cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState1507

Reference/UniProt Q9JID0
type: UnificationXref
id: Q9JID0
db: UniProt

Protein/19360/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

Gastrointestinal Tract
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000511

direct_interaction
type: InteractionVocabulary

Reference/UniProt P0DP28
type: UnificationXref
id: P0DP28
db: UniProt

Serotonin
type: SmallMolecule
entity reference: Serotonin

Transport16264
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Lung
conversion direction: LEFT_TO_RIGHT

BiologicalState1671
type: BioSource
xref: Reference/TAXONOMY 10090
name: Mus musculus, Gastrointestinal Tract
tissue: Gastrointestinal Tract

Reference/UniProt Q9CQZ2
type: UnificationXref
id: Q9CQZ2
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q99LG5
organism: BiologicalState1507

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Protein/19558 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Protein/19763 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

ReactionCatalysis209025
type: Catalysis
controller: Adenylyl cyclase complex
controlled: 4.6.1.1
control type: ACTIVATION

Protein/19770 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000353/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

BiologicalState1562
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 10090
name: Mus musculus, Brain, Neuron
tissue: Brain

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Protein/19865 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-3
stoichiometric coefficient: 1.0

ProteinComplex/11049 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Protein kinase A
type: Complex
component stoichiometry: Protein/19763/Stoichiometry/1.0
component stoichiometry: Protein/19756/Stoichiometry/1.0
component stoichiometry: Protein/19767/Stoichiometry/1.0
component stoichiometry: Protein/19360/Stoichiometry/1.0
component stoichiometry: Protein/19760/Stoichiometry/1.0
component stoichiometry: Protein/19770/Stoichiometry/1.0
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/PathWhiz PW129312
type: UnificationXref
id: PW129312
db: PathWhiz

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gs Serotonergic Smooth Muscle Contraction
type: Pathway
pathway order: PathwayInteraction/5572
pathway order: PathwayInteraction/5295
pathway order: PathwayEnzymeReaction/2552855
pathway order: PathwayEnzymeReaction/2552856
pathway order: PathwayEnzymeReaction/2552853
pathway order: PathwayEnzymeReaction/2552854
pathway order: PathwayEnzymeReaction/2552851
pathway order: PathwayEnzymeReaction/2552852
pathway order: PathwaySubPathway/122668
pathway order: PathwayEnzymeReaction/2552850
pathway order: PathwaySubPathway/122667
pathway order: PathwayInteraction/5317
pathway order: PathwayTransport/2552857
pathway order: PathwayTransport/2552858
pathway order: PathwayTransport/2552859
pathway order: PathwayInteraction/5570
pathway order: PathwayInteraction/5571
pathway component: Interaction5295
pathway component: Interaction5570
pathway component: Interaction5572
pathway component: TransportCatalysis6009
pathway component: Interaction5571
pathway component: 2.7.11.18
pathway component: Muscle Relaxation
pathway component: Reaction219643
pathway component: Muscle Contraction
pathway component: Reaction219642
pathway component: 4.6.1.1
pathway component: ReactionCatalysis208999
pathway component: ReactionCatalysis208998
pathway component: Reaction219306
pathway component: ReactionCatalysis209025
pathway component: Reaction219624
pathway component: 3.1.3.16
pathway component: Transport10243
pathway component: Interaction5317
pathway component: Transport16264
pathway component: Transport16273
xref: Reference/PathWhiz PW129312
xref: Reference/SMPDB SMP0127693
organism: Mus musculus

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/19767/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

ProteinComplex/11049/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Protein/19707/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000763
type: UnificationXref
id: BTO:0000763
db: BRENDA TISSUE ONTOLOGY

TransportCatalysis6009
type: Catalysis
controller: L-type calcium channel
controlled: Transport16264
control type: ACTIVATION

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/UniProt P12367
type: UnificationXref
id: P12367
db: UniProt

Unknown
type: Protein
cellular location: post-synaptic membrane
entity reference: Unknown

Protein/19767 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/UniProt Q9JHR6
type: UnificationXref
id: Q9JHR6
db: UniProt

Reference/UniProt Q9ERD3
type: UnificationXref
id: Q9ERD3
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/UniProt Q8BRZ7
type: UnificationXref
id: Q8BRZ7
db: UniProt

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q5SS89
organism: BiologicalState346

Reference/BRENDA TISSUE ONTOLOGY BTO 0000511
type: UnificationXref
id: BTO:0000511
db: BRENDA TISSUE ONTOLOGY

Intermediate conductance calcium-activated potassium channel protein 4
type: Complex
component stoichiometry: Protein/7736 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Reaction219643
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11049/Stoichiometry/1.0
participant stoichiometry: Protein/19707/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate receptor type 1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Inositol 1,4,5-trisphosphate receptor
conversion direction: LEFT_TO_RIGHT

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reaction219642
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16643 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11049 Cytosol/Stoichiometry/1.0
right: Intermediate conductance calcium-activated potassium channel protein 4
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Intermediate conductance calcium-activated potassium channel protein 4
conversion direction: LEFT_TO_RIGHT

BiologicalState346
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10090
name: Mus musculus, Muscle, Myocyte
tissue: Muscle

Transport10243
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

L-type calcium channel
type: Complex
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Unknown

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/UniProt Q5SS89
type: UnificationXref
id: Q5SS89
db: UniProt

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Calmodulin-3
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-3

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Protein/19360 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState1507

ReactionCatalysis208999
type: Catalysis
controller: Unknown
controlled: 3.1.3.16
control type: ACTIVATION

Unknown
type: Protein
entity reference: Unknown

ReactionCatalysis208998
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: 2.7.11.18
control type: ACTIVATION

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/UniProt Q99LG5
type: UnificationXref
id: Q99LG5
db: UniProt

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Adenylate cyclase type 2
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 2

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Interaction5295
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Mus musculus) activates Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Mus musculus)
participant: Myosin light chain kinase, smooth muscle

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Unknown
type: Protein
entity reference: Unknown

BoundComplex/647 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Mus musculus)
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt Q3UTH5
organism: BiologicalState1507

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

5-hydroxytryptamine receptor 4
type: ProteinReference
xref: Reference/UniProt Q9R2A4
organism: BiologicalState1671

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Reference/SMPDB SMP0127693
type: UnificationXref
id: SMP0127693
db: SMPDB

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P12367
organism: BiologicalState1507

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

ProteinComplex/16643 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Intermediate conductance calcium-activated potassium channel protein 4
stoichiometric coefficient: 1.0

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Adenylyl cyclase complex
type: Complex
cellular location: Cytoplasm
component: Adenylate cyclase type 1
component: Unknown
component: Adenylate cyclase type 2

Lung
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000763

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState1507

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState1507

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19558 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Adenosine triphosphate
left: Myosin light chain 3
name: Adenosine triphosphate + Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState1507

Reaction219624
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/647 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19865 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Mus musculus)
spontaneous: false
left: Calmodulin-3
left: Calcium
name: Calcium + Calmodulin → Calcium + Calmodulin (Mus musculus)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/19558 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q9ERD3
organism: BiologicalState1507

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt Q9CQZ2
organism: BiologicalState1507

Protein kinase A
type: Complex
component stoichiometry: Protein/19360 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19760 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19770 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19756 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19763 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19767 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Unknown
type: ProteinReference
organism: BiologicalState1562

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

BiologicalState1507
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10090
name: Mus musculus, Lung, Myocyte
tissue: Lung

Unknown
type: Protein
cellular location: post-synaptic membrane
entity reference: Unknown

Calcium_Calmodulin (Mus musculus)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19865 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin-3
component: Calcium

SubPathwayInteraction122667
type: Interaction
name: SubPathwayReaction
name: SubPathway122667Reaction
participant: Myosin light chain 3

SubPathwayInteraction122668
type: Interaction
name: SubPathway122668Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

Protein/19760 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Unknown
type: ProteinReference
organism: BiologicalState1507

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState1507

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway122668
pathway component: SubPathwayInteraction122668
name: SubPathway

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway122667
pathway component: SubPathwayInteraction122667
name: SubPathway

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState346

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Adenylate cyclase type 1
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 1

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Protein/19756 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Protein/19760/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Protein/19770/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Protein/19756/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Interaction5317
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: PKA complex
participant: cAMP

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP28
organism: BiologicalState1507

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/UniProt Q9R2A4
type: UnificationXref
id: Q9R2A4
db: UniProt

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Calcium
type: SmallMolecule
entity reference: Calcium

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9JID0
organism: BiologicalState1507

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Interaction5570
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Adenyly cyclase 5
participant: Unknown

Protein/7736 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Interaction5572
type: MolecularInteraction
interaction type: direct_interaction
name: Serotonin activates 5-hydroxytryptamine receptor 4
participant: Serotonin
participant: 5-hydroxytryptamine receptor 4

Interaction5571
type: MolecularInteraction
interaction type: direct_interaction
name: 5-hydroxytryptamine receptor 4 activates Guanine nucleotide-binding protein alpha
participant: Unknown
participant: 5-hydroxytryptamine receptor 4

Reference/UniProt Q3UTH5
type: UnificationXref
id: Q3UTH5
db: UniProt

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Reference/UniProt P12849
type: UnificationXref
id: P12849
db: UniProt

5-hydroxytryptamine receptor 4
type: Protein
entity reference: 5-hydroxytryptamine receptor 4

Protein/19763/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q9JHR6
organism: BiologicalState1507

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P12849
organism: BiologicalState1507

Transport16273
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Mus musculus, Muscle, Myocyte, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q8BRZ7
organism: BiologicalState1507

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0