Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

direct_interaction
type: InteractionVocabulary

Reference/UniProt P0DP28
type: UnificationXref
id: P0DP28
db: UniProt

Transport16264
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Lung
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q9CQZ2
type: UnificationXref
id: Q9CQZ2
db: UniProt

Transport16263
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Cell, Sarcoplasmic Reticulum to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q99LG5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9Z2T5
organism: BiologicalState1505

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState1505

Phosphatidylinositol-4,5-bisphosphate
type: SmallMoleculeReference

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Protein/19558 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Compound/PW C000353/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Protein/19865 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-3
stoichiometric coefficient: 1.0

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

ProteinComplex/16629 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P20444
organism: BiologicalState1505

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

TransportCatalysis6009
type: Catalysis
controller: L-type calcium channel
controlled: Transport16264
control type: ACTIVATION

TransportCatalysis6008
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport16263
control type: ACTIVATION

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/Generic402 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate
stoichiometric coefficient: 1.0

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/UniProt Q9ERD3
type: UnificationXref
id: Q9ERD3
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1505

Reference/UniProt Q9Z2T5
type: UnificationXref
id: Q9Z2T5
db: UniProt

Adrenergic Receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState1505

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState1505

G protein complex
type: Complex
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Gγ

Transport10243
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

L-type calcium channel
type: Complex
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Unknown

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Calmodulin-3
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-3

Reaction219662
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16629 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/10405 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein gamma-beta
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein gamma-beta
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62874
organism: BiologicalState1505

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19707/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121753
pathway component: SubPathwayInteraction121753
name: SubPathway

ReactionCatalysis208999
type: Catalysis
controller: Unknown
controlled: 3.1.3.16
control type: ACTIVATION

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121752
pathway component: SubPathwayInteraction121752
name: SubPathway

ReactionCatalysis208998
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: 2.7.11.18
control type: ACTIVATION

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Protein/19349 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

L-type calcium channel
type: Complex
cellular location: Cytosol
component: Unknown
component: Voltage-dependent L-type calcium channel subunit beta-1

Interaction1705
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Reference/UniProt Q99LG5
type: UnificationXref
id: Q99LG5
db: UniProt

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Interaction5295
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Mus musculus) activates Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Mus musculus)
participant: Myosin light chain kinase, smooth muscle

Interaction5297
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Phospholipase C, beta 1
participant: Unknown
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Interaction5296
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates L-type calcium channel
participant: L-type calcium channel
participant: Protein kinase C alpha type

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Unknown
type: Protein
entity reference: Unknown

BoundComplex/647 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Mus musculus)
stoichiometric coefficient: 1.0

Interaction5298
type: MolecularInteraction
interaction type: direct_interaction
name: Adrenergic Receptor activates G protein complex
participant: G protein complex
participant: Adrenergic Receptor

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C097908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Interaction1041
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Adrenergic Receptor
type: Protein
cellular location: Cell Membrane
entity reference: Adrenergic Receptor

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Protein/19707/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Diacylglycerol
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(T) subunit gamma-T1

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reaction219627
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16629 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/7725 Cell Membrane/Stoichiometry/1.0
right: Unknown
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein alpha
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q9CR01
type: UnificationXref
id: Q9CR01
db: UniProt

Protein/19752 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(T) subunit gamma-T1
stoichiometric coefficient: 1.0

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19558 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Adenosine triphosphate
left: Myosin light chain 3
name: Adenosine triphosphate + Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Protein/7725 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reaction219625
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic402 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate
name: Phosphatidylinositol-4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction219624
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/647 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19865 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Mus musculus)
spontaneous: false
left: Calmodulin-3
left: Calcium
name: Calcium + Calmodulin → Calcium + Calmodulin (Mus musculus)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/19558 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q9ERD3
organism: BiologicalState1505

Reference/SMPDB SMP0126904
type: UnificationXref
id: SMP0126904
db: SMPDB

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt Q9CQZ2
organism: BiologicalState1505

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Unknown
type: ProteinReference
organism: BiologicalState1505

ProteinComplex/10405 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein gamma-beta
stoichiometric coefficient: 1.0

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

Reference/PathWhiz PW128519
type: UnificationXref
id: PW128519
db: PathWhiz

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

BiologicalState1505
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10090
name: Mus musculus, Muscle, Myocyte
tissue: Muscle

Calcium_Calmodulin (Mus musculus)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19865 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin-3
component: Calcium

Gq Adrenergic Smooth Muscle Contraction
type: Pathway
pathway order: PathwayInteraction/5296
pathway order: PathwayInteraction/5295
pathway order: PathwayTransport/2539787
pathway order: PathwayTransport/2539786
pathway order: PathwayTransport/2539785
pathway order: PathwayEnzymeReaction/2539784
pathway order: PathwayEnzymeReaction/2539781
pathway order: PathwaySubPathway/121752
pathway order: PathwayEnzymeReaction/2539780
pathway order: PathwayInteraction/1705
pathway order: PathwayEnzymeReaction/2539782
pathway order: PathwaySubPathway/121753
pathway order: PathwayEnzymeReaction/2539778
pathway order: PathwayEnzymeReaction/2539777
pathway order: PathwayEnzymeReaction/2539779
pathway order: PathwayEnzymeReaction/2540730
pathway order: PathwayInteraction/5298
pathway order: PathwayInteraction/1041
pathway order: PathwayInteraction/5297
pathway component: Interaction5295
pathway component: Interaction5297
pathway component: Reaction219627
pathway component: TransportCatalysis6009
pathway component: Interaction5296
pathway component: TransportCatalysis6008
pathway component: 2.7.11.18
pathway component: Muscle Relaxation
pathway component: ReactionCatalysis208999
pathway component: Interaction1041
pathway component: Muscle Contraction
pathway component: ReactionCatalysis208998
pathway component: Reaction219306
pathway component: Reaction219625
pathway component: Interaction5298
pathway component: Reaction219624
pathway component: 3.1.3.16
pathway component: Transport10243
pathway component: Interaction1705
pathway component: Reaction219662
pathway component: Transport16264
pathway component: Reaction115846
pathway component: Transport16263
xref: Reference/SMPDB SMP0126904
xref: Reference/PathWhiz PW128519
organism: Mus musculus

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Unknown
type: ProteinReference
organism: BiologicalState1505

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Reference/UniProt P62874
type: UnificationXref
id: P62874
db: UniProt

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/UniProt P20444
type: UnificationXref
id: P20444
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097908 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction121753
type: Interaction
name: SubPathway121753Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP28
organism: BiologicalState1505

SubPathwayInteraction121752
type: Interaction
name: SubPathwayReaction
name: SubPathway121752Reaction
participant: Myosin light chain 3

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Guanine nucleotide-binding protein gamma-beta
type: Complex
component stoichiometry: Protein/19752 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/19349 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(T) subunit gamma-T1

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
entity reference: Calcium

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: Reference/UniProt Q9CR01
organism: BiologicalState1505

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Phosphatidylinositol-4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0