ReactionCatalysis57172
type: Catalysis
controller: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
controlled: Reaction560118
control type: ACTIVATION

Reference/HMDB HMDB0010570
type: UnificationXref
id: HMDB0010570
db: HMDB

ReactionCatalysis57170
type: Catalysis
controller: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
controlled: 2.7.8.5
control type: ACTIVATION

Phosphatidate cytidylyltransferase 2
type: ProteinReference
xref: Reference/UniProt O95674

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ReactionCatalysis57179
type: Catalysis
controller: Cardiolipin synthase
controlled: Reaction560415
control type: ACTIVATION

Reference/PubChem-compound 439162
type: UnificationXref
id: 439162
db: PubChem-compound

NADH
type: SmallMolecule
entity reference: NADH

Reference/UniProt Q9NUQ2
type: UnificationXref
id: Q9NUQ2
db: UniProt

Cytidine triphosphate
type: SmallMolecule
entity reference: Cytidine triphosphate

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

CDP-DG(8:0/i-13:0)
type: SmallMoleculeReference
chemical formula: C33H59N3O15P2
molecular weight: 799.34216

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 371
type: UnificationXref
id: 371
db: ChemSpider

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/HMDB HMDB0112243
type: UnificationXref
id: HMDB0112243
db: HMDB

Compound/PW C006578/Stoichiometry/1.0
type: Stoichiometry
physical entity: PG(16:0/16:0)
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Cardiolipin Biosynthesis CL(8:0/i-13:0/14:0/i-24:0)
type: Pathway
pathway order: PathwayEnzymeReaction/5462771
pathway order: PathwayEnzymeReaction/5462766
pathway order: PathwayEnzymeReaction/5462767
pathway order: PathwayEnzymeReaction/5462765
pathway order: PathwayEnzymeReaction/5462768
pathway order: PathwayEnzymeReaction/5462769
pathway order: PathwayTransport/5462764
pathway order: PathwayEnzymeReaction/5462770
pathway order: PathwaySubPathway/368138
pathway component: ReactionCatalysis57172
pathway component: Reaction56279
pathway component: 2.7.7.41
pathway component: ReactionCatalysis57162
pathway component: 2.7.8.5
pathway component: Reaction560111
pathway component: Glycolysis
pathway component: ReactionCatalysis57170
pathway component: ReactionCatalysis57179
pathway component: ReactionCatalysis57167
pathway component: ReactionCatalysis45939
pathway component: Transport34100
pathway component: Reaction55814
pathway component: ReactionCatalysis45940
pathway component: Reaction560118
pathway component: Reaction560415
xref: Reference/SMPDB SMP0377870
xref: Reference/PathWhiz PW384436
organism: Homo sapiens

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Compound/PW C000064/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001070
type: UnificationXref
id: HMDB0001070
db: HMDB

NAD
type: SmallMolecule
entity reference: NAD

Compound/PW C062929/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPA(8:0/0:0)
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00681
type: UnificationXref
id: C00681
db: KEGG Compound

Octanoyl-CoA
type: SmallMolecule
entity reference: Octanoyl-CoA

ChemicalStructure/PW C062929
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCC(=O)OCC(O)COP(O)(O)=O

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reaction55814
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NAD
right: Glycerol 3-phosphate
spontaneous: false
left: NADH
left: Dihydroxyacetone phosphate
left: Hydrogen Ion
name: Dihydroxyacetone phosphate + Hydrogen Ion + NADH → Glycerol 3-phosphate + NAD
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

SubPathwayInteraction368138
type: Interaction
name: SubPathwayReaction
name: SubPathway368138Reaction
participant: Dihydroxyacetone phosphate

Reference/PubChem-compound 5497152
type: UnificationXref
id: 5497152
db: PubChem-compound

Reference/BioCyc CPD-196
type: UnificationXref
id: CPD-196
db: BioCyc

Reference/PubChem-compound 380
type: UnificationXref
id: 380
db: PubChem-compound

Isotridecanoyl-CoA
type: SmallMolecule
entity reference: Isotridecanoyl-CoA

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

CL(8:0/i-13:0/14:0/i-24:0)
type: SmallMolecule
entity reference: CL(8:0/i-13:0/14:0/i-24:0)

Compound/PW C000845/Stoichiometry/1.0
type: Stoichiometry
physical entity: Octanoyl-CoA
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Cardiolipin synthase
type: Protein
entity reference: Cardiolipin synthase

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
type: Protein
entity reference: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Isotridecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 71437
xref: Reference/HMDB HMDB0112243
xref: Reference/PubChem-compound 70680281
chemical formula: C34H60N7O17P3S
molecular weight: 963.2979
structure: ChemicalStructure/PW C063858

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

CL(8:0/i-13:0/14:0/i-24:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0120559
chemical formula: C68H132O17P2
molecular weight: 1282.8939
structure: ChemicalStructure/PW C209300

ReactionCatalysis57162
type: Catalysis
controller: 1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon
controlled: Reaction560111
control type: ACTIVATION

Reference/ChEBI CHEBI 71437
type: UnificationXref
id: CHEBI:71437
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ReactionCatalysis57167
type: Catalysis
controller: Phosphatidate cytidylyltransferase 2
controlled: 2.7.7.41
control type: ACTIVATION

Reference/KEGG Compound C00344
type: UnificationXref
id: C00344
db: KEGG Compound

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

CDP-DG(14:0/i-24:0)
type: SmallMoleculeReference
chemical formula: C50H93N3O15P2
molecular weight: 1037.6082

Reference/BioCyc ACYL-SN-GLYCEROL-3P
type: UnificationXref
id: ACYL-SN-GLYCEROL-3P
db: BioCyc

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

Reference/ChEBI CHEBI 16975
type: UnificationXref
id: CHEBI:16975
db: ChEBI

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/PathWhiz PW384436
type: UnificationXref
id: PW384436
db: PathWhiz

Protein/782/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
stoichiometric coefficient: 2.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Glycerol-3-phosphate acyltransferase 1, mitochondrial
type: Protein
entity reference: Glycerol-3-phosphate acyltransferase 1, mitochondrial

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Protein
entity reference: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Compound/PW C000057/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0114740
type: UnificationXref
id: HMDB0114740
db: HMDB

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChEBI CHEBI 15533
type: UnificationXref
id: CHEBI:15533
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/UniProt Q9HCL2
type: UnificationXref
id: Q9HCL2
db: UniProt

Glycerol 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GLYCEROL-3P
xref: Reference/HMDB HMDB0000126
xref: Reference/ChemSpider 388308
xref: Reference/CAS 17989-41-2
xref: Reference/KEGG Compound C00093
xref: Reference/ChEBI CHEBI 15978
xref: Reference/PubChem-compound 439162
chemical formula: C3H9O6P
molecular weight: 172.01367
structure: ChemicalStructure/PW C000081

ChemicalStructure/PW C064071
type: ChemicalStructure
structure format: SMILES

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Glycerol 3-phosphate
type: SmallMolecule
entity reference: Glycerol 3-phosphate

Octanoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01944
xref: Reference/ChEBI CHEBI 15533
xref: Reference/HMDB HMDB0001070
xref: Reference/ChemSpider 371
xref: Reference/BioCyc CPD-196
xref: Reference/PubChem-compound 380
xref: Reference/CAS 1264-52-4
chemical formula: C29H50N7O17P3S
molecular weight: 893.21967
structure: ChemicalStructure/PW C000845

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

PGP(8:0/i-13:0)
type: SmallMolecule
entity reference: PGP(8:0/i-13:0)

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/BioCyc L-PHOSPHATIDATE
type: UnificationXref
id: L-PHOSPHATIDATE
db: BioCyc

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

ChemicalStructure/PW C006578
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15978
type: UnificationXref
id: CHEBI:15978
db: ChEBI

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Compound/PW C246454/Stoichiometry/1.0
type: Stoichiometry
physical entity: PGP(8:0/i-13:0)
stoichiometric coefficient: 1.0

Compound/PW C247102/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-DG(14:0/i-24:0)
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Compound/PW C064071 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PA(8:0/i-13:0)
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388308
type: UnificationXref
id: 388308
db: ChemSpider

Reference/BioCyc L-1-PHOSPHATIDYL-GLYCEROL
type: UnificationXref
id: L-1-PHOSPHATIDYL-GLYCEROL
db: BioCyc

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Cardiolipin synthase
type: ProteinReference
xref: Reference/UniProt Q9UJA2

Compound/PW C063858/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isotridecanoyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis45939
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
controlled: Reaction55814
control type: ACTIVATION

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q32NB8

Cytidine monophosphate
type: SmallMolecule
entity reference: Cytidine monophosphate

Reference/UniProt Q9UJA2
type: UnificationXref
id: Q9UJA2
db: UniProt

Compound/PW C209300/Stoichiometry/1.0
type: Stoichiometry
physical entity: CL(8:0/i-13:0/14:0/i-24:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000126
type: UnificationXref
id: HMDB0000126
db: HMDB

PGP(8:0/i-13:0)
type: SmallMoleculeReference
chemical formula: C27H54O13P2
molecular weight: 648.30396

ReactionCatalysis45940
type: Catalysis
controller: Glycerol-3-phosphate acyltransferase 1, mitochondrial
controlled: Reaction56279
control type: ACTIVATION

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

2.7.7.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C247254/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C064071/Stoichiometry/1.0
right: CDP-DG(8:0/i-13:0)
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.41
left: Cytidine triphosphate
left: PA(8:0/i-13:0)
name: Cytidine triphosphate + PA(8:0/i-13:0) → CDP-DG(8:0/i-13:0) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.7.8.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C247254/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081/Stoichiometry/1.0
participant stoichiometry: Compound/PW C246454/Stoichiometry/1.0
right: Cytidine monophosphate
right: PGP(8:0/i-13:0)
spontaneous: false
EC number: 2.7.8.5
left: CDP-DG(8:0/i-13:0)
left: Glycerol 3-phosphate
name: CDP-DG(8:0/i-13:0) + Glycerol 3-phosphate → Cytidine monophosphate + PGP(8:0/i-13:0)
conversion direction: LEFT_TO_RIGHT

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reaction560111
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C064071/Stoichiometry/1.0
participant stoichiometry: Compound/PW C062929/Stoichiometry/1.0
participant stoichiometry: Compound/PW C063858/Stoichiometry/1.0
right: Coenzyme A
right: PA(8:0/i-13:0)
spontaneous: false
left: LysoPA(8:0/0:0)
left: Isotridecanoyl-CoA
name: Isotridecanoyl-CoA + LysoPA(8:0/0:0) → Coenzyme A + PA(8:0/i-13:0)
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 73205
type: UnificationXref
id: CHEBI:73205
db: ChEBI

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/UniProt Q32NB8
type: UnificationXref
id: Q32NB8
db: UniProt

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C000845
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Glycerol-3-phosphate acyltransferase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9HCL2

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate
name: SubPathwayOutput

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: ProteinReference
xref: Reference/UniProt P21695

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

Reference/UniProt P21695
type: UnificationXref
id: P21695
db: UniProt

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Reaction560118
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C246454/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006578/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: PG(16:0/16:0)
right: Phosphate
spontaneous: false
left: Water
left: PGP(8:0/i-13:0)
name: PGP(8:0/i-13:0) + Water → PG(16:0/16:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C064071/Stoichiometry/1.0
type: Stoichiometry
physical entity: PA(8:0/i-13:0)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C063858
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C209300
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Reference/PubChem-compound 70680281
type: UnificationXref
id: 70680281
db: PubChem-compound

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
type: Protein
entity reference: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon
type: Protein
entity reference: 1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Reference/UniProt Q8WUK0
type: UnificationXref
id: Q8WUK0
db: UniProt

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/ChemSpider 393791
type: UnificationXref
id: 393791
db: ChemSpider

Reaction56279
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000081/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C062929/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000845/Stoichiometry/1.0
right: Coenzyme A
right: LysoPA(8:0/0:0)
spontaneous: false
left: Octanoyl-CoA
left: Glycerol 3-phosphate
name: Glycerol 3-phosphate + Octanoyl-CoA → Coenzyme A + LysoPA(8:0/0:0)
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C01944
type: UnificationXref
id: C01944
db: KEGG Compound

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

CDP-DG(14:0/i-24:0)
type: SmallMolecule
entity reference: CDP-DG(14:0/i-24:0)

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

LysoPA(8:0/0:0)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16975
xref: Reference/PubChem-compound 5497152
xref: Reference/HMDB HMDB0114740
xref: Reference/KEGG Compound C00681
xref: Reference/BioCyc ACYL-SN-GLYCEROL-3P
chemical formula: C11H23O7P
molecular weight: 298.11813
structure: ChemicalStructure/PW C062929

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Compound/PW C001134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Compound/PW C064071 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PA(8:0/i-13:0)
stoichiometric coefficient: 1.0

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

LysoPA(8:0/0:0)
type: SmallMolecule
entity reference: LysoPA(8:0/0:0)

Reference/SMPDB SMP0377870
type: UnificationXref
id: SMP0377870
db: SMPDB

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt O95674
type: UnificationXref
id: O95674
db: UniProt

Reference/ChEBI CHEBI 16337
type: UnificationXref
id: CHEBI:16337
db: ChEBI

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

PG(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010570
xref: Reference/PubChem-compound 446440
xref: Reference/ChEBI CHEBI 73205
xref: Reference/BioCyc L-1-PHOSPHATIDYL-GLYCEROL
xref: Reference/KEGG Compound C00344
xref: Reference/ChemSpider 393791
chemical formula: C38H75O10P
molecular weight: 722.50977
structure: ChemicalStructure/PW C006578

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Phosphatidate cytidylyltransferase 2
type: Protein
entity reference: Phosphatidate cytidylyltransferase 2

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/CAS 17989-41-2
type: UnificationXref
id: 17989-41-2
db: CAS

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc GLYCEROL-3P
type: UnificationXref
id: GLYCEROL-3P
db: BioCyc

PA(8:0/i-13:0)
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: PA(8:0/i-13:0)

Transport34100
type: Transport
participant stoichiometry: Compound/PW C064071 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C064071 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: PA(8:0/i-13:0)
spontaneous: false
left: PA(8:0/i-13:0)
name: PA(8:0/i-13:0) (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Inner Membrane
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00093
type: UnificationXref
id: C00093
db: KEGG Compound

Reference/HMDB HMDB0115686
type: UnificationXref
id: HMDB0115686
db: HMDB

Reference/CAS 1264-52-4
type: UnificationXref
id: 1264-52-4
db: CAS

Reference/KEGG Compound C00416
type: UnificationXref
id: C00416
db: KEGG Compound

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
type: ProteinReference
xref: Reference/UniProt Q8WUK0

PA(8:0/i-13:0)
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: PA(8:0/i-13:0)

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway368138
pathway component: SubPathwayInteraction368138
name: SubPathway

PA(8:0/i-13:0)
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00416
xref: Reference/BioCyc L-PHOSPHATIDATE
xref: Reference/ChEBI CHEBI 16337
xref: Reference/HMDB HMDB0115686
chemical formula: C24H47O8P
molecular weight: 494.30084
structure: ChemicalStructure/PW C064071

1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon
type: ProteinReference
xref: Reference/UniProt Q9NUQ2

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Complex
component stoichiometry: Protein/782/Stoichiometry/2.0
component: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

PG(16:0/16:0)
type: SmallMolecule
entity reference: PG(16:0/16:0)

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0120559
type: UnificationXref
id: HMDB0120559
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reaction560415
type: BiochemicalReaction
participant stoichiometry: Compound/PW C209300/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C247102/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006578/Stoichiometry/1.0
right: Cytidine monophosphate
right: CL(8:0/i-13:0/14:0/i-24:0)
spontaneous: false
left: PG(16:0/16:0)
left: CDP-DG(14:0/i-24:0)
name: CDP-DG(14:0/i-24:0) + PG(16:0/16:0) → CL(8:0/i-13:0/14:0/i-24:0) + Cytidine monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Compound/PW C247254/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-DG(8:0/i-13:0)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C000081/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 446440
type: UnificationXref
id: 446440
db: PubChem-compound

CDP-DG(8:0/i-13:0)
type: SmallMolecule
entity reference: CDP-DG(8:0/i-13:0)

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

PA(8:0/i-13:0)
type: SmallMolecule
entity reference: PA(8:0/i-13:0)

ChemicalStructure/PW C000081
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)COP(O)(O)=O