cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState1515

BoundComplex/651 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Bos taurus)
stoichiometric coefficient: 1.0

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

direct_interaction
type: InteractionVocabulary

Transport16268
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Lung
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Transport16267
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Bos taurus, Cell, Sarcoplasmic Reticulum to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

G protein complex
type: Complex
cellular location: Cytosol
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Reference/UniProt Q2KJE6
type: UnificationXref
id: Q2KJE6
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q7M2U0
organism: BiologicalState1515

Phosphatidylinositol-4,5-bisphosphate
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState1515

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: Protein
cellular location: Cytosol
entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121764
pathway component: SubPathwayInteraction121764
name: SubPathway

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121763
pathway component: SubPathwayInteraction121763
name: SubPathway

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: Protein kinase, cAMP-dependent, regulatory, type I, beta
component: cAMP-dependent protein kinase type I-alpha regulatory subunit

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q2KJC0
organism: BiologicalState1515

Compound/PW C000353/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q7M2U0
type: UnificationXref
id: Q7M2U0
db: UniProt

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Protein/19755 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt P10894
organism: BiologicalState1515

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

ProteinComplex/11041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Protein/7764 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Interaction1108
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor
participant: Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Gi Adrenergic Smooth Muscle Contraction
type: Pathway
pathway order: PathwayEnzymeReaction/2539972
pathway order: PathwayEnzymeReaction/2539971
pathway order: PathwayEnzymeReaction/2539974
pathway order: PathwayEnzymeReaction/2539973
pathway order: PathwaySubPathway/121763
pathway order: PathwayEnzymeReaction/2539970
pathway order: PathwaySubPathway/121764
pathway order: PathwayInteraction/1108
pathway order: PathwayEnzymeReaction/2539976
pathway order: PathwayEnzymeReaction/2539975
pathway order: PathwayInteraction/5307
pathway order: PathwayInteraction/5305
pathway order: PathwayInteraction/5304
pathway order: PathwayInteraction/5325
pathway order: PathwayInteraction/5324
pathway order: PathwayInteraction/5323
pathway order: PathwayInteraction/2076
pathway order: PathwayTransport/2539980
pathway order: PathwayEnzymeReaction/2539969
pathway order: PathwayEnzymeReaction/2539968
pathway order: PathwayEnzymeReaction/2539965
pathway order: PathwayEnzymeReaction/2539967
pathway order: PathwayEnzymeReaction/2539966
pathway order: PathwayTransport/2539978
pathway order: PathwayTransport/2539977
pathway order: PathwayTransport/2539979
pathway component: Interaction5325
pathway component: Interaction5324
pathway component: Interaction5305
pathway component: Interaction5304
pathway component: Reaction219306
pathway component: Interaction2076
pathway component: Interaction5323
pathway component: Transport16268
pathway component: Reaction219651
pathway component: Interaction5307
pathway component: Transport16267
pathway component: Interaction1108
pathway component: TransportCatalysis6013
pathway component: TransportCatalysis6012
pathway component: Reaction219638
pathway component: Reaction219655
pathway component: Reaction219654
pathway component: Reaction219653
pathway component: Muscle Relaxation
pathway component: Reaction219652
pathway component: Muscle Contraction
pathway component: Reaction219637
pathway component: Reaction219636
pathway component: ReactionCatalysis209004
pathway component: 3.1.3.16
pathway component: Transport10257
pathway component: 2.7.11.18
pathway component: ReactionCatalysis209005
pathway component: Transport16275
pathway component: Reaction115846
xref: Reference/PathWhiz PW128533
xref: Reference/SMPDB SMP0126918
organism: Bos taurus

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/UniProt Q2KJC0
type: UnificationXref
id: Q2KJC0
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: Reference/UniProt Q2KI31
organism: BiologicalState1515

Protein/3625 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P04409
organism: BiologicalState1515

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Protein/19759 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/UniProt Q9MZL6
type: UnificationXref
id: Q9MZL6
db: UniProt

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/Generic402 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate
stoichiometric coefficient: 1.0

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19709/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

ReactionCatalysis209004
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: 2.7.11.18
control type: ACTIVATION

Transport10257
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis209005
type: Catalysis
controller: Unknown
controlled: 3.1.3.16
control type: ACTIVATION

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1515

Adrenergic Receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState1515

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Protein/19559 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reaction219651
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Protein kinase A
type: Complex
component stoichiometry: Protein/20105 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19759 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19769 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19358 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19755 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19765 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: Protein kinase, cAMP-dependent, regulatory, type I, beta
component: cAMP-dependent protein kinase type I-alpha regulatory subunit

Protein/17406 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
stoichiometric coefficient: 1.0

Reaction219655
type: BiochemicalReaction
participant stoichiometry: Protein/21586 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/16639 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(i) subunit alpha-1
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(i) subunit alpha-1
conversion direction: LEFT_TO_RIGHT

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/UniProt P85100
type: UnificationXref
id: P85100
db: UniProt

Reaction219654
type: BiochemicalReaction
participant stoichiometry: Protein/17406 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11041 Cytosol/Stoichiometry/1.0
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Phospholipase C
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reaction219653
type: BiochemicalReaction
participant stoichiometry: Protein/19709 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11041 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate receptor type 1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Inositol 1,4,5-trisphosphate receptor
conversion direction: LEFT_TO_RIGHT

Reaction219652
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11041 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/16651 Cytosol/Stoichiometry/1.0
right: Intermediate conductance calcium-activated potassium channel protein 4
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Intermediate conductance calcium-activated potassium channel protein 4
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Protein/19769 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

L-type calcium channel
type: Complex
component: Unknown
component: Voltage-dependent L-type calcium channel subunit beta-1

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

ProteinComplex/16651 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Intermediate conductance calcium-activated potassium channel protein 4
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: Reference/UniProt Q17QF5
organism: BiologicalState1515

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Protein/19358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q3MHF1
organism: BiologicalState1515

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P24256
organism: BiologicalState1515

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Reference/UniProt Q2KI31
type: UnificationXref
id: Q2KI31
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Adrenergic Receptor
type: Protein
cellular location: Cytosol
entity reference: Adrenergic Receptor

Compound/PW C097908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

L-type calcium channel
type: Complex
cellular location: Cytosol
component: Unknown
component: Voltage-dependent L-type calcium channel subunit beta-1

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/UniProt P00517
type: UnificationXref
id: P00517
db: UniProt

Protein/20105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase, cAMP-dependent, regulatory, type I, beta
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Protein/19863 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

BoundComplex/652 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Bos taurus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Bos taurus)
stoichiometric coefficient: 1.0

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/UniProt P00515
type: UnificationXref
id: P00515
db: UniProt

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Reference/UniProt Q3MHF1
type: UnificationXref
id: Q3MHF1
db: UniProt

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Diacylglycerol
type: SmallMoleculeReference

Reference/PathWhiz PW128533
type: UnificationXref
id: PW128533
db: PathWhiz

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/SMPDB SMP0126918
type: UnificationXref
id: SMP0126918
db: SMPDB

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Protein/19350 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
stoichiometric coefficient: 1.0

Protein/19709/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Interaction5305
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates L-type calcium channel
participant: Protein kinase C alpha type
participant: L-type calcium channel

Interaction5304
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Bos taurus) activates Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Bos taurus)
participant: Myosin light chain kinase, smooth muscle

Protein/19765 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Interaction5307
type: MolecularInteraction
interaction type: direct_interaction
name: Adrenergic Receptor activates G protein complex
participant: G protein complex
participant: Adrenergic Receptor

Unknown
type: Protein
entity reference: Unknown

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q28824
organism: BiologicalState1515

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

ProteinComplex/16639 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P85100
organism: BiologicalState1515

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Reaction219638
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16639 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/652 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Bos taurus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Bos taurus)
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Bos taurus) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Bos taurus)
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Bos taurus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Bos taurus)
type: Complex
component stoichiometry: Protein/19350 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Protein/19709 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reaction219637
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic402 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate
name: Phosphatidylinositol-4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction219636
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19863 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/651 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Bos taurus)
spontaneous: false
left: Calmodulin
left: Calcium
name: Calcium + Calmodulin → Calcium + Calmodulin (Bos taurus)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/19559 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19559 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Adenosine triphosphate
left: Myosin light chain 3
name: Adenosine triphosphate + Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q17QP8
type: UnificationXref
id: Q17QP8
db: UniProt

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Interaction5325
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP inhibits Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: cAMP

Interaction5324
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein G(i) subunit alpha-1 inhibits Adenylyl Cyclase
participant: Unknown
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Interaction5323
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: PKA complex
participant: cAMP

BiologicalState1515
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9913
name: Bos taurus, Muscle, Myocyte
tissue: Muscle

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein/21586 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(i) subunit alpha-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

TransportCatalysis6013
type: Catalysis
controller: L-type calcium channel
controlled: Transport16268
control type: ACTIVATION

SubPathwayInteraction121764
type: Interaction
name: SubPathway121764Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

TransportCatalysis6012
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport16267
control type: ACTIVATION

SubPathwayInteraction121763
type: Interaction
name: SubPathwayReaction
name: SubPathway121763Reaction
participant: Myosin light chain 3

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P31322
type: UnificationXref
id: P31322
db: UniProt

Calcium_Calmodulin (Bos taurus)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19863 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin
component: Calcium

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/UniProt Q17QF5
type: UnificationXref
id: Q17QF5
db: UniProt

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097908 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

Calmodulin
type: ProteinReference
xref: Reference/UniProt Q2KJE6
organism: BiologicalState1515

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/UniProt P04409
type: UnificationXref
id: P04409
db: UniProt

G protein complex
type: Complex
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
component: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/UniProt P10894
type: UnificationXref
id: P10894
db: UniProt

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt Q28824
type: UnificationXref
id: Q28824
db: UniProt

Interaction2076
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Calmodulin
type: Protein
cellular location: Cytosol
entity reference: Calmodulin

Calcium
type: SmallMolecule
entity reference: Calcium

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P00517
organism: BiologicalState1515

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q17QP8
organism: BiologicalState1515

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q9MZL6

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Reference/UniProt P24256
type: UnificationXref
id: P24256
db: UniProt

Unknown
type: ProteinReference
organism: BiologicalState1515

Phosphatidylinositol-4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Transport16275
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Bos taurus, Muscle, Myocyte, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31322
organism: BiologicalState1515

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P00515
organism: BiologicalState1515

Intermediate conductance calcium-activated potassium channel protein 4
type: Complex
component stoichiometry: Protein/7764 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt