Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/UniProt C7X6C1
type: UnificationXref
id: C7X6C1
db: UniProt

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Compound/PW C000936/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/TAXONOMY 563193
type: UnificationXref
id: 563193
db: TAXONOMY

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 6267
type: UnificationXref
id: 6267
db: PubChem-compound

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

Reference/HMDB HMDB0000536
type: UnificationXref
id: HMDB0000536
db: HMDB

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Argininosuccinic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03406
xref: Reference/ChemSpider 16059
xref: Reference/HMDB HMDB0000052
xref: Reference/PubChem-compound 16950
xref: Reference/CAS 2387-71-5
xref: Reference/ChEBI CHEBI 15682
chemical formula: C10H18N4O6
molecular weight: 290.12262
structure: ChemicalStructure/PW C000036

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/SMPDB SMP0385518
type: UnificationXref
id: SMP0385518
db: SMPDB

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

N-carbamoyl-L-aspartate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 21960964
chemical formula: C5H6N2O5
molecular weight: 174.02876
structure: ChemicalStructure/PW C040852

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Compound/PW C000036/Stoichiometry/1.0
type: Stoichiometry
physical entity: Argininosuccinic acid
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Parabacteroides sp. D13
type: BioSource
xref: Reference/TAXONOMY 563193

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Citrulline
type: SmallMolecule
entity reference: Citrulline

Reference/UniProt C7X6T5
type: UnificationXref
id: C7X6T5
db: UniProt

Reference/UniProt C7X642
type: UnificationXref
id: C7X642
db: UniProt

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Compound/PW C000413 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylsuccinic acid
stoichiometric coefficient: 1.0

Reference/CAS 131-99-7
type: UnificationXref
id: 131-99-7
db: CAS

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Aspartate--ammonia ligase
type: ProteinReference
xref: Reference/UniProt C7X642
organism: Parabacteroides sp. D13

Protein/42859 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate--ammonia ligase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 17202
type: UnificationXref
id: CHEBI:17202
db: ChEBI

NAD Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway386343
pathway component: SubPathwayInteraction386343
xref: Reference/PathWhiz PW000829
xref: Reference/SMPDB SMP0000849
name: SubPathway

Reference/PubChem-compound 8582
type: UnificationXref
id: 8582
db: PubChem-compound

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

adenylosuccinate lyase 2
type: Complex
component stoichiometry: Protein/42864 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Adenylosuccinate lyase

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc ASN
type: UnificationXref
id: ASN
db: BioCyc

Argininosuccinic acid
type: SmallMolecule
entity reference: Argininosuccinic acid

Compound/PW C000413/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylsuccinic acid
stoichiometric coefficient: 1.0

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Ammonia
type: SmallMolecule
entity reference: Ammonia

L-Arginine
type: SmallMolecule
entity reference: L-Arginine

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Unknown
type: ProteinReference

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

Compound/PW C000088 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/UniProt C7X617
type: UnificationXref
id: C7X617
db: UniProt

Oxalacetic acid
type: SmallMolecule
entity reference: Oxalacetic acid

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Protein/42866/Stoichiometry/6.0
type: Stoichiometry
physical entity: Aspartate carbamoyltransferase regulatory chain
stoichiometric coefficient: 6.0

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/PubChem-compound 16950
type: UnificationXref
id: 16950
db: PubChem-compound

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/ChemSpider 6031
type: UnificationXref
id: 6031
db: ChemSpider

Compound/PW C000110 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Asparagine
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000829
type: UnificationXref
id: PW000829
db: PathWhiz

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

SubPathwayInteraction386344
type: Interaction
name: SubPathway386344Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

Reference/UniProt C7X7D5
type: UnificationXref
id: C7X7D5
db: UniProt

SubPathwayInteraction386342
type: Interaction
name: SubPathway386342Reaction
name: SubPathwayReaction
participant: Oxalacetic acid

Reference/UniProt C7X7D6
type: UnificationXref
id: C7X7D6
db: UniProt

SubPathwayInteraction386343
type: Interaction
name: SubPathwayReaction
name: SubPathway386343Reaction
participant: L-Aspartic acid

Reference/PubChem-compound 21960964
type: UnificationXref
id: 21960964
db: PubChem-compound

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

ReactionCatalysis608329
type: Catalysis
controller: asparagine synthetase II
controlled: 6.3.5.4
control type: ACTIVATION

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Fumaric acid

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Adenylsuccinic acid
type: SmallMolecule
entity reference: Adenylsuccinic acid

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

asparagine synthetase
type: Complex
component stoichiometry: Protein/42859 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Aspartate--ammonia ligase

Reference/SMPDB SMP0000849
type: UnificationXref
id: SMP0000849
db: SMPDB

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Protein/42867/Stoichiometry/6.0
type: Stoichiometry
physical entity: Aspartate carbamoyltransferase
stoichiometric coefficient: 6.0

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/PathWhiz PW393941
type: UnificationXref
id: PW393941
db: PathWhiz

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/PathWhiz PW000779
type: UnificationXref
id: PW000779
db: PathWhiz

1.4.3.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Hydrogen peroxide
right: Ammonia
right: Oxalacetic acid
spontaneous: false
EC number: 1.4.3.16
left: Water
left: L-Aspartic acid
left: Oxygen
name: L-Aspartic acid + Oxygen + Water → Ammonia + Hydrogen peroxide + Oxalacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

4.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Ammonia
right: Fumaric acid
spontaneous: false
EC number: 4.3.1.1
left: L-Aspartic acid
name: L-Aspartic acid → Ammonia + Fumaric acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

6.3.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000413/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Guanosine diphosphate
right: Adenylsuccinic acid
right: Phosphate
spontaneous: false
EC number: 6.3.4.4
left: L-Aspartic acid
left: Inosinic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Inosinic acid + L-Aspartic acid → Adenylsuccinic acid + Guanosine diphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction614397
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000723/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000036/Stoichiometry/1.0
right: Adenosine monophosphate
right: Argininosuccinic acid
right: Pyrophosphate
spontaneous: false
left: L-Aspartic acid
left: Citrulline
left: Adenosine triphosphate
name: Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

beta-Alanine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway386344
pathway component: SubPathwayInteraction386344
xref: Reference/PathWhiz PW000896
xref: Reference/SMPDB SMP0000915
name: SubPathway

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000896
type: UnificationXref
id: PW000896
db: PathWhiz

6.3.5.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000110/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
right: L-Glutamic acid
right: L-Asparagine
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.4
left: Water
left: L-Aspartic acid
left: L-Glutamine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water → Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/CAS 19046-78-7
type: UnificationXref
id: 19046-78-7
db: CAS

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Compound/PW C000148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Fumaric acid
type: SmallMolecule
entity reference: Fumaric acid

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Compound/PW C000123/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

N-carbamoyl-L-aspartate
type: SmallMolecule
entity reference: N-carbamoyl-L-aspartate

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

Reference/KEGG Compound C03406
type: UnificationXref
id: C03406
db: KEGG Compound

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

TCA Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway386342
pathway component: SubPathwayInteraction386342
xref: Reference/SMPDB SMP0000802
xref: Reference/PathWhiz PW000779
name: SubPathway

Reference/KEGG Compound C00130
type: UnificationXref
id: C00130
db: KEGG Compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ChemicalStructure/PW C000110
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(N)=O)C(O)=O

L-aspartate oxidase
type: Protein
entity reference: L-aspartate oxidase

Reference/ChemSpider 8264
type: UnificationXref
id: 8264
db: ChemSpider

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

3-dehydroquinate dehydratase
type: Protein
entity reference: 3-dehydroquinate dehydratase

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ChemicalStructure/PW C000114
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Aspartate carbamoyltransferase
type: Protein
entity reference: Aspartate carbamoyltransferase

Aspartate carbamoyltransferase regulatory chain
type: Protein
entity reference: Aspartate carbamoyltransferase regulatory chain

Argininosuccinate lyase
type: Protein
entity reference: Argininosuccinate lyase

Adenylosuccinate synthetase
type: Protein
entity reference: Adenylosuccinate synthetase

Aspartate ammonia-lyase
type: Protein
entity reference: Aspartate ammonia-lyase

Protein/29077 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

L-Asparagine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Asparagine

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

ReactionCatalysis608330
type: Catalysis
controller: L-aspartate oxidase
controlled: 1.4.3.16
control type: ACTIVATION

Adenylosuccinate lyase
type: Protein
cellular location: Cytosol
entity reference: Adenylosuccinate lyase

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

ReactionCatalysis608334
type: Catalysis
controller: Argininosuccinate lyase
controlled: 4.3.2.1
control type: ACTIVATION

ReactionCatalysis608333
type: Catalysis
controller: argininosuccinate synthase
controlled: Reaction614397
control type: ACTIVATION

ReactionCatalysis608332
type: Catalysis
controller: adenylosuccinate synthase
controlled: 6.3.4.4
control type: ACTIVATION

Aspartate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/5576429
pathway order: PathwaySubPathway/386343
pathway order: PathwaySubPathway/386344
pathway order: PathwayEnzymeReaction/5576427
pathway order: PathwayEnzymeReaction/5576428
pathway order: PathwaySubPathway/386342
pathway order: PathwayEnzymeReaction/5576425
pathway order: PathwayEnzymeReaction/5576426
pathway order: PathwayEnzymeReaction/5576423
pathway order: PathwayEnzymeReaction/5576424
pathway order: PathwayEnzymeReaction/5576432
pathway order: PathwayEnzymeReaction/5576430
pathway order: PathwayEnzymeReaction/5576431
pathway component: 1.4.3.16
pathway component: 4.3.1.1
pathway component: ReactionCatalysis608329
pathway component: 6.3.4.4
pathway component: Reaction614397
pathway component: NAD Biosynthesis
pathway component: beta-Alanine Metabolism
pathway component: 6.3.5.4
pathway component: TCA Cycle
pathway component: ReactionCatalysis608330
pathway component: ReactionCatalysis608334
pathway component: 4.3.2.2
pathway component: ReactionCatalysis608333
pathway component: ReactionCatalysis608332
pathway component: ReactionCatalysis608331
pathway component: 4.3.2.1
pathway component: ReactionCatalysis608338
pathway component: 2.1.3.2
pathway component: ReactionCatalysis608337
pathway component: Reaction614400
pathway component: ReactionCatalysis608336
pathway component: ReactionCatalysis608335
pathway component: 6.3.1.1
xref: Reference/PathWhiz PW393941
xref: Reference/SMPDB SMP0385518
organism: Parabacteroides sp. D13

ReactionCatalysis608331
type: Catalysis
controller: aspartate ammonia-lyase
controlled: 4.3.1.1
control type: ACTIVATION

Reference/ChemSpider 16059
type: UnificationXref
id: 16059
db: ChemSpider

ReactionCatalysis608338
type: Catalysis
controller: adenylosuccinate lyase 2
controlled: 4.3.2.2
control type: ACTIVATION

ReactionCatalysis608337
type: Catalysis
controller: asparagine synthetase
controlled: 6.3.1.1
control type: ACTIVATION

ReactionCatalysis608336
type: Catalysis
controller: aspartate transaminase
controlled: Reaction614400
control type: ACTIVATION

ReactionCatalysis608335
type: Catalysis
controller: aspartate carbamoyltransferase
controlled: 2.1.3.2
control type: ACTIVATION

Protein/29077/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Compound/PW C000396/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000802
type: UnificationXref
id: SMP0000802
db: SMPDB

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C00152
type: UnificationXref
id: C00152
db: KEGG Compound

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/ChEBI CHEBI 15682
type: UnificationXref
id: CHEBI:15682
db: ChEBI

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

Protein/42863/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenylosuccinate synthetase
stoichiometric coefficient: 2.0

Oxalacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalacetic acid
name: SubPathwayInput

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/BioCyc IMP
type: UnificationXref
id: IMP
db: BioCyc

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Protein/42864 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Adenylosuccinate lyase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 17196
type: UnificationXref
id: CHEBI:17196
db: ChEBI

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/KEGG Compound C03794
type: UnificationXref
id: C03794
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/UniProt C7X3W5
type: UnificationXref
id: C7X3W5
db: UniProt

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000110/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Asparagine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

aspartate transaminase
type: Complex
component stoichiometry: Protein/29077 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Compound/PW C000723/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ChemicalStructure/PW C000036
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

4.3.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000396/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000036/Stoichiometry/1.0
right: Fumaric acid
right: L-Arginine
spontaneous: false
EC number: 4.3.2.1
left: Argininosuccinic acid
name: Argininosuccinic acid → Fumaric acid + L-Arginine
conversion direction: LEFT_TO_RIGHT

aspartate carbamoyltransferase
type: Complex
component stoichiometry: Protein/42867/Stoichiometry/6.0
component stoichiometry: Protein/42866/Stoichiometry/6.0
component: Aspartate carbamoyltransferase
component: Aspartate carbamoyltransferase regulatory chain

2.1.3.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040852/Stoichiometry/1.0
right: N-carbamoyl-L-aspartate
spontaneous: false
EC number: 2.1.3.2
left: L-Aspartic acid
name: L-Aspartic acid → N-carbamoyl-L-aspartate
conversion direction: LEFT_TO_RIGHT

argininosuccinate synthase
type: Complex
component stoichiometry: Protein/29077/Stoichiometry/4.0
component: Unknown

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

adenylosuccinate synthase
type: Complex
component stoichiometry: Protein/42863/Stoichiometry/2.0
component: Adenylosuccinate synthetase

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

aspartate ammonia-lyase
type: Complex
component stoichiometry: Protein/42862/Stoichiometry/4.0
component: Aspartate ammonia-lyase

asparagine synthetase II
type: Complex
component stoichiometry: Protein/42860/Stoichiometry/2.0
component: 3-dehydroquinate dehydratase

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Adenylsuccinic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440122
xref: Reference/HMDB HMDB0000536
xref: Reference/CAS 19046-78-7
xref: Reference/KEGG Compound C03794
xref: Reference/ChEBI CHEBI 15919
xref: Reference/ChemSpider 389122
chemical formula: C14H18N5O11P
molecular weight: 463.07404
structure: ChemicalStructure/PW C000413

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Compound/PW C000114/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosinic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/CAS 2387-71-5
type: UnificationXref
id: 2387-71-5
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0000168
type: UnificationXref
id: HMDB0000168
db: HMDB

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Guanosine diphosphate
type: SmallMolecule
entity reference: Guanosine diphosphate

Protein/42862/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aspartate ammonia-lyase
stoichiometric coefficient: 4.0

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/UniProt C7X429
type: UnificationXref
id: C7X429
db: UniProt

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/UniProt C7X666
type: UnificationXref
id: C7X666
db: UniProt

Reference/ChemSpider 389122
type: UnificationXref
id: 389122
db: ChemSpider

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Compound/PW C040852/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-carbamoyl-L-aspartate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

L-Asparagine
type: SmallMoleculeReference
xref: Reference/ChemSpider 6031
xref: Reference/HMDB HMDB0000168
xref: Reference/CAS 70-47-3
xref: Reference/ChEBI CHEBI 17196
xref: Reference/BioCyc ASN
xref: Reference/KEGG Compound C00152
xref: Reference/PubChem-compound 6267
chemical formula: C4H8N2O3
molecular weight: 132.0535
structure: ChemicalStructure/PW C000110

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0000052
type: UnificationXref
id: HMDB0000052
db: HMDB

Reference/ChEBI CHEBI 15919
type: UnificationXref
id: CHEBI:15919
db: ChEBI

Reference/HMDB HMDB0000175
type: UnificationXref
id: HMDB0000175
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Inosinic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 8264
xref: Reference/ChEBI CHEBI 17202
xref: Reference/CAS 131-99-7
xref: Reference/PubChem-compound 8582
xref: Reference/BioCyc IMP
xref: Reference/KEGG Compound C00130
xref: Reference/HMDB HMDB0000175
chemical formula: C10H13N4O8P
molecular weight: 348.0471
structure: ChemicalStructure/PW C000114

L-aspartate oxidase
type: ProteinReference
xref: Reference/UniProt C7X3W5

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Aspartate ammonia-lyase
type: ProteinReference
xref: Reference/UniProt C7X6T5

Adenylosuccinate synthetase
type: ProteinReference
xref: Reference/UniProt C7X6C1

ChemicalStructure/PW C000413
type: ChemicalStructure
structure format: SMILES

Adenylosuccinate lyase
type: ProteinReference
xref: Reference/UniProt C7X666
organism: Parabacteroides sp. D13

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Argininosuccinate lyase
type: ProteinReference
xref: Reference/UniProt C7X617

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Aspartate carbamoyltransferase regulatory chain
type: ProteinReference
xref: Reference/UniProt C7X7D5

Aspartate carbamoyltransferase
type: ProteinReference
xref: Reference/UniProt C7X7D6

Adenylsuccinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenylsuccinic acid

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

L-Aspartic acid
type: SmallMolecule
entity reference: L-Aspartic acid

3-dehydroquinate dehydratase
type: ProteinReference
xref: Reference/UniProt C7X429

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Inosinic acid
type: SmallMolecule
entity reference: Inosinic acid

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Protein/42860/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-dehydroquinate dehydratase
stoichiometric coefficient: 2.0

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid
name: SubPathwayInput

Reference/PubChem-compound 440122
type: UnificationXref
id: 440122
db: PubChem-compound

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

L-Asparagine
type: SmallMolecule
entity reference: L-Asparagine

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Compound/PW C000148/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

ChemicalStructure/PW C040852
type: ChemicalStructure
structure format: SMILES
structure data: OC(=N)NC(CC([O-])=O)C([O-])=O

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Reference/SMPDB SMP0000915
type: UnificationXref
id: SMP0000915
db: SMPDB

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/CAS 70-47-3
type: UnificationXref
id: 70-47-3
db: CAS

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

4.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000088 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000413 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: Fumaric acid
spontaneous: false
EC number: 4.3.2.2
left: Adenylsuccinic acid
name: Adenylsuccinic acid → Adenosine monophosphate + Fumaric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000088/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Aspartate--ammonia ligase
type: Protein
cellular location: Cytosol
entity reference: Aspartate--ammonia ligase

Reaction614400
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
right: L-Aspartic acid
right: Oxoglutaric acid
spontaneous: false
left: Oxalacetic acid
left: L-Glutamic acid
name: L-Glutamic acid + Oxalacetic acid → L-Aspartic acid + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

6.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000110 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Asparagine
right: Pyrophosphate
spontaneous: false
EC number: 6.3.1.1
left: L-Aspartic acid
left: Adenosine triphosphate
left: Ammonia
name: Adenosine triphosphate + Ammonia + L-Aspartic acid → Adenosine monophosphate + L-Asparagine + Pyrophosphate
conversion direction: LEFT_TO_RIGHT