Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

SubPathwayControl122014
type: Interaction
name: SubPathway122014Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
participant: Voltage-depenent L-type calcium channel

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransportCatalysis4
type: Catalysis
controller: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
controlled: 3.6.3.8
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

TransportCatalysis93
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport35
control type: ACTIVATION

Dopamine
type: SmallMolecule
entity reference: Dopamine

direct_interaction
type: InteractionVocabulary

TransportCatalysis90
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport119
control type: ACTIVATION

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Transport119
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

SubPathwayControl122015
type: Interaction
name: SubPathway122015Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Ryanodine receptor 2
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

SubPathwayControl122016
type: Interaction
name: SubPathway122016Control
name: ActivatingSubPathwayControl
participant: Ryanodine receptor 2
participant: Calcium
participant: Calcium activates Ryanodine receptor 2

TransportCatalysis2095
type: Catalysis
controller: calcium voltage-gated channel subunit alpha
controlled: Transport10934
control type: ACTIVATION

SubPathwayControl122017
type: Interaction
name: SubPathway122017Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit
participant: Beta-1 adrenergic receptor
participant: G-Protein Signaling Cascade

SubPathwayControl122018
type: Interaction
name: SubPathway122018Control
name: InhibitorySubPathwayControl
participant: Muscle Contraction

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Troponin
left: Calcium
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

TransportCatalysis9
type: Catalysis
controller: Voltage-depenent L-type calcium channel
controlled: Transport35
control type: ACTIVATION

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayActivator

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/1845/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/1845 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1
name: SubPathwayActivation

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Ryanodine receptor 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Ryanodine receptor 2

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/PathWhiz PW000728
type: UnificationXref
id: PW000728
db: PathWhiz

Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Dopamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Dopamine

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Calcium_Troponin
type: Complex
component stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Troponin
component: Calcium

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Transport14067
type: Transport
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Nervous System, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14066
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Nervous System, Neuron, Synapse to Homo sapiens, Nervous System, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Protein/3291 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Adenosine diphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine diphosphate

Reference/UniProt O43497
type: UnificationXref
id: O43497
db: UniProt

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Transport10934
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: true
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: REVERSIBLE

TransportCatalysis4985
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14003
control type: ACTIVATION

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Interaction3996
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine inhibits Sodium-dependent noradrenaline transporter
participant: Sodium-dependent noradrenaline transporter
participant: Dopamine

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

TransportCatalysis5033
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport14067
control type: ACTIVATION

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

TransportCatalysis5032
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14066
control type: ACTIVATION

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Phosphate

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Protein/3290 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Water
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Water

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Troponin
type: ProteinReference
organism: BiologicalState50

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

BiologicalState73
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Reference/BRENDA TISSUE ONTOLOGY BTO 0001832
type: UnificationXref
id: BTO:0001832
db: BRENDA TISSUE ONTOLOGY

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
name: SubPathwayActivation

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Muscle Contraction
type: Pathway
name: InhibitorySubPathway

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: ProteinReference
xref: Reference/UniProt P16615
organism: BiologicalState47

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt P32418

Calcium activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
type: Pathway
name: ActivatingSubPathway

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P09493
type: UnificationXref
id: P09493
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

BiologicalState47
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Cardiomyocyte

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Protein/2706 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

Compound/PW C000142 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState1060

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

BiologicalState50
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

BiologicalState1014
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Heart, Cardiomyocyte
tissue: Heart

Norepinephrine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Norepinephrine

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

calcium voltage-gated channel subunit alpha
type: Complex
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/SMPDB SMP0127069
type: UnificationXref
id: SMP0127069
db: SMPDB

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState47

Adenosine triphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine triphosphate

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Troponin
type: Protein
cellular location: Cytoplasm
entity reference: Troponin

Reference/SMPDB SMP0000751
type: UnificationXref
id: SMP0000751
db: SMPDB

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Norepinephrine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Norepinephrine

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

BiologicalState828
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Heart
tissue: Heart

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

TransportCatalysis10
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport36
control type: ACTIVATION

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Transport14003
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron, Cytosol to Homo sapiens, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Transport14004
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron, Exocytic Vesicle to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt P07951
type: UnificationXref
id: P07951
db: UniProt

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Heart
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000562

Protein/1845/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Interaction4789
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-1 adrenergic receptor ADRB1
participant: Norepinephrine
participant: Beta-1 adrenergic receptor

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

BiologicalState1060
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Sympathetic Nervous System, Neuron
tissue: Sympathetic Nervous System

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Protein/Generic536 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Sympathetic Nervous System
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001832

Tropomyosin
type: Complex
component stoichiometry: Protein/3291 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3290 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Tropomyosin alpha-1 chain
component: Tropomyosin beta chain

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Beta-1 adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayActivator

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: Reference/UniProt Q00975

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt O43497

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Dopamine Action Pathway
type: Pathway
pathway order: PathwayTransport/2542345
pathway order: PathwayTransport/2542344
pathway order: PathwayTransport/2542347
pathway order: PathwayTransport/2542346
pathway order: PathwayTransport/2542341
pathway order: PathwayTransport/2542351
pathway order: PathwayTransport/2542343
pathway order: PathwayTransport/2542342
pathway order: PathwayTransport/2542349
pathway order: PathwaySubPathway/122017
pathway order: PathwayTransport/2542348
pathway order: PathwaySubPathway/122018
pathway order: PathwaySubPathway/122015
pathway order: PathwaySubPathway/122016
pathway order: PathwaySubPathway/122014
pathway order: PathwayInteraction/3933
pathway order: PathwayEnzymeReaction/2542339
pathway order: PathwayEnzymeReaction/2542338
pathway order: PathwayInteraction/4789
pathway order: PathwayInteraction/3996
pathway order: PathwayInteraction/2851
pathway order: PathwayTransport/2542350
pathway order: PathwayEnzymeReaction/2542340
pathway component: SubPathwayControl122014
pathway component: 1.14.17.1
pathway component: ReactionCoupledTransportCatalysis4
pathway component: Interaction2851
pathway component: TransportCatalysis10
pathway component: Transport14003
pathway component: TransportCatalysis93
pathway component: Transport14004
pathway component: TransportCatalysis90
pathway component: Transport14067
pathway component: Transport14066
pathway component: Transport119
pathway component: SubPathwayControl122015
pathway component: SubPathwayControl122016
pathway component: TransportCatalysis2095
pathway component: SubPathwayControl122017
pathway component: SubPathwayControl122018
pathway component: Reaction179579
pathway component: TransportCatalysis9
pathway component: Transport10934
pathway component: TransportCatalysis4985
pathway component: Transport35
pathway component: Transport15627
pathway component: Transport36
pathway component: Interaction3996
pathway component: 3.6.3.8
pathway component: Interaction4789
pathway component: Interaction3933
pathway component: Transport15660
pathway component: TransportCatalysis5033
pathway component: ReactionCatalysis118
pathway component: TransportCatalysis5032
xref: Reference/SMPDB SMP0127069
xref: Reference/PathWhiz PW128688
organism: Homo sapiens

Transport35
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
cellular location: Sarcoplasmic Reticulum
component: Ryanodine receptor 2
name: SubPathwayActivation

Transport36
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Homo sapiens, Cardiomyocyte, Sarcoplasmic Reticulum to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha
name: SubPathwayActivation
name: SubPathwayActivator

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Transport15660
type: Transport
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Sympathetic Nervous System, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Cell Membrane
entity reference: Sodium-dependent noradrenaline transporter

Reference/UniProt O95180
type: UnificationXref
id: O95180
db: UniProt

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin alpha-1 chain

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt O95180

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Compound/PW C000052/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState1014

Reference/PathWhiz PW128688
type: UnificationXref
id: PW128688
db: PathWhiz

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState828

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt P16615
type: UnificationXref
id: P16615
db: UniProt

Interaction2851
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Troponin activates Tropomyosin
participant: Calcium_Troponin
participant: Tropomyosin

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Protein/2706/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

G-Protein Signaling Cascade
type: Pathway
xref: Reference/SMPDB SMP0000751
xref: Reference/PathWhiz PW000728
name: ActivatingSubPathway

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/UniProt P32418
type: UnificationXref
id: P32418
db: UniProt

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Interaction3933
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Norepinephrine
participant: Norepinephrine
participant: Calcium

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/UniProt Q00975
type: UnificationXref
id: Q00975
db: UniProt

Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0000562
type: UnificationXref
id: BTO:0000562
db: BRENDA TISSUE ONTOLOGY

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

BoundComplex/507 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Tropomyosin beta chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin beta chain

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Protein/1845 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Transport15627
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cell Membrane/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Nervous System, Neuron, Synapse to Homo sapiens, Heart, Cardiomyocyte, Cell Membrane
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

3.6.3.8
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Phosphate
right: Calcium
right: Adenosine diphosphate
spontaneous: false
EC number: 3.6.3.8
left: Adenosine triphosphate
left: Calcium
left: Water
name: Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
conversion direction: LEFT_TO_RIGHT

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P07951
organism: BiologicalState50

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt P09493
organism: BiologicalState50

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Dopamine

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202