Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/UniProt P0ABQ4
type: UnificationXref
id: P0ABQ4
db: UniProt

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 7057990
type: UnificationXref
id: 7057990
db: PubChem-compound

Reference/UniProt P08192
type: UnificationXref
id: P08192
db: UniProt

direct_interaction
type: InteractionVocabulary

Sulfamethizole
type: SmallMolecule
cellular location: Cytosol
entity reference: Sulfamethizole

Dihydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrofolic acid

Reference/TAXONOMY 83333
type: UnificationXref
id: 83333
db: TAXONOMY

Reference/KEGG Compound C00568
type: UnificationXref
id: C00568
db: KEGG Compound

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Dihydrofolic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00415
xref: Reference/BioCyc DIHYDROFOLATE
xref: Reference/ChEBI CHEBI 15633
xref: Reference/ChemSpider 89228
xref: Reference/PubChem-compound 98792
xref: Reference/HMDB HMDB0001056
xref: Reference/CAS 4033-27-6
chemical formula: C19H21N7O6
molecular weight: 443.15533
structure: ChemicalStructure/PW C000831

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reaction219585
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001090 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113097 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: 7,8-Dihydropteroic acid
right: Pyrophosphate
spontaneous: false
left: p-Aminobenzoic acid
left: 7,8-Dihydropterin pyrophosphate
name: 7,8-Dihydropterin pyrophosphate + p-Aminobenzoic acid ↔ 7,8-Dihydropteroic acid + Pyrophosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/KEGG Compound C08050
type: UnificationXref
id: C08050
db: KEGG Compound

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrofolic acid
name: SubPathwayInput

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/HMDB HMDB0014715
type: UnificationXref
id: HMDB0014715
db: HMDB

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reaction219587
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001221 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: NADP
spontaneous: false
left: Dihydrofolic acid
left: Hydrogen Ion
left: NADPH
name: Dihydrofolic acid + Hydrogen Ion + NADPH ↔ NADP + Tetrahydrofolic acid
conversion direction: REVERSIBLE

Reaction219586
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001090 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dihydrofolic acid
right: Adenosine diphosphate
spontaneous: false
left: 7,8-Dihydropteroic acid
left: Adenosine triphosphate
left: L-Glutamic acid
name: 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid ↔ Adenosine diphosphate + Dihydrofolic acid + Phosphate
conversion direction: REVERSIBLE

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Purine synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121554
pathway component: SubPathwayInteraction121554
name: SubPathway

Reference/ChemSpider 953
type: UnificationXref
id: 953
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Transport16121
type: Transport
participant stoichiometry: Compound/PW C009068/Stoichiometry/1.0
right: Sulfamethizole
spontaneous: false
left: Sulfamethizole
name: Sulfamethizole (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport16120
type: Transport
participant stoichiometry: Compound/PW C009068/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009068 Periplasmic Space/Stoichiometry/1.0
right: Sulfamethizole
spontaneous: false
left: Sulfamethizole
name: Sulfamethizole (→) Transport: Homo sapiens, Blood Vessel to Escherichia coli (strain K12), Cell, Periplasmic Space
conversion direction: LEFT_TO_RIGHT

7,8-Dihydropterin pyrophosphate
type: SmallMoleculeReference

Sulfamethizole
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014715
xref: Reference/PubChem-compound 5328
xref: Reference/KEGG Compound C08050
xref: Reference/ChEBI CHEBI 9331
xref: Reference/ChemSpider 5137
xref: Reference/CAS 144-82-1
chemical formula: C9H10N4O2S2
molecular weight: 270.0245
structure: ChemicalStructure/PW C009068

Compound/PW C001090 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydropteroic acid
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

ReactionCatalysis208967
type: Catalysis
controller: Dihydrofolate reductase
controlled: Reaction219587
control type: ACTIVATION

Bifunctional protein folC
type: ProteinReference
xref: Reference/UniProt P08192
organism: Escherichia coli (strain K12)

ReactionCatalysis208966
type: Catalysis
controller: Bifunctional protein folC
controlled: Reaction219586
control type: ACTIVATION

ReactionCatalysis208965
type: Catalysis
controller: dihydropteroate synthase
controlled: Reaction219585
control type: ACTIVATION

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Transport16118
type: Transport
participant stoichiometry: Compound/PW C009068 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009068 Periplasmic Space/Stoichiometry/1.0
right: Sulfamethizole
spontaneous: false
left: Sulfamethizole
name: Sulfamethizole (→) Transport: Escherichia coli (strain K12), Cell, Periplasmic Space to Escherichia coli (strain K12), Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Reference/HMDB HMDB0001412
type: UnificationXref
id: HMDB0001412
db: HMDB

Reference/ChEBI CHEBI 4581
type: UnificationXref
id: CHEBI:4581
db: ChEBI

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

ChemicalStructure/PW C001090
type: ChemicalStructure
structure format: SMILES

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

dihydropteroate synthase
type: Complex
component stoichiometry: Protein/6193 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dihydropteroate synthase

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C009068
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00921
type: UnificationXref
id: C00921
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 9331
type: UnificationXref
id: CHEBI:9331
db: ChEBI

7,8-Dihydropterin pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 7,8-Dihydropterin pyrophosphate

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 150-13-0
type: UnificationXref
id: 150-13-0
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 144-82-1
type: UnificationXref
id: 144-82-1
db: CAS

Reference/SMPDB SMP0126785
type: UnificationXref
id: SMP0126785
db: SMPDB

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PathWhiz PW128389
type: UnificationXref
id: PW128389
db: PathWhiz

Unknown
type: Protein
entity reference: Unknown

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt P0AC13
type: UnificationXref
id: P0AC13
db: UniProt

Reference/ChEBI CHEBI 15633
type: UnificationXref
id: CHEBI:15633
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Sulfamethizole Action Pathway
type: Pathway
pathway order: PathwayTransport/2538176
pathway order: PathwayTransport/2538177
pathway order: PathwayInteraction/5191
pathway order: PathwayEnzymeReaction/2537793
pathway order: PathwayEnzymeReaction/2537794
pathway order: PathwaySubPathway/121554
pathway order: PathwayTransport/2538173
pathway order: PathwayEnzymeReaction/2537792
pathway component: TransportCatalysis5964
pathway component: Interaction5191
pathway component: TransportCatalysis5962
pathway component: Reaction219587
pathway component: ReactionCatalysis208967
pathway component: Reaction219586
pathway component: ReactionCatalysis208966
pathway component: Purine synthesis
pathway component: ReactionCatalysis208965
pathway component: Transport16118
pathway component: Reaction219585
pathway component: Transport16121
pathway component: Transport16120
xref: Reference/SMPDB SMP0126785
xref: Reference/PathWhiz PW128389
organism: Escherichia coli (strain K12)

Reference/PubChem-compound 98792
type: UnificationXref
id: 98792
db: PubChem-compound

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Reference/BioCyc 7,8-dihydropteroate
type: UnificationXref
id: 7,8-dihydropteroate
db: BioCyc

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Compound/PW C009068 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfamethizole
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

7,8-Dihydropteroic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 7,8-Dihydropteroic acid

Interaction5191
type: MolecularInteraction
interaction type: direct_interaction
name: Sulfamethizole inhibits dihydropteroate synthase
participant: dihydropteroate synthase
participant: Sulfamethizole

Reference/PubChem-compound 5328
type: UnificationXref
id: 5328
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Dihydropteroate synthase
type: Protein
cellular location: Cytosol
entity reference: Dihydropteroate synthase

Compound/PW C009068/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfamethizole
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DIHYDROFOLATE
type: UnificationXref
id: DIHYDROFOLATE
db: BioCyc

Dihydrofolate reductase
type: ProteinReference
xref: Reference/UniProt P0ABQ4
organism: Escherichia coli (strain K12)

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000831 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrofolic acid
stoichiometric coefficient: 1.0

7,8-Dihydropteroic acid
type: SmallMoleculeReference
xref: Reference/CAS 2134-76-1
xref: Reference/KEGG Compound C00921
xref: Reference/HMDB HMDB0001412
xref: Reference/ChEBI CHEBI 4581
xref: Reference/PubChem-compound 170
xref: Reference/ChemSpider 165
xref: Reference/BioCyc 7,8-dihydropteroate
chemical formula: C14H14N6O3
molecular weight: 314.11273
structure: ChemicalStructure/PW C001090

SubPathwayInteraction121554
type: Interaction
name: SubPathwayReaction
name: SubPathway121554Reaction
participant: Tetrahydrofolic acid

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Dihydropteroate synthase
type: ProteinReference
xref: Reference/UniProt P0AC13
organism: Escherichia coli (strain K12)

Compound/PW C001077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Aminobenzoic acid
stoichiometric coefficient: 1.0

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000831
type: ChemicalStructure
structure format: SMILES

Reference/CAS 4033-27-6
type: UnificationXref
id: 4033-27-6
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

p-Aminobenzoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30753
xref: Reference/KEGG Compound C00568
xref: Reference/BioCyc P-AMINO-BENZOATE
xref: Reference/CAS 150-13-0
xref: Reference/PubChem-compound 7057990
xref: Reference/HMDB HMDB0001392
xref: Reference/ChemSpider 953
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C001077

Reference/BioCyc P-AMINO-BENZOATE
type: UnificationXref
id: P-AMINO-BENZOATE
db: BioCyc

TransportCatalysis5964
type: Catalysis
controller: Unknown
controlled: Transport16120
control type: ACTIVATION

TransportCatalysis5962
type: Catalysis
controller: Unknown
controlled: Transport16118
control type: ACTIVATION

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChEBI CHEBI 30753
type: UnificationXref
id: CHEBI:30753
db: ChEBI

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Escherichia coli (strain K12)
type: BioSource
xref: Reference/TAXONOMY 83333

Reference/PubChem-compound 170
type: UnificationXref
id: 170
db: PubChem-compound

Sulfamethizole
type: SmallMolecule
entity reference: Sulfamethizole

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

p-Aminobenzoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: p-Aminobenzoic acid

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C113097 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydropterin pyrophosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

ChemicalStructure/PW C001077
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=C(C=C1)C(O)=O

Reference/ChemSpider 165
type: UnificationXref
id: 165
db: ChemSpider

Reference/HMDB HMDB0001392
type: UnificationXref
id: HMDB0001392
db: HMDB

Reference/KEGG Compound C00415
type: UnificationXref
id: C00415
db: KEGG Compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 89228
type: UnificationXref
id: 89228
db: ChemSpider

Dihydrofolate reductase
type: Protein
cellular location: Cytosol
entity reference: Dihydrofolate reductase

Reference/CAS 2134-76-1
type: UnificationXref
id: 2134-76-1
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C001221 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Compound/PW C009068 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfamethizole
stoichiometric coefficient: 1.0

Protein/6193 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydropteroate synthase
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Unknown
type: ProteinReference

Sulfamethizole
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Sulfamethizole

Bifunctional protein folC
type: Protein
cellular location: Cytosol
entity reference: Bifunctional protein folC

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/ChemSpider 5137
type: UnificationXref
id: 5137
db: ChemSpider

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Reference/HMDB HMDB0001056
type: UnificationXref
id: HMDB0001056
db: HMDB