Reaction263722
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005440/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007963/Stoichiometry/1.0
right: PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
right: Carbon dioxide
spontaneous: false
left: PS(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
name: PS(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) → Carbon dioxide + PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
conversion direction: LEFT_TO_RIGHT

Reaction263721
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001201/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005440/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003562/Stoichiometry/1.0
right: Cytidine monophosphate
right: PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
spontaneous: false
left: CDP-ethanolamine
left: DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0)
name: CDP-ethanolamine + DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0) → Cytidine monophosphate + PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

O-Phosphoethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000224
xref: Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
xref: Reference/ChemSpider 990
xref: Reference/PubChem-compound 1015
xref: Reference/KEGG Compound C00346
xref: Reference/ChEBI CHEBI 17553
xref: Reference/CAS 1071-23-4
chemical formula: C2H8NO4P
molecular weight: 141.01909
structure: ChemicalStructure/PW C000149

Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
type: UnificationXref
id: PHOSPHORYL-ETHANOLAMINE
db: BioCyc

Reference/KEGG Compound C02737
type: UnificationXref
id: C02737
db: KEGG Compound

2.7.7.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001201/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149/Stoichiometry/1.0
right: CDP-ethanolamine
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.14
left: Cytidine triphosphate
left: O-Phosphoethanolamine
name: Cytidine triphosphate + O-Phosphoethanolamine → CDP-ethanolamine + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.7.7.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001202/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043034/Stoichiometry/1.0
right: CDP-Choline
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.15
left: Cytidine triphosphate
left: Phosphorylcholine
name: Cytidine triphosphate + Phosphorylcholine → CDP-Choline + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 1014
type: UnificationXref
id: 1014
db: PubChem-compound

Reference/PubChem-compound 1015
type: UnificationXref
id: 1015
db: PubChem-compound

Cytidine triphosphate
type: SmallMolecule
entity reference: Cytidine triphosphate

Reference/BioCyc L-1-PHOSPHATIDYL-ETHANOLAMINE
type: UnificationXref
id: L-1-PHOSPHATIDYL-ETHANOLAMINE
db: BioCyc

DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0)
type: SmallMolecule
entity reference: DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0)

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/ChEBI CHEBI 15958
type: UnificationXref
id: CHEBI:15958
db: ChEBI

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Reaction263726
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004484/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003562/Stoichiometry/1.0
right: Cytidine monophosphate
right: PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
right: Hydrogen Ion
spontaneous: false
left: DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0)
left: CDP-Choline
name: CDP-Choline + DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0) → Cytidine monophosphate + Hydrogen Ion + PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

2.1.1.71
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C060353/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004484/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
spontaneous: false
EC number: 2.1.1.71
left: PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
left: S-Adenosylmethionine
name: PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) + S-Adenosylmethionine → PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

2.1.1.71
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C060353/Stoichiometry/1.0
participant stoichiometry: Compound/PW C059558/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
spontaneous: false
EC number: 2.1.1.71
left: PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
left: S-Adenosylmethionine
name: PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) + S-Adenosylmethionine → PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reaction263723
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005440/Stoichiometry/1.0
participant stoichiometry: Compound/PW C059558/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
spontaneous: false
left: PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
left: S-Adenosylmethionine
name: PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) + S-Adenosylmethionine → PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)) + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Reference/ChemSpider 13207
type: UnificationXref
id: 13207
db: ChemSpider

Compound/PW C000064/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/KEGG Compound C01241
type: UnificationXref
id: C01241
db: KEGG Compound

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C005440/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/BioCyc CDP-ETHANOLAMINE
type: UnificationXref
id: CDP-ETHANOLAMINE
db: BioCyc

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/ChemSpider 110296
type: UnificationXref
id: 110296
db: ChemSpider

Compound/PW C000065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/PubChem-compound 700
type: UnificationXref
id: 700
db: PubChem-compound

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C000149/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoethanolamine
stoichiometric coefficient: 1.0

Compound/PW C043034/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-Choline
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00570
type: UnificationXref
id: C00570
db: KEGG Compound

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/SMPDB SMP0166567
type: UnificationXref
id: SMP0166567
db: SMPDB

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/HMDB HMDB0113432
type: UnificationXref
id: HMDB0113432
db: HMDB

ChemicalStructure/PW C005440
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@](COC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC

Reference/BioCyc CPD-405
type: UnificationXref
id: CPD-405
db: BioCyc

Reference/ChEBI CHEBI 18303
type: UnificationXref
id: CHEBI:18303
db: ChEBI

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMolecule
entity reference: PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))

O-Phosphoethanolamine
type: SmallMolecule
entity reference: O-Phosphoethanolamine

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

ChemicalStructure/PW C059558
type: ChemicalStructure
structure format: SMILES

Phosphatidylethanolamine N-methyltransferase
type: Protein
entity reference: Phosphatidylethanolamine N-methyltransferase

Reference/KEGG Compound C00588
type: UnificationXref
id: C00588
db: KEGG Compound

Reference/KEGG Compound C00346
type: UnificationXref
id: C00346
db: KEGG Compound

Reference/ChEBI CHEBI 16000
type: UnificationXref
id: CHEBI:16000
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/UniProt Q66H21
type: UnificationXref
id: Q66H21
db: UniProt

Reference/HMDB HMDB0001413
type: UnificationXref
id: HMDB0001413
db: HMDB

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/HMDB HMDB0007511
type: UnificationXref
id: HMDB0007511
db: HMDB

ChemicalStructure/PW C004484
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04308
xref: Reference/HMDB HMDB0114334
xref: Reference/BioCyc CPD-160
xref: Reference/ChEBI CHEBI 52332
chemical formula: C45H76NO8P
molecular weight: 789.5309
structure: ChemicalStructure/PW C060353

Reference/ChEBI CHEBI 16732
type: UnificationXref
id: CHEBI:16732
db: ChEBI

Reference/HMDB HMDB0012436
type: UnificationXref
id: HMDB0012436
db: HMDB

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Reference/KEGG Compound C00350
type: UnificationXref
id: C00350
db: KEGG Compound

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

Reference/BioCyc PHOSPHATIDYLCHOLINE
type: UnificationXref
id: PHOSPHATIDYLCHOLINE
db: BioCyc

Reference/CAS 1071-23-4
type: UnificationXref
id: 1071-23-4
db: CAS

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Compound/PW C003562/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0)
stoichiometric coefficient: 1.0

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Choline-phosphate cytidylyltransferase A
type: Protein
entity reference: Choline-phosphate cytidylyltransferase A

Ethanolamine
type: SmallMolecule
entity reference: Ethanolamine

Reference/ChemSpider 24767097
type: UnificationXref
id: 24767097
db: ChemSpider

PS(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMolecule
entity reference: PS(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))

Compound/PW C000057/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/BioCyc CDP-CHOLINE
type: UnificationXref
id: CDP-CHOLINE
db: BioCyc

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChemSpider 24766205
type: UnificationXref
id: 24766205
db: ChemSpider

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/HMDB HMDB0009392
type: UnificationXref
id: HMDB0009392
db: HMDB

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Compound/PW C004484/Stoichiometry/1.0
type: Stoichiometry
physical entity: PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt O88637
type: UnificationXref
id: O88637
db: UniProt

Reference/HMDB HMDB0000224
type: UnificationXref
id: HMDB0000224
db: HMDB

Reference/PathWhiz PW168236
type: UnificationXref
id: PW168236
db: PathWhiz

Reference/ChemSpider 13835336
type: UnificationXref
id: 13835336
db: ChemSpider

Phosphatidylserine decarboxylase proenzyme, mitochondrial
type: Protein
entity reference: Phosphatidylserine decarboxylase proenzyme, mitochondrial

ChemicalStructure/PW C043034
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Choline-phosphate cytidylyltransferase
type: Complex
component stoichiometry: Protein/16288/Stoichiometry/2.0
component: Choline-phosphate cytidylyltransferase A

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/UniProt Q08388
type: UnificationXref
id: Q08388
db: UniProt

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Choline/ethanolamine kinase
type: Complex
component stoichiometry: Protein/17692/Stoichiometry/2.0
component: Choline kinase alpha

Reference/PubChem-compound 53478297
type: UnificationXref
id: 53478297
db: PubChem-compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/PW C000096/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanolamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 52332
type: UnificationXref
id: CHEBI:52332
db: ChEBI

Reference/HMDB HMDB0001564
type: UnificationXref
id: HMDB0001564
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01241
xref: Reference/BioCyc CPD-405
xref: Reference/HMDB HMDB0113432
xref: Reference/ChEBI CHEBI 15958
chemical formula: C44H74NO8P
molecular weight: 775.5152
structure: ChemicalStructure/PW C059558

Reference/HMDB HMDB0001565
type: UnificationXref
id: HMDB0001565
db: HMDB

Compound/PW C001202/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

DG(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z)/0:0)
type: SmallMoleculeReference
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/ChemSpider 24766205
xref: Reference/HMDB HMDB0007511
xref: Reference/KEGG Compound C00165
xref: Reference/PubChem-compound 53478297
chemical formula: C41H66O5
molecular weight: 638.491
structure: ChemicalStructure/PW C003562

ChemicalStructure/PW C001202
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP(O)(O)=O

ChemicalStructure/PW C001201
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMolecule
entity reference: PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Protein/16288/Stoichiometry/2.0
type: Stoichiometry
physical entity: Choline-phosphate cytidylyltransferase A
stoichiometric coefficient: 2.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMolecule
entity reference: S-Adenosylhomocysteine

Reference/PubChem-compound 52923299
type: UnificationXref
id: 52923299
db: PubChem-compound

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Cholinephosphotransferase 1
type: Protein
entity reference: Cholinephosphotransferase 1

Cytidine monophosphate
type: SmallMolecule
entity reference: Cytidine monophosphate

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Choline
type: SmallMolecule
entity reference: Choline

Reference/BioCyc PHOSPHORYL-CHOLINE
type: UnificationXref
id: PHOSPHORYL-CHOLINE
db: BioCyc

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

Phosphatidylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q08388

Phosphatidylcholine Biosynthesis PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: Pathway
pathway order: PathwayEnzymeReaction/2735276
pathway order: PathwayEnzymeReaction/2735277
pathway order: PathwayEnzymeReaction/2735278
pathway order: PathwayEnzymeReaction/2735279
pathway order: PathwayEnzymeReaction/2735273
pathway order: PathwayEnzymeReaction/2735274
pathway order: PathwayEnzymeReaction/2735275
pathway order: PathwayEnzymeReaction/2735280
pathway order: PathwayEnzymeReaction/2735281
pathway order: PathwayEnzymeReaction/2735282
pathway component: Reaction263722
pathway component: Reaction263721
pathway component: 2.7.7.14
pathway component: 2.7.7.15
pathway component: ReactionCatalysis132812
pathway component: ReactionCatalysis132813
pathway component: 2.7.1.82
pathway component: ReactionCatalysis132816
pathway component: ReactionCatalysis132817
pathway component: Reaction142743
pathway component: ReactionCatalysis253050
pathway component: ReactionCatalysis253046
pathway component: ReactionCatalysis253045
pathway component: ReactionCatalysis253049
pathway component: ReactionCatalysis253048
pathway component: ReactionCatalysis253047
pathway component: Reaction263726
pathway component: 2.1.1.71
pathway component: Reaction263723
xref: Reference/SMPDB SMP0166567
xref: Reference/PathWhiz PW168236
organism: Rattus norvegicus

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Reference/KEGG Compound C00157
type: UnificationXref
id: C00157
db: KEGG Compound

Choline kinase alpha
type: Protein
entity reference: Choline kinase alpha

ChemicalStructure/PW C003562
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](CO)(COC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)OC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Ethanolamine-phosphate cytidylyltransferase
type: Protein
entity reference: Ethanolamine-phosphate cytidylyltransferase

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMoleculeReference
xref: Reference/BioCyc L-1-PHOSPHATIDYL-ETHANOLAMINE
xref: Reference/PubChem-compound 52924648
xref: Reference/HMDB HMDB0009392
xref: Reference/ChemSpider 24768843
xref: Reference/KEGG Compound C00350
chemical formula: C43H72NO8P
molecular weight: 761.4996
structure: ChemicalStructure/PW C005440

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/KEGG Compound C00165
type: UnificationXref
id: C00165
db: KEGG Compound

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Phosphatidylserine decarboxylase proenzyme, mitochondrial
type: ProteinReference
xref: Reference/UniProt D3ZAW2

PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMoleculeReference
xref: Reference/ChemSpider 24767097
xref: Reference/PubChem-compound 52923299
xref: Reference/HMDB HMDB0008436
xref: Reference/KEGG Compound C00157
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
chemical formula: C46H78NO8P
molecular weight: 803.5465
structure: ChemicalStructure/PW C004484

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000149
type: UnificationXref
id: HMDB0000149
db: HMDB

PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMolecule
entity reference: PC(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))

ChemicalStructure/PW C060353
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Reference/ChEBI CHEBI 18132
type: UnificationXref
id: CHEBI:18132
db: ChEBI

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

ChemicalStructure/PW C000149
type: ChemicalStructure
structure format: SMILES
structure data: NCCOP(O)(O)=O

ReactionCatalysis132816
type: Catalysis
controller: Choline/ethanolamine kinase
controlled: 2.7.1.82
control type: ACTIVATION

PS(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 52925744
xref: Reference/ChEBI CHEBI 18303
xref: Reference/ChemSpider 13628254
xref: Reference/HMDB HMDB0012436
xref: Reference/BioCyc L-1-PHOSPHATIDYL-SERINE
xref: Reference/KEGG Compound C02737
chemical formula: C44H72NO10P
molecular weight: 805.4894
structure: ChemicalStructure/PW C007963

ReactionCatalysis132817
type: Catalysis
controller: Choline/ethanolamine kinase
controlled: Reaction142743
control type: ACTIVATION

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

ReactionCatalysis253050
type: Catalysis
controller: Cholinephosphotransferase 1
controlled: Reaction263726
control type: ACTIVATION

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
type: SmallMolecule
entity reference: PE(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))

Reference/BioCyc ETHANOL-AMINE
type: UnificationXref
id: ETHANOL-AMINE
db: BioCyc

Choline-phosphate cytidylyltransferase A
type: ProteinReference
xref: Reference/UniProt P19836

Reference/HMDB HMDB0008436
type: UnificationXref
id: HMDB0008436
db: HMDB

Ethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000149
xref: Reference/ChemSpider 13835336
xref: Reference/PubChem-compound 700
xref: Reference/CAS 141-43-5
xref: Reference/BioCyc ETHANOL-AMINE
xref: Reference/ChEBI CHEBI 16000
xref: Reference/KEGG Compound C00189
chemical formula: C2H7NO
molecular weight: 61.052765
structure: ChemicalStructure/PW C000096

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChemSpider 13628254
type: UnificationXref
id: 13628254
db: ChemSpider

Reference/KEGG Compound C04308
type: UnificationXref
id: C04308
db: KEGG Compound

Compound/PW C001201/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-ethanolamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 24768843
type: UnificationXref
id: 24768843
db: ChemSpider

Reference/UniProt P19836
type: UnificationXref
id: P19836
db: UniProt

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/KEGG Compound C00189
type: UnificationXref
id: C00189
db: KEGG Compound

Reference/CAS 107-73-3
type: UnificationXref
id: 107-73-3
db: CAS

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Reference/CAS 3036-18-8
type: UnificationXref
id: 3036-18-8
db: CAS

ReactionCatalysis253046
type: Catalysis
controller: Phosphatidylserine decarboxylase proenzyme, mitochondrial
controlled: Reaction263722
control type: ACTIVATION

ReactionCatalysis253045
type: Catalysis
controller: Cholinephosphotransferase 1
controlled: Reaction263721
control type: ACTIVATION

Reference/CAS 987-78-0
type: UnificationXref
id: 987-78-0
db: CAS

ReactionCatalysis253049
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: 2.1.1.71
control type: ACTIVATION

ReactionCatalysis253048
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: 2.1.1.71
control type: ACTIVATION

ReactionCatalysis253047
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: Reaction263723
control type: ACTIVATION

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C000096
type: ChemicalStructure
structure format: SMILES
structure data: NCCO

Reference/UniProt D3ZAW2
type: UnificationXref
id: D3ZAW2
db: UniProt

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

ChemicalStructure/PW C007963
type: ChemicalStructure
structure format: SMILES

CDP-ethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001564
xref: Reference/ChEBI CHEBI 16732
xref: Reference/PubChem-compound 123727
xref: Reference/CAS 3036-18-8
xref: Reference/BioCyc CDP-ETHANOLAMINE
xref: Reference/KEGG Compound C00570
xref: Reference/ChemSpider 110296
chemical formula: C11H20N4O11P2
molecular weight: 446.0604
structure: ChemicalStructure/PW C001201

Phosphorylcholine
type: SmallMoleculeReference
xref: Reference/CAS 107-73-3
xref: Reference/HMDB HMDB0001565
xref: Reference/BioCyc PHOSPHORYL-CHOLINE
xref: Reference/PubChem-compound 1014
xref: Reference/ChEBI CHEBI 18132
xref: Reference/KEGG Compound C00588
xref: Reference/ChemSpider 989
chemical formula: C5H15NO4P
molecular weight: 184.07387
structure: ChemicalStructure/PW C001202

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PubChem-compound 52924648
type: UnificationXref
id: 52924648
db: PubChem-compound

Reference/BioCyc L-1-PHOSPHATIDYL-SERINE
type: UnificationXref
id: L-1-PHOSPHATIDYL-SERINE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C007963/Stoichiometry/1.0
type: Stoichiometry
physical entity: PS(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
stoichiometric coefficient: 1.0

ReactionCatalysis132812
type: Catalysis
controller: Choline-phosphate cytidylyltransferase
controlled: 2.7.7.15
control type: ACTIVATION

ReactionCatalysis132813
type: Catalysis
controller: Ethanolamine-phosphate cytidylyltransferase
controlled: 2.7.7.14
control type: ACTIVATION

Reference/ChEBI CHEBI 17553
type: UnificationXref
id: CHEBI:17553
db: ChEBI

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Reference/PubChem-compound 123727
type: UnificationXref
id: 123727
db: PubChem-compound

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/PubChem-compound 11583971
type: UnificationXref
id: 11583971
db: PubChem-compound

Reference/PubChem-compound 52925744
type: UnificationXref
id: 52925744
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Reference/ChEBI CHEBI 16436
type: UnificationXref
id: CHEBI:16436
db: ChEBI

Compound/PW C059558/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE-NMe(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
stoichiometric coefficient: 1.0

Phosphorylcholine
type: SmallMolecule
entity reference: Phosphorylcholine

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Ethanolamine-phosphate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt O88637

CDP-ethanolamine
type: SmallMolecule
entity reference: CDP-ethanolamine

Compound/PW C000749/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Choline kinase alpha
type: ProteinReference
xref: Reference/UniProt Q01134

Protein/17692/Stoichiometry/2.0
type: Stoichiometry
physical entity: Choline kinase alpha
stoichiometric coefficient: 2.0

Reference/ChemSpider 990
type: UnificationXref
id: 990
db: ChemSpider

Cholinephosphotransferase 1
type: ProteinReference
xref: Reference/UniProt Q66H21

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/KEGG Compound C00307
type: UnificationXref
id: C00307
db: KEGG Compound

Reference/CAS 141-43-5
type: UnificationXref
id: 141-43-5
db: CAS

Compound/PW C060353/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:3(9Z,12Z,15Z))
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Reference/ChemSpider 989
type: UnificationXref
id: 989
db: ChemSpider

Reference/BioCyc CPD-160
type: UnificationXref
id: CPD-160
db: BioCyc

Reference/UniProt Q01134
type: UnificationXref
id: Q01134
db: UniProt

2.7.1.82
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000096/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: O-Phosphoethanolamine
spontaneous: false
EC number: 2.7.1.82
left: Ethanolamine
left: Adenosine triphosphate
name: Adenosine triphosphate + Ethanolamine → Adenosine diphosphate + Hydrogen Ion + O-Phosphoethanolamine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reaction142743
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphorylcholine
spontaneous: false
left: Choline
left: Adenosine triphosphate
name: Adenosine triphosphate + Choline → Adenosine diphosphate + Phosphorylcholine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/HMDB HMDB0114334
type: UnificationXref
id: HMDB0114334
db: HMDB

CDP-Choline
type: SmallMolecule
entity reference: CDP-Choline

CDP-Choline
type: SmallMoleculeReference
xref: Reference/BioCyc CDP-CHOLINE
xref: Reference/ChemSpider 13207
xref: Reference/HMDB HMDB0001413
xref: Reference/ChEBI CHEBI 16436
xref: Reference/KEGG Compound C00307
xref: Reference/PubChem-compound 11583971
xref: Reference/CAS 987-78-0
chemical formula: C14H26N4O11P2
molecular weight: 488.10733
structure: ChemicalStructure/PW C043034