Compound/PW C001240 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelic acid
stoichiometric coefficient: 1.0

Interaction4032
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-2 adrenergic receptor
participant: Norepinephrine
participant: Beta-2 adrenergic receptor

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Catechol O-methyltransferase
type: ProteinReference
xref: Reference/UniProt P21964
organism: BiologicalState789

3,4-Dihydroxymandelic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 85782
xref: Reference/HMDB HMDB0001866
xref: Reference/KEGG Compound C05580
xref: Reference/ChEBI CHEBI 27637
xref: Reference/CAS 775-01-9
xref: Reference/ChemSpider 77371
chemical formula: C8H8O5
molecular weight: 184.03717
structure: ChemicalStructure/PW C001240

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Ammonia

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/HMDB HMDB0001866
type: UnificationXref
id: HMDB0001866
db: HMDB

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState789

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/CAS 775-01-9
type: UnificationXref
id: 775-01-9
db: CAS

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Reference/UniProt P07550
type: UnificationXref
id: P07550
db: UniProt

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Reference/KEGG Compound C05577
type: UnificationXref
id: C05577
db: KEGG Compound

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

Reference/UniProt P21964
type: UnificationXref
id: P21964
db: UniProt

ReactionCatalysis207891
type: Catalysis
controller: Catechol O-methyltransferase
controlled: Reaction218460
control type: ACTIVATION

Reference/KEGG Compound C05584
type: UnificationXref
id: C05584
db: KEGG Compound

ReactionCatalysis207890
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: Reaction218459
control type: ACTIVATION

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Reference/KEGG Compound C05580
type: UnificationXref
id: C05580
db: KEGG Compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Compound/PW C002683 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

ReactionCatalysis207629
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: Reaction218277
control type: ACTIVATION

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Moclobemide
type: SmallMolecule
cellular location: Synapse
entity reference: Moclobemide

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/PubChem-compound 736172
type: UnificationXref
id: 736172
db: PubChem-compound

Compound/PW C009585 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Moclobemide
stoichiometric coefficient: 1.0

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Aldehyde dehydrogenase, dimeric NADP-preferring
type: ProteinReference
xref: Reference/UniProt P30838
organism: BiologicalState789

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: BiologicalState789

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Moclobemide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Moclobemide

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Compound/PW C002683 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/ChemSpider 4087
type: UnificationXref
id: 4087
db: ChemSpider

Norepinephrine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Norepinephrine

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

3,4-Dihydroxymandelaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27852
xref: Reference/PubChem-compound 151725
xref: Reference/ChemSpider 133725
xref: Reference/CAS 13023-73-9
xref: Reference/HMDB HMDB0006242
xref: Reference/KEGG Compound C05577
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C002683

Aldehyde dehydrogenase, dimeric NADP-preferring
type: Protein
cellular location: Cytosol
entity reference: Aldehyde dehydrogenase, dimeric NADP-preferring

Reference/ChEBI CHEBI 83531
type: UnificationXref
id: CHEBI:83531
db: ChEBI

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

SubPathwayControl121378
type: Interaction
name: SubPathway121378Control
name: ActivatingSubPathwayControl
participant: Beta-2 adrenergic receptor
participant: Beta-1 adrenergic receptor
participant: Gs signaling cascade

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Amine oxidase [flavin-containing] A

Reference/SMPDB SMP0126685
type: UnificationXref
id: SMP0126685
db: SMPDB

Reference/PathWhiz PW128289
type: UnificationXref
id: PW128289
db: PathWhiz

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Compound/PW C009585 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Moclobemide
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Beta-1 adrenergic receptor
type: Protein
cellular location: Cytosol
entity reference: Beta-1 adrenergic receptor
name: SubPathwayActivator

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C009585 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Moclobemide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/ChEBI CHEBI 27637
type: UnificationXref
id: CHEBI:27637
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Moclobemide
type: SmallMolecule
entity reference: Moclobemide

Vanillylmandelic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 643307
xref: Reference/KEGG Compound C05584
xref: Reference/CAS 55-10-7
xref: Reference/HMDB HMDB0000291
xref: Reference/ChEBI CHEBI 1127735
xref: Reference/PubChem-compound 736172
chemical formula: C9H10O5
molecular weight: 198.05283
structure: ChemicalStructure/PW C000197

Vanillylmandelic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Vanillylmandelic acid

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Transport15928
type: Transport
participant stoichiometry: Compound/PW C009585 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009585 Synapse/Stoichiometry/1.0
right: Moclobemide
spontaneous: false
left: Moclobemide
name: Moclobemide (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Transport15927
type: Transport
participant stoichiometry: Compound/PW C009585/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009585 Extracellular Space/Stoichiometry/1.0
right: Moclobemide
spontaneous: false
left: Moclobemide
name: Moclobemide (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Beta-2 adrenergic receptor
type: Protein
cellular location: Cytosol
entity reference: Beta-2 adrenergic receptor
name: SubPathwayActivator

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

ChemicalStructure/PW C002683
type: ChemicalStructure
structure format: SMILES
structure data: OC(C=O)C1=CC(O)=C(O)C=C1

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

ReactionCatalysis852
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/PubChem-compound 85782
type: UnificationXref
id: 85782
db: PubChem-compound

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Oxygen
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Oxygen

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Beta-2 adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Beta-2 adrenergic receptor

Interaction5062
type: MolecularInteraction
interaction type: direct_interaction
name: Moclobemide inhibits Amine oxidase [flavin-containing] A
participant: Amine oxidase [flavin-containing] A
participant: Moclobemide

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/ChEBI CHEBI 1127735
type: UnificationXref
id: CHEBI:1127735
db: ChEBI

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState789

Reaction218459
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Ammonia
right: 3,4-Dihydroxymandelaldehyde
right: Hydrogen peroxide
spontaneous: false
left: Norepinephrine
left: Oxygen
left: Water
name: Norepinephrine + Oxygen + Water ↔ 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide
conversion direction: REVERSIBLE

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 27852
type: UnificationXref
id: CHEBI:27852
db: ChEBI

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 3,4-Dihydroxymandelaldehyde

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Alpha-1A adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayInput

Reaction218460
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000197 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001240 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Vanillylmandelic acid
spontaneous: false
left: 3,4-Dihydroxymandelic acid
left: S-Adenosylmethionine
name: 3,4-Dihydroxymandelic acid + S-Adenosylmethionine ↔ S-Adenosylhomocysteine + Vanillylmandelic acid
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

TransportCatalysis5916
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport15928
control type: ACTIVATION

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

SubPathwayInteraction121377
type: Interaction
name: SubPathway121377Reaction
name: SubPathwayReaction
participant: Alpha-1A adrenergic receptor

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Compound/PW C001783 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxymandelaldehyde

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Beta-1 adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Beta-1 adrenergic receptor

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Gs signaling cascade
type: Pathway
name: ActivatingSubPathway

Gq signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121377
pathway component: SubPathwayInteraction121377
name: SubPathway

Compound/PW C000142 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Water

Reference/UniProt P30838
type: UnificationXref
id: P30838
db: UniProt

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/PubChem-compound 4235
type: UnificationXref
id: 4235
db: PubChem-compound

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Reference/ChemSpider 77371
type: UnificationXref
id: 77371
db: ChemSpider

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Transport14113
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Transport14112
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Transport14114
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/HMDB HMDB0006242
type: UnificationXref
id: HMDB0006242
db: HMDB

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001240 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: 3,4-Dihydroxymandelic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.2.1.5
left: NAD
left: 3,4-Dihydroxymandelaldehyde
left: Water
name: 3,4-Dihydroxymandelaldehyde + NAD + Water → 3,4-Dihydroxymandelic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

ChemicalStructure/PW C001240
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(O)=O)C1=CC=C(O)C(O)=C1

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/PubChem-compound 151725
type: UnificationXref
id: 151725
db: PubChem-compound

Moclobemide
type: SmallMolecule
cellular location: Cytosol
entity reference: Moclobemide

Moclobemide
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Moclobemide

Reference/CAS 13023-73-9
type: UnificationXref
id: 13023-73-9
db: CAS

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Hydrogen peroxide

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Moclobemide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0015302
xref: Reference/CAS 71320-77-9
xref: Reference/ChEBI CHEBI 83531
xref: Reference/PubChem-compound 4235
xref: Reference/ChemSpider 4087
chemical formula: C13H17ClN2O2
molecular weight: 268.09787
structure: ChemicalStructure/PW C009585

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Compound/PW C009585/Stoichiometry/1.0
type: Stoichiometry
physical entity: Moclobemide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C000197 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vanillylmandelic acid
stoichiometric coefficient: 1.0

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/HMDB HMDB0015302
type: UnificationXref
id: HMDB0015302
db: HMDB

Reference/ChemSpider 643307
type: UnificationXref
id: 643307
db: ChemSpider

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Interaction3141
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-1 adrenergic receptor
participant: Norepinephrine
participant: Beta-1 adrenergic receptor

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState789

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reaction218277
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: Tetrahydrobiopterin
name: L-Tyrosine + Oxygen + Tetrahydrobiopterin ↔ Dihydrobiopterin + L-Dopa + Water
conversion direction: REVERSIBLE

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 71320-77-9
type: UnificationXref
id: 71320-77-9
db: CAS

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Reference/HMDB HMDB0000291
type: UnificationXref
id: HMDB0000291
db: HMDB

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C009585
type: ChemicalStructure
structure format: SMILES
structure data: ClC1=CC=C(C=C1)C(=O)NCCN1CCOCC1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Catechol O-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Catechol O-methyltransferase

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

Norepinephrine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Norepinephrine

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/ChemSpider 133725
type: UnificationXref
id: 133725
db: ChemSpider

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Moclobemide Action Pathway
type: Pathway
pathway order: PathwayTransport/2536184
pathway order: PathwayInteraction/3140
pathway order: PathwayTransport/2536195
pathway order: PathwayTransport/2536183
pathway order: PathwayTransport/2536185
pathway order: PathwayInteraction/5062
pathway order: PathwayEnzymeReaction/2536182
pathway order: PathwayEnzymeReaction/2536181
pathway order: PathwayEnzymeReaction/2536180
pathway order: PathwayEnzymeReaction/2536179
pathway order: PathwaySubPathway/121378
pathway order: PathwayEnzymeReaction/2536178
pathway order: PathwaySubPathway/121377
pathway order: PathwayEnzymeReaction/2536177
pathway order: PathwayTransport/2536193
pathway order: PathwayInteraction/3141
pathway order: PathwayInteraction/4032
pathway component: Interaction3140
pathway component: Interaction4032
pathway component: Interaction3141
pathway component: 1.14.17.1
pathway component: ReactionCatalysis207629
pathway component: Interaction5062
pathway component: Reaction218277
pathway component: Gq signaling cascade
pathway component: Reaction218459
pathway component: Reaction218460
pathway component: TransportCatalysis5069
pathway component: Transport15928
pathway component: Transport15927
pathway component: TransportCatalysis5916
pathway component: Transport14113
pathway component: Transport14112
pathway component: TransportCatalysis5072
pathway component: ReactionCatalysis207891
pathway component: Transport14114
pathway component: TransportCatalysis5070
pathway component: ReactionCatalysis207890
pathway component: 4.1.1.28
pathway component: ReactionCatalysis118
pathway component: 1.2.1.5
pathway component: SubPathwayControl121378
pathway component: ReactionCatalysis214
pathway component: ReactionCatalysis852
xref: Reference/SMPDB SMP0126685
xref: Reference/PathWhiz PW128289
organism: Homo sapiens

3,4-Dihydroxymandelic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxymandelic acid

ChemicalStructure/PW C000197
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(=C1)[C@H](O)C(O)=O

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

TransportCatalysis5069
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14112
control type: ACTIVATION

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Beta-2 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P07550
organism: BiologicalState789

TransportCatalysis5072
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14113
control type: ACTIVATION

TransportCatalysis5070
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14114
control type: ACTIVATION

Reference/CAS 55-10-7
type: UnificationXref
id: 55-10-7
db: CAS

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202