methamphetamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Methamphetamine

5-hydroxytryptamine receptor 2A
type: Protein
cellular location: Synapse
entity reference: 5-hydroxytryptamine receptor 2A

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

5-hydroxytryptamine receptor 2A
type: Protein
cellular location: post-synaptic membrane
entity reference: 5-hydroxytryptamine receptor 2A
name: SubPathwayInput

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

5-Hydroxy-L-tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-L-tryptophan

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Reference/HMDB HMDB0000763
type: UnificationXref
id: HMDB0000763
db: HMDB

Nervous System
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001484

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202

TransportCatalysis5074
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14119
control type: ACTIVATION