Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Reference/PubChem-compound 439280
type: UnificationXref
id: 439280
db: PubChem-compound

Interaction4035
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Serotonin
participant: Calcium
participant: Serotonin

Compound/PW C000178 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

TransportCatalysis2096
type: Catalysis
controller: L type Calcium channel
controlled: Transport10935
control type: ACTIVATION

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/UniProt P31645
type: UnificationXref
id: P31645
db: UniProt

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

5-hydroxytryptamine receptor 3
type: Complex
component stoichiometry: Protein/2156 post-synaptic membrane/Stoichiometry/5.0
cellular location: post-synaptic membrane
component: 5-hydroxytryptamine receptor 3A

Compound/PW C009341/Stoichiometry/1.0
type: Stoichiometry
physical entity: Granisetron
stoichiometric coefficient: 1.0

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Activation of emetic reflex
type: Pathway
name: ActivatingSubPathway

Vagus nerve stimulation
type: Pathway
name: InhibitorySubPathway

Sodium-dependent serotonin transporter
type: Protein
entity reference: Sodium-dependent serotonin transporter

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Activation of emetic reflex
type: Pathway
name: ActivatingSubPathway

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Transport10935
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: true
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: REVERSIBLE

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Compound/PW C000358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-L-tryptophan
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/PubChem-compound 3510
type: UnificationXref
id: 3510
db: PubChem-compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/HMDB HMDB0015026
type: UnificationXref
id: HMDB0015026
db: HMDB

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Serotonin
type: SmallMolecule
cellular location: Synapse
entity reference: Serotonin

Compound/PW C009341 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Granisetron
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Granisetron
type: SmallMolecule
entity reference: Granisetron

Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Protein/2156 post-synaptic membrane/Stoichiometry/5.0
type: Stoichiometry
physical entity: 5-hydroxytryptamine receptor 3A
stoichiometric coefficient: 5.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Reference/ChemSpider 388413
type: UnificationXref
id: 388413
db: ChemSpider

Serotonin
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Serotonin

Reference/SMPDB SMP0126787
type: UnificationXref
id: SMP0126787
db: SMPDB

Interaction5183
type: MolecularInteraction
interaction type: direct_interaction
name: Granisetron inhibits 5-hydroxytryptamine receptor 3
participant: 5-hydroxytryptamine receptor 3
participant: Granisetron

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Reference/UniProt P46098
type: UnificationXref
id: P46098
db: UniProt

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Granisetron
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Granisetron

Reaction219552
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium ↔ Sodium
conversion direction: REVERSIBLE

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
type: UnificationXref
id: 5-HYDROXY-TRYPTOPHAN
db: BioCyc

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Reference/HMDB HMDB0000472
type: UnificationXref
id: HMDB0000472
db: HMDB

Sodium-dependent serotonin transporter
type: ProteinReference
xref: Reference/UniProt P31645

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

ChemicalStructure/PW C000358
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

1.14.16.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: 5-Hydroxy-L-tryptophan
spontaneous: false
EC number: 1.14.16.4
left: Oxygen
left: L-Tryptophan
left: Tetrahydrobiopterin
name: L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Serotonin
spontaneous: false
EC number: 4.1.1.28
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/PathWhiz PW128391
type: UnificationXref
id: PW128391
db: PathWhiz

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Reference/ChEBI CHEBI 154547
type: UnificationXref
id: CHEBI:154547
db: ChEBI

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Granisetron Serotonin antagonist Action Pathway
type: Pathway
pathway order: PathwayInteraction/3591
pathway order: PathwayInteraction/5183
pathway order: PathwaySubPathway/121558
pathway order: PathwaySubPathway/121557
pathway order: PathwaySubPathway/121556
pathway order: PathwayEnzymeReaction/2537820
pathway order: PathwayTransport/2537821
pathway order: PathwayTransport/2537822
pathway order: PathwayTransport/2537831
pathway order: PathwayInteraction/4035
pathway order: PathwayEnzymeReaction/2537818
pathway order: PathwayTransport/2537823
pathway order: PathwayEnzymeReaction/2537819
pathway order: PathwayTransport/2537824
pathway component: Interaction3591
pathway component: Transport10935
pathway component: Interaction5183
pathway component: Transport14117
pathway component: Transport14119
pathway component: Transport14118
pathway component: Interaction4035
pathway component: Reaction219552
pathway component: 1.14.16.4
pathway component: SubPathwayControl121557
pathway component: 4.1.1.28
pathway component: TransportCatalysis2096
pathway component: SubPathwayControl121558
pathway component: Transport16096
pathway component: ReactionCatalysis1364
pathway component: ReactionCatalysis1363
pathway component: TransportCatalysis5073
pathway component: TransportCatalysis5074
pathway component: SubPathwayControl121556
xref: Reference/SMPDB SMP0126787
xref: Reference/PathWhiz PW128391
organism: Homo sapiens

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/ChemSpider 3390
type: UnificationXref
id: 3390
db: ChemSpider

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

Reference/CAS 4350-09-8
type: UnificationXref
id: 4350-09-8
db: CAS

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

Transport14117
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Transport14119
type: Transport
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14118
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

5-hydroxytryptamine receptor 3A
type: Protein
cellular location: post-synaptic membrane
entity reference: 5-hydroxytryptamine receptor 3A

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Serotonin
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Serotonin

Reference/UniProt P17752
type: UnificationXref
id: P17752
db: UniProt

SubPathwayControl121557
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway121557Control
participant: Activation of emetic reflex

SubPathwayControl121558
type: Interaction
name: SubPathway121558Control
name: ActivatingSubPathwayControl
participant: Activation of emetic reflex

Transport16096
type: Transport
participant stoichiometry: Compound/PW C009341/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009341 post-synaptic membrane/Stoichiometry/1.0
right: Granisetron
spontaneous: true
left: Granisetron
name: Granisetron (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, post-synaptic membrane
conversion direction: REVERSIBLE

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Compound/PW C000178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

SubPathwayControl121556
type: Interaction
name: InhibitorySubPathwayControl
name: SubPathway121556Control
participant: Vagus nerve stimulation

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Granisetron
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07023
xref: Reference/ChemSpider 3390
xref: Reference/CAS 109889-09-0
xref: Reference/PubChem-compound 3510
xref: Reference/ChEBI CHEBI 154547
xref: Reference/HMDB HMDB0015026
chemical formula: C18H24N4O
molecular weight: 312.195
structure: ChemicalStructure/PW C009341

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Interaction3591
type: MolecularInteraction
interaction type: direct_interaction
name: Serotonin activates 5-hydroxytryptamine receptor 3
participant: 5-hydroxytryptamine receptor 3
participant: Serotonin

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

5-hydroxytryptamine receptor 3A
type: ProteinReference
xref: Reference/UniProt P46098
organism: BiologicalState789

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: Reference/UniProt P17752
organism: BiologicalState789

Reference/KEGG Compound C07023
type: UnificationXref
id: C07023
db: KEGG Compound

Tryptophan 5-hydroxylase 1
type: Protein
cellular location: Cytosol
entity reference: Tryptophan 5-hydroxylase 1

Reference/CAS 109889-09-0
type: UnificationXref
id: 109889-09-0
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Reference/ChEBI CHEBI 17780
type: UnificationXref
id: CHEBI:17780
db: ChEBI

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Serotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: Serotonin

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

ReactionCatalysis1364
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

ReactionCatalysis1363
type: Catalysis
controller: Tryptophan 5-hydroxylase 1
controlled: 1.14.16.4
control type: ACTIVATION

ChemicalStructure/PW C009341
type: ChemicalStructure
structure format: SMILES

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

5-Hydroxy-L-tryptophan
type: SmallMoleculeReference
xref: Reference/ChemSpider 388413
xref: Reference/CAS 4350-09-8
xref: Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
xref: Reference/ChEBI CHEBI 17780
xref: Reference/KEGG Compound C00643
xref: Reference/PubChem-compound 439280
xref: Reference/HMDB HMDB0000472
chemical formula: C11H12N2O3
molecular weight: 220.0848
structure: ChemicalStructure/PW C000358

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/KEGG Compound C00643
type: UnificationXref
id: C00643
db: KEGG Compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Sodium

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

5-Hydroxy-L-tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-L-tryptophan

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

TransportCatalysis5073
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14117
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202

TransportCatalysis5074
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport14119
control type: ACTIVATION