Reference/CAS 454-29-5
type: UnificationXref
id: 454-29-5
db: CAS

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Protein/28262/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

N5-methyl--tetrahydropteroyl tri-L-glutamate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58207
chemical formula: C30H35N9O12
molecular weight: 713.24274
structure: ChemicalStructure/PW C042907

Succinic acid
type: SmallMolecule
entity reference: Succinic acid

Reference/KEGG Compound C05330
type: UnificationXref
id: C05330
db: KEGG Compound

ReactionCatalysis789491
type: Catalysis
controller: Unknown
controlled: 2.1.1.14
control type: ACTIVATION

ChemicalStructure/PW C000570
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCO)C(O)=O

Reference/ChEBI CHEBI 58207
type: UnificationXref
id: CHEBI:58207
db: ChEBI

Reference/ChEBI CHEBI 58020
type: UnificationXref
id: CHEBI:58020
db: ChEBI

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000099
type: UnificationXref
id: HMDB0000099
db: HMDB

ChemicalStructure/PW C019513
type: ChemicalStructure
structure format: SMILES
structure data: C[S+](C)CCC(N)C(O)=O

Reference/KEGG Compound C00441
type: UnificationXref
id: C00441
db: KEGG Compound

Reference/ChEBI CHEBI 17230
type: UnificationXref
id: CHEBI:17230
db: ChEBI

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Escherichia coli APEC O1
type: BioSource
xref: Reference/TAXONOMY 405955

Reference/PubChem-compound 49791978
type: UnificationXref
id: 49791978
db: PubChem-compound

ChemicalStructure/PW C040921
type: ChemicalStructure
structure format: SMILES
structure data: NC(=C)C([O-])=O

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ChemicalStructure/PW C040920
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

ChemicalStructure/PW C040924
type: ChemicalStructure
structure format: SMILES

L-Methionine
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Methionine

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/KEGG Compound C04144
type: UnificationXref
id: C04144
db: KEGG Compound

Reference/BioCyc L-CYSTATHIONINE
type: UnificationXref
id: L-CYSTATHIONINE
db: BioCyc

Compound/PW C000067/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cystathionine
stoichiometric coefficient: 1.0

Compound/PW C000548 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Compound/PW C000448/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Tetrahydropteroyltri-L-glutamate
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydropteroyltri-L-glutamate

ReactionCatalysis789488
type: Catalysis
controller: Unknown
controlled: 2.1.1.10
control type: ACTIVATION

ReactionCatalysis789487
type: Catalysis
controller: aspartate kinase / homoserine dehydrogenase
controlled: 2.7.2.4
control type: ACTIVATION

NADPH
type: SmallMolecule
entity reference: NADPH

ReactionCatalysis789489
type: Catalysis
controller: Unknown
controlled: 2.1.1.13
control type: ACTIVATION

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis789484
type: Catalysis
controller: O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase
controlled: 2.5.1.48
control type: ACTIVATION

ReactionCatalysis789483
type: Catalysis
controller: homoserine O-succinyltransferase
controlled: 2.3.1.46
control type: ACTIVATION

ReactionCatalysis789486
type: Catalysis
controller: cystathionine-β-lyase / L-cysteine desulfhydrase
controlled: 4.4.1.8
control type: ACTIVATION

NADP
type: SmallMolecule
entity reference: NADP

Reference/CAS 13065-25-3
type: UnificationXref
id: 13065-25-3
db: CAS

ReactionCatalysis789485
type: Catalysis
controller: bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon
controlled: 4.4.1.8
control type: ACTIVATION

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/ChEBI CHEBI 58140
type: UnificationXref
id: CHEBI:58140
db: ChEBI

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/SMPDB SMP0000794
type: UnificationXref
id: SMP0000794
db: SMPDB

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

O-succinyl-L-homoserine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16160
chemical formula: C8H13NO6
molecular weight: 219.07428
structure: ChemicalStructure/PW C040920

2-aminoprop-2-enoate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58020
chemical formula: C3H4NO2
molecular weight: 86.02475
structure: ChemicalStructure/PW C040921

Reference/CAS 672-15-1
type: UnificationXref
id: 672-15-1
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

N5-methyl--tetrahydropteroyl tri-L-glutamate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58140
chemical formula: C30H35N9O12
molecular weight: 713.24274
structure: ChemicalStructure/PW C040924

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C019513/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Methylmethionine
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000771
type: UnificationXref
id: PW000771
db: PathWhiz

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/PubChem-compound 16722112
type: UnificationXref
id: 16722112
db: PubChem-compound

Tetrahydropteroyltri-L-glutamate
type: SmallMoleculeReference
xref: Reference/ChemSpider 17625690
xref: Reference/KEGG Compound C04144
xref: Reference/HMDB HMDB0012290
xref: Reference/BioCyc CPD-1302
xref: Reference/PubChem-compound 16722112
xref: Reference/ChEBI CHEBI 17420
chemical formula: C29H37N9O12
molecular weight: 703.25616
structure: ChemicalStructure/PW C007828

Compound/PW C040924 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N5-methyl--tetrahydropteroyl tri-L-glutamate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/ChemSpider 445
type: UnificationXref
id: 445
db: ChemSpider

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/ChEBI CHEBI 17482
type: UnificationXref
id: CHEBI:17482
db: ChEBI

Compound/PW C000590/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

Compound/PW C007828 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydropteroyltri-L-glutamate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Homocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: Homocysteine

Compound/PW C000570/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Homoserine
stoichiometric coefficient: 1.0

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

ChemicalStructure/PW C000590
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCS)C(O)=O

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Reference/ChemSpider 12126
type: UnificationXref
id: 12126
db: ChemSpider

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/PubChem-compound 458
type: UnificationXref
id: 458
db: PubChem-compound

Reference/BioCyc CPD-1302
type: UnificationXref
id: CPD-1302
db: BioCyc

Reference/ChEBI CHEBI 16160
type: UnificationXref
id: CHEBI:16160
db: ChEBI

Reference/KEGG Compound C00263
type: UnificationXref
id: C00263
db: KEGG Compound

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/CAS 56-88-2
type: UnificationXref
id: 56-88-2
db: CAS

Compound/PW C007794/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartate-semialdehyde
stoichiometric coefficient: 1.0

L-Cystathionine
type: SmallMolecule
entity reference: L-Cystathionine

ChemicalStructure/PW C007794
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC=O)C(O)=O

L-Cystathionine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C02291
xref: Reference/BioCyc L-CYSTATHIONINE
xref: Reference/PubChem-compound 25243997
xref: Reference/ChEBI CHEBI 17482
xref: Reference/ChemSpider 388392
xref: Reference/CAS 56-88-2
xref: Reference/HMDB HMDB0000099
chemical formula: C7H14N2O4S
molecular weight: 222.06743
structure: ChemicalStructure/PW C000067

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

S-Methylmethionine
type: SmallMolecule
entity reference: S-Methylmethionine

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Compound/PW C040920/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-succinyl-L-homoserine
stoichiometric coefficient: 1.0

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

L-Homoserine
type: SmallMolecule
entity reference: L-Homoserine

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Lysine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway414522
pathway component: SubPathwayInteraction414522
xref: Reference/PathWhiz PW000771
xref: Reference/SMPDB SMP0000794
name: SubPathway

Reference/ChEBI CHEBI 15699
type: UnificationXref
id: CHEBI:15699
db: ChEBI

Reference/HMDB HMDB0012249
type: UnificationXref
id: HMDB0012249
db: HMDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

N5-methyl--tetrahydropteroyl tri-L-glutamate
type: SmallMolecule
cellular location: Cytosol
entity reference: N5-methyl--tetrahydropteroyl tri-L-glutamate

L-Cysteine
type: SmallMolecule
entity reference: L-Cysteine

Compound/PW C000808/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Compound/PW C040921/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-aminoprop-2-enoate
stoichiometric coefficient: 1.0

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C000548/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000067
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O

Transport53160
type: Transport
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Periplasmic Space/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Methionine
spontaneous: false
left: Hydrogen Ion
left: L-Methionine
name: L-Methionine (→), Hydrogen Ion (←) Transport: Escherichia coli APEC O1, Cytosol to Escherichia coli APEC O1, Periplasmic Space
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

N5-methyl--tetrahydropteroyl tri-L-glutamate
type: SmallMolecule
cellular location: Cytosol
entity reference: N5-methyl--tetrahydropteroyl tri-L-glutamate

Reference/PubChem-compound 12647
type: UnificationXref
id: 12647
db: PubChem-compound

Reference/PathWhiz PW415043
type: UnificationXref
id: PW415043
db: PathWhiz

Reference/ChemSpider 17625690
type: UnificationXref
id: 17625690
db: ChemSpider

TransportCatalysis34351
type: Catalysis
controller: Unknown
controlled: Transport53160
control type: ACTIVATION

L-Aspartate-semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartate-semialdehyde
name: SubPathwayOutput

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Unknown
type: ProteinReference

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0403630
type: UnificationXref
id: SMP0403630
db: SMPDB

O-succinyl-L-homoserine
type: SmallMolecule
entity reference: O-succinyl-L-homoserine

2-aminoprop-2-enoate
type: SmallMolecule
entity reference: 2-aminoprop-2-enoate

L-Methionine
type: SmallMolecule
entity reference: L-Methionine

Reference/HMDB HMDB0000719
type: UnificationXref
id: HMDB0000719
db: HMDB

SubPathwayInteraction414522
type: Interaction
name: SubPathway414522Reaction
name: SubPathwayReaction
participant: L-Aspartate-semialdehyde

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Compound/PW C042907 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N5-methyl--tetrahydropteroyl tri-L-glutamate
stoichiometric coefficient: 1.0

Protein/28262/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Compound/PW C000174/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 388392
type: UnificationXref
id: 388392
db: ChemSpider

Reference/ChEBI CHEBI 17420
type: UnificationXref
id: CHEBI:17420
db: ChEBI

L-Methionine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Methionine

Reference/PubChem-compound 439235
type: UnificationXref
id: 439235
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

cystathionine-β-lyase / L-cysteine desulfhydrase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/4.0
component: Unknown

aspartate kinase / homoserine dehydrogenase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/2.0
component: Unknown

Reference/CAS 15106-57-7
type: UnificationXref
id: 15106-57-7
db: CAS

bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/2.0
component: Unknown

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/4.0
component: Unknown

Homocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05330
xref: Reference/CAS 454-29-5
xref: Reference/HMDB HMDB0000742
xref: Reference/ChEBI CHEBI 17230
xref: Reference/ChemSpider 757
xref: Reference/PubChem-compound 49791978
xref: Reference/BioCyc HOMO-CYS
chemical formula: C4H9NO2S
molecular weight: 135.0354
structure: ChemicalStructure/PW C000590

homoserine O-succinyltransferase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/2.0
component: Unknown

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Succinyl-CoA
type: SmallMolecule
entity reference: Succinyl-CoA

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000590 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

Reference/BioCyc HOMO-CYS
type: UnificationXref
id: HOMO-CYS
db: BioCyc

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/HMDB HMDB0000742
type: UnificationXref
id: HMDB0000742
db: HMDB

L-Aspartate-semialdehyde
type: SmallMolecule
entity reference: L-Aspartate-semialdehyde

L-Aspartate-semialdehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439235
xref: Reference/HMDB HMDB0012249
xref: Reference/ChEBI CHEBI 18051
xref: Reference/KEGG Compound C00441
xref: Reference/ChemSpider 388372
xref: Reference/CAS 15106-57-7
xref: Reference/BioCyc L-ASPARTATE-SEMIALDEHYDE
chemical formula: C4H7NO3
molecular weight: 117.042595
structure: ChemicalStructure/PW C007794

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 25243997
type: UnificationXref
id: 25243997
db: PubChem-compound

Reference/ChemSpider 388372
type: UnificationXref
id: 388372
db: ChemSpider

ChemicalStructure/PW C042907
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/ChemSpider 757
type: UnificationXref
id: 757
db: ChemSpider

Reference/BioCyc L-ASPARTATE-SEMIALDEHYDE
type: UnificationXref
id: L-ASPARTATE-SEMIALDEHYDE
db: BioCyc

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc HOMO-SER
type: UnificationXref
id: HOMO-SER
db: BioCyc

Homocysteine
type: SmallMolecule
entity reference: Homocysteine

Reference/TAXONOMY 405955
type: UnificationXref
id: 405955
db: TAXONOMY

Reference/ChEBI CHEBI 18051
type: UnificationXref
id: CHEBI:18051
db: ChEBI

Reference/HMDB HMDB0012290
type: UnificationXref
id: HMDB0012290
db: HMDB

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

L-Homoserine
type: SmallMoleculeReference
xref: Reference/BioCyc HOMO-SER
xref: Reference/ChEBI CHEBI 15699
xref: Reference/CAS 672-15-1
xref: Reference/KEGG Compound C00263
xref: Reference/PubChem-compound 12647
xref: Reference/HMDB HMDB0000719
xref: Reference/ChemSpider 12126
chemical formula: C4H9NO3
molecular weight: 119.05824
structure: ChemicalStructure/PW C000570

S-Methylmethionine
type: SmallMoleculeReference
xref: Reference/ChemSpider 445
xref: Reference/HMDB HMDB0038670
xref: Reference/CAS 13065-25-3
xref: Reference/PubChem-compound 458
chemical formula: C6H14NO2S
molecular weight: 164.07452
structure: ChemicalStructure/PW C019513

Compound/PW C000548 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0038670
type: UnificationXref
id: HMDB0038670
db: HMDB

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

ChemicalStructure/PW C007828
type: ChemicalStructure
structure format: SMILES

2.1.1.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000590/Stoichiometry/1.0
participant stoichiometry: Compound/PW C019513/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Methionine
spontaneous: false
EC number: 2.1.1.10
left: S-Methylmethionine
left: Homocysteine
name: Homocysteine + S-Methylmethionine ↔ Hydrogen Ion + 2 L-Methionine
conversion direction: REVERSIBLE

Methionine Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/5894533
pathway order: PathwayEnzymeReaction/5894534
pathway order: PathwayEnzymeReaction/5894535
pathway order: PathwayEnzymeReaction/5894536
pathway order: PathwaySubPathway/414522
pathway order: PathwayEnzymeReaction/5894537
pathway order: PathwayEnzymeReaction/5894538
pathway order: PathwayEnzymeReaction/5894539
pathway order: PathwayTransport/5894541
pathway order: PathwayEnzymeReaction/5894540
pathway component: ReactionCatalysis789488
pathway component: ReactionCatalysis789487
pathway component: ReactionCatalysis789489
pathway component: 2.1.1.10
pathway component: 2.1.1.13
pathway component: 2.1.1.14
pathway component: ReactionCatalysis789491
pathway component: TransportCatalysis34351
pathway component: 2.3.1.46
pathway component: ReactionCatalysis789484
pathway component: ReactionCatalysis789483
pathway component: 2.5.1.48
pathway component: 4.4.1.8
pathway component: ReactionCatalysis789486
pathway component: ReactionCatalysis789485
pathway component: 2.7.2.4
pathway component: Transport53160
pathway component: Lysine Biosynthesis
xref: Reference/SMPDB SMP0403630
xref: Reference/PathWhiz PW415043
organism: Escherichia coli APEC O1

2.1.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042907 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007828 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Tetrahydropteroyltri-L-glutamate
right: L-Methionine
spontaneous: false
EC number: 2.1.1.13
left: N5-methyl--tetrahydropteroyl tri-L-glutamate
left: Homocysteine
name: Homocysteine + N5-methyl--tetrahydropteroyl tri-L-glutamate → L-Methionine + Tetrahydropteroyltri-L-glutamate
conversion direction: LEFT_TO_RIGHT

2.1.1.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007828 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040924 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Tetrahydropteroyltri-L-glutamate
right: L-Methionine
spontaneous: false
EC number: 2.1.1.14
left: N5-methyl--tetrahydropteroyl tri-L-glutamate
left: Homocysteine
name: N5-methyl--tetrahydropteroyl tri-L-glutamate + Homocysteine → L-Methionine + Tetrahydropteroyltri-L-glutamate
conversion direction: LEFT_TO_RIGHT

2.3.1.46
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040920/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
right: Coenzyme A
right: O-succinyl-L-homoserine
spontaneous: false
EC number: 2.3.1.46
left: L-Homoserine
left: Succinyl-CoA
name: L-Homoserine + Succinyl-CoA → Coenzyme A + O-succinyl-L-homoserine
conversion direction: LEFT_TO_RIGHT

2.5.1.48
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000448/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040920/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000067/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Succinic acid
right: L-Cystathionine
right: Hydrogen Ion
spontaneous: false
EC number: 2.5.1.48
left: O-succinyl-L-homoserine
left: L-Cysteine
name: L-Cysteine + O-succinyl-L-homoserine → Hydrogen Ion + L-Cystathionine + Succinic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C02291
type: UnificationXref
id: C02291
db: KEGG Compound

4.4.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000067/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Homocysteine
right: Hydrogen Ion
right: 2-aminoprop-2-enoate
spontaneous: false
EC number: 4.4.1.8
left: L-Cystathionine
name: L-Cystathionine → 2-aminoprop-2-enoate + Homocysteine + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

2.7.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007794/Stoichiometry/1.0
right: L-Homoserine
right: NADP
spontaneous: false
EC number: 2.7.2.4
left: L-Aspartate-semialdehyde
left: Hydrogen Ion
left: NADPH
name: Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP
conversion direction: LEFT_TO_RIGHT

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS