Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

D(2) dopamine receptor
type: Protein
cellular location: Synapse
entity reference: D(2) dopamine receptor

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState1554

Reference/PubChem-compound 439280
type: UnificationXref
id: 439280
db: PubChem-compound

Interaction4035
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Serotonin
participant: Calcium
participant: Serotonin

Compound/PW C000178 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

BiologicalState1554
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9913
name: Bos taurus, Brain, Neuron
tissue: Brain

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

ReactionCatalysis209024
type: Catalysis
controller: Adenylyl cyclase complex
controlled: 4.6.1.1
control type: ACTIVATION

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q2KJC0
organism: BiologicalState1554

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

ReactionCatalysis136589
type: Catalysis
controller: Phenylalanine-4-hydroxylase
controlled: 1.14.16.4
control type: ACTIVATION

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt Q0V8S3
organism: BiologicalState1554

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Adenylyl cyclase complex
type: Complex
cellular location: post-synaptic membrane
component: Adenylate cyclase type 1
component: Unknown
component: Adenylate cyclase type 2

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/UniProt Q2KJC0
type: UnificationXref
id: Q2KJC0
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: Reference/UniProt Q2KI31
organism: BiologicalState1554

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Guanosine diphosphate
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Guanosine diphosphate

Reference/UniProt Q9MZL6
type: UnificationXref
id: Q9MZL6
db: UniProt

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: post-synaptic membrane
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ReactionCatalysis136590
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt P19754
organism: BiologicalState1554

Guanosine triphosphate
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Guanosine triphosphate

Compound/PW C000358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-L-tryptophan
stoichiometric coefficient: 1.0

Voltage-dependent P/Q-type calcium channel subunit alpha
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1554

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Phenylalanine-4-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Phenylalanine-4-hydroxylase

Compound/PW C000936 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q1ADE7
type: UnificationXref
id: Q1ADE7
db: UniProt

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Transport16343
type: Transport
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Bos taurus, Brain, Neuron, Synapse to Bos taurus, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Serotonin
type: SmallMolecule
cellular location: Synapse
entity reference: Serotonin

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Transport16341
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Bos taurus, Brain, Neuron, Cytosol to Bos taurus, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport16342
type: Transport
participant stoichiometry: Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Synapse/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Bos taurus, Brain, Neuron, Exocytic Vesicle to Bos taurus, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P20288
type: UnificationXref
id: P20288
db: UniProt

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Transport16340
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: true
left: Calcium
name: Calcium (→) Transport: Bos taurus, Neuron, Extracellular Space to Bos taurus, Neuron, Cytosol
conversion direction: REVERSIBLE

Compound/PW C000178 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: Protein
cellular location: post-synaptic membrane
entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Pyrophosphate
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Pyrophosphate

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Reference/ChemSpider 388413
type: UnificationXref
id: 388413
db: ChemSpider

Serotonin
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Serotonin

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: Reference/UniProt Q17QF5
organism: BiologicalState1554

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Neuronal serotonin Gi protein cascade
type: Pathway
pathway order: PathwayTransport/2541553
pathway order: PathwayTransport/2541552
pathway order: PathwayTransport/2541555
pathway order: PathwayTransport/2541554
pathway order: PathwayEnzymeReaction/2541549
pathway order: PathwayInteraction/5419
pathway order: PathwayEnzymeReaction/2541548
pathway order: PathwayInteraction/5418
pathway order: PathwayEnzymeReaction/2541547
pathway order: PathwayInteraction/5323
pathway order: PathwayInteraction/5422
pathway order: PathwayEnzymeReaction/2541551
pathway order: PathwayInteraction/4035
pathway order: PathwayInteraction/5421
pathway order: PathwayEnzymeReaction/2541550
pathway order: PathwayInteraction/5420
pathway component: ReactionCatalysis136589
pathway component: 4.6.1.1
pathway component: ReactionCatalysis209024
pathway component: Interaction5420
pathway component: Reaction219306
pathway component: Interaction5323
pathway component: Interaction5422
pathway component: Interaction4035
pathway component: Interaction5421
pathway component: TransportCatalysis6040
pathway component: 4.1.1.28
pathway component: 1.14.16.4
pathway component: Reaction219552
pathway component: Transport16343
pathway component: Transport16341
pathway component: Interaction5419
pathway component: Transport16342
pathway component: Interaction5418
pathway component: ReactionCatalysis136590
pathway component: Transport16340
pathway component: TransportCatalysis6043
pathway component: TransportCatalysis6042
xref: Reference/SMPDB SMP0127018
xref: Reference/PathWhiz PW128637
organism: Bos taurus

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000986 post-synaptic membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 post-synaptic membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reaction219552
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium ↔ Sodium
conversion direction: REVERSIBLE

Calcium voltage-gated channel auxiliary subunit alpha2delta 2
type: Protein
entity reference: Calcium voltage-gated channel auxiliary subunit alpha2delta 2

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
type: UnificationXref
id: 5-HYDROXY-TRYPTOPHAN
db: BioCyc

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Reference/UniProt F1MX37
type: UnificationXref
id: F1MX37
db: UniProt

Reference/HMDB HMDB0000472
type: UnificationXref
id: HMDB0000472
db: HMDB

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: post-synaptic membrane
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000358
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 post-synaptic membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 post-synaptic membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 post-synaptic membrane/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Sodium-dependent serotonin transporter
type: ProteinReference
xref: Reference/UniProt Q9XT49

Reference/UniProt Q2KI31
type: UnificationXref
id: Q2KI31
db: UniProt

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/UniProt P19754
type: UnificationXref
id: P19754
db: UniProt

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt P00517
type: UnificationXref
id: P00517
db: UniProt

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

Compound/PW C000986 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/UniProt P00515
type: UnificationXref
id: P00515
db: UniProt

Reference/CAS 4350-09-8
type: UnificationXref
id: 4350-09-8
db: CAS

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Serotonin
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Serotonin

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Compound/PW C000178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Interaction5420
type: MolecularInteraction
interaction type: direct_interaction
name: G protein complex inhibits Adenylyl cyclase complex
participant: G protein complex
participant: Adenylyl cyclase complex

Protein/20517/Stoichiometry/2.0
type: Stoichiometry
physical entity: Calcium voltage-gated channel auxiliary subunit alpha2delta 2
stoichiometric coefficient: 2.0

Interaction5422
type: MolecularInteraction
interaction type: direct_interaction
name: 5-hydroxytryptamine receptor 1B activates G protein complex
participant: Unknown
participant: G protein complex

Interaction5421
type: MolecularInteraction
interaction type: direct_interaction
name: Serotonin activates 5-hydroxytryptamine receptor 1B
participant: Serotonin
participant: Unknown

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: Reference/UniProt Q1ADE7

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Unknown
type: Protein
entity reference: Unknown

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: post-synaptic membrane
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

PKA complex
type: Complex
cellular location: post-synaptic membrane
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: Protein kinase, cAMP-dependent, regulatory, type I, beta
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Protein/20519/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: post-synaptic membrane
entity reference: Unknown

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/PathWhiz PW128637
type: UnificationXref
id: PW128637
db: PathWhiz

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Adenosine triphosphate

Interaction5419
type: MolecularInteraction
interaction type: direct_interaction
name: G protein complex activates 5-hydroxytryptamine receptor 1A
participant: D(2) dopamine receptor
participant: G protein complex

Interaction5418
type: MolecularInteraction
interaction type: direct_interaction
name: Serotonin activates 5-hydroxytryptamine receptor 1A
participant: Serotonin
participant: D(2) dopamine receptor

L type Calcium channel
type: Complex
component stoichiometry: Protein/20519/Stoichiometry/1.0
component stoichiometry: Protein/20782/Stoichiometry/1.0
component stoichiometry: Protein/20517/Stoichiometry/2.0
component: Calcium voltage-gated channel auxiliary subunit alpha2delta 2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha

Reference/UniProt Q17QP8
type: UnificationXref
id: Q17QP8
db: UniProt

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Reference/SMPDB SMP0127018
type: UnificationXref
id: SMP0127018
db: SMPDB

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Reference/ChEBI CHEBI 17780
type: UnificationXref
id: CHEBI:17780
db: ChEBI

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Serotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: Serotonin

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState1554

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Protein/20782/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: Protein
cellular location: post-synaptic membrane
entity reference: Adenylate cyclase type 2

Interaction5323
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: cAMP
participant: PKA complex

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Compound/PW C000170 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

cAMP
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: cAMP

Reference/UniProt Q9XT49
type: UnificationXref
id: Q9XT49
db: UniProt

D(2) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(2) dopamine receptor

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

G protein complex
type: Complex
cellular location: post-synaptic membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/UniProt P31322
type: UnificationXref
id: P31322
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

5-Hydroxy-L-tryptophan
type: SmallMoleculeReference
xref: Reference/ChemSpider 388413
xref: Reference/CAS 4350-09-8
xref: Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
xref: Reference/ChEBI CHEBI 17780
xref: Reference/KEGG Compound C00643
xref: Reference/PubChem-compound 439280
xref: Reference/HMDB HMDB0000472
chemical formula: C11H12N2O3
molecular weight: 220.0848
structure: ChemicalStructure/PW C000358

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/KEGG Compound C00643
type: UnificationXref
id: C00643
db: KEGG Compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Sodium

Reference/UniProt Q17QF5
type: UnificationXref
id: Q17QF5
db: UniProt

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

Phenylalanine-4-hydroxylase
type: ProteinReference
xref: Reference/UniProt A5D9G6
organism: BiologicalState1554

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Adenylate cyclase type 1
type: Protein
cellular location: post-synaptic membrane
entity reference: Adenylate cyclase type 1

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Serotonin
spontaneous: false
EC number: 4.1.1.28
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
conversion direction: LEFT_TO_RIGHT

1.14.16.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: 5-Hydroxy-L-tryptophan
spontaneous: false
EC number: 1.14.16.4
left: Oxygen
left: L-Tryptophan
left: Tetrahydrobiopterin
name: L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: post-synaptic membrane
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Compound/PW C000041 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

D(2) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P20288
organism: BiologicalState1554

Sodium-dependent serotonin transporter
type: Protein
entity reference: Sodium-dependent serotonin transporter

Reference/UniProt A5D9G6
type: UnificationXref
id: A5D9G6
db: UniProt

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P00517
organism: BiologicalState1554

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q17QP8
organism: BiologicalState1554

Reference/UniProt Q0V8S3
type: UnificationXref
id: Q0V8S3
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q9MZL6

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Calcium voltage-gated channel auxiliary subunit alpha2delta 2
type: ProteinReference
xref: Reference/UniProt F1MX37

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

5-Hydroxy-L-tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-L-tryptophan

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Unknown
type: ProteinReference
organism: BiologicalState1554

TransportCatalysis6040
type: Catalysis
controller: L type Calcium channel
controlled: Transport16340
control type: ACTIVATION

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: post-synaptic membrane
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31322
organism: BiologicalState1554

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P00515
organism: BiologicalState1554

TransportCatalysis6043
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport16343
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

TransportCatalysis6042
type: Catalysis
controller: Unknown
controlled: Transport16341
control type: ACTIVATION

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202