Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

L-Valine
type: SmallMoleculeReference
xref: Reference/CAS 72-18-4
xref: Reference/PubChem-compound 6287
xref: Reference/ChemSpider 6050
xref: Reference/HMDB HMDB0000883
xref: Reference/KEGG Compound C00183
xref: Reference/ChEBI CHEBI 16414
xref: Reference/BioCyc VAL
chemical formula: C5H11NO2
molecular weight: 117.07898
structure: ChemicalStructure/PW C000704

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ChemicalStructure/PW C000569
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CC(O)=O

Protein/50054/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetolactate synthase
stoichiometric coefficient: 2.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChEBI CHEBI 28484
type: UnificationXref
id: CHEBI:28484
db: ChEBI

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Ketol-acid reductoisomerase (NADP(+))
type: Protein
entity reference: Ketol-acid reductoisomerase (NADP(+))

Compound/PW C007699 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-2,3-Dihydroxy-isovalerate
stoichiometric coefficient: 1.0

Dihydroxy-acid dehydratase
type: ProteinReference
xref: Reference/UniProt F3QKB6
organism: Parasutterella excrementihominis YIT 11859

branched-chain-amino-acid transaminase
type: ProteinReference
xref: Reference/UniProt F3QNE6

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/PubChem-compound 6287
type: UnificationXref
id: 6287
db: PubChem-compound

Protein/30044 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydroxy-acid dehydratase
stoichiometric coefficient: 2.0

Compound/PW C000704 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Valine
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

SubPathwayInteraction399596
type: Interaction
name: SubPathway399596Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ChemicalStructure/PW C002974
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)[C@](C)(O)C(O)=O

branched-chain-amino-acid transaminase
type: Protein
entity reference: branched-chain-amino-acid transaminase

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 18409
type: UnificationXref
id: CHEBI:18409
db: ChEBI

L-Valine
type: SmallMolecule
entity reference: L-Valine

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

(R)-2,3-Dihydroxy-isovalerate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440279
xref: Reference/ChEBI CHEBI 15684
xref: Reference/KEGG Compound C04272
xref: Reference/HMDB HMDB0012141
xref: Reference/ChemSpider 389255
xref: Reference/BioCyc DIOH-ISOVALERATE
chemical formula: C5H10O4
molecular weight: 134.0579
structure: ChemicalStructure/PW C007699

Reference/PubChem-compound 440279
type: UnificationXref
id: 440279
db: PubChem-compound

(R)-2,3-Dihydroxy-isovalerate
type: SmallMolecule
entity reference: (R)-2,3-Dihydroxy-isovalerate

L-Valine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Valine

NADP
type: SmallMolecule
entity reference: NADP

Reference/KEGG Compound C04272
type: UnificationXref
id: C04272
db: KEGG Compound

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Protein/50053/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetolactate synthase small subunit
stoichiometric coefficient: 2.0

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PathWhiz PW000785
type: UnificationXref
id: PW000785
db: PathWhiz

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000704 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Valine
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/ChemSpider 6050
type: UnificationXref
id: 6050
db: ChemSpider

ChemicalStructure/PW C007699
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(O)[C@@H](O)C(O)=O

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Glycolysis and Pyruvate Dehydrogenase
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway399596
pathway component: SubPathwayInteraction399596
xref: Reference/PathWhiz PW000785
xref: Reference/SMPDB SMP0000807
name: SubPathway

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid
name: SubPathwayOutput

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/SMPDB SMP0394606
type: UnificationXref
id: SMP0394606
db: SMPDB

L-Valine
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Valine

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: Reference/UniProt F3QGK2

Protein/47836/Stoichiometry/6.0
type: Stoichiometry
physical entity: branched-chain-amino-acid transaminase
stoichiometric coefficient: 6.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt F3QI24
type: UnificationXref
id: F3QI24
db: UniProt

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/PubChem-compound 440878
type: UnificationXref
id: 440878
db: PubChem-compound

Protein/50052/Stoichiometry/2.0
type: Stoichiometry
physical entity: Putative molybdate ABC transporter, permease protein
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/BioCyc DIOH-ISOVALERATE
type: UnificationXref
id: DIOH-ISOVALERATE
db: BioCyc

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/KEGG Compound C06010
type: UnificationXref
id: C06010
db: KEGG Compound

Compound/PW C000704/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Valine
stoichiometric coefficient: 1.0

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15684
type: UnificationXref
id: CHEBI:15684
db: ChEBI

(R)-2,3-Dihydroxy-isovalerate
type: SmallMolecule
cellular location: Cytosol
entity reference: (R)-2,3-Dihydroxy-isovalerate

Compound/PW C002974/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-2-Acetolactate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16414
type: UnificationXref
id: CHEBI:16414
db: ChEBI

Reference/SMPDB SMP0000807
type: UnificationXref
id: SMP0000807
db: SMPDB

4.2.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007699 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000569 Cytosol/Stoichiometry/1.0
right: Isovaleric acid
right: Water
spontaneous: false
EC number: 4.2.1.9
left: (R)-2,3-Dihydroxy-isovalerate
name: (R)-2,3-Dihydroxy-isovalerate → Isovaleric acid + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

L-valine efflux transporter
type: Complex
component: Efflux pump membrane transporter
component: Putative azaleucine resistance protein AzlC

Dihydroxy-acid dehydratase
type: Protein
cellular location: Cytosol
entity reference: Dihydroxy-acid dehydratase

Reference/TAXONOMY 762966
type: UnificationXref
id: 762966
db: TAXONOMY

(S)-2-Acetolactate
type: SmallMoleculeReference
xref: Reference/ChemSpider 389710
xref: Reference/HMDB HMDB0006855
xref: Reference/KEGG Compound C06010
xref: Reference/ChEBI CHEBI 18409
xref: Reference/PubChem-compound 440878
chemical formula: C5H8O4
molecular weight: 132.04225
structure: ChemicalStructure/PW C002974

Valine Transaminase
type: Complex
component stoichiometry: Protein/47836/Stoichiometry/6.0
component: branched-chain-amino-acid transaminase

acetohydroxybutanoate synthase / acetolactate synthase
type: Complex
component stoichiometry: Protein/50054/Stoichiometry/2.0
component stoichiometry: Protein/50053/Stoichiometry/2.0
component: Acetolactate synthase small subunit
component: Acetolactate synthase

acetolactate synthase / acetohydroxybutanoate synthase
type: Complex
component stoichiometry: Protein/50052/Stoichiometry/2.0
component stoichiometry: Protein/50053/Stoichiometry/2.0
component: Putative molybdate ABC transporter, permease protein
component: Acetolactate synthase small subunit

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Isovaleric acid
type: SmallMolecule
entity reference: Isovaleric acid

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Parasutterella excrementihominis YIT 11859
type: BioSource
xref: Reference/TAXONOMY 762966

Putative molybdate ABC transporter, permease protein
type: Protein
entity reference: Putative molybdate ABC transporter, permease protein

Acetolactate synthase small subunit
type: Protein
entity reference: Acetolactate synthase small subunit

Acetolactate synthase
type: Protein
entity reference: Acetolactate synthase

Efflux pump membrane transporter
type: Protein
entity reference: Efflux pump membrane transporter

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Putative azaleucine resistance protein AzlC
type: Protein
entity reference: Putative azaleucine resistance protein AzlC

(S)-2-Acetolactate
type: SmallMolecule
entity reference: (S)-2-Acetolactate

ChemicalStructure/PW C000704
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)[C@H](N)C(O)=O

Reference/CAS 72-18-4
type: UnificationXref
id: 72-18-4
db: CAS

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00183
type: UnificationXref
id: C00183
db: KEGG Compound

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C000569 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isovaleric acid
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/ChemSpider 389710
type: UnificationXref
id: 389710
db: ChemSpider

Reaction698569
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002974/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007699/Stoichiometry/1.0
right: (R)-2,3-Dihydroxy-isovalerate
right: NADP
spontaneous: false
left: Hydrogen Ion
left: NADPH
left: (S)-2-Acetolactate
name: (S)-2-Acetolactate + Hydrogen Ion + NADPH → (R)-2,3-Dihydroxy-isovalerate + NADP
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW404841
type: UnificationXref
id: PW404841
db: PathWhiz

Reaction698568
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000704/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000569/Stoichiometry/1.0
right: L-Valine
right: Oxoglutaric acid
spontaneous: false
left: L-Glutamic acid
left: Isovaleric acid
name: Isovaleric acid + L-Glutamic acid → L-Valine + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

acetohydroxy acid isomeroreductase
type: Complex
component stoichiometry: Protein/30039/Stoichiometry/4.0
component: Ketol-acid reductoisomerase (NADP(+))

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

2.2.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002974/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Carbon dioxide
right: (S)-2-Acetolactate
spontaneous: false
EC number: 2.2.1.6
left: Hydrogen Ion
left: Pyruvic acid
name: Hydrogen Ion + 2 Pyruvic acid → (S)-2-Acetolactate + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Putative molybdate ABC transporter, permease protein
type: ProteinReference
xref: Reference/UniProt F3QGV9

2.2.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002974/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Carbon dioxide
right: (S)-2-Acetolactate
spontaneous: false
EC number: 2.2.1.6
left: Hydrogen Ion
left: Pyruvic acid
name: Hydrogen Ion + 2 Pyruvic acid → (S)-2-Acetolactate + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/UniProt F3QGK4
type: UnificationXref
id: F3QGK4
db: UniProt

Acetolactate synthase
type: ProteinReference
xref: Reference/UniProt F3QGK4

Reference/UniProt F3QGK2
type: UnificationXref
id: F3QGK2
db: UniProt

Acetolactate synthase small subunit
type: ProteinReference
xref: Reference/UniProt F3QGK3

Reference/UniProt F3QGK3
type: UnificationXref
id: F3QGK3
db: UniProt

Reference/HMDB HMDB0000718
type: UnificationXref
id: HMDB0000718
db: HMDB

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0012141
type: UnificationXref
id: HMDB0012141
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Putative azaleucine resistance protein AzlC
type: ProteinReference
xref: Reference/UniProt F3QNB0

Efflux pump membrane transporter
type: ProteinReference
xref: Reference/UniProt F3QI24

Reference/UniProt F3QKB6
type: UnificationXref
id: F3QKB6
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Valine Biosynthesis
type: Pathway
pathway order: PathwaySubPathway/399596
pathway order: PathwayEnzymeReaction/5742337
pathway order: PathwayEnzymeReaction/5742338
pathway order: PathwayTransport/5742343
pathway order: PathwayEnzymeReaction/5742339
pathway order: PathwayEnzymeReaction/5742340
pathway order: PathwayEnzymeReaction/5742341
pathway component: ReactionCatalysis696562
pathway component: Glycolysis and Pyruvate Dehydrogenase
pathway component: ReactionCatalysis696564
pathway component: ReactionCatalysis696563
pathway component: Reaction698569
pathway component: Reaction698568
pathway component: ReactionCatalysis696566
pathway component: 2.2.1.6
pathway component: ReactionCatalysis696565
pathway component: TransportCatalysis35686
pathway component: 4.2.1.9
pathway component: Transport54649
xref: Reference/PathWhiz PW404841
xref: Reference/SMPDB SMP0394606
organism: Parasutterella excrementihominis YIT 11859

Reference/UniProt F3QGV9
type: UnificationXref
id: F3QGV9
db: UniProt

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000164/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Reference/ChemSpider 10001
type: UnificationXref
id: 10001
db: ChemSpider

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Protein/30039/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ketol-acid reductoisomerase (NADP(+))
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/PubChem-compound 10430
type: UnificationXref
id: 10430
db: PubChem-compound

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

TransportCatalysis35686
type: Catalysis
controller: L-valine efflux transporter
controlled: Transport54649
control type: ACTIVATION

Reference/ChemSpider 389255
type: UnificationXref
id: 389255
db: ChemSpider

Reference/BioCyc VAL
type: UnificationXref
id: VAL
db: BioCyc

Reference/UniProt F3QNB0
type: UnificationXref
id: F3QNB0
db: UniProt

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ReactionCatalysis696562
type: Catalysis
controller: acetolactate synthase / acetohydroxybutanoate synthase
controlled: 2.2.1.6
control type: ACTIVATION

Isovaleric acid
type: SmallMoleculeReference
xref: Reference/CAS 503-74-2
xref: Reference/PubChem-compound 10430
xref: Reference/KEGG Compound C08262
xref: Reference/ChemSpider 10001
xref: Reference/HMDB HMDB0000718
xref: Reference/ChEBI CHEBI 28484
chemical formula: C5H10O2
molecular weight: 102.06808
structure: ChemicalStructure/PW C000569

ReactionCatalysis696564
type: Catalysis
controller: Valine Transaminase
controlled: Reaction698568
control type: ACTIVATION

ReactionCatalysis696563
type: Catalysis
controller: acetohydroxybutanoate synthase / acetolactate synthase
controlled: 2.2.1.6
control type: ACTIVATION

ReactionCatalysis696566
type: Catalysis
controller: dihydroxy acid dehydratase
controlled: 4.2.1.9
control type: ACTIVATION

ReactionCatalysis696565
type: Catalysis
controller: acetohydroxy acid isomeroreductase
controlled: Reaction698569
control type: ACTIVATION

Transport54649
type: Transport
participant stoichiometry: Compound/PW C000704 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000704 Cytosol/Stoichiometry/1.0
right: L-Valine
spontaneous: false
left: L-Valine
name: L-Valine (→) Transport: Parasutterella excrementihominis YIT 11859, Cytosol to Parasutterella excrementihominis YIT 11859, Periplasmic Space
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/HMDB HMDB0006855
type: UnificationXref
id: HMDB0006855
db: HMDB

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/KEGG Compound C08262
type: UnificationXref
id: C08262
db: KEGG Compound

Reference/UniProt F3QNE6
type: UnificationXref
id: F3QNE6
db: UniProt

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/CAS 503-74-2
type: UnificationXref
id: 503-74-2
db: CAS

Isovaleric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Isovaleric acid

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000569/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isovaleric acid
stoichiometric coefficient: 1.0

Compound/PW C007699/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-2,3-Dihydroxy-isovalerate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000883
type: UnificationXref
id: HMDB0000883
db: HMDB

dihydroxy acid dehydratase
type: Complex
component stoichiometry: Protein/30044 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dihydroxy-acid dehydratase