Protein/41661/Stoichiometry/6.0
type: Stoichiometry
physical entity: Metallo-beta-lactamase domain-containing protein
stoichiometric coefficient: 6.0

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

L-xylulose -5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: L-xylulose -5-phosphate

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000691 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xylulose 5-phosphate
stoichiometric coefficient: 1.0

Dehydroascorbic acid
type: SmallMolecule
entity reference: Dehydroascorbic acid

NADH
type: SmallMolecule
entity reference: NADH

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

ChemicalStructure/PW C000691
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O

Carbohydrate kinase
type: ProteinReference
xref: Reference/UniProt I9S3V1

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/HMDB HMDB0006511
type: UnificationXref
id: HMDB0006511
db: HMDB

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

dehydroascorbate (bicyclic form)
type: SmallMolecule
entity reference: dehydroascorbate (bicyclic form)

L-ribulose 5-phosphate
type: SmallMolecule
entity reference: L-ribulose 5-phosphate

L-xylulose -5-phosphate
type: SmallMolecule
entity reference: L-xylulose -5-phosphate

3-keto-L-gulonate 6-phosphate
type: SmallMolecule
entity reference: 3-keto-L-gulonate 6-phosphate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

NAD
type: SmallMolecule
entity reference: NAD

Reference/PubChem-compound 439273
type: UnificationXref
id: 439273
db: PubChem-compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

L-ascorbate 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61698
chemical formula: C6H6O9P
molecular weight: 252.9766
structure: ChemicalStructure/PW C040859

Reference/ChEBI CHEBI 16142
type: UnificationXref
id: CHEBI:16142
db: ChEBI

Reference/ChEBI CHEBI 58226
type: UnificationXref
id: CHEBI:58226
db: ChEBI

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 3445-22-5
type: UnificationXref
id: 3445-22-5
db: CAS

Class II aldolase/adducin N-terminal domain-containing protein
type: Protein
cellular location: Cytosol
entity reference: Class II aldolase/adducin N-terminal domain-containing protein

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/UniProt I9GIX4
type: UnificationXref
id: I9GIX4
db: UniProt

3-keto-L-gulonate 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58774
chemical formula: C6H9O10P
molecular weight: 271.99445
structure: ChemicalStructure/PW C040860

dehydroascorbate (bicyclic form)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17242
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C040861

L-ribulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58226
chemical formula: C5H9O8P
molecular weight: 228.00461
structure: ChemicalStructure/PW C040862

L-xylulose -5-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 23615403
xref: Reference/ChEBI CHEBI 57829
chemical formula: C7H13O6P
molecular weight: 224.04607
structure: ChemicalStructure/PW C040863

Protein/28947 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Aspartokinase
type: ProteinReference
xref: Reference/UniProt I8X5A9
organism: Bacteroides nordii CL02T12C05

ChemicalStructure/PW C002724
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H](O)[C@@H](O)C(=O)[C@H](O)C(O)=O

Reference/ChemSpider 388330
type: UnificationXref
id: 388330
db: ChemSpider

Ascorbic acid
type: SmallMolecule
entity reference: Ascorbic acid

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Aspartokinase
type: Protein
cellular location: Inner Membrane
entity reference: Aspartokinase

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 57829
type: UnificationXref
id: CHEBI:57829
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Carbohydrate kinase
type: Protein
entity reference: Carbohydrate kinase

Reference/PathWhiz PW393019
type: UnificationXref
id: PW393019
db: PathWhiz

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

histidine kinase
type: Protein
cellular location: Inner Membrane
entity reference: histidine kinase

Reference/ChEBI CHEBI 58774
type: UnificationXref
id: CHEBI:58774
db: ChEBI

Reference/KEGG Compound C00231
type: UnificationXref
id: C00231
db: KEGG Compound

Compound/PW C002724/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Dehydro-L-gulonate
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/UniProt I9S7E8
type: UnificationXref
id: I9S7E8
db: UniProt

Reaction2702
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Ascorbic acid
right: Water
right: Dehydroascorbic acid
spontaneous: true
left: Ascorbic acid
left: Hydrogen peroxide
left: Hydrogen Ion
name: 2 Ascorbic acid + Hydrogen Ion + Hydrogen peroxide → Ascorbic acid + Dehydroascorbic acid + 2 Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reaction2700
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040861/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 2,3-Diketo-L-gulonate
right: Hydrogen Ion
spontaneous: true
left: dehydroascorbate (bicyclic form)
name: dehydroascorbate (bicyclic form) → 2,3-Diketo-L-gulonate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reaction2701
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000977/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040861/Stoichiometry/1.0
right: dehydroascorbate (bicyclic form)
spontaneous: true
left: Water
left: Dehydroascorbic acid
name: Dehydroascorbic acid + Water → dehydroascorbate (bicyclic form)
conversion direction: LEFT_TO_RIGHT

L-xylulose kinase
type: Complex
component stoichiometry: Protein/30738/Stoichiometry/2.0
component: Carbohydrate kinase

2,3-diketo-L-gulonate reductase
type: Complex
component stoichiometry: Protein/41662/Stoichiometry/2.0
component: Alkaline phosphatase

L-ascorbate 6-phosphate lactonase
type: Complex
component stoichiometry: Protein/41661/Stoichiometry/6.0
component: Metallo-beta-lactamase domain-containing protein

L-ascorbate PTS permease
type: Complex
cellular location: Inner Membrane
component: DNA mismatch repair proteins mutS family domain-containing protein
component: histidine kinase
component: Aspartokinase

Reference/PathWhiz PW000893
type: UnificationXref
id: PW000893
db: PathWhiz

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C04575
type: UnificationXref
id: C04575
db: KEGG Compound

Pentose Phosphate Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway384820
pathway component: SubPathwayInteraction384820
xref: Reference/PathWhiz PW000893
xref: Reference/SMPDB SMP0000912
name: SubPathway

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/SMPDB SMP0384695
type: UnificationXref
id: SMP0384695
db: SMPDB

TonB-dependent receptor plug domain-containing protein
type: Protein
cellular location: Cytosol
entity reference: TonB-dependent receptor plug domain-containing protein

Reference/PubChem-compound 439190
type: UnificationXref
id: 439190
db: PubChem-compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

Reference/ChEBI CHEBI 15622
type: UnificationXref
id: CHEBI:15622
db: ChEBI

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

L-ascorbate 6-phosphate
type: SmallMolecule
entity reference: L-ascorbate 6-phosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/BioCyc 2,3-diketo-l-gulonate
type: UnificationXref
id: 2,3-diketo-l-gulonate
db: BioCyc

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Bacteroides nordii CL02T12C05
type: BioSource
xref: Reference/TAXONOMY 997884

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0006334
type: UnificationXref
id: HMDB0006334
db: HMDB

Reference/CAS 60802-29-1
type: UnificationXref
id: 60802-29-1
db: CAS

Reference/TAXONOMY 997884
type: UnificationXref
id: 997884
db: TAXONOMY

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Alkaline phosphatase
type: Protein
entity reference: Alkaline phosphatase

Metallo-beta-lactamase domain-containing protein
type: Protein
entity reference: Metallo-beta-lactamase domain-containing protein

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C002783
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H](O)C(O)C(=O)C(=O)C(O)=O

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Orotidine 5'-phosphate decarboxylase
type: Protein
entity reference: Orotidine 5'-phosphate decarboxylase

Mannonate dehydratase
type: Protein
entity reference: Mannonate dehydratase

ChemicalStructure/PW C040862
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@@H](O)[C@@H](O)COP([O-])([O-])=O

ChemicalStructure/PW C040861
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Compound/PW C040863 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-xylulose -5-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040860
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP([O-])([O-])=O)C(O)C(=O)C(O)C(O)=O

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040863
type: ChemicalStructure
structure format: SMILES
structure data: CC(COP([O-])([O-])=O)C(C)C(=O)CO

Reference/UniProt I8X999
type: UnificationXref
id: I8X999
db: UniProt

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

3-Dehydro-L-gulonate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00618
xref: Reference/ChemSpider 388406
xref: Reference/HMDB HMDB0006334
xref: Reference/PubChem-compound 439273
xref: Reference/ChEBI CHEBI 16142
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C002724

Reference/UniProt I8X5A9
type: UnificationXref
id: I8X5A9
db: UniProt

L-ascorbate 6-phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-ascorbate 6-phosphate

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Xylulose 5-phosphate
type: SmallMolecule
entity reference: Xylulose 5-phosphate

Water
type: SmallMolecule
entity reference: Water

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Reference/ChEBI CHEBI 61698
type: UnificationXref
id: CHEBI:61698
db: ChEBI

Protein/41662/Stoichiometry/2.0
type: Stoichiometry
physical entity: Alkaline phosphatase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Ascorbate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/5567719
pathway order: PathwaySubPathway/384820
pathway order: PathwayEnzymeReaction/5567721
pathway order: PathwayEnzymeReaction/5567720
pathway order: PathwayEnzymeReaction/5567723
pathway order: PathwayEnzymeReaction/5567722
pathway order: PathwayEnzymeReaction/5567725
pathway order: PathwayEnzymeReaction/5567724
pathway order: PathwayEnzymeReaction/5567716
pathway order: PathwayEnzymeReaction/5567727
pathway order: PathwayEnzymeReaction/5567726
pathway order: PathwayEnzymeReaction/5567718
pathway order: PathwayEnzymeReaction/5567717
pathway order: PathwayEnzymeReaction/5567728
pathway component: ReactionCatalysis602278
pathway component: ReactionCatalysis602279
pathway component: Pentose Phosphate Pathway
pathway component: Reaction608410
pathway component: ReactionCoupledTransportCatalysis6798
pathway component: 3.1.1.-
pathway component: 2.7.1.-
pathway component: 1.1.1.130
pathway component: 4.1.1.85
pathway component: Reaction608406
pathway component: 5.1.3.4
pathway component: Reaction608408
pathway component: ReactionCatalysis602280
pathway component: Reaction2702
pathway component: ReactionCatalysis602281
pathway component: ReactionCatalysis602282
pathway component: Reaction2700
pathway component: ReactionCatalysis602283
pathway component: Reaction2701
pathway component: ReactionCatalysis602275
pathway component: ReactionCatalysis602276
pathway component: ReactionCatalysis602277
xref: Reference/SMPDB SMP0384695
xref: Reference/PathWhiz PW393019
organism: Bacteroides nordii CL02T12C05

Reference/ChemSpider 388406
type: UnificationXref
id: 388406
db: ChemSpider

Reference/UniProt I8XF38
type: UnificationXref
id: I8XF38
db: UniProt

Compound/PW C000031/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 2.0

Compound/PW C040861/Stoichiometry/1.0
type: Stoichiometry
physical entity: dehydroascorbate (bicyclic form)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Compound/PW C040860/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-keto-L-gulonate 6-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/KEGG Compound C00618
type: UnificationXref
id: C00618
db: KEGG Compound

Reference/PubChem-compound 53477844
type: UnificationXref
id: 53477844
db: PubChem-compound

Compound/PW C000031 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Class II aldolase/adducin N-terminal domain-containing protein
type: ProteinReference
xref: Reference/UniProt I9H476
organism: Bacteroides nordii CL02T12C05

Compound/PW C000691/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xylulose 5-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Unknown
type: ProteinReference

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/PubChem-compound 23615403
type: UnificationXref
id: 23615403
db: PubChem-compound

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

2.7.1.-
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000031 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/28947 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040859 Inner Membrane/Stoichiometry/1.0
right: Unknown
right: L-ascorbate 6-phosphate
spontaneous: false
EC number: 2.7.1.-
left: Ascorbic acid
left: Unknown
name: Ascorbic acid + HPr - phosphorylated → HPr + L-ascorbate 6-phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis602280
type: Catalysis
controller: Unknown
controlled: 5.1.3.4
control type: ACTIVATION

ReactionCatalysis602281
type: Catalysis
controller: TonB-dependent receptor plug domain-containing protein
controlled: Reaction608408
control type: ACTIVATION

ReactionCatalysis602282
type: Catalysis
controller: Class II aldolase/adducin N-terminal domain-containing protein
controlled: 5.1.3.4
control type: ACTIVATION

ReactionCatalysis602283
type: Catalysis
controller: Mannonate dehydratase
controlled: Reaction608410
control type: ACTIVATION

Reference/UniProt I9RMZ9
type: UnificationXref
id: I9RMZ9
db: UniProt

ReactionCatalysis602278
type: Catalysis
controller: Orotidine 5'-phosphate decarboxylase
controlled: 4.1.1.85
control type: ACTIVATION

Reference/UniProt I8X1M0
type: UnificationXref
id: I8X1M0
db: UniProt

ReactionCatalysis602279
type: Catalysis
controller: Orotidine 5'-phosphate decarboxylase
controlled: Reaction608406
control type: ACTIVATION

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Protein/30738/Stoichiometry/2.0
type: Stoichiometry
physical entity: Carbohydrate kinase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

3-Dehydro-L-gulonate
type: SmallMolecule
entity reference: 3-Dehydro-L-gulonate

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C000977/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Compound/PW C040863/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-xylulose -5-phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

ReactionCatalysis602275
type: Catalysis
controller: L-ascorbate 6-phosphate lactonase
controlled: 3.1.1.-
control type: ACTIVATION

ReactionCatalysis602276
type: Catalysis
controller: L-xylulose kinase
controlled: 2.7.1.-
control type: ACTIVATION

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

ReactionCatalysis602277
type: Catalysis
controller: 2,3-diketo-L-gulonate reductase
controlled: 1.1.1.130
control type: ACTIVATION

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Alkaline phosphatase
type: ProteinReference
xref: Reference/UniProt I8XLV0

Reference/UniProt I9H476
type: UnificationXref
id: I9H476
db: UniProt

Mannonate dehydratase
type: ProteinReference
xref: Reference/UniProt I8X999

TonB-dependent receptor plug domain-containing protein
type: ProteinReference
xref: Reference/UniProt I9GIX4
organism: Bacteroides nordii CL02T12C05

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: Reference/UniProt I9S7E8

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

histidine kinase
type: ProteinReference
xref: Reference/UniProt I9RMZ9
organism: Bacteroides nordii CL02T12C05

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/ChEBI CHEBI 16332
type: UnificationXref
id: CHEBI:16332
db: ChEBI

DNA mismatch repair proteins mutS family domain-containing protein
type: ProteinReference
xref: Reference/UniProt I8X1M0
organism: Bacteroides nordii CL02T12C05

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Metallo-beta-lactamase domain-containing protein
type: ProteinReference
xref: Reference/UniProt I8XF38

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/UniProt I9S3V1
type: UnificationXref
id: I9S3V1
db: UniProt

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Xylulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Xylulose 5-phosphate
name: SubPathwayInput

Ascorbic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Ascorbic acid

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

2,3-Diketo-L-gulonate
type: SmallMolecule
entity reference: 2,3-Diketo-L-gulonate

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

2,3-Diketo-L-gulonate
type: SmallMoleculeReference
xref: Reference/CAS 3445-22-5
xref: Reference/KEGG Compound C04575
xref: Reference/PubChem-compound 53477844
xref: Reference/ChEBI CHEBI 15622
xref: Reference/HMDB HMDB0006511
xref: Reference/BioCyc 2,3-diketo-l-gulonate
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C002783

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

SubPathwayInteraction384820
type: Interaction
name: SubPathway384820Reaction
name: SubPathwayReaction
participant: Xylulose 5-phosphate

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/HMDB HMDB0000868
type: UnificationXref
id: HMDB0000868
db: HMDB

Compound/PW C040859 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-ascorbate 6-phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc XYLULOSE-5-PHOSPHATE
type: UnificationXref
id: XYLULOSE-5-PHOSPHATE
db: BioCyc

ReactionCoupledTransportCatalysis6798
type: Catalysis
controller: L-ascorbate PTS permease
controlled: 2.7.1.-
control type: ACTIVATION

3.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040859/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040860/Stoichiometry/1.0
right: 3-keto-L-gulonate 6-phosphate
spontaneous: false
EC number: 3.1.1.-
left: Water
left: L-ascorbate 6-phosphate
name: L-ascorbate 6-phosphate + Water → 3-keto-L-gulonate 6-phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C002783/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-Diketo-L-gulonate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Compound/PW C040862/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-ribulose 5-phosphate
stoichiometric coefficient: 1.0

L-ribulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: L-ribulose 5-phosphate

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Xylulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000868
xref: Reference/KEGG Compound C00231
xref: Reference/BioCyc XYLULOSE-5-PHOSPHATE
xref: Reference/PubChem-compound 439190
xref: Reference/CAS 60802-29-1
xref: Reference/ChEBI CHEBI 16332
xref: Reference/ChemSpider 388330
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000691

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/SMPDB SMP0000912
type: UnificationXref
id: SMP0000912
db: SMPDB

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ChemicalStructure/PW C040859
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)COP([O-])([O-])=O

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Compound/PW C000031/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reaction608410
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040862/Stoichiometry/1.0
right: L-ribulose 5-phosphate
spontaneous: false
left: L-xylulose -5-phosphate
name: L-xylulose -5-phosphate → L-ribulose 5-phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002724/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040860/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: 3-keto-L-gulonate 6-phosphate
spontaneous: false
EC number: 2.7.1.-
left: 3-Dehydro-L-gulonate
left: Adenosine triphosphate
name: 3-Dehydro-L-gulonate + Adenosine triphosphate → 3-keto-L-gulonate 6-phosphate + Adenosine diphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Reference/UniProt I8XLV0
type: UnificationXref
id: I8XLV0
db: UniProt

1.1.1.130
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002724/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 3-Dehydro-L-gulonate
right: NAD
spontaneous: false
EC number: 1.1.1.130
left: 2,3-Diketo-L-gulonate
left: NADH
left: Hydrogen Ion
name: 2,3-Diketo-L-gulonate + Hydrogen Ion + NADH → 3-Dehydro-L-gulonate + NAD
conversion direction: LEFT_TO_RIGHT

4.1.1.85
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040860/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-xylulose -5-phosphate
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.85
left: Hydrogen Ion
left: 3-keto-L-gulonate 6-phosphate
name: 3-keto-L-gulonate 6-phosphate + Hydrogen Ion → Carbon dioxide + L-xylulose -5-phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reaction608406
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040860/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-xylulose -5-phosphate
right: Carbon dioxide
spontaneous: false
left: Hydrogen Ion
left: 3-keto-L-gulonate 6-phosphate
name: 3-keto-L-gulonate 6-phosphate + Hydrogen Ion → Carbon dioxide + L-xylulose -5-phosphate
conversion direction: LEFT_TO_RIGHT

5.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040862/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000691/Stoichiometry/1.0
right: Xylulose 5-phosphate
spontaneous: false
EC number: 5.1.3.4
left: L-ribulose 5-phosphate
name: L-ribulose 5-phosphate → Xylulose 5-phosphate
conversion direction: LEFT_TO_RIGHT

DNA mismatch repair proteins mutS family domain-containing protein
type: Protein
cellular location: Inner Membrane
entity reference: DNA mismatch repair proteins mutS family domain-containing protein

Reaction608408
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040863 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040862 Cytosol/Stoichiometry/1.0
right: L-ribulose 5-phosphate
spontaneous: false
left: L-xylulose -5-phosphate
name: L-xylulose -5-phosphate → L-ribulose 5-phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C040859/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-ascorbate 6-phosphate
stoichiometric coefficient: 1.0

5.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000691 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040862 Cytosol/Stoichiometry/1.0
right: Xylulose 5-phosphate
spontaneous: false
EC number: 5.1.3.4
left: L-ribulose 5-phosphate
name: L-ribulose 5-phosphate → Xylulose 5-phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C040862 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-ribulose 5-phosphate
stoichiometric coefficient: 1.0