Reference/CAS 7196-09-0
type: UnificationXref
id: 7196-09-0
db: CAS

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Compound/PW C001178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methylene-THF
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

2-dehydropantoate
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-dehydropantoate

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Compound/PW C000136 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pantothenic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C043187
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(O)C(O)C(O)=O

Escherichia coli IAI1
type: BioSource
xref: Reference/TAXONOMY 585034

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Valine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway346902
pathway component: SubPathwayInteraction346902
xref: Reference/SMPDB SMP0000832
xref: Reference/PathWhiz PW000812
name: SubPathway

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

dihydroxy acid dehydratase
type: Complex
component stoichiometry: Protein/28270/Stoichiometry/2.0
component: Unknown

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

2-dehydropantoate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 11561
chemical formula: C6H9O4
molecular weight: 145.05008
structure: ChemicalStructure/PW C040972

(R)-pantoate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15980
chemical formula: C6H11O4
molecular weight: 147.06628
structure: ChemicalStructure/PW C040973

4'-phosphopantetheine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61723
chemical formula: C12H23N2O6PS
molecular weight: 354.10254
structure: ChemicalStructure/PW C040974

Reference/PubChem-compound 239
type: UnificationXref
id: 239
db: PubChem-compound

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

pantothenate synthetase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/ChemSpider 128
type: UnificationXref
id: 128
db: ChemSpider

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/ChemSpider 48
type: UnificationXref
id: 48
db: ChemSpider

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000012/Stoichiometry/2.0
type: Stoichiometry
physical entity: α-Ketoisovaleric acid
stoichiometric coefficient: 2.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

β-Alanine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000056
xref: Reference/ChemSpider 234
xref: Reference/PubChem-compound 239
xref: Reference/ChEBI CHEBI 16958
xref: Reference/KEGG Compound C00099
xref: Reference/CAS 107-95-9
xref: Reference/BioCyc B-ALANINE
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000040

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrofolic acid

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BioCyc DEPHOSPHO-COA
type: UnificationXref
id: DEPHOSPHO-COA
db: BioCyc

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Protein/28270 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/BioCyc R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE
type: UnificationXref
id: R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE
db: BioCyc

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

SubPathwayInteraction346902
type: Interaction
name: SubPathway346902Reaction
name: SubPathwayReaction
participant: α-Ketoisovaleric acid

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

D-4'-Phosphopantothenate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03492
xref: Reference/HMDB HMDB0001016
xref: Reference/BioCyc 4-P-PANTOTHENATE
xref: Reference/ChEBI CHEBI 15905
xref: Reference/PubChem-compound 131
xref: Reference/ChemSpider 128
chemical formula: C9H18NO8P
molecular weight: 299.077
structure: ChemicalStructure/PW C000804

SubPathwayInteraction346903
type: Interaction
name: SubPathwayReaction
name: SubPathway346903Reaction
participant: L-Aspartic acid

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 759-05-7
type: UnificationXref
id: 759-05-7
db: CAS

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Reference/PubChem-compound 439175
type: UnificationXref
id: 439175
db: PubChem-compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

α-Ketoisovaleric acid
type: SmallMoleculeReference
xref: Reference/CAS 759-05-7
xref: Reference/PubChem-compound 49
xref: Reference/ChemSpider 48
xref: Reference/HMDB HMDB0000019
xref: Reference/BioCyc 2-KETO-ISOVALERATE
xref: Reference/KEGG Compound C00141
xref: Reference/ChEBI CHEBI 16530
chemical formula: C5H8O3
molecular weight: 116.04734
structure: ChemicalStructure/PW C000012

Compound/PW C000804 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-4'-Phosphopantothenate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Pantothenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 963
xref: Reference/HMDB HMDB0000210
xref: Reference/KEGG Compound C00864
xref: Reference/BioCyc PANTOTHENATE
xref: Reference/PubChem-compound 988
xref: Reference/CAS 79-83-4
xref: Reference/ChEBI CHEBI 7916
chemical formula: C9H17NO5
molecular weight: 219.11067
structure: ChemicalStructure/PW C000136

Reference/BioCyc METHYLENE-THF
type: UnificationXref
id: METHYLENE-THF
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/PubChem-compound 131
type: UnificationXref
id: 131
db: PubChem-compound

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Cytidine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Cytidine monophosphate

Reference/ChemSpider 388463
type: UnificationXref
id: 388463
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001533
type: UnificationXref
id: HMDB0001533
db: HMDB

Adenine
type: SmallMolecule
entity reference: Adenine

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/BioCyc 2-KETO-ISOVALERATE
type: UnificationXref
id: 2-KETO-ISOVALERATE
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Adenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000034
xref: Reference/BioCyc ADENINE
xref: Reference/PubChem-compound 190
xref: Reference/ChemSpider 185
xref: Reference/KEGG Compound C00147
xref: Reference/ChEBI CHEBI 16708
xref: Reference/CAS 73-24-5
chemical formula: C5H5N5
molecular weight: 135.05449
structure: ChemicalStructure/PW C000024

3-methyl-2-oxobutanoate hydroxymethyltransferase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/10.0
cellular location: Cytosol
component: Unknown

4'-Phosphopantothenoylcysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: 4'-Phosphopantothenoylcysteine

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

2'-(5-Triphosphoribosyl)-3'-dephospho-CoA
type: SmallMolecule
entity reference: 2'-(5-Triphosphoribosyl)-3'-dephospho-CoA

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PANTOTHENATE
type: UnificationXref
id: PANTOTHENATE
db: BioCyc

Reference/PathWhiz PW000787
type: UnificationXref
id: PW000787
db: PathWhiz

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

1.1.1.169
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040973 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040972 Cytosol/Stoichiometry/1.0
right: (R)-pantoate
right: NADP
spontaneous: false
EC number: 1.1.1.169
left: Hydrogen Ion
left: 2-dehydropantoate
left: NADPH
name: 2-dehydropantoate + Hydrogen Ion + NADPH → (R)-pantoate + NADP
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

6.3.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040973 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000136 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: Pantothenic acid
right: Hydrogen Ion
right: Pyrophosphate
spontaneous: false
EC number: 6.3.2.1
left: Adenosine triphosphate
left: β-Alanine
left: (R)-pantoate
name: (R)-pantoate + Adenosine triphosphate + β-Alanine → Adenosine monophosphate + Hydrogen Ion + Pantothenic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000064 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000804
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/PubChem-compound 25203684
type: UnificationXref
id: 25203684
db: PubChem-compound

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Reference/HMDB HMDB0000210
type: UnificationXref
id: HMDB0000210
db: HMDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/BioCyc 4-P-PANTOTHENATE
type: UnificationXref
id: 4-P-PANTOTHENATE
db: BioCyc

ChemicalStructure/PW C000136
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(CO)[C@@H](O)C(=O)NCCC(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000012
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C(=O)C(O)=O

fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/12.0
cellular location: Cytosol
component: Unknown

4'-Phosphopantothenoylcysteine
type: SmallMoleculeReference
xref: Reference/CAS 7196-09-0
xref: Reference/KEGG Compound C04352
xref: Reference/HMDB HMDB0001117
xref: Reference/ChEBI CHEBI 15769
xref: Reference/BioCyc R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE
xref: Reference/PubChem-compound 440304
xref: Reference/ChemSpider 389278
chemical formula: C12H23N2O9PS
molecular weight: 402.08618
structure: ChemicalStructure/PW C000872

2.1.2.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000012 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040972 Cytosol/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: 2-dehydropantoate
spontaneous: false
EC number: 2.1.2.11
left: α-Ketoisovaleric acid
left: 5,10-Methylene-THF
left: Water
name: 5,10-Methylene-THF + Water + α-Ketoisovaleric acid → 2-dehydropantoate + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Dephospho-CoA
type: SmallMolecule
entity reference: Dephospho-CoA

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/PubChem-compound 677
type: UnificationXref
id: 677
db: PubChem-compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

ReactionCatalysis476591
type: Catalysis
controller: 3-methyl-2-oxobutanoate hydroxymethyltransferase
controlled: 2.1.2.11
control type: ACTIVATION

Reference/BioCyc ADENINE
type: UnificationXref
id: ADENINE
db: BioCyc

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 388320
type: UnificationXref
id: 388320
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Dephospho-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Dephospho-CoA

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

2.7.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000136 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000804 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: D-4'-Phosphopantothenate
spontaneous: false
EC number: 2.7.1.33
left: Adenosine triphosphate
left: Pantothenic acid
name: Adenosine triphosphate + Pantothenic acid → Adenosine diphosphate + D-4'-Phosphopantothenate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

5,10-Methylene-THF
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001533
xref: Reference/CAS 3432-99-3
xref: Reference/PubChem-compound 439175
xref: Reference/ChEBI CHEBI 15636
xref: Reference/KEGG Compound C00143
xref: Reference/BioCyc METHYLENE-THF
xref: Reference/ChemSpider 388320
chemical formula: C20H23N7O6
molecular weight: 457.171
structure: ChemicalStructure/PW C001178

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000024
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C2NC=NC2=NC=N1

ReactionCatalysis476595
type: Catalysis
controller: pantothenate kinase
controlled: 2.7.1.33
control type: ACTIVATION

Reaction487637
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Cytosol/Stoichiometry/1.0
right: β-Alanine
right: Carbon dioxide
spontaneous: false
left: L-Aspartic acid
left: Hydrogen Ion
name: Hydrogen Ion + L-Aspartic acid → Carbon dioxide + β-Alanine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis476594
type: Catalysis
controller: pantothenate synthetase
controlled: 6.3.2.1
control type: ACTIVATION

Reference/ChEBI CHEBI 15769
type: UnificationXref
id: CHEBI:15769
db: ChEBI

Compound/PW C001061/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dephospho-CoA
stoichiometric coefficient: 1.0

Protein/28270 Cytosol/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

ReactionCatalysis476593
type: Catalysis
controller: Unknown
controlled: 1.1.1.169
control type: ACTIVATION

Reference/CAS 107-95-9
type: UnificationXref
id: 107-95-9
db: CAS

2.4.2.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000024/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041248/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001061/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 2'-(5-Triphosphoribosyl)-3'-dephospho-CoA
right: Adenine
spontaneous: false
EC number: 2.4.2.52
left: Hydrogen Ion
left: Dephospho-CoA
left: Adenosine triphosphate
name: Adenosine triphosphate + Dephospho-CoA + Hydrogen Ion → 2'-(5-Triphosphoribosyl)-3'-dephospho-CoA + Adenine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis476592
type: Catalysis
controller: acetohydroxy acid isomeroreductase
controlled: 1.1.1.169
control type: ACTIVATION

Reaction487636
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000012/Stoichiometry/2.0
participant stoichiometry: Compound/PW C043187/Stoichiometry/1.0
right: Water
right: α-Ketoisovaleric acid
spontaneous: false
left: 2,3-Dihydroxyisovaleric acid
name: 2,3-Dihydroxyisovaleric acid ↔ Water + 2 α-Ketoisovaleric acid
conversion direction: REVERSIBLE

2.7.7.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040974 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001061 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: Dephospho-CoA
spontaneous: false
EC number: 2.7.7.3
left: 4'-phosphopantetheine
left: Adenosine triphosphate
left: Hydrogen Ion
name: 4'-phosphopantetheine + Adenosine triphosphate + Hydrogen Ion → Dephospho-CoA + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis476599
type: Catalysis
controller: Unknown
controlled: 2.7.1.24
control type: ACTIVATION

ReactionCatalysis476598
type: Catalysis
controller: phosphopantetheine adenylyltransferase
controlled: 2.7.7.3
control type: ACTIVATION

2.7.1.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001061 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Coenzyme A
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.24
left: Adenosine triphosphate
left: Dephospho-CoA
name: Adenosine triphosphate + Dephospho-CoA → Adenosine diphosphate + Coenzyme A + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

4.1.1.36,6.3.2.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000872 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000804 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Pyrophosphate
right: 4'-Phosphopantothenoylcysteine
right: Cytidine monophosphate
spontaneous: false
EC number: 4.1.1.36,6.3.2.5
left: L-Cysteine
left: Cytidine triphosphate
left: D-4'-Phosphopantothenate
name: Cytidine triphosphate + D-4'-Phosphopantothenate + L-Cysteine → 4'-Phosphopantothenoylcysteine + Cytidine monophosphate + Hydrogen Ion + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis476597
type: Catalysis
controller: fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase
controlled: Reaction487632
control type: ACTIVATION

ReactionCatalysis476596
type: Catalysis
controller: fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase
controlled: 4.1.1.36,6.3.2.5
control type: ACTIVATION

Reaction487632
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040974 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000872 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: 4'-phosphopantetheine
right: Carbon dioxide
spontaneous: false
left: Hydrogen Ion
left: 4'-Phosphopantothenoylcysteine
name: 4'-Phosphopantothenoylcysteine + Hydrogen Ion → 4'-phosphopantetheine + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Protein/28270/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway346903
pathway component: SubPathwayInteraction346903
xref: Reference/PathWhiz PW000787
xref: Reference/SMPDB SMP0000809
name: SubPathway

Reference/PubChem-compound 49
type: UnificationXref
id: 49
db: PubChem-compound

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Protein/28270 Cytosol/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Reference/ChEBI CHEBI 15980
type: UnificationXref
id: CHEBI:15980
db: ChEBI

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/ChemSpider 234
type: UnificationXref
id: 234
db: ChemSpider

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Reference/ChEBI CHEBI 16708
type: UnificationXref
id: CHEBI:16708
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

2'-(5-Triphosphoribosyl)-3'-dephospho-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25203684
chemical formula: C26H46N7O26P5S
molecular weight: 1059.0901
structure: ChemicalStructure/PW C041248

Reference/ChEBI CHEBI 15636
type: UnificationXref
id: CHEBI:15636
db: ChEBI

Compound/PW C001061 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dephospho-CoA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00143
type: UnificationXref
id: C00143
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00141
type: UnificationXref
id: C00141
db: KEGG Compound

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/KEGG Compound C00147
type: UnificationXref
id: C00147
db: KEGG Compound

Reference/CAS 3432-99-3
type: UnificationXref
id: 3432-99-3
db: CAS

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Reference/ChEBI CHEBI 16958
type: UnificationXref
id: CHEBI:16958
db: ChEBI

Reference/ChEBI CHEBI 61723
type: UnificationXref
id: CHEBI:61723
db: ChEBI

Compound/PW C000057 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Reference/CAS 73-24-5
type: UnificationXref
id: 73-24-5
db: CAS

Reference/ChEBI CHEBI 15689
type: UnificationXref
id: CHEBI:15689
db: ChEBI

Reference/CAS 79-83-4
type: UnificationXref
id: 79-83-4
db: CAS

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Reference/SMPDB SMP0000809
type: UnificationXref
id: SMP0000809
db: SMPDB

Reference/CAS 3633-59-8
type: UnificationXref
id: 3633-59-8
db: CAS

Reference/PubChem-compound 440304
type: UnificationXref
id: 440304
db: PubChem-compound

Reference/ChEBI CHEBI 16530
type: UnificationXref
id: CHEBI:16530
db: ChEBI

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

ReactionCatalysis476602
type: Catalysis
controller: aspartate 1-decarboxylase
controlled: Reaction487637
control type: ACTIVATION

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

ReactionCatalysis476601
type: Catalysis
controller: dihydroxy acid dehydratase
controlled: Reaction487636
control type: ACTIVATION

Water
type: SmallMolecule
entity reference: Water

ReactionCatalysis476600
type: Catalysis
controller: Unknown
controlled: 2.4.2.52
control type: ACTIVATION

Compound/PW C000024/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

Compound/PW C041248/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2'-(5-Triphosphoribosyl)-3'-dephospho-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000019
type: UnificationXref
id: HMDB0000019
db: HMDB

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

2,3-Dihydroxyisovaleric acid
type: SmallMolecule
entity reference: 2,3-Dihydroxyisovaleric acid

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/TAXONOMY 585034
type: UnificationXref
id: 585034
db: TAXONOMY

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/BioCyc B-ALANINE
type: UnificationXref
id: B-ALANINE
db: BioCyc

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0001117
type: UnificationXref
id: HMDB0001117
db: HMDB

Reference/PathWhiz PW357774
type: UnificationXref
id: PW357774
db: PathWhiz

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Protein/28270 Cytosol/Stoichiometry/12.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 12.0

Reference/ChEBI CHEBI 7916
type: UnificationXref
id: CHEBI:7916
db: ChEBI

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Pantothenic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pantothenic acid

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000872 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4'-Phosphopantothenoylcysteine
stoichiometric coefficient: 1.0

(R)-pantoate
type: SmallMolecule
cellular location: Cytosol
entity reference: (R)-pantoate

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Pantothenate and CoA Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/5141669
pathway order: PathwayEnzymeReaction/5141678
pathway order: PathwayEnzymeReaction/5141679
pathway order: PathwayEnzymeReaction/5141676
pathway order: PathwayEnzymeReaction/5141677
pathway order: PathwayEnzymeReaction/5141674
pathway order: PathwaySubPathway/346903
pathway order: PathwayEnzymeReaction/5141675
pathway order: PathwayEnzymeReaction/5141672
pathway order: PathwayEnzymeReaction/5141673
pathway order: PathwaySubPathway/346902
pathway order: PathwayEnzymeReaction/5141670
pathway order: PathwayEnzymeReaction/5141671
pathway order: PathwayEnzymeReaction/5141680
pathway component: Aspartate Metabolism
pathway component: 1.1.1.169
pathway component: 6.3.2.1
pathway component: ReactionCatalysis476602
pathway component: ReactionCatalysis476601
pathway component: ReactionCatalysis476600
pathway component: 2.1.2.11
pathway component: Valine Biosynthesis
pathway component: ReactionCatalysis476591
pathway component: 2.7.1.33
pathway component: ReactionCatalysis476595
pathway component: Reaction487637
pathway component: ReactionCatalysis476594
pathway component: ReactionCatalysis476593
pathway component: 2.4.2.52
pathway component: ReactionCatalysis476592
pathway component: Reaction487636
pathway component: 2.7.7.3
pathway component: ReactionCatalysis476599
pathway component: ReactionCatalysis476598
pathway component: 2.7.1.24
pathway component: 4.1.1.36,6.3.2.5
pathway component: ReactionCatalysis476597
pathway component: ReactionCatalysis476596
pathway component: Reaction487632
xref: Reference/PathWhiz PW357774
xref: Reference/SMPDB SMP0351985
organism: Escherichia coli IAI1

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000034
type: UnificationXref
id: HMDB0000034
db: HMDB

Reference/PubChem-compound 439335
type: UnificationXref
id: 439335
db: PubChem-compound

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Protein/28270 Cytosol/Stoichiometry/8.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 8.0

5,10-Methylene-THF
type: SmallMolecule
cellular location: Cytosol
entity reference: 5,10-Methylene-THF

2,3-Dihydroxyisovaleric acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 677
xref: Reference/ChEBI CHEBI 15689
chemical formula: C5H10O4
molecular weight: 134.0579
structure: ChemicalStructure/PW C043187

Dephospho-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439335
xref: Reference/ChEBI CHEBI 15468
xref: Reference/BioCyc DEPHOSPHO-COA
xref: Reference/HMDB HMDB0001373
xref: Reference/CAS 3633-59-8
xref: Reference/KEGG Compound C00882
xref: Reference/ChemSpider 388463
chemical formula: C21H35N7O13P2S
molecular weight: 687.14886
structure: ChemicalStructure/PW C001061

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/KEGG Compound C00864
type: UnificationXref
id: C00864
db: KEGG Compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/SMPDB SMP0000832
type: UnificationXref
id: SMP0000832
db: SMPDB

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

pantothenate kinase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/ChemSpider 389278
type: UnificationXref
id: 389278
db: ChemSpider

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0001016
type: UnificationXref
id: HMDB0001016
db: HMDB

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

β-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: β-Alanine

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000040
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(O)=O

Reference/HMDB HMDB0001373
type: UnificationXref
id: HMDB0001373
db: HMDB

Unknown
type: ProteinReference
organism: Escherichia coli IAI1

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/ChEBI CHEBI 11561
type: UnificationXref
id: CHEBI:11561
db: ChEBI

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0000056
type: UnificationXref
id: HMDB0000056
db: HMDB

α-Ketoisovaleric acid
type: SmallMolecule
entity reference: α-Ketoisovaleric acid

Reference/PathWhiz PW000812
type: UnificationXref
id: PW000812
db: PathWhiz

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C001061
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

acetohydroxy acid isomeroreductase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

ChemicalStructure/PW C041248
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000040 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-Alanine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00882
type: UnificationXref
id: C00882
db: KEGG Compound

Reference/ChemSpider 963
type: UnificationXref
id: 963
db: ChemSpider

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

4'-phosphopantetheine
type: SmallMolecule
cellular location: Cytosol
entity reference: 4'-phosphopantetheine

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

α-Ketoisovaleric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: α-Ketoisovaleric acid
name: SubPathwayInput

Compound/PW C040973 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-pantoate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 988
type: UnificationXref
id: 988
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Reference/ChEBI CHEBI 15468
type: UnificationXref
id: CHEBI:15468
db: ChEBI

aspartate 1-decarboxylase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/8.0
cellular location: Cytosol
component: Unknown

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Cytidine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Cytidine triphosphate

D-4'-Phosphopantothenate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-4'-Phosphopantothenate

Reference/KEGG Compound C00099
type: UnificationXref
id: C00099
db: KEGG Compound

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Protein/28270 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/KEGG Compound C03492
type: UnificationXref
id: C03492
db: KEGG Compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

phosphopantetheine adenylyltransferase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/6.0
cellular location: Cytosol
component: Unknown

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid
name: SubPathwayInput

Compound/PW C001221 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Compound/PW C040974 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4'-phosphopantetheine
stoichiometric coefficient: 1.0

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000872
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 190
type: UnificationXref
id: 190
db: PubChem-compound

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Compound/PW C000012 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-Ketoisovaleric acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040972
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(CO)C(=O)C([O-])=O

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ChemicalStructure/PW C040974
type: ChemicalStructure
structure format: SMILES
structure data: CC(C(=O)NCCC(=O)NCCS)C(C)(C)COP([O-])([O-])=O

ChemicalStructure/PW C040973
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(CO)C(O)C([O-])=O

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Compound/PW C043187/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-Dihydroxyisovaleric acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0351985
type: UnificationXref
id: SMP0351985
db: SMPDB

Reference/KEGG Compound C04352
type: UnificationXref
id: C04352
db: KEGG Compound

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001178
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/ChemSpider 185
type: UnificationXref
id: 185
db: ChemSpider

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/ChEBI CHEBI 15905
type: UnificationXref
id: CHEBI:15905
db: ChEBI

Compound/PW C040972 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-dehydropantoate
stoichiometric coefficient: 1.0