Solute carrier family 2, facilitated glucose transporter member 10
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 10

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C01089
type: UnificationXref
id: C01089
db: KEGG Compound

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Unknown
type: ProteinReference

SubPathwayInteraction239430
type: Interaction
name: SubPathway239430Reaction
name: SubPathwayReaction
participant: D-Glucose
participant: Pyruvate

Reference/PubChem-compound 58838673
type: UnificationXref
id: 58838673
db: PubChem-compound

Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetyl-CoA

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway239430
pathway component: SubPathwayInteraction239430
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/SMPDB SMP0126987
type: UnificationXref
id: SMP0126987
db: SMPDB

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

(R)-3-Hydroxybutyric acid
type: SmallMoleculeReference
xref: Reference/CAS 625-72-9
xref: Reference/BioCyc CPD-335
xref: Reference/PubChem-compound 92135
xref: Reference/KEGG Compound C01089
xref: Reference/ChemSpider 83181
xref: Reference/HMDB HMDB0000011
xref: Reference/ChEBI CHEBI 17066
chemical formula: C4H8O3
molecular weight: 104.04734
structure: ChemicalStructure/PW C000006

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

ReactionCatalysis209016
type: Catalysis
controller: Pyruvate dehydrogenase E1
controlled: 1.2.4.1
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ReactionCatalysis209018
type: Catalysis
controller: Acyl-coenzyme A thioesterase 8
controlled: 3.1.2.27
control type: ACTIVATION

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

ReactionCatalysis209019
type: Catalysis
controller: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
controlled: Reaction219669
control type: ACTIVATION

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

Protein/512 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis207991
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: 2.3.1.9
control type: ACTIVATION

Pyruvate
type: SmallMoleculeReference
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C108870

SubPathwayInteraction121854
type: Interaction
name: SubPathway121854Reaction
name: SubPathwayReaction
participant: (R)-3-Hydroxybutyric acid

SubPathwayInteraction121853
type: Interaction
name: SubPathwayReaction
name: SubPathway121853Reaction
participant: (R)-3-Hydroxybutyric acid

SubPathwayInteraction121856
type: Interaction
name: SubPathwayReaction
name: SubPathway121856Reaction
participant: (R)-3-Hydroxybutyric acid

SubPathwayInteraction121855
type: Interaction
name: SubPathway121855Reaction
name: SubPathwayReaction
participant: (R)-3-Hydroxybutyric acid

SubPathwayInteraction121852
type: Interaction
name: SubPathway121852Reaction
name: SubPathwayReaction
participant: (R)-3-Hydroxybutyric acid

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
component stoichiometry: Protein/23919 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Unknown

Metabolism and Physiological Effects of β-Hydroxybutyric acid
type: Pathway
pathway order: PathwaySubPathway/239430
pathway order: PathwayEnzymeReaction/4294349
pathway order: PathwaySubPathway/121855
pathway order: PathwaySubPathway/121854
pathway order: PathwaySubPathway/121856
pathway order: PathwayTransport/2541205
pathway order: PathwayTransport/2541207
pathway order: PathwaySubPathway/121853
pathway order: PathwayTransport/2541206
pathway order: PathwayTransport/2541217
pathway order: PathwaySubPathway/121852
pathway order: PathwayTransport/4294396
pathway order: PathwayEnzymeReaction/2541216
pathway order: PathwayEnzymeReaction/2541215
pathway order: PathwayEnzymeReaction/2541213
pathway component: 1.2.4.1
pathway component: Reduced Mitochondrial Biogenesis
pathway component: Cardiac Fibrosis
pathway component: Regulate Gene Expression
pathway component: Transport16318
pathway component: Reaction219669
pathway component: Transport16319
pathway component: Transport16316
pathway component: 3.1.2.27
pathway component: Transport16317
pathway component: ReactionCatalysis209016
pathway component: Transport16315
pathway component: ReactionCatalysis209018
pathway component: ReactionCatalysis207991
pathway component: ReactionCatalysis209019
pathway component: Glycolysis
pathway component: Nephrolithiasis
pathway component: 2.3.1.9
pathway component: Impaired Bone Health
pathway component: TransportCatalysis6035
pathway component: TransportCatalysis6033
xref: Reference/SMPDB SMP0126987
xref: Reference/PathWhiz PW128604
organism: Homo sapiens

Protein/23919 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Compound/PW C000006 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-3-Hydroxybutyric acid
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-335
type: UnificationXref
id: CPD-335
db: BioCyc

Acyl-coenzyme A thioesterase 8
type: Protein
cellular location: Mitochondrion
entity reference: Acyl-coenzyme A thioesterase 8

Reduced Mitochondrial Biogenesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121854
pathway component: SubPathwayInteraction121854
name: SubPathway

Cardiac Fibrosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121853
pathway component: SubPathwayInteraction121853
name: SubPathway

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ChemicalStructure/PW C000006
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)CC(O)=O

Regulate Gene Expression
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121852
pathway component: SubPathwayInteraction121852
name: SubPathway

Reference/PathWhiz PW128604
type: UnificationXref
id: PW128604
db: PathWhiz

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Nephrolithiasis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121856
pathway component: SubPathwayInteraction121856
name: SubPathway

Impaired Bone Health
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121855
pathway component: SubPathwayInteraction121855
name: SubPathway

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reference/ChemSpider 83181
type: UnificationXref
id: 83181
db: ChemSpider

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Compound/PW C000006/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-3-Hydroxybutyric acid
stoichiometric coefficient: 1.0

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.9
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

Hydrogen
type: SmallMoleculeReference
xref: Reference/PubChem-compound 58838673
xref: Reference/CAS 1333-74-0
xref: Reference/ChemSpider 762
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/KEGG Compound C00282
xref: Reference/HMDB HMDB0001362
xref: Reference/ChEBI CHEBI 18276
chemical formula: H2
molecular weight: 2.01565
structure: ChemicalStructure/PW C001051

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Carbon dioxide
spontaneous: false
EC number: 1.2.4.1
left: Coenzyme A
left: Pyruvate
left: NAD
name: Coenzyme A + NAD + Pyruvate → Acetyl-CoA + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Reaction219669
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000006 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: (R)-3-Hydroxybutyric acid
right: NAD
spontaneous: false
left: Acetoacetic acid
left: Hydrogen
left: NADH
name: Acetoacetic acid + Hydrogen + NADH ↔ (R)-3-Hydroxybutyric acid + NAD
conversion direction: REVERSIBLE

3.1.2.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: Coenzyme A
right: Acetoacetic acid
right: Hydrogen
spontaneous: false
EC number: 3.1.2.27
left: Acetoacetyl-CoA
left: Water
name: Acetoacetyl-CoA + Water → Acetoacetic acid + Coenzyme A + Hydrogen
conversion direction: LEFT_TO_RIGHT

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Solute carrier family 2, facilitated glucose transporter member 10
type: ProteinReference
xref: Reference/UniProt O95528

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P11177
organism: BiologicalState961

Pyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvate
name: SubPathwayOutput

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Transport16318
type: Transport
participant stoichiometry: Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108870 Cytosol/Stoichiometry/1.0
right: Pyruvate
spontaneous: false
left: Pyruvate
name: Pyruvate (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Hydrogen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen

Transport16319
type: Transport
participant stoichiometry: Compound/PW C000006 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000006/Stoichiometry/1.0
right: (R)-3-Hydroxybutyric acid
spontaneous: false
left: (R)-3-Hydroxybutyric acid
name: (R)-3-Hydroxybutyric acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrion to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport16316
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport16317
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Transport16315
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens to Homo sapiens, Intestine, Epithelial Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Pyruvate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvate

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference
organism: BiologicalState961

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

Compound/PW C108870 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/ChEBI CHEBI 18276
type: UnificationXref
id: CHEBI:18276
db: ChEBI

Reference/ChEBI CHEBI 17066
type: UnificationXref
id: CHEBI:17066
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00282
type: UnificationXref
id: C00282
db: KEGG Compound

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayInput

Acetoacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetic acid

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/HMDB HMDB0000011
type: UnificationXref
id: HMDB0000011
db: HMDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/UniProt O95528
type: UnificationXref
id: O95528
db: UniProt

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Compound/PW C108870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C108870
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/ChemSpider 762
type: UnificationXref
id: 762
db: ChemSpider

Unknown
type: Protein
cellular location: Mitochondrion
entity reference: Unknown

D-beta-hydroxybutyrate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/512 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: D-beta-hydroxybutyrate dehydrogenase, mitochondrial

Protein/44 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
stoichiometric coefficient: 2.0

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: Reference/UniProt P08559
organism: BiologicalState961

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

BiologicalState961
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/UniProt O14734
type: UnificationXref
id: O14734
db: UniProt

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

(R)-3-Hydroxybutyric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (R)-3-Hydroxybutyric acid

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001362
type: UnificationXref
id: HMDB0001362
db: HMDB

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Pyruvate dehydrogenase E1
type: Complex
component stoichiometry: Protein/44 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/12 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 1333-74-0
type: UnificationXref
id: 1333-74-0
db: CAS

Reference/UniProt P08559
type: UnificationXref
id: P08559
db: UniProt

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/UniProt Q02338
type: UnificationXref
id: Q02338
db: UniProt

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Acyl-coenzyme A thioesterase 8
type: ProteinReference
xref: Reference/UniProt O14734
organism: BiologicalState961

Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/CAS 625-72-9
type: UnificationXref
id: 625-72-9
db: CAS

D-beta-hydroxybutyrate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: D-beta-hydroxybutyrate dehydrogenase, mitochondrial

Reference/PubChem-compound 92135
type: UnificationXref
id: 92135
db: PubChem-compound

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Protein/12 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

(R)-3-Hydroxybutyric acid
type: SmallMolecule
entity reference: (R)-3-Hydroxybutyric acid
name: SubPathwayInput

D-beta-hydroxybutyrate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q02338
organism: BiologicalState961

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Reference/UniProt P11177
type: UnificationXref
id: P11177
db: UniProt

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Compound/PW C001051 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

TransportCatalysis6035
type: Catalysis
controller: Unknown
controlled: Transport16319
control type: ACTIVATION

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

TransportCatalysis6033
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 10
controlled: Transport16317
control type: ACTIVATION

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001051
type: ChemicalStructure
structure format: SMILES
structure data: [H][H]