Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: BiologicalState1056

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState51

5-hydroxytryptamine receptor 1B
type: Protein
entity reference: 5-hydroxytryptamine receptor 1B

Reference/ChemSpider 5165
type: UnificationXref
id: 5165
db: ChemSpider

direct_interaction
type: InteractionVocabulary

SubPathwayInteraction121843
type: Interaction
name: SubPathway121843Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

SubPathwayInteraction121842
type: Interaction
name: SubPathwayReaction
name: SubPathway121842Reaction
participant: Myosin light chain 3

TransportCatalysis5124
type: Catalysis
controller: L type Calcium channel
controlled: Transport14228
control type: ACTIVATION

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Reference/CAS 103628-46-2
type: UnificationXref
id: 103628-46-2
db: CAS

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState51

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Reference/UniProt Q8NFM4
type: UnificationXref
id: Q8NFM4
db: UniProt

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt P51828
type: UnificationXref
id: P51828
db: UniProt

cAMP
type: SmallMolecule
entity reference: cAMP

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P40145
type: UnificationXref
id: P40145
db: UniProt

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/SMPDB SMP0126984
type: UnificationXref
id: SMP0126984
db: SMPDB

Interaction5384
type: MolecularInteraction
interaction type: direct_interaction
name: 5-hydroxytryptamine receptor 1B activates G protein complex
participant: G protein complex
participant: 5-hydroxytryptamine receptor 1B

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

G protein complex
type: Complex
component: Gγ
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1

ReactionCatalysis202856
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: 2.7.11.18
control type: ACTIVATION

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Interaction3400
type: MolecularInteraction
interaction type: direct_interaction
name: G protein complex inhibits Adenylyl cyclase complex
participant: G protein complex
participant: Adenylyl cyclase complex

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Interaction5389
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Myosin LC-P
participant: PKA complex
participant: Myosin light chain 3

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

SubPathwayInteraction121858
type: Interaction
name: SubPathway121858Reaction
name: SubPathwayReaction

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/UniProt O60266
type: UnificationXref
id: O60266
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState51

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW128601
type: UnificationXref
id: PW128601
db: PathWhiz

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: BiologicalState1056

Sumatriptan Mechanism of Action Action Pathway
type: Pathway
pathway order: PathwayInteraction/5384
pathway order: PathwayInteraction/5390
pathway order: PathwaySubPathway/121858
pathway order: PathwayEnzymeReaction/2541090
pathway order: PathwaySubPathway/121843
pathway order: PathwayInteraction/2849
pathway order: PathwaySubPathway/121842
pathway order: PathwayTransport/2541093
pathway order: PathwayInteraction/3400
pathway order: PathwayInteraction/5389
pathway order: PathwayEnzymeReaction/2541089
pathway order: PathwayEnzymeReaction/2541177
pathway order: PathwayEnzymeReaction/2541088
pathway order: PathwayInteraction/3231
pathway component: Reaction213775
pathway component: 3.1.3.16
pathway component: Interaction5384
pathway component: 4.6.1.1
pathway component: ReactionCatalysis169637
pathway component: Interaction5390
pathway component: ReactionCatalysis202856
pathway component: Muscle Relaxation
pathway component: Interaction3400
pathway component: Muscle Contraction
pathway component: 2.7.11.18
pathway component: Interaction3231
pathway component: Interaction5389
pathway component: Transport14228
pathway component: ReactionCatalysis203360
pathway component: Interaction2849
pathway component: Vasoconstriction
pathway component: TransportCatalysis5124
xref: Reference/SMPDB SMP0126984
xref: Reference/PathWhiz PW128601
organism: Homo sapiens

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState51

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Vasoconstriction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121858
pathway component: SubPathwayInteraction121858
name: SubPathway

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Adenylate cyclase type 4
type: Protein
entity reference: Adenylate cyclase type 4

Adenylate cyclase type 7
type: Protein
entity reference: Adenylate cyclase type 7

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

5-hydroxytryptamine receptor 1B
type: ProteinReference
xref: Reference/UniProt P28222
organism: BiologicalState51

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Interaction5390
type: MolecularInteraction
interaction type: direct_interaction
name: Sumatriptan activates 5-hydroxytryptamine receptor 1B
participant: Sumatriptan
participant: 5-hydroxytryptamine receptor 1B

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/KEGG Compound C07319
type: UnificationXref
id: C07319
db: KEGG Compound

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121843
pathway component: SubPathwayInteraction121843
name: SubPathway

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121842
pathway component: SubPathwayInteraction121842
name: SubPathway

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Adenylate cyclase type 3
type: Protein
entity reference: Adenylate cyclase type 3

Adenylate cyclase type 9
type: Protein
entity reference: Adenylate cyclase type 9

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Adenylate cyclase type 1
type: Protein
entity reference: Adenylate cyclase type 1

Adenylate cyclase type 6
type: Protein
entity reference: Adenylate cyclase type 6

Adenylate cyclase type 8
type: Protein
entity reference: Adenylate cyclase type 8

Adenylate cyclase type 5
type: Protein
entity reference: Adenylate cyclase type 5

Sumatriptan
type: SmallMolecule
entity reference: Sumatriptan

Sumatriptan
type: SmallMoleculeReference
xref: Reference/CAS 103628-46-2
xref: Reference/KEGG Compound C07319
xref: Reference/PubChem-compound 5358
xref: Reference/ChEBI CHEBI 10650
xref: Reference/HMDB HMDB0005037
xref: Reference/ChemSpider 5165
chemical formula: C14H21N3O2S
molecular weight: 295.13544
structure: ChemicalStructure/PW C002380

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/UniProt P28222
type: UnificationXref
id: P28222
db: UniProt

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState51

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: BiologicalState1056

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Adenylyl cyclase complex
type: Complex
component: Adenylate cyclase type 3
component: Adenylate cyclase type 9
component: Adenylate cyclase type 1
component: Adenylate cyclase type 6
component: Adenylate cyclase type 8
component: Adenylate cyclase type 5
component: Adenylate cyclase type 2
component: Adenylate cyclase type 4
component: Adenylate cyclase type 7

BiologicalState1139
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, Myocyte
tissue: Blood Vessel

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/UniProt O60503
type: UnificationXref
id: O60503
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Adenylate cyclase type 4
type: ProteinReference
xref: Reference/UniProt Q8NFM4
organism: BiologicalState51

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Adenylate cyclase type 7
type: ProteinReference
xref: Reference/UniProt P51828
organism: BiologicalState51

Adenylate cyclase type 2
type: Protein
entity reference: Adenylate cyclase type 2

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Adenylate cyclase type 9
type: ProteinReference
xref: Reference/UniProt O60503
organism: BiologicalState51

Adenylate cyclase type 8
type: ProteinReference
xref: Reference/UniProt P40145
organism: BiologicalState51

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: BiologicalState51

Adenylate cyclase type 3
type: ProteinReference
xref: Reference/UniProt O60266
organism: BiologicalState51

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenylate cyclase type 5
type: ProteinReference
xref: Reference/UniProt O95622
organism: BiologicalState51

Adenylate cyclase type 6
type: ProteinReference
xref: Reference/UniProt O43306
organism: BiologicalState51

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

Reference/HMDB HMDB0005037
type: UnificationXref
id: HMDB0005037
db: HMDB

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState51

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState51

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState51

Reference/PubChem-compound 5358
type: UnificationXref
id: 5358
db: PubChem-compound

Reference/ChEBI CHEBI 10650
type: UnificationXref
id: CHEBI:10650
db: ChEBI

Transport14228
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Muscle, Myocyte, Extracellular Space to Homo sapiens, Muscle, Myocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

BiologicalState1056
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/UniProt O95622
type: UnificationXref
id: O95622
db: UniProt

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Interaction3231
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: cAMP
participant: PKA complex

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/UniProt O43306
type: UnificationXref
id: O43306
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState51

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState51

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Adenosine triphosphate
left: Myosin light chain 3
name: Adenosine triphosphate + Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

PKA complex
type: Complex
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

ReactionCatalysis169637
type: Catalysis
controller: Adenylyl cyclase complex
controlled: 4.6.1.1
control type: ACTIVATION

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: BiologicalState1056

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Compound/PW C000041/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Gγ
type: Protein
entity reference: Gγ

ChemicalStructure/PW C002380
type: ChemicalStructure
structure format: SMILES
structure data: CNS(=O)(=O)CC1=CC2=C(NC=C2CCN(C)C)C=C1

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1