Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C002771 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-L-glutamate 5-semialdehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00437
type: UnificationXref
id: C00437
db: KEGG Compound

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/SMPDB SMP0387377
type: UnificationXref
id: SMP0387377
db: SMPDB

Reference/PubChem-compound 6262
type: UnificationXref
id: 6262
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Compound/PW C001092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Putrescine
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/28263 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Succinic acid semialdehyde
type: SmallMolecule
entity reference: Succinic acid semialdehyde

Reference/KEGG Compound C00555
type: UnificationXref
id: C00555
db: KEGG Compound

NAD+-dependent succinate semialdehyde dehydrogenase
type: Complex
component stoichiometry: Protein/28263 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/BioCyc 4-AMINO-BUTYRALDEHYDE
type: UnificationXref
id: 4-AMINO-BUTYRALDEHYDE
db: BioCyc

Protein/28263/Stoichiometry/12.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 12.0

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

acetylornithine deacetylase
type: Complex
component stoichiometry: Protein/28263/Stoichiometry/2.0
component: Unknown

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000972 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid semialdehyde
stoichiometric coefficient: 1.0

γ-glutamyl-γ-aminobutyrate hydrolase
type: Complex
component stoichiometry: Protein/28263/Stoichiometry/2.0
component: Unknown

acetylglutamate kinase
type: Complex
component stoichiometry: Protein/28263/Stoichiometry/2.0
component: Unknown

N-acetylglutamate synthase
type: Complex
component stoichiometry: Protein/28263/Stoichiometry/6.0
component: Unknown

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

GLUTAMINE-PUTRESCINE LIGASE
type: Complex
component stoichiometry: Protein/28263/Stoichiometry/12.0
component: Unknown

Reference/ChemSpider 388369
type: UnificationXref
id: 388369
db: ChemSpider

4-Aminobutyraldehyde
type: SmallMolecule
entity reference: 4-Aminobutyraldehyde

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Reference/ChEBI CHEBI 16265
type: UnificationXref
id: CHEBI:16265
db: ChEBI

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C007776
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCNC(=O)CC[C@H](N)C(O)=O

Escherichia coli E24377A
type: BioSource
xref: Reference/TAXONOMY 331111

Reference/TAXONOMY 331111
type: UnificationXref
id: 331111
db: TAXONOMY

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001080
type: UnificationXref
id: HMDB0001080
db: HMDB

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/KEGG Compound C00334
type: UnificationXref
id: C00334
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/PubChem-compound 192878
type: UnificationXref
id: 192878
db: PubChem-compound

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001092
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCN

Reference/PubChem-compound 23724570
type: UnificationXref
id: 23724570
db: PubChem-compound

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/CAS 5105-96-4
type: UnificationXref
id: 5105-96-4
db: CAS

Reference/ChEBI CHEBI 17148
type: UnificationXref
id: CHEBI:17148
db: ChEBI

Ammonium
type: SmallMolecule
entity reference: Ammonium

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/KEGG Compound C00232
type: UnificationXref
id: C00232
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/ChEBI CHEBI 49260
type: UnificationXref
id: CHEBI:49260
db: ChEBI

Protein/28263 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/CAS 110-60-1
type: UnificationXref
id: 110-60-1
db: CAS

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

N-Acetylornithine
type: SmallMolecule
entity reference: N-Acetylornithine

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/BioCyc CPD-9000
type: UnificationXref
id: CPD-9000
db: BioCyc

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

N-Acetyl-L-glutamic acid
type: SmallMolecule
entity reference: N-Acetyl-L-glutamic acid

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/CAS 6205-08-9
type: UnificationXref
id: 6205-08-9
db: CAS

Glycolysis and Pyruvate Dehydrogenase
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway389203
pathway component: SubPathwayInteraction389203
xref: Reference/PathWhiz PW000785
xref: Reference/SMPDB SMP0000807
name: SubPathway

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

TCA Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway389202
pathway component: SubPathwayInteraction389202
xref: Reference/SMPDB SMP0000802
xref: Reference/PathWhiz PW000779
name: SubPathway

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Compound/PW C000071 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Ornithine Metabolism
type: Pathway
pathway order: PathwaySubPathway/389203
pathway order: PathwaySubPathway/389202
pathway order: PathwayEnzymeReaction/5612328
pathway order: PathwayEnzymeReaction/5612339
pathway order: PathwayEnzymeReaction/5612338
pathway order: PathwayEnzymeReaction/5612329
pathway order: PathwayEnzymeReaction/5612324
pathway order: PathwayEnzymeReaction/5612335
pathway order: PathwayEnzymeReaction/5612323
pathway order: PathwayEnzymeReaction/5612334
pathway order: PathwayEnzymeReaction/5612337
pathway order: PathwayEnzymeReaction/5612325
pathway order: PathwayEnzymeReaction/5612336
pathway order: PathwayEnzymeReaction/5612331
pathway order: PathwayEnzymeReaction/5612330
pathway order: PathwayEnzymeReaction/5612333
pathway order: PathwayEnzymeReaction/5612332
pathway component: Glycolysis and Pyruvate Dehydrogenase
pathway component: TCA Cycle
pathway component: ReactionCatalysis630296
pathway component: ReactionCatalysis630295
pathway component: ReactionCatalysis630298
pathway component: ReactionCatalysis630297
pathway component: ReactionCatalysis630299
pathway component: Reaction635837
pathway component: ReactionCatalysis630290
pathway component: 1.2.1.38
pathway component: ReactionCatalysis630292
pathway component: 2.7.2.8
pathway component: ReactionCatalysis630291
pathway component: ReactionCatalysis630294
pathway component: ReactionCatalysis630293
pathway component: Reaction635851
pathway component: 4.1.1.17
pathway component: ReactionCatalysis630304
pathway component: ReactionCatalysis630303
pathway component: ReactionCatalysis630300
pathway component: ReactionCatalysis630302
pathway component: ReactionCatalysis630301
pathway component: Reaction635846
pathway component: 1.2.1.79
pathway component: 2.6.1.19
pathway component: 1.2.1.16
pathway component: 1.2.1.19
pathway component: 6.3.1.11
pathway component: 1.2.1.5
pathway component: 1.4.3.-
pathway component: 2.6.1.82
pathway component: 3.5.1.94
xref: Reference/SMPDB SMP0387377
xref: Reference/PathWhiz PW396174
organism: Escherichia coli E24377A

4-Aminobutyraldehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 115
xref: Reference/CAS 4390-05-0
xref: Reference/ChEBI CHEBI 17769
xref: Reference/HMDB HMDB0001080
xref: Reference/PubChem-compound 118
xref: Reference/KEGG Compound C00555
xref: Reference/BioCyc 4-AMINO-BUTYRALDEHYDE
chemical formula: C4H9NO
molecular weight: 87.06841
structure: ChemicalStructure/PW C000849

Reference/KEGG Compound C00134
type: UnificationXref
id: C00134
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/HMDB HMDB0006456
type: UnificationXref
id: HMDB0006456
db: HMDB

Compound/PW C001856/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylornithine
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Succinic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001259
xref: Reference/BioCyc SUCC-S-ALD
xref: Reference/ChemSpider 1080
xref: Reference/CAS 692-29-5
xref: Reference/KEGG Compound C00232
xref: Reference/PubChem-compound 1112
xref: Reference/ChEBI CHEBI 16265
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000972

Compound/PW C002771/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-L-glutamate 5-semialdehyde
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

γ-aminobutyraldehyde dehydrogenase
type: Complex
component stoichiometry: Protein/28263 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Compound/PW C040858/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(γ-glutamylamino)butanal
stoichiometric coefficient: 1.0

Reference/BioCyc PUTRESCINE
type: UnificationXref
id: PUTRESCINE
db: BioCyc

Reference/SMPDB SMP0000802
type: UnificationXref
id: SMP0000802
db: SMPDB

ReactionCatalysis630296
type: Catalysis
controller: γ-glutamyl-γ-aminobutyrate hydrolase
controlled: 3.5.1.94
control type: ACTIVATION

Compound/PW C000888/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-L-glutamic acid
stoichiometric coefficient: 1.0

ReactionCatalysis630295
type: Catalysis
controller: Unknown
controlled: 1.2.1.5
control type: ACTIVATION

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

ReactionCatalysis630298
type: Catalysis
controller: succinate-semialdehyde dehydrogenase (NADP+)
controlled: 1.2.1.79
control type: ACTIVATION

ReactionCatalysis630297
type: Catalysis
controller: Unknown
controlled: 2.6.1.82
control type: ACTIVATION

Reference/SMPDB SMP0000807
type: UnificationXref
id: SMP0000807
db: SMPDB

Reference/HMDB HMDB0012230
type: UnificationXref
id: HMDB0012230
db: HMDB

ReactionCatalysis630299
type: Catalysis
controller: acetylornithine deacetylase
controlled: Reaction635846
control type: ACTIVATION

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ReactionCatalysis630290
type: Catalysis
controller: N-acetylglutamate synthase
controlled: Reaction635837
control type: ACTIVATION

Water
type: SmallMolecule
entity reference: Water

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

ReactionCatalysis630292
type: Catalysis
controller: Unknown
controlled: 1.2.1.38
control type: ACTIVATION

ReactionCatalysis630291
type: Catalysis
controller: acetylglutamate kinase
controlled: 2.7.2.8
control type: ACTIVATION

Reference/KEGG Compound C01250
type: UnificationXref
id: C01250
db: KEGG Compound

ReactionCatalysis630294
type: Catalysis
controller: Unknown
controlled: 1.4.3.-
control type: ACTIVATION

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

ReactionCatalysis630293
type: Catalysis
controller: GLUTAMINE-PUTRESCINE LIGASE
controlled: 6.3.1.11
control type: ACTIVATION

Reference/KEGG Compound C15767
type: UnificationXref
id: C15767
db: KEGG Compound

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

N-Acetyl-L-glutamate 5-semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetyl-L-glutamate 5-semialdehyde

N-Acetyl-L-glutamyl 5-phosphate
type: SmallMolecule
entity reference: N-Acetyl-L-glutamyl 5-phosphate

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

N-Acetylornithine
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetylornithine

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Compound/PW C001092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Putrescine
stoichiometric coefficient: 1.0

N-Acetyl-L-glutamic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00624
xref: Reference/ChEBI CHEBI 12575
xref: Reference/HMDB HMDB0001138
xref: Reference/BioCyc ACETYL-GLU
xref: Reference/CAS 1188-37-0
xref: Reference/PubChem-compound 185
xref: Reference/ChemSpider 180
chemical formula: C7H11NO5
molecular weight: 189.06372
structure: ChemicalStructure/PW C000888

Reference/CAS 4390-05-0
type: UnificationXref
id: 4390-05-0
db: CAS

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

N-Acetylornithine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16543
xref: Reference/ChemSpider 388369
xref: Reference/KEGG Compound C00437
xref: Reference/CAS 6205-08-9
xref: Reference/HMDB HMDB0003357
xref: Reference/PubChem-compound 439232
xref: Reference/BioCyc N-ALPHA-ACETYLORNITHINE
chemical formula: C7H14N2O3
molecular weight: 174.10045
structure: ChemicalStructure/PW C001856

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Unknown
type: ProteinReference

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000972/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid semialdehyde
stoichiometric coefficient: 1.0

Compound/PW C000849 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Aminobutyraldehyde
stoichiometric coefficient: 1.0

Compound/PW C002749/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-L-glutamyl 5-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0001138
type: UnificationXref
id: HMDB0001138
db: HMDB

Reference/HMDB HMDB0001259
type: UnificationXref
id: HMDB0001259
db: HMDB

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

succinate-semialdehyde dehydrogenase (NADP+)
type: Complex
component stoichiometry: Protein/28263/Stoichiometry/4.0
component: Unknown

Reference/KEGG Compound C00077
type: UnificationXref
id: C00077
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ChemicalStructure/PW C007718
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

N-Acetyl-L-glutamate 5-semialdehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 192878
xref: Reference/ChemSpider 167387
xref: Reference/CAS 13074-21-0
xref: Reference/KEGG Compound C01250
xref: Reference/HMDB HMDB0006488
xref: Reference/ChEBI CHEBI 16319
chemical formula: C7H11NO4
molecular weight: 173.0688
structure: ChemicalStructure/PW C002771

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Reference/CAS 15383-57-0
type: UnificationXref
id: 15383-57-0
db: CAS

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/HMDB HMDB0012161
type: UnificationXref
id: HMDB0012161
db: HMDB

Putrescine
type: SmallMolecule
cellular location: Cytosol
entity reference: Putrescine

Reference/KEGG Compound C15699
type: UnificationXref
id: C15699
db: KEGG Compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

N-Acetyl-L-glutamyl 5-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04133
xref: Reference/BioCyc N-ACETYL-GLUTAMYL-P
xref: Reference/ChEBI CHEBI 16878
xref: Reference/CAS 15383-57-0
xref: Reference/ChemSpider 389220
xref: Reference/HMDB HMDB0006456
xref: Reference/PubChem-compound 440236
chemical formula: C7H12NO8P
molecular weight: 269.03006
structure: ChemicalStructure/PW C002749

N-Acetyl-L-glutamate 5-semialdehyde
type: SmallMolecule
entity reference: N-Acetyl-L-glutamate 5-semialdehyde

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/BioCyc 4-AMINO-BUTYRATE
type: UnificationXref
id: 4-AMINO-BUTYRATE
db: BioCyc

4-Aminobutyraldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Aminobutyraldehyde

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C000140 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ornithine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000071
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC(O)=O

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040858
type: ChemicalStructure
structure format: SMILES
structure data: NC(CCC(=O)NCCCC=O)C([O-])=O

Reference/ChemSpider 21865667
type: UnificationXref
id: 21865667
db: ChemSpider

Reference/PathWhiz PW396174
type: UnificationXref
id: PW396174
db: PathWhiz

Reference/HMDB HMDB0003357
type: UnificationXref
id: HMDB0003357
db: HMDB

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChEBI CHEBI 12575
type: UnificationXref
id: CHEBI:12575
db: ChEBI

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

ChemicalStructure/PW C002749
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O

Succinic acid
type: SmallMolecule
entity reference: Succinic acid

Reaction635837
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000888/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: Hydrogen Ion
right: N-Acetyl-L-glutamic acid
spontaneous: false
left: L-Glutamic acid
left: Acetyl-CoA
name: Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetyl-L-glutamic acid
conversion direction: LEFT_TO_RIGHT

1.2.1.38
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002771/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: N-Acetyl-L-glutamate 5-semialdehyde
right: NADP
right: Phosphate
spontaneous: false
EC number: 1.2.1.38
left: Hydrogen Ion
left: N-Acetyl-L-glutamyl 5-phosphate
left: NADPH
name: Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-Acetyl-L-glutamate 5-semialdehyde + NADP + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 13074-21-0
type: UnificationXref
id: 13074-21-0
db: CAS

2.7.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000888/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002749/Stoichiometry/1.0
right: Adenosine diphosphate
right: N-Acetyl-L-glutamyl 5-phosphate
spontaneous: false
EC number: 2.7.2.8
left: N-Acetyl-L-glutamic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + N-Acetyl-L-glutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Reference/ChemSpider 13837702
type: UnificationXref
id: 13837702
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayOutput

Succinic acid semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinic acid semialdehyde

Reference/PubChem-compound 119
type: UnificationXref
id: 119
db: PubChem-compound

Reference/PubChem-compound 118
type: UnificationXref
id: 118
db: PubChem-compound

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

4-(γ-glutamylamino)butanal
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61508
chemical formula: C9H15N2O4
molecular weight: 215.10373
structure: ChemicalStructure/PW C040858

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04133
type: UnificationXref
id: C04133
db: KEGG Compound

Reference/ChEBI CHEBI 61508
type: UnificationXref
id: CHEBI:61508
db: ChEBI

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C000849/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Aminobutyraldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15729
type: UnificationXref
id: CHEBI:15729
db: ChEBI

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase
type: Complex
component stoichiometry: Protein/28263 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/CAS 70-26-8
type: UnificationXref
id: 70-26-8
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/ChemSpider 6026
type: UnificationXref
id: 6026
db: ChemSpider

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

Ornithine
type: SmallMolecule
entity reference: Ornithine

Reference/HMDB HMDB0001414
type: UnificationXref
id: HMDB0001414
db: HMDB

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Protein/28263/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Ornithine
type: SmallMoleculeReference
xref: Reference/CAS 70-26-8
xref: Reference/HMDB HMDB0000214
xref: Reference/PubChem-compound 6262
xref: Reference/KEGG Compound C00077
xref: Reference/BioCyc L-ORNITHINE
xref: Reference/ChemSpider 6026
xref: Reference/ChEBI CHEBI 15729
chemical formula: C5H12N2O2
molecular weight: 132.08987
structure: ChemicalStructure/PW C000140

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Reference/PathWhiz PW000785
type: UnificationXref
id: PW000785
db: PathWhiz

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: γ-Aminobutyric acid

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/BioCyc GAMMA-GLUTAMYL-PUTRESCINE
type: UnificationXref
id: GAMMA-GLUTAMYL-PUTRESCINE
db: BioCyc

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

γ-Aminobutyric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000112
xref: Reference/ChemSpider 116
xref: Reference/PubChem-compound 119
xref: Reference/CAS 56-12-2
xref: Reference/BioCyc 4-AMINO-BUTYRATE
xref: Reference/ChEBI CHEBI 16865
xref: Reference/KEGG Compound C00334
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000071

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000214
type: UnificationXref
id: HMDB0000214
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/CAS 692-29-5
type: UnificationXref
id: 692-29-5
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/PathWhiz PW000779
type: UnificationXref
id: PW000779
db: PathWhiz

SubPathwayInteraction389203
type: Interaction
name: SubPathway389203Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

SubPathwayInteraction389202
type: Interaction
name: SubPathwayReaction
name: SubPathway389202Reaction
participant: Succinic acid

Reference/ChEBI CHEBI 16865
type: UnificationXref
id: CHEBI:16865
db: ChEBI

Reference/BioCyc ACETYL-GLU
type: UnificationXref
id: ACETYL-GLU
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

4-(Glutamylamino) butanoate
type: SmallMolecule
entity reference: 4-(Glutamylamino) butanoate

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000140
type: ChemicalStructure
structure format: SMILES
structure data: NCCC[C@H](N)C(O)=O

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C007718/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(Glutamylamino) butanoate
stoichiometric coefficient: 1.0

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000174 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

4-(γ-glutamylamino)butanal
type: SmallMolecule
entity reference: 4-(γ-glutamylamino)butanal

Reference/PubChem-compound 1112
type: UnificationXref
id: 1112
db: PubChem-compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Reference/HMDB HMDB0000112
type: UnificationXref
id: HMDB0000112
db: HMDB

Reference/ChemSpider 116
type: UnificationXref
id: 116
db: ChemSpider

Reference/ChemSpider 115
type: UnificationXref
id: 115
db: ChemSpider

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

ChemicalStructure/PW C002771
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)N[C@@H](CCC=O)C(O)=O

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 1188-37-0
type: UnificationXref
id: 1188-37-0
db: CAS

Reaction635851
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002771 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001856 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
right: Oxoglutaric acid
right: N-Acetylornithine
spontaneous: false
left: N-Acetyl-L-glutamate 5-semialdehyde
left: L-Glutamic acid
name: L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

4.1.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000140 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Putrescine
spontaneous: false
EC number: 4.1.1.17
left: Hydrogen Ion
left: Ornithine
name: Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine
conversion direction: LEFT_TO_RIGHT

γ-Aminobutyric acid
type: SmallMolecule
entity reference: γ-Aminobutyric acid

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Protein/28263/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reaction635846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000140/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001856/Stoichiometry/1.0
right: Ornithine
right: Acetic acid
spontaneous: false
left: Water
left: N-Acetylornithine
name: N-Acetylornithine + Water → Acetic acid + Ornithine
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

1.2.1.79
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Succinic acid
right: Hydrogen Ion
right: NADPH
spontaneous: false
EC number: 1.2.1.79
left: Water
left: NADP
left: Succinic acid semialdehyde
name: NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid
conversion direction: LEFT_TO_RIGHT

2.6.1.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cytosol/Stoichiometry/1.0
right: L-Glutamic acid
right: Succinic acid semialdehyde
spontaneous: false
EC number: 2.6.1.19
left: Oxoglutaric acid
left: γ-Aminobutyric acid
name: Oxoglutaric acid + γ-Aminobutyric acid → L-Glutamic acid + Succinic acid semialdehyde
conversion direction: LEFT_TO_RIGHT

1.2.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Succinic acid
right: NADH
spontaneous: false
EC number: 1.2.1.16
left: NAD
left: Succinic acid semialdehyde
left: Water
name: NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

1.2.1.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000849 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: γ-Aminobutyric acid
right: NADH
spontaneous: false
EC number: 1.2.1.19
left: NAD
left: 4-Aminobutyraldehyde
left: Water
name: 4-Aminobutyraldehyde + NAD + Water → Hydrogen Ion + NADH + γ-Aminobutyric acid
conversion direction: LEFT_TO_RIGHT

6.3.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007776/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: γ-glutamyl-L-putrescine
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.1.11
left: L-Glutamic acid
left: Putrescine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Glutamic acid + Putrescine → Adenosine diphosphate + Hydrogen Ion + Phosphate + γ-glutamyl-L-putrescine
conversion direction: LEFT_TO_RIGHT

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040858/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007718/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Hydrogen Ion
right: 4-(Glutamylamino) butanoate
right: NADPH
spontaneous: false
EC number: 1.2.1.5
left: Water
left: NADP
left: 4-(γ-glutamylamino)butanal
name: 4-(γ-glutamylamino)butanal + NADP + Water → 4-(Glutamylamino) butanoate + 2 Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

1.4.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040858/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007776/Stoichiometry/1.0
right: Hydrogen peroxide
right: Ammonium
right: 4-(γ-glutamylamino)butanal
spontaneous: false
EC number: 1.4.3.-
left: γ-glutamyl-L-putrescine
left: Water
left: Oxygen
name: Oxygen + Water + γ-glutamyl-L-putrescine → 4-(γ-glutamylamino)butanal + Ammonium + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

2.6.1.82
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000849/Stoichiometry/1.0
right: 4-Aminobutyraldehyde
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.82
left: Oxoglutaric acid
left: Putrescine
name: Oxoglutaric acid + Putrescine → 4-Aminobutyraldehyde + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

3.5.1.94
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007718/Stoichiometry/1.0
right: L-Glutamic acid
right: γ-Aminobutyric acid
spontaneous: false
EC number: 3.5.1.94
left: Water
left: 4-(Glutamylamino) butanoate
name: 4-(Glutamylamino) butanoate + Water → L-Glutamic acid + γ-Aminobutyric acid
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000849
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC=O

Reference/BioCyc SUCC-S-ALD
type: UnificationXref
id: SUCC-S-ALD
db: BioCyc

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

ornithine decarboxylase
type: Complex
component stoichiometry: Protein/28263 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Compound/PW C040034 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

ChemicalStructure/PW C000972
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC=O

Reference/ChEBI CHEBI 16543
type: UnificationXref
id: CHEBI:16543
db: ChEBI

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Ornithine
type: SmallMolecule
cellular location: Cytosol
entity reference: Ornithine

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/ChemSpider 1080
type: UnificationXref
id: 1080
db: ChemSpider

Reference/HMDB HMDB0006488
type: UnificationXref
id: HMDB0006488
db: HMDB

Putrescine
type: SmallMolecule
entity reference: Putrescine

Compound/PW C000140/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ornithine
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Putrescine
type: SmallMoleculeReference
xref: Reference/CAS 110-60-1
xref: Reference/BioCyc PUTRESCINE
xref: Reference/ChEBI CHEBI 17148
xref: Reference/HMDB HMDB0001414
xref: Reference/ChemSpider 13837702
xref: Reference/KEGG Compound C00134
xref: Reference/PubChem-compound 1045
chemical formula: C4H12N2
molecular weight: 88.10005
structure: ChemicalStructure/PW C001092

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/ChEBI CHEBI 16878
type: UnificationXref
id: CHEBI:16878
db: ChEBI

4-(Glutamylamino) butanoate
type: SmallMoleculeReference
xref: Reference/CAS 5105-96-4
xref: Reference/ChEBI CHEBI 49260
xref: Reference/ChemSpider 21865667
xref: Reference/HMDB HMDB0012161
xref: Reference/BioCyc CPD-9000
xref: Reference/KEGG Compound C15767
xref: Reference/PubChem-compound 23724570
chemical formula: C9H16N2O5
molecular weight: 232.10593
structure: ChemicalStructure/PW C007718

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Protein/28263/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/ChemSpider 20148392
type: UnificationXref
id: 20148392
db: ChemSpider

Reference/KEGG Compound C00624
type: UnificationXref
id: C00624
db: KEGG Compound

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Succinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinic acid
name: SubPathwayInput

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc N-ALPHA-ACETYLORNITHINE
type: UnificationXref
id: N-ALPHA-ACETYLORNITHINE
db: BioCyc

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ChemicalStructure/PW C000888
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)N[C@@H](CCC(O)=O)C(O)=O

ChemicalStructure/PW C001856
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)N[C@@H](CCCN)C(O)=O

Compound/PW C000174/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Reference/PubChem-compound 439232
type: UnificationXref
id: 439232
db: PubChem-compound

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ReactionCatalysis630304
type: Catalysis
controller: acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase
controlled: Reaction635851
control type: ACTIVATION

ReactionCatalysis630303
type: Catalysis
controller: ornithine decarboxylase
controlled: 4.1.1.17
control type: ACTIVATION

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc N-ACETYL-GLUTAMYL-P
type: UnificationXref
id: N-ACETYL-GLUTAMYL-P
db: BioCyc

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ReactionCatalysis630300
type: Catalysis
controller: NAD+-dependent succinate semialdehyde dehydrogenase
controlled: 1.2.1.16
control type: ACTIVATION

ReactionCatalysis630302
type: Catalysis
controller: γ-aminobutyraldehyde dehydrogenase
controlled: 1.2.1.19
control type: ACTIVATION

Reference/PubChem-compound 1045
type: UnificationXref
id: 1045
db: PubChem-compound

ReactionCatalysis630301
type: Catalysis
controller: Unknown
controlled: 2.6.1.19
control type: ACTIVATION

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C001856 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylornithine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChemSpider 167387
type: UnificationXref
id: 167387
db: ChemSpider

Reference/ChEBI CHEBI 17769
type: UnificationXref
id: CHEBI:17769
db: ChEBI

Reference/CAS 56-12-2
type: UnificationXref
id: 56-12-2
db: CAS

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

Reference/ChemSpider 389220
type: UnificationXref
id: 389220
db: ChemSpider

Reference/PubChem-compound 185
type: UnificationXref
id: 185
db: PubChem-compound

Reference/PubChem-compound 20841830
type: UnificationXref
id: 20841830
db: PubChem-compound

Compound/PW C007776/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-glutamyl-L-putrescine
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Compound/PW C000071/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 440236
type: UnificationXref
id: 440236
db: PubChem-compound

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

γ-glutamyl-L-putrescine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 20841830
xref: Reference/ChemSpider 20148392
xref: Reference/HMDB HMDB0012230
xref: Reference/BioCyc GAMMA-GLUTAMYL-PUTRESCINE
xref: Reference/ChEBI CHEBI 48005
xref: Reference/KEGG Compound C15699
chemical formula: C9H19N3O3
molecular weight: 217.14264
structure: ChemicalStructure/PW C007776

γ-glutamyl-L-putrescine
type: SmallMolecule
entity reference: γ-glutamyl-L-putrescine

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/ChEBI CHEBI 16319
type: UnificationXref
id: CHEBI:16319
db: ChEBI

Reference/BioCyc L-ORNITHINE
type: UnificationXref
id: L-ORNITHINE
db: BioCyc

Reference/ChemSpider 180
type: UnificationXref
id: 180
db: ChemSpider

Reference/ChEBI CHEBI 48005
type: UnificationXref
id: CHEBI:48005
db: ChEBI