Reference/UniProt Q6UA68
type: UnificationXref
id: Q6UA68
db: UniProt

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState1512

Reference/UniProt P0DP31
type: UnificationXref
id: P0DP31
db: UniProt

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19708/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

G protein-coupled receptor
type: ProteinReference
organism: BiologicalState1510

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

direct_interaction
type: InteractionVocabulary

Transport16265
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Rattus norvegicus, Cell, Sarcoplasmic Reticulum to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ProteinComplex/11046/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

ProteinComplex/16634 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Reference/UniProt Q8K1M2
type: UnificationXref
id: Q8K1M2
db: UniProt

Protein/19764/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt P10687
organism: BiologicalState1512

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic536 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytosol/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Calcium
left: Troponin
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q62869
organism: BiologicalState1512

Phosphatidylinositol-4,5-bisphosphate
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState1512

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q45QN2
organism: BiologicalState1512

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Protein/19766/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Calcium_Troponin
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/Generic536 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Troponin

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Protein kinase A
type: Complex
component stoichiometry: Protein/19766/Stoichiometry/1.0
component stoichiometry: Protein/19758/Stoichiometry/1.0
component stoichiometry: Protein/19359/Stoichiometry/1.0
component stoichiometry: Protein/19764/Stoichiometry/1.0
component stoichiometry: Protein/19771/Stoichiometry/1.0
component stoichiometry: Protein/19757/Stoichiometry/1.0
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000763
type: UnificationXref
id: BTO:0000763
db: BRENDA TISSUE ONTOLOGY

Protein/3625 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Reference/PathWhiz PW128595
type: UnificationXref
id: PW128595
db: PathWhiz

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P12369
type: UnificationXref
id: P12369
db: UniProt

Ion Channel
type: ProteinReference
organism: BiologicalState1510

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/Generic402 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate
stoichiometric coefficient: 1.0

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Interaction5376
type: MolecularInteraction
interaction type: direct_interaction
name: G protein-coupled receptor activates G protein complex
participant: G protein complex
participant: G protein-coupled receptor

Interaction5378
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Ion Channel
participant: Ion Channel
participant: PKA complex

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Interaction5377
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates Ion Channel
participant: Protein kinase C complex
participant: Ion Channel

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt P68403
organism: BiologicalState1510

Reference/SMPDB SMP0126978
type: UnificationXref
id: SMP0126978
db: SMPDB

Protein/19766 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P05696
organism: BiologicalState1512

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1512

Reference/UniProt Q9QWG8
type: UnificationXref
id: Q9QWG8
db: UniProt

ProteinComplex/11046 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Reaction219649
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11046 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17407 Cytosol/Stoichiometry/1.0
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Phospholipase C
conversion direction: LEFT_TO_RIGHT

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Ion Channel
type: Protein
cellular location: Cell Membrane
entity reference: Ion Channel

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reaction219648
type: BiochemicalReaction
participant stoichiometry: Protein/19708/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11046/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate receptor type 1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Inositol 1,4,5-trisphosphate receptor
conversion direction: LEFT_TO_RIGHT

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState1512

Reaction219646
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

Troponin
type: ProteinReference
organism: BiologicalState1510

Calcium_Calmodulin (Rattus norvegicus)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19864 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin-3
component: Calcium

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Protein kinase C complex
type: Complex
cellular location: Cell Membrane
component: Protein kinase C beta type
component: Protein kinase C alpha type

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Protein/19771/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/UniProt P05696
type: UnificationXref
id: P05696
db: UniProt

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Protein kinase C alpha type
type: Protein
cellular location: Cell Membrane
entity reference: Protein kinase C alpha type

Protein/Generic536 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Troponin
type: Protein
cellular location: Cytosol
entity reference: Troponin

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Interaction2448
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q9QWG8
organism: BiologicalState1512

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Reference/UniProt Q45QN2
type: UnificationXref
id: Q45QN2
db: UniProt

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

BoundComplex/650 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
stoichiometric coefficient: 1.0

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P68182
organism: BiologicalState1512

Muscular Gs Protein Cascade
type: Pathway
pathway order: PathwayTransport/2540999
pathway order: PathwayEnzymeReaction/2540989
pathway order: PathwayEnzymeReaction/2540998
pathway order: PathwayEnzymeReaction/2540997
pathway order: PathwayInteraction/2448
pathway order: PathwayEnzymeReaction/2540996
pathway order: PathwayEnzymeReaction/2540995
pathway order: PathwayEnzymeReaction/2540994
pathway order: PathwayEnzymeReaction/2540993
pathway order: PathwayEnzymeReaction/2540992
pathway order: PathwayEnzymeReaction/2540991
pathway order: PathwayInteraction/5334
pathway order: PathwayInteraction/5378
pathway order: PathwayEnzymeReaction/2540990
pathway order: PathwayInteraction/5377
pathway order: PathwayInteraction/5376
pathway order: PathwayInteraction/5320
pathway order: PathwayInteraction/1162
pathway component: Reaction179579
pathway component: Reaction219649
pathway component: Reaction219633
pathway component: Reaction219632
pathway component: Reaction219631
pathway component: Reaction219630
pathway component: Interaction1162
pathway component: Reaction219648
pathway component: Interaction5376
pathway component: Reaction219306
pathway component: Interaction5320
pathway component: Reaction219646
pathway component: Interaction5334
pathway component: Interaction5378
pathway component: Interaction5377
pathway component: Interaction2448
pathway component: Transport16265
pathway component: Reaction115846
pathway component: TransportCatalysis6010
xref: Reference/PathWhiz PW128595
xref: Reference/SMPDB SMP0126978
organism: Rattus norvegicus

Protein/19758/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Inositol 1,4,5-trisphosphate
type: SmallMolecule
entity reference: Inositol 1,4,5-trisphosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Protein/19348 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Protein/19708/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Compound/PW C097908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Interaction1162
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

BoundComplex/649 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Rattus norvegicus)
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q8K1M2
organism: BiologicalState1512

Protein/19757 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Protein/19359 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/UniProt P10687
type: UnificationXref
id: P10687
db: UniProt

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P09456
type: UnificationXref
id: P09456
db: UniProt

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Diacylglycerol
type: SmallMoleculeReference

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Protein/19708/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Protein kinase C beta type
type: Protein
cellular location: Cell Membrane
entity reference: Protein kinase C beta type

Lung
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000763

Protein kinase A
type: Complex
component stoichiometry: Protein/19359 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19771 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19758 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19757 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19764 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19766 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

G protein complex
type: Complex
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Gγ

Protein/17407 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
stoichiometric coefficient: 1.0

Reference/UniProt Q62869
type: UnificationXref
id: Q62869
db: UniProt

Reference/UniProt P68403
type: UnificationXref
id: P68403
db: UniProt

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Protein/19764 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reaction219633
type: BiochemicalReaction
participant stoichiometry: Protein/7758 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/16634 Cell Membrane/Stoichiometry/1.0
right: Unknown
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein alpha
conversion direction: LEFT_TO_RIGHT

Reaction219632
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16634 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/650 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
conversion direction: LEFT_TO_RIGHT

Reaction219631
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic402 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate
name: Phosphatidylinositol-4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction219630
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/649 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19864 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Rattus norvegicus)
spontaneous: false
left: Calmodulin-3
left: Calcium
name: Calcium + Calmodulin → Calcium + Calmodulin (Rattus norvegicus)
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Calmodulin-3
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-3

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

BoundComplex/507 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

PKA complex
type: Complex
cellular location: Cell Membrane
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt P68182
type: UnificationXref
id: P68182
db: UniProt

Protein/19771 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Protein/19758 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Interaction5320
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: PKA complex
participant: cAMP

Protein/19864 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-3
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

BiologicalState1510
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Muscle, Myocyte
tissue: Muscle

TransportCatalysis6010
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport16265
control type: ACTIVATION

BiologicalState1512
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Lung, Myocyte
tissue: Lung

Protein/19757/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

G protein-coupled receptor
type: Protein
cellular location: Cell Membrane
entity reference: G protein-coupled receptor

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/19348 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP31
organism: BiologicalState1512

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097908 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/UniProt P81377
type: UnificationXref
id: P81377
db: UniProt

Unknown
type: ProteinReference
organism: BiologicalState1512

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P09456
organism: BiologicalState1512

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt Q6UA68
organism: BiologicalState1512

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Protein/19359/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate

Interaction5334
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein G(i) subunit alpha-1 activates Adenylyl Cyclase
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1
participant: Unknown

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Protein/7758 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P81377
organism: BiologicalState1512

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P12369
organism: BiologicalState1512

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt