Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: BiologicalState1139

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1055

Protein/1134/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState1139

Intermediate conductance calcium-activated potassium channel protein 4
type: Protein
cellular location: Cytosol
entity reference: Intermediate conductance calcium-activated potassium channel protein 4

Transport15735
type: Transport
participant stoichiometry: Compound/PW C009401/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009401 Extracellular Space/Stoichiometry/1.0
right: Pindolol
spontaneous: false
left: Pindolol
name: Pindolol (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

Protein kinase A
type: Complex
component stoichiometry: Protein/1315 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3359 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3358 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1990 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1134 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3357 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

direct_interaction
type: InteractionVocabulary

Pindolol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 4828
xref: Reference/ChEBI CHEBI 8214
xref: Reference/HMDB HMDB0015095
xref: Reference/CAS 13523-86-9
xref: Reference/ChemSpider 4662
xref: Reference/KEGG Compound C07445
chemical formula: C14H20N2O2
molecular weight: 248.15248
structure: ChemicalStructure/PW C009401

Interaction3988
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates L-type calcium channel
participant: L-type calcium channel
participant: Protein kinase C alpha type

Protein/1134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Protein/3359/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState1055

Reference/PathWhiz PW128256
type: UnificationXref
id: PW128256
db: PathWhiz

Phosphatidylinositol-4,5-bisphosphate
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState1055

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt O15554
type: UnificationXref
id: O15554
db: UniProt

Reference/UniProt P07550
type: UnificationXref
id: P07550
db: UniProt

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Protein/3358/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Interaction4944
type: MolecularInteraction
interaction type: direct_interaction
name: Pindolol activates Beta-2 adrenergic receptor
participant: Pindolol
participant: Beta-2 adrenergic receptor

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Compound/PW C000353/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

ReactionCatalysis202856
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: 2.7.11.18
control type: ACTIVATION

Protein/3357/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Pindolol
type: SmallMolecule
entity reference: Pindolol

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0000763
type: UnificationXref
id: BTO:0000763
db: BRENDA TISSUE ONTOLOGY

Protein/3625 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252
organism: BiologicalState1139

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

TransportCatalysis4984
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport14002
control type: ACTIVATION

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121303
pathway component: SubPathwayInteraction121303
name: SubPathway

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121302
pathway component: SubPathwayInteraction121302
name: SubPathway

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/Generic402 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate
stoichiometric coefficient: 1.0

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

ProteinComplex/7708 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reaction219365
type: BiochemicalReaction
participant stoichiometry: BoundComplex/532 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/14553 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

BoundComplex/532 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
stoichiometric coefficient: 1.0

L-type calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1

Protein/2126/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 1.0

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1055

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Protein/3359 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: BiologicalState1139

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState1055

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/1315/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

ProteinComplex/15522 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Intermediate conductance calcium-activated potassium channel protein 4
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Protein/1315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Protein/3357 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/ChemSpider 4662
type: UnificationXref
id: 4662
db: ChemSpider

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Intermediate conductance calcium-activated potassium channel protein 4
type: ProteinReference
xref: Reference/UniProt O15554
organism: BiologicalState1139

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Compound/PW C009401/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pindolol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState1139

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Adenylate cyclase type 9
type: ProteinReference
xref: Reference/UniProt O60503
organism: BiologicalState1139

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Transport14944
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Muscle, Myocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: BiologicalState1139

ProteinComplex/7708/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Reference/KEGG Compound C07445
type: UnificationXref
id: C07445
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/ChEBI CHEBI 8214
type: UnificationXref
id: CHEBI:8214
db: ChEBI

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Protein/216 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
stoichiometric coefficient: 1.0

Interaction4416
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein G(i) subunit alpha-1 activates Adenylyl Cyclase
participant: Adenylate cyclase type 9
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
type: Complex
component stoichiometry: Protein/3618 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Gβ
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Beta-2 adrenergic receptor
type: Protein
entity reference: Beta-2 adrenergic receptor

Interaction4
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

BiologicalState1139
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, Myocyte
tissue: Blood Vessel

Reference/SMPDB SMP0126653
type: UnificationXref
id: SMP0126653
db: SMPDB

Reference/UniProt P54289
type: UnificationXref
id: P54289
db: UniProt

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/CAS 13523-86-9
type: UnificationXref
id: 13523-86-9
db: CAS

Reaction219314
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/7708 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/216 Cytosol/Stoichiometry/1.0
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Phospholipase C
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Reaction219313
type: BiochemicalReaction
participant stoichiometry: Protein/2126/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7708/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate receptor type 1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Inositol 1,4,5-trisphosphate receptor
conversion direction: LEFT_TO_RIGHT

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reaction219312
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/7708 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/15522 Cytosol/Stoichiometry/1.0
right: Intermediate conductance calcium-activated potassium channel protein 4
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Intermediate conductance calcium-activated potassium channel protein 4
conversion direction: LEFT_TO_RIGHT

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState1139

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Inositol 1,4,5-trisphosphate
type: SmallMolecule
entity reference: Inositol 1,4,5-trisphosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt O60503
type: UnificationXref
id: O60503
db: UniProt

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reaction2159
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

Protein/23969 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Intermediate conductance calcium-activated potassium channel protein 4
stoichiometric coefficient: 4.0

Compound/PW C097908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643
organism: BiologicalState51

Protein/1990 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Transport14925
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Lung
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Transport14002
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Sarcoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Beta-2 adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Beta-2 adrenergic receptor

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Adenylate cyclase type 9
type: Protein
cellular location: Cell Membrane
entity reference: Adenylate cyclase type 9

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Diacylglycerol
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState1055

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Protein/1262/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Interaction509
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Protein/3358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Lung
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000763

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: ProteinReference
xref: Reference/UniProt P54289

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState1139

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState1139

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState1139

Reference/PubChem-compound 4828
type: UnificationXref
id: 4828
db: PubChem-compound

Protein/1990/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

BiologicalState1055
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Lung, Myocyte
tissue: Lung

ChemicalStructure/PW C009401
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)NCC(O)COC1=CC=CC2=C1C=CN2

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Interaction3231
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: PKA complex
participant: cAMP

Pindolol
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Pindolol

Pindolol B2-Adrenergic Vasodilation Action Pathway
type: Pathway
pathway order: PathwayTransport/2535497
pathway order: PathwayTransport/2535496
pathway order: PathwayEnzymeReaction/2535493
pathway order: PathwayEnzymeReaction/2535492
pathway order: PathwayInteraction/509
pathway order: PathwayEnzymeReaction/2535491
pathway order: PathwayEnzymeReaction/2535490
pathway order: PathwayEnzymeReaction/2535495
pathway order: PathwaySubPathway/121303
pathway order: PathwayEnzymeReaction/2535494
pathway order: PathwaySubPathway/121302
pathway order: PathwayInteraction/3988
pathway order: PathwayInteraction/4416
pathway order: PathwayEnzymeReaction/2535486
pathway order: PathwayEnzymeReaction/2535485
pathway order: PathwayEnzymeReaction/2535484
pathway order: PathwayInteraction/2849
pathway order: PathwayEnzymeReaction/2535489
pathway order: PathwayEnzymeReaction/2535488
pathway order: PathwayEnzymeReaction/2535487
pathway order: PathwayTransport/2535519
pathway order: PathwayInteraction/4944
pathway order: PathwayInteraction/4228
pathway order: PathwayTransport/2535499
pathway order: PathwayTransport/2535498
pathway order: PathwayInteraction/3231
pathway order: PathwayInteraction/4
pathway component: ReactionCatalysis202856
pathway component: Transport14925
pathway component: Reaction219366
pathway component: Transport15735
pathway component: 2.7.11.18
pathway component: Reaction219306
pathway component: Transport14944
pathway component: ReactionCatalysis203360
pathway component: Transport14002
pathway component: Interaction4416
pathway component: Interaction3988
pathway component: Interaction4
pathway component: Reaction213775
pathway component: 3.1.3.16
pathway component: Reaction110955
pathway component: TransportCatalysis4984
pathway component: TransportCatalysis5632
pathway component: Reaction219314
pathway component: Reaction219313
pathway component: Muscle Relaxation
pathway component: Reaction219312
pathway component: Muscle Contraction
pathway component: Transport3328
pathway component: Interaction3231
pathway component: Interaction2849
pathway component: Interaction509
pathway component: Reaction219365
pathway component: Interaction4944
pathway component: Interaction4228
pathway component: Reaction115846
pathway component: Reaction2159
xref: Reference/SMPDB SMP0126653
xref: Reference/PathWhiz PW128256
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: BiologicalState1139

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0015095
type: UnificationXref
id: HMDB0015095
db: HMDB

Protein/1601 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState1139

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reaction219366
type: BiochemicalReaction
participant stoichiometry: Protein/1601 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/14553 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein alpha
conversion direction: LEFT_TO_RIGHT

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Adenosine triphosphate
left: Myosin light chain 3
name: Adenosine triphosphate + Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Intermediate conductance calcium-activated potassium channel protein 4
type: Complex
component stoichiometry: Protein/23969 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Intermediate conductance calcium-activated potassium channel protein 4

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reaction110955
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic402 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate
name: Phosphatidylinositol-4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Protein kinase A
type: Complex
component stoichiometry: Protein/1990/Stoichiometry/1.0
component stoichiometry: Protein/1262/Stoichiometry/1.0
component stoichiometry: Protein/3358/Stoichiometry/1.0
component stoichiometry: Protein/1134/Stoichiometry/1.0
component stoichiometry: Protein/3357/Stoichiometry/1.0
component stoichiometry: Protein/1315/Stoichiometry/1.0
component stoichiometry: Protein/3359/Stoichiometry/1.0
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Interaction4228
type: MolecularInteraction
interaction type: direct_interaction
name: Beta-2 adrenergic receptor activates G protein complex
participant: Beta-2 adrenergic receptor
participant: G protein complex

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097908 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

G protein complex
type: Complex
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Gγ

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Protein/3618 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: Protein
entity reference: Protein kinase C alpha type

ProteinComplex/14553 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: BiologicalState1139

Calcium
type: SmallMolecule
entity reference: Calcium

SubPathwayInteraction121303
type: Interaction
name: SubPathway121303Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

SubPathwayInteraction121302
type: Interaction
name: SubPathway121302Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Compound/PW C009401 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pindolol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Gβ
type: Protein
cellular location: Cell Membrane
entity reference: Gβ

TransportCatalysis5632
type: Catalysis
controller: L-type calcium channel
controlled: Transport14925
control type: ACTIVATION

Protein/1262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate

Transport3328
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Beta-2 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P07550
organism: BiologicalState1055

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt