Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

L,L-diaminopimelate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57609
chemical formula: C7H14N2O4
molecular weight: 190.09535
structure: ChemicalStructure/PW C040840

meso-diaminopimelate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57791
chemical formula: C7H14N2O4
molecular weight: 190.09535
structure: ChemicalStructure/PW C040841

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

SubPathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway385898
pathway component: SubPathwayInteraction385898

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/CAS 22138-53-0
type: UnificationXref
id: 22138-53-0
db: CAS

Compound/PW C040839 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-2,3,4,5-tetrahydrodipicolinate
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Methionine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway385900
pathway component: SubPathwayInteraction385900
xref: Reference/SMPDB SMP0000834
xref: Reference/PathWhiz PW000814
name: SubPathway

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

N-succinyldiaminopimelate aminotransferase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

L,L-diaminopimelate
type: SmallMolecule
cellular location: Cytosol
entity reference: L,L-diaminopimelate

Reference/ChemSpider 809
type: UnificationXref
id: 809
db: ChemSpider

N-Succinyl-L,L-2,6-diaminopimelate
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Succinyl-L,L-2,6-diaminopimelate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5962
type: UnificationXref
id: 5962
db: PubChem-compound

Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

(S)-2,3,4,5-tetrahydrodipicolinate
type: SmallMolecule
cellular location: Cytosol
entity reference: (S)-2,3,4,5-tetrahydrodipicolinate

Protein/29235 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/PubChem-compound 25202447
type: UnificationXref
id: 25202447
db: PubChem-compound

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Succinic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/ChemSpider 5747
type: UnificationXref
id: 5747
db: ChemSpider

TransportCatalysis26562
type: Catalysis
controller: Unknown
controlled: Transport44391
control type: ACTIVATION

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

TransportCatalysis26561
type: Catalysis
controller: Unknown
controlled: Transport44390
control type: ACTIVATION

TransportCatalysis26560
type: Catalysis
controller: Unknown
controlled: Transport44389
control type: ACTIVATION

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

aspartate semialdehyde dehydrogenase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Lysine Biosynthesis
type: Pathway
pathway order: PathwayTransport/5573791
pathway order: PathwayTransport/5573790
pathway order: PathwaySubPathway/385900
pathway order: PathwaySubPathway/385898
pathway order: PathwaySubPathway/385899
pathway order: PathwayTransport/5573789
pathway order: PathwayTransport/5573788
pathway order: PathwayEnzymeReaction/5573777
pathway order: PathwayEnzymeReaction/5573779
pathway order: PathwayEnzymeReaction/5573767
pathway order: PathwayEnzymeReaction/5573772
pathway order: PathwayEnzymeReaction/5573783
pathway order: PathwayEnzymeReaction/5573775
pathway order: PathwayEnzymeReaction/5573786
pathway order: PathwayEnzymeReaction/5573774
pathway order: PathwayEnzymeReaction/5573785
pathway order: PathwayInteraction/7050
pathway order: PathwayInteraction/7051
pathway order: PathwayEnzymeReaction/5573781
pathway component: ReactionCatalysis606428
pathway component: TransportCatalysis26562
pathway component: TransportCatalysis26561
pathway component: ReactionCoupledTransportCatalysis6151
pathway component: TransportCatalysis26560
pathway component: SubPathway
pathway component: 2.7.2.4
pathway component: 4.1.1.20
pathway component: 1.2.1.11
pathway component: ReactionCatalysis606441
pathway component: Methionine Biosynthesis
pathway component: 5.1.1.7
pathway component: Transport44389
pathway component: Lysine Degradation
pathway component: ReactionCatalysis606444
pathway component: Transport44391
pathway component: ReactionCatalysis606439
pathway component: ReactionCatalysis606437
pathway component: ReactionCoupledTransport6089
pathway component: Interaction7050
pathway component: Interaction7051
pathway component: Transport44390
pathway component: 3.5.1.18
pathway component: Transport40698
pathway component: Reaction612526
pathway component: ReactionCatalysis606430
pathway component: 4.3.3.7
pathway component: ReactionCatalysis606431
pathway component: TransportCatalysis23513
pathway component: 2.3.1.117
pathway component: ReactionCatalysis606435
pathway component: 1.17.1.8
pathway component: ReactionCatalysis606433
xref: Reference/SMPDB SMP0385276
xref: Reference/PathWhiz PW393666
organism: Proteus mirabilis ATCC 29906

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/BioCyc LYS
type: UnificationXref
id: LYS
db: BioCyc

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChemSpider 389314
type: UnificationXref
id: 389314
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C040840 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L,L-diaminopimelate
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/SMPDB SMP0000795
type: UnificationXref
id: SMP0000795
db: SMPDB

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

L-aspartic 4-semialdehyde
type: SmallMolecule
entity reference: L-aspartic 4-semialdehyde
name: SubPathwayInput

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

2.7.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007795 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: L-Aspartyl-4-phosphate
spontaneous: false
EC number: 2.7.2.4
left: L-Aspartic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + L-Aspartyl-4-phosphate
conversion direction: LEFT_TO_RIGHT

4.1.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000118/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040841/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Carbon dioxide
right: L-Lysine
spontaneous: false
EC number: 4.1.1.20
left: meso-diaminopimelate
left: Hydrogen Ion
name: Hydrogen Ion + meso-diaminopimelate → Carbon dioxide + L-Lysine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/CAS 56-87-1
type: UnificationXref
id: 56-87-1
db: CAS

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

1.2.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040837 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007795 Cytosol/Stoichiometry/1.0
right: Phosphate
right: L-aspartic 4-semialdehyde
right: NADP
spontaneous: false
EC number: 1.2.1.11
left: Hydrogen Ion
left: L-Aspartyl-4-phosphate
left: NADPH
name: Hydrogen Ion + L-Aspartyl-4-phosphate + NADPH → L-aspartic 4-semialdehyde + NADP + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Compound/PW C000808 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

L-Lysine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Lysine
name: SubPathwayInput

diaminopimelate epimerase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/PathWhiz PW000772
type: UnificationXref
id: PW000772
db: PathWhiz

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

ReactionCoupledTransport6089
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000123 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Hydrogen Ion
right: L-Aspartic acid
spontaneous: false
left: Water
left: Adenosine triphosphate
left: L-Aspartic acid
name: Adenosine triphosphate + L-Aspartic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Aspartic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C040841/Stoichiometry/1.0
type: Stoichiometry
physical entity: meso-diaminopimelate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

L-Aspartic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Aspartic acid

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

3.5.1.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040840 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007811 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: L,L-diaminopimelate
right: Succinic acid
spontaneous: false
EC number: 3.5.1.18
left: N-Succinyl-L,L-2,6-diaminopimelate
left: Water
name: N-Succinyl-L,L-2,6-diaminopimelate + Water → L,L-diaminopimelate + Succinic acid
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reaction612526
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007811 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007810 Cytosol/Stoichiometry/1.0
right: Oxoglutaric acid
right: N-Succinyl-L,L-2,6-diaminopimelate
spontaneous: false
left: N-Succinyl-2-amino-6-ketopimelate
left: L-Glutamic acid
name: L-Glutamic acid + N-Succinyl-2-amino-6-ketopimelate → N-Succinyl-L,L-2,6-diaminopimelate + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000123 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03082
type: UnificationXref
id: C03082
db: KEGG Compound

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Protein/29235 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

4.3.3.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040837 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040838 Cytosol/Stoichiometry/1.0
right: (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
right: Hydrogen Ion
right: Water
spontaneous: false
EC number: 4.3.3.7
left: Pyruvic acid
left: L-aspartic 4-semialdehyde
name: L-aspartic 4-semialdehyde + Pyruvic acid → (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

TransportCatalysis23513
type: Catalysis
controller: Unknown
controlled: Transport40698
control type: ACTIVATION

2.3.1.117
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007810 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000808 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040839 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: N-Succinyl-2-amino-6-ketopimelate
spontaneous: false
EC number: 2.3.1.117
left: (S)-2,3,4,5-tetrahydrodipicolinate
left: Succinyl-CoA
left: Water
name: (S)-2,3,4,5-tetrahydrodipicolinate + Succinyl-CoA + Water → Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
conversion direction: LEFT_TO_RIGHT

1.17.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040838 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040839 Cytosol/Stoichiometry/1.0
right: (S)-2,3,4,5-tetrahydrodipicolinate
right: NADP
right: Water
spontaneous: false
EC number: 1.17.1.8
left: (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
left: Hydrogen Ion
left: NADPH
name: (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + NADPH → (S)-2,3,4,5-tetrahydrodipicolinate + NADP + Water
conversion direction: LEFT_TO_RIGHT

Succinyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinyl-CoA

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

L-Aspartic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Aspartic acid

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Compound/PW C000174 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

ReactionCoupledTransportCatalysis6151
type: Catalysis
controller: Unknown
controlled: ReactionCoupledTransport6089
control type: ACTIVATION

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Reference/ChEBI CHEBI 67139
type: UnificationXref
id: CHEBI:67139
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

meso-diaminopimelate
type: SmallMolecule
entity reference: meso-diaminopimelate

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/ChEBI CHEBI 16845
type: UnificationXref
id: CHEBI:16845
db: ChEBI

Reference/TAXONOMY 525369
type: UnificationXref
id: 525369
db: TAXONOMY

ChemicalStructure/PW C000118
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC[C@H](N)C(O)=O

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

L-aspartic 4-semialdehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 537519
chemical formula: C4H7NO3
molecular weight: 117.042595
structure: ChemicalStructure/PW C040837

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 67139
chemical formula: C7H7NO5
molecular weight: 185.03352
structure: ChemicalStructure/PW C040838

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

(S)-2,3,4,5-tetrahydrodipicolinate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16845
chemical formula: C7H7NO4
molecular weight: 169.0386
structure: ChemicalStructure/PW C040839

tetrahydrodipicolinate succinylase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Protein/29235/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

N-Succinyl-L,L-2,6-diaminopimelate
type: SmallMoleculeReference
xref: Reference/BioCyc N-SUCCINYLLL-2-6-DIAMINOPIMELATE
xref: Reference/HMDB HMDB0012267
xref: Reference/PubChem-compound 25202447
xref: Reference/CAS 26605-36-7
xref: Reference/KEGG Compound C04421
chemical formula: C11H18N2O7
molecular weight: 290.1114
structure: ChemicalStructure/PW C007811

N-Succinyl-2-amino-6-ketopimelate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012266
xref: Reference/ChemSpider 389314
xref: Reference/KEGG Compound C04462
xref: Reference/BioCyc N-SUCCINYL-2-AMINO-6-KETOPIMELATE
xref: Reference/PubChem-compound 440349
xref: Reference/ChEBI CHEBI 35266
chemical formula: C11H15NO8
molecular weight: 289.07977
structure: ChemicalStructure/PW C007810

ChemicalStructure/PW C007795
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)OP(O)(O)=O)C(O)=O

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Compound/PW C000123 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine triphosphate

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Compound/PW C040841 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: meso-diaminopimelate
stoichiometric coefficient: 1.0

Compound/PW C040034 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Lysine Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway385899
pathway component: SubPathwayInteraction385899
xref: Reference/PathWhiz PW000772
xref: Reference/SMPDB SMP0000795
name: SubPathway

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Phosphate

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C007810 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Succinyl-2-amino-6-ketopimelate
stoichiometric coefficient: 1.0

Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Reference/KEGG Compound C00047
type: UnificationXref
id: C00047
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C007811
type: ChemicalStructure
structure format: SMILES

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Compound/PW C040837 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-aspartic 4-semialdehyde
stoichiometric coefficient: 1.0

ChemicalStructure/PW C007810
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Compound/PW C040034 Periplasmic Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Aspartate kinase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

Reference/ChEBI CHEBI 18019
type: UnificationXref
id: CHEBI:18019
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/HMDB HMDB0012250
type: UnificationXref
id: HMDB0012250
db: HMDB

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/BioCyc L-BETA-ASPARTYL-P
type: UnificationXref
id: L-BETA-ASPARTYL-P
db: BioCyc

Unknown
type: ProteinReference

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

5.1.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040840 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040841 Cytosol/Stoichiometry/1.0
right: meso-diaminopimelate
spontaneous: false
EC number: 5.1.1.7
left: L,L-diaminopimelate
name: L,L-diaminopimelate → meso-diaminopimelate
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/HMDB HMDB0012266
type: UnificationXref
id: HMDB0012266
db: HMDB

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/HMDB HMDB0012267
type: UnificationXref
id: HMDB0012267
db: HMDB

Reference/SMPDB SMP0000834
type: UnificationXref
id: SMP0000834
db: SMPDB

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 57791
type: UnificationXref
id: CHEBI:57791
db: ChEBI

N-succinyl-L-diaminopimelate desuccinylase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C007811 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Succinyl-L,L-2,6-diaminopimelate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Compound/PW C000174 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04421
type: UnificationXref
id: C04421
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/ChEBI CHEBI 35266
type: UnificationXref
id: CHEBI:35266
db: ChEBI

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

SubPathwayInteraction385898
type: Interaction
name: SubPathwayReaction
name: SubPathway385898Reaction
participant: meso-diaminopimelate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
type: SmallMolecule
cellular location: Cytosol
entity reference: (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

diaminopimelate decarboxylase
type: Complex
component stoichiometry: Protein/29235/Stoichiometry/4.0
component: Unknown

SubPathwayInteraction385899
type: Interaction
name: SubPathway385899Reaction
name: SubPathwayReaction
participant: L-Lysine

Succinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinic acid

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 26605-36-7
type: UnificationXref
id: 26605-36-7
db: CAS

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

ReactionCatalysis606428
type: Catalysis
controller: diaminopimelate decarboxylase
controlled: 4.1.1.20
control type: ACTIVATION

Reference/SMPDB SMP0385276
type: UnificationXref
id: SMP0385276
db: SMPDB

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Proteus mirabilis ATCC 29906
type: BioSource
xref: Reference/TAXONOMY 525369

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/PubChem-compound 440349
type: UnificationXref
id: 440349
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

4-hydroxy-tetrahydrodipicolinate synthase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Reference/BioCyc N-SUCCINYL-2-AMINO-6-KETOPIMELATE
type: UnificationXref
id: N-SUCCINYL-2-AMINO-6-KETOPIMELATE
db: BioCyc

Compound/PW C000118/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lysine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 537519
type: UnificationXref
id: CHEBI:537519
db: ChEBI

Reference/PathWhiz PW393666
type: UnificationXref
id: PW393666
db: PathWhiz

Transport44389
type: Transport
participant stoichiometry: Compound/PW C000123 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Periplasmic Space/Stoichiometry/1.0
right: L-Aspartic acid
right: Succinic acid
spontaneous: false
left: L-Aspartic acid
left: Succinic acid
name: L-Aspartic acid (→), Succinic acid (←) Transport: Proteus mirabilis ATCC 29906, Periplasmic Space to Proteus mirabilis ATCC 29906, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C040838 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Compound/PW C007795 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartyl-4-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Reference/PathWhiz PW000814
type: UnificationXref
id: PW000814
db: PathWhiz

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

L-Lysine
type: SmallMoleculeReference
xref: Reference/BioCyc LYS
xref: Reference/ChEBI CHEBI 18019
xref: Reference/ChemSpider 5747
xref: Reference/CAS 56-87-1
xref: Reference/HMDB HMDB0000182
xref: Reference/PubChem-compound 5962
xref: Reference/KEGG Compound C00047
chemical formula: C6H14N2O2
molecular weight: 146.10553
structure: ChemicalStructure/PW C000118

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

4-hydroxy-tetrahydrodipicolinate reductase
type: Complex
component stoichiometry: Protein/29235 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/PubChem-compound 832
type: UnificationXref
id: 832
db: PubChem-compound

Interaction7050
type: MolecularInteraction
interaction type: direct_interaction
name: L-Lysine inhibits 4-hydroxy-tetrahydrodipicolinate synthase
participant: 4-hydroxy-tetrahydrodipicolinate synthase
participant: L-Lysine

Interaction7051
type: MolecularInteraction
interaction type: direct_interaction
name: L-Lysine inhibits Aspartate kinase
participant: Aspartate kinase
participant: L-Lysine

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C040837
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC=O)C(O)=O

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ChemicalStructure/PW C040839
type: ChemicalStructure
structure format: SMILES
structure data: [O-]C(=O)C1CCCC(=N1)C([O-])=O

ChemicalStructure/PW C040838
type: ChemicalStructure
structure format: SMILES
structure data: OC1CC(N=C(C1)C([O-])=O)C([O-])=O

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Transport40698
type: Transport
participant stoichiometry: Compound/PW C000123 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
right: L-Aspartic acid
spontaneous: false
left: L-Aspartic acid
name: L-Aspartic acid (→) Transport: Proteus mirabilis ATCC 29906, Periplasmic Space to Proteus mirabilis ATCC 29906, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

L-Aspartyl-4-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc L-BETA-ASPARTYL-P
xref: Reference/KEGG Compound C03082
xref: Reference/ChemSpider 809
xref: Reference/PubChem-compound 832
xref: Reference/CAS 22138-53-0
xref: Reference/HMDB HMDB0012250
chemical formula: C4H8NO7P
molecular weight: 213.00385
structure: ChemicalStructure/PW C007795

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 57609
type: UnificationXref
id: CHEBI:57609
db: ChEBI

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/HMDB HMDB0000182
type: UnificationXref
id: HMDB0000182
db: HMDB

L-aspartic 4-semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: L-aspartic 4-semialdehyde

ChemicalStructure/PW C040840
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC[C@H](N)C(O)=O)C(O)=O

ChemicalStructure/PW C040841
type: ChemicalStructure
structure format: SMILES

L-Lysine
type: SmallMolecule
entity reference: L-Lysine

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04462
type: UnificationXref
id: C04462
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

SubPathwayInteraction385900
type: Interaction
name: SubPathwayReaction
name: SubPathway385900Reaction
participant: L-aspartic 4-semialdehyde

ReactionCatalysis606441
type: Catalysis
controller: N-succinyl-L-diaminopimelate desuccinylase
controlled: 3.5.1.18
control type: ACTIVATION

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

ReactionCatalysis606444
type: Catalysis
controller: diaminopimelate epimerase
controlled: 5.1.1.7
control type: ACTIVATION

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/BioCyc N-SUCCINYLLL-2-6-DIAMINOPIMELATE
type: UnificationXref
id: N-SUCCINYLLL-2-6-DIAMINOPIMELATE
db: BioCyc

Transport44391
type: Transport
participant stoichiometry: Compound/PW C000123 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
right: L-Aspartic acid
right: Hydrogen Ion
spontaneous: false
left: L-Aspartic acid
left: Hydrogen Ion
name: L-Aspartic acid (→), Hydrogen Ion (→) Transport: Proteus mirabilis ATCC 29906, Periplasmic Space to Proteus mirabilis ATCC 29906, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis606439
type: Catalysis
controller: N-succinyldiaminopimelate aminotransferase
controlled: Reaction612526
control type: ACTIVATION

ReactionCatalysis606437
type: Catalysis
controller: tetrahydrodipicolinate succinylase
controlled: 2.3.1.117
control type: ACTIVATION

meso-diaminopimelate
type: SmallMolecule
cellular location: Cytosol
entity reference: meso-diaminopimelate
name: SubPathwayInput

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

L-Aspartyl-4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartyl-4-phosphate

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

N-Succinyl-2-amino-6-ketopimelate
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Succinyl-2-amino-6-ketopimelate

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Transport44390
type: Transport
participant stoichiometry: Compound/PW C000123 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/2.0
right: L-Aspartic acid
right: Hydrogen Ion
spontaneous: false
left: L-Aspartic acid
left: Hydrogen Ion
name: L-Aspartic acid (→), Hydrogen Ion (→) Transport: Proteus mirabilis ATCC 29906, Periplasmic Space to Proteus mirabilis ATCC 29906, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ReactionCatalysis606430
type: Catalysis
controller: Aspartate kinase
controlled: 2.7.2.4
control type: ACTIVATION

ReactionCatalysis606431
type: Catalysis
controller: aspartate semialdehyde dehydrogenase
controlled: 1.2.1.11
control type: ACTIVATION

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Adenosine diphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine diphosphate

ReactionCatalysis606435
type: Catalysis
controller: 4-hydroxy-tetrahydrodipicolinate reductase
controlled: 1.17.1.8
control type: ACTIVATION

Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis606433
type: Catalysis
controller: 4-hydroxy-tetrahydrodipicolinate synthase
controlled: 4.3.3.7
control type: ACTIVATION